Lars Pahlman

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. pmc 1p36 deletion is a marker for tumour dissemination in microsatellite stable stage II-III colon cancer
    Markus Mayrhofer
    Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Box 3056, Uppsala 750 03, Sweden
    BMC Cancer 14:872. 2014
  2. pmc Short-course radiotherapy followed by neo-adjuvant chemotherapy in locally advanced rectal cancer--the RAPIDO trial
    Per J Nilsson
    Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Surgical Gastroenterology, Karolinska University Hospital, Solna P9 03, SE 171 76 Stockholm, Sweden
    BMC Cancer 13:279. 2013
  3. pmc Preoperative mechanical preparation of the colon: the patient's experience
    Barbel Jung
    University of Umeå and Department of Surgery, Visby Hospital, Visby Sweden
    BMC Surg 7:5. 2007
  4. pmc Rectal cancer treatment and outcome in the elderly: an audit based on the Swedish Rectal Cancer Registry 1995-2004
    Barbel Jung
    Department of Surgery and Perioperative Sciences, University of Umea, Umea, Sweden
    BMC Cancer 9:68. 2009
  5. ncbi request reprint Division of Coloproctology (UEMS)
    Lars Pahlman
    Chairman, Division of Coloproctology, Professor of Surgery, Uppsala, Sweden
    Colorectal Dis 8:616-7. 2006
  6. ncbi request reprint ESCP Report. Division of Coloproctology (UEMS) (2007)
    Lars Pahlman
    Division of Coloproctology, Uppsala, Sweden
    Colorectal Dis 9:663-4. 2007
  7. ncbi request reprint Preoperative radiotherapy in rectal cancers: why a standard in Europe and not in the US?
    Lars Pahlman
    Colorectal Unit, Department of Surgery, University Hospital, Uppsala, Sweden
    Nat Clin Pract Oncol 1:56-7. 2004
  8. ncbi request reprint Indications for neoadjuvant long-term radiotherapy
    Lars Pahlman
    Department of Surgery, Colorectal Unit, University Hospital, 75185 Uppsala, Sweden
    Recent Results Cancer Res 165:212-20. 2005
  9. ncbi request reprint Teaching efforts to spread TME surgery in Sweden
    Lars Pahlman
    Colorectal Unit, Department of Surgery, University Hospital, 751 85 Uppsala, Sweden
    Recent Results Cancer Res 165:82-5. 2005
  10. doi request reprint Rectal cancer staging: is there an optimal method?
    Lars Pahlman
    Radiology Department of Oncology, Radiology and Clinical Immunology, Section of Radiology, Uppsala University, Uppsala, Sweden
    Future Oncol 7:93-100. 2011

Collaborators

Detail Information

Publications44

  1. pmc 1p36 deletion is a marker for tumour dissemination in microsatellite stable stage II-III colon cancer
    Markus Mayrhofer
    Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Box 3056, Uppsala 750 03, Sweden
    BMC Cancer 14:872. 2014
    ..We investigated 115 selected stage II-IV primary colon cancers for associations between chromosomal alterations and tumour dissemination...
  2. pmc Short-course radiotherapy followed by neo-adjuvant chemotherapy in locally advanced rectal cancer--the RAPIDO trial
    Per J Nilsson
    Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Surgical Gastroenterology, Karolinska University Hospital, Solna P9 03, SE 171 76 Stockholm, Sweden
    BMC Cancer 13:279. 2013
    ..The concept of neo-adjuvant chemotherapy has been proven successful in gastric cancer, hepatic metastases from colorectal cancer and is currently tested in primary colon cancer...
  3. pmc Preoperative mechanical preparation of the colon: the patient's experience
    Barbel Jung
    University of Umeå and Department of Surgery, Visby Hospital, Visby Sweden
    BMC Surg 7:5. 2007
    ..Preoperative mechanical bowel preparation can be questioned as standard procedure in colon surgery, based on the result from several randomised trials...
  4. pmc Rectal cancer treatment and outcome in the elderly: an audit based on the Swedish Rectal Cancer Registry 1995-2004
    Barbel Jung
    Department of Surgery and Perioperative Sciences, University of Umea, Umea, Sweden
    BMC Cancer 9:68. 2009
    ..Limited information is available regarding the effect of age on choice of surgical and oncological treatment for rectal cancer. The objective of this study was to assess the influence of age on treatment and outcome of rectal cancer...
  5. ncbi request reprint Division of Coloproctology (UEMS)
    Lars Pahlman
    Chairman, Division of Coloproctology, Professor of Surgery, Uppsala, Sweden
    Colorectal Dis 8:616-7. 2006
  6. ncbi request reprint ESCP Report. Division of Coloproctology (UEMS) (2007)
    Lars Pahlman
    Division of Coloproctology, Uppsala, Sweden
    Colorectal Dis 9:663-4. 2007
  7. ncbi request reprint Preoperative radiotherapy in rectal cancers: why a standard in Europe and not in the US?
    Lars Pahlman
    Colorectal Unit, Department of Surgery, University Hospital, Uppsala, Sweden
    Nat Clin Pract Oncol 1:56-7. 2004
  8. ncbi request reprint Indications for neoadjuvant long-term radiotherapy
    Lars Pahlman
    Department of Surgery, Colorectal Unit, University Hospital, 75185 Uppsala, Sweden
    Recent Results Cancer Res 165:212-20. 2005
    ..If radiotherapy is considered in the management of a rectal cancer, there is very strong evidence supporting preoperative settings. To avoid treatment to cases where surgery alone is enough, exact preoperative staging with MRI is crucial...
  9. ncbi request reprint Teaching efforts to spread TME surgery in Sweden
    Lars Pahlman
    Colorectal Unit, Department of Surgery, University Hospital, 751 85 Uppsala, Sweden
    Recent Results Cancer Res 165:82-5. 2005
    ..A tremendous change has been seen in our country over the last two decades, and it is in part a result of registration and quality auditing, where the results are displayed to the surgeons...
  10. doi request reprint Rectal cancer staging: is there an optimal method?
    Lars Pahlman
    Radiology Department of Oncology, Radiology and Clinical Immunology, Section of Radiology, Uppsala University, Uppsala, Sweden
    Future Oncol 7:93-100. 2011
    ..This will preferably be done with colonoscopy or CT-colonography and sometimes barium enema. This article discusses the imaging techniques used for local staging and distant metastases...
  11. ncbi request reprint [Too pessimistic view on screening and follow-up of colorectal cancer]
    Lars Pahlman
    Kirurgiska kliniken, Kolorektalsektionen, Akademiska sjukhuset, Uppsala
    Lakartidningen 100:2954. 2003
  12. ncbi request reprint [Radiotherapy in rectal cancer requires careful preoperative investigation. More benefits than risks for the right patients]
    Lars Pahlman
    Kirurgkliniken, Akademiska sjukhuset, Uppsala
    Lakartidningen 104:2314-5. 2007
  13. ncbi request reprint [A working group will present a suggestion concerning screening for colorectal cancer]
    Lars Pahlman
    Kirurgiska kliniken, Akademiska sjukhuset, Uppsala
    Lakartidningen 100:3696. 2003
  14. ncbi request reprint Adverse effects of preoperative radiation therapy for rectal cancer: long-term follow-up of the Swedish Rectal Cancer Trial
    Helgi Birgisson
    Department of Surgery, Akademiska sjukhuset, S 751 85 Uppsala, Sweden
    J Clin Oncol 23:8697-705. 2005
    ..To analyze the occurrence of subacute and late adverse effects in patients treated with preoperative irradiation for rectal cancer...
  15. pmc Microsatellite instability and mutations in BRAF and KRAS are significant predictors of disseminated disease in colon cancer
    Helgi Birgisson
    Department of Surgical Sciences, Colorectal Surgery, Uppsala University, 75185, Uppsala, Sweden
    BMC Cancer 15:125. 2015
    ....
  16. doi request reprint The effect of age and gender on outcome after treatment for colon carcinoma. A population-based study in the Uppsala and Stockholm region
    Barbara L van Leeuwen
    Department of Surgery, University Hospital Uppsala, Sweden
    Crit Rev Oncol Hematol 67:229-36. 2008
    ..The aim of this study was to assess whether there are differences in treatment strategy and outcome between different age cohorts among men and women with colon cancer...
  17. pmc Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa
    Stefan Enroth
    The Linnaeus Centre for Bioinformatics, Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Sweden
    BMC Cancer 11:450. 2011
    ..In order to evaluate their importance in colorectal cancer (CRC), we generated the first genome-wide histone modification profiles in paired normal colon mucosa and tumor samples...
  18. doi request reprint The effects of short-course preoperative irradiation on local recurrence rate and survival in rectal cancer: a population-based nationwide study
    Marit Tiefenthal
    Department of Surgery, Ersta Hospital, Stockholm, Sweden
    Dis Colon Rectum 54:672-80. 2011
    ..Preoperative irradiation with 5 × 5 Gy in randomized trials reduces local recurrence rate and may improve survival in patients with resectable rectal cancer...
  19. doi request reprint The impact of hospital volume on surgical outcome in patients with rectal cancer
    Marit Kressner
    Department of Surgery, Ersta Hospital, Stockholm, Sweden
    Dis Colon Rectum 52:1542-9. 2009
    ..This study was designed to investigate, in a population-based setting, the surgical outcome in patients with rectal cancer according to the hospital volume...
  20. ncbi request reprint Bowel habits in hemorrhoid patients and normal subjects
    Helgi Orn Johannsson
    Department of Surgery, Falun District Hospital, 791 82 Falun, Sweden
    Am J Gastroenterol 100:401-6. 2005
    ..The aim of this study was to compare patients with hemorrhoids with a control population regarding functional bowel symptoms and anorectal complaints...
  21. doi request reprint The prognostic significance of tryptophanyl-tRNA synthetase in colorectal cancer
    Arezo Ghanipour
    Department of Surgery, University of Uppsala, Uppsala, Sweden
    Cancer Epidemiol Biomarkers Prev 18:2949-56. 2009
    ..The aim of this study was to analyze the correlation of TrpRS to the prognosis of patients diagnosed and treated for CRC within a defined population...
  22. ncbi request reprint Adjuvant chemotherapy in colorectal cancer: a joint analysis of randomised trials by the Nordic Gastrointestinal Tumour Adjuvant Therapy Group
    Bengt Glimelius
    Department of Oncology, Radiology and Clinical Immunology, University Hospital, Uppsala, Sweden
    Acta Oncol 44:904-12. 2005
    ..15), favouring chemotherapy, was seen. The present analyses corroborate a small but clinically meaningful survival gain from adjuvant chemotherapy in colon cancer stage III, but not in the other presentations...
  23. ncbi request reprint Septic complications and prognosis after surgery for rectal cancer
    Ulf Kressner
    Department of Surgery, University Hospital, University of Uppsala, Sweden
    Dis Colon Rectum 45:316-21. 2002
    ..This study was performed to investigate whether an abdominal or perineal septic complication was associated with rectal cancer recurrence...
  24. ncbi request reprint Occurrence of second cancers in patients treated with radiotherapy for rectal cancer
    Helgi Birgisson
    Department of Surgery, Akademiska sjukhuset, S 751 85 Uppsala, Sweden
    J Clin Oncol 23:6126-31. 2005
    ..To analyze the occurrence of second cancers in patients with rectal cancer treated with external radiotherapy (RT) in addition to surgery...
  25. ncbi request reprint Swedish Rectal Cancer Trial: long lasting benefits from radiotherapy on survival and local recurrence rate
    Joakim Folkesson
    Department of Surgical Sciences and Oncology, Uppsala University Hospital, 751 85 Uppsala, Sweden
    J Clin Oncol 23:5644-50. 2005
    ..To evaluate the long-term effects on survival and recurrence rates of preoperative radiotherapy in the treatment of curatively operated rectal cancer patients...
  26. doi request reprint The correlation between a family history of colorectal cancer and survival of patients with colorectal cancer
    Helgi Birgisson
    Centre for Clinical Research, Uppsala University, Central Hospital, Vasteras, Sweden
    Fam Cancer 8:555-61. 2009
    ..The value of family history taking in patients with colon cancer is therefore not only to identify families with hereditary colorectal cancer, but also to add information to the prognosis of the patients...
  27. ncbi request reprint Late adverse effects of radiation therapy for rectal cancer - a systematic overview
    Helgi Birgisson
    Department of Surgery, University Hospital, University of Uppsala, Uppsala, Sweden
    Acta Oncol 46:504-16. 2007
    ..Despite these benefits, the adverse effects of radiation therapy limit its use. The aim of this review was to present a comprehensive overview of published studies on late adverse effects related to the RT for rectal cancer...
  28. doi request reprint Can DNA sampling from the rectal mucosa be a novel tool for the detection of colorectal cancer?
    Ulrik Wallin
    Department of Surgery, Akademiska sjukhuset, 75185 Uppsala, Sweden
    Int J Colorectal Dis 25:1071-8. 2010
    ..The objective was to evaluate a new method for DNA sampling from the rectal mucosa for the detection of colorectal cancer or any clinically significant pathology in the colon and rectum...
  29. doi request reprint Rectal cancer survival in the Nordic countries and Scotland
    Joakim Folkesson
    Department of Surgery, Uppsala University Hospital, Uppsala, Sweden
    Int J Cancer 125:2406-12. 2009
    ..The study emphasizes the need for high quality and detailed data in order to understand international survival differences, and cautions comparisons between large national samples and those of smaller areas...
  30. ncbi request reprint Short-course preoperative radiotherapy with delayed surgery in rectal cancer - a retrospective study
    Calin Radu
    Department of Oncology, Radiology and Clinical Immunology, Uppsala University Hospital, Upssala, Sweden
    Radiother Oncol 87:343-9. 2008
    ..The aim is to describe our experience of using this approach in patients not eligible for standard treatment...
  31. doi request reprint Microsatellite instability and mutations in BRAF and KRAS are significant predictors of disseminated disease in colon cancer
    Helgi Birgisson
    Department of Surgical Sciences, Colorectal Surgery, Uppsala University, 75185, Uppsala, Sweden
    BMC Cancer 15:1144. 2015
    ....
  32. doi request reprint CT-colonography in the follow-up of acute diverticulitis: patient acceptance and diagnostic accuracy
    Abbas Chabok
    Colorectal Unit, Department of Surgery and Centre for Clinical Research, Uppsala University, Västmanlands Hospital, Vasteras, Sweden
    Scand J Gastroenterol 48:979-86. 2013
    ..The aim of this study was to assess CT-colonography (CTC) in the follow-up of diverticulitis regarding patient acceptance and diagnostic accuracy for diverticular disease, adenomas and cancer, with colonoscopy as a reference standard...
  33. doi request reprint Randomised multicentre trial of circular stapling devices
    Joakim Folkesson
    Department of Surgery, Uppsala University Hospital, 751 85, Uppsala, Sweden
    Int J Colorectal Dis 27:227-32. 2012
    ..Based on those data, a randomised multicentre study was started to explore the risk of an anastomotic leakage based upon the surgical device...
  34. doi request reprint Bowel obstruction after laparoscopic and open colon resection for cancer: results of 5 years of follow-up in a randomized trial
    Johnna Schölin
    Department of Surgery, Område 2, Sahlgrenska University Hospital Ostra, SE 416 85 Goteborg, Sweden
    Surg Endosc 25:3755-60. 2011
    ..This study was designed to compare the incidence of bowel obstruction in a randomized trial where laparoscopic and open resection for colon cancer was compared...
  35. ncbi request reprint Cost-effectiveness of preoperative radiotherapy in rectal cancer: results from the Swedish Rectal Cancer Trial
    Michael Dahlberg
    Department of Surgery, Akademiska sjukhuset, Uppsala, Sweden
    Int J Radiat Oncol Biol Phys 54:654-60. 2002
    ..This has had an impact on the primary treatment of rectal cancer. The current study investigated the cost-effectiveness of the new combined approach...
  36. ncbi request reprint Small-bowel obstruction after restorative proctocolectomy in patients with ulcerative colitis
    Hanna Aberg
    Department of Surgical Sciences, Section of Surgery, University Hospital, 751 85, Uppsala, Sweden
    Int J Colorectal Dis 22:637-42. 2007
    ..The reported risk of small-bowel obstruction (SBO) after major abdominal surgery varies. The aim of this study was to study frequency and risk factors of SBO after ileal pouch-anal anastomosis for ulcerative colitis...
  37. ncbi request reprint Evaluation of the paradoxical sphincter contraction by a strain/squeeze index in constipated patients
    Urban Karlbom
    Department of Surgical Sciences, Section for Surgery, University Hospital, Uppsala, Sweden
    Dis Colon Rectum 48:1923-9. 2005
    ..The aims of this study were to evaluate the importance of needle placement in sphincter-electromyography and to evaluate a strain/squeeze index in constipated patients and control subjects...
  38. ncbi request reprint [Chemoprevention can hardly substitute for screening for colorectal cancer]
    Lars Pahlman
    Akademiska sjukhuset, Uppsala
    Lakartidningen 99:1917. 2002
  39. doi request reprint Functional and structural abnormalities after milligan hemorrhoidectomy: a comparison with healthy subjects
    Helgi Orn Johannsson
    Department of Surgery, Falu Central Hospital, Center for Clinical Research, Falun, Sweden
    Dis Colon Rectum 56:903-8. 2013
    ..Fecal incontinence is a rare but well-known adverse effect of hemorrhoidectomy...
  40. doi request reprint Novel activity of acriflavine against colorectal cancer tumor cells
    Saadia Hassan
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Cancer Sci 102:2206-13. 2011
    ..Mechanistic studies indicated acriflavine to be a dual topoisomerase I and II inhibitor. In conclusion, the strategy used seems promising for identification of new diagnosis-specific cancer drugs...
  41. ncbi request reprint [Burdensome rules for clinical trials are not in proportion to benefits for the patient]
    Anders Vahlquist
    Akademiska sjukhuset, Uppsala
    Lakartidningen 102:1832, 1834; discussion 1834. 2005
  42. ncbi request reprint The accuracy of clinical examination in the diagnosis of rectal intussusception
    Urban Karlbom
    Department of Surgical Sciences, University Hospital, SE 751 85, Uppsala, Sweden
    Dis Colon Rectum 47:1533-8. 2004
    ..This study was designed to compare routine clinical examination and defecography in the diagnosis of rectal intussusception in constipated patients and study relationships between rectal intussusception and symptoms...
  43. ncbi request reprint Histone H3 lysine 27 trimethylation in adult differentiated colon associated to cancer DNA hypermethylation
    Alvaro Rada-Iglesias
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Epigenetics 4:107-13. 2009
    ..Therefore, the suggested polycomb pre-marking of genes for cancer DNA hypermethylation is not necessarily limited to ES or early precursor cells but can occur later in differentiated tissues...
  44. ncbi request reprint Long-term results of haemorrhoidectomy
    Helgi O Jóhannsson
    Department of Surgery, Falu District Hospital, Falun, Sweden
    Eur J Surg 168:485-9. 2002
    ..To assess the long-term functional results of Milligan-Morgan haemorrhoidectomy...