Arunkumar Krishnan

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. pmc Identification of distant Agouti-like sequences and re-evaluation of the evolutionary history of the Agouti-related peptide (AgRP)
    Åke Västermark
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    PLoS ONE 7:e40982. 2012
  2. doi The early origin of melanocortin receptors, agouti-related peptide, agouti signalling peptide, and melanocortin receptor-accessory proteins, with emphasis on pufferfishes, elephant shark, lampreys, and amphioxus
    Åke Västermark
    Department of Neuroscience, BMC, Uppsala University, 751 24 Uppsala, Sweden
    Eur J Pharmacol 660:61-9. 2011
  3. pmc Functional specialization in nucleotide sugar transporters occurred through differentiation of the gene cluster EamA (DUF6) before the radiation of Viridiplantae
    Åke Västermark
    Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, Box 593, 751 24, Uppsala, Sweden
    BMC Evol Biol 11:123. 2011
  4. doi Remarkable similarities between the hemichordate (Saccoglossus kowalevskii) and vertebrate GPCR repertoire
    Arunkumar Krishnan
    Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, Box 593, 751 24 Uppsala, Sweden
    Gene 526:122-33. 2013
  5. doi Evolutionary hierarchy of vertebrate-like heterotrimeric G protein families
    Arunkumar Krishnan
    Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, Box 593, 751 24 Uppsala, Sweden Electronic address
    Mol Phylogenet Evol 91:27-40. 2015
  6. doi Early vertebrate origin of melanocortin 2 receptor accessory proteins (MRAPs)
    Ravisankar Valsalan
    Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC Uppsala, Sweden
    Gen Comp Endocrinol 188:123-32. 2013
  7. pmc Topology based identification and comprehensive classification of four-transmembrane helix containing proteins (4TMs) in the human genome
    Misty M Attwood
    Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, Box 593, 751 24, Uppsala, Sweden
    BMC Genomics 17:268. 2016
  8. pmc The GPCR repertoire in the demosponge Amphimedon queenslandica: insights into the GPCR system at the early divergence of animals
    Arunkumar Krishnan
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Biomedical Center, Box 593, 75 124, Uppsala, Sweden
    BMC Evol Biol 14:270. 2014
  9. pmc Insights into the origin of nematode chemosensory GPCRs: putative orthologs of the Srw family are found across several phyla of protostomes
    Arunkumar Krishnan
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
    PLoS ONE 9:e93048. 2014
  10. pmc The origin of GPCRs: identification of mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in fungi
    Arunkumar Krishnan
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
    PLoS ONE 7:e29817. 2012

Collaborators

Detail Information

Publications12

  1. pmc Identification of distant Agouti-like sequences and re-evaluation of the evolutionary history of the Agouti-related peptide (AgRP)
    Åke Västermark
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    PLoS ONE 7:e40982. 2012
    ....
  2. doi The early origin of melanocortin receptors, agouti-related peptide, agouti signalling peptide, and melanocortin receptor-accessory proteins, with emphasis on pufferfishes, elephant shark, lampreys, and amphioxus
    Åke Västermark
    Department of Neuroscience, BMC, Uppsala University, 751 24 Uppsala, Sweden
    Eur J Pharmacol 660:61-9. 2011
    ..rubripes) has both genes. This study shows that the most ancient presence of these melanocortin-related sequences is found in elephant shark and lampreys considering the current available sequence data...
  3. pmc Functional specialization in nucleotide sugar transporters occurred through differentiation of the gene cluster EamA (DUF6) before the radiation of Viridiplantae
    Åke Västermark
    Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, Box 593, 751 24, Uppsala, Sweden
    BMC Evol Biol 11:123. 2011
    ..We use a method that combines the strengths of hidden Markov models and maximum likelihood to find relationships between drug/metabolite transporter families, and branches within families...
  4. doi Remarkable similarities between the hemichordate (Saccoglossus kowalevskii) and vertebrate GPCR repertoire
    Arunkumar Krishnan
    Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, Box 593, 751 24 Uppsala, Sweden
    Gene 526:122-33. 2013
    ....
  5. doi Evolutionary hierarchy of vertebrate-like heterotrimeric G protein families
    Arunkumar Krishnan
    Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, Box 593, 751 24 Uppsala, Sweden Electronic address
    Mol Phylogenet Evol 91:27-40. 2015
    ..Our robust classification/hierarchy is essential to further understand the differential roles of GPCR/G protein mediated intracellular signaling system across various metazoan lineages. ..
  6. doi Early vertebrate origin of melanocortin 2 receptor accessory proteins (MRAPs)
    Ravisankar Valsalan
    Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC Uppsala, Sweden
    Gen Comp Endocrinol 188:123-32. 2013
    ..An evolutionary rate shift analysis indicated that these genes were under high purifying selection. Overall, this study provides a comprehensive analysis of the evolution and gene repertoire of MRAP and MRAP2...
  7. pmc Topology based identification and comprehensive classification of four-transmembrane helix containing proteins (4TMs) in the human genome
    Misty M Attwood
    Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, Box 593, 751 24, Uppsala, Sweden
    BMC Genomics 17:268. 2016
    ..We functionally characterize this dataset and evaluate the resulting groups and ubiquitous functions, and furthermore describe disease and drug target involvement...
  8. pmc The GPCR repertoire in the demosponge Amphimedon queenslandica: insights into the GPCR system at the early divergence of animals
    Arunkumar Krishnan
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Biomedical Center, Box 593, 75 124, Uppsala, Sweden
    BMC Evol Biol 14:270. 2014
    ..Furthermore, phylogenetic comparisons of sponge GPCRs with eumetazoan and bilaterian GPCRs will be essential to our understanding of the GPCR system at the roots of metazoan evolution...
  9. pmc Insights into the origin of nematode chemosensory GPCRs: putative orthologs of the Srw family are found across several phyla of protostomes
    Arunkumar Krishnan
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
    PLoS ONE 9:e93048. 2014
    ..Overall, this study provides further insights into the evolutionary events that shaped the GPCR chemosensory system in protostome species. ..
  10. pmc The origin of GPCRs: identification of mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in fungi
    Arunkumar Krishnan
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
    PLoS ONE 7:e29817. 2012
    ..Overall, this study provides the first evidence of the presence of four of the five main GRAFS families in Fungi and clarifies the early evolutionary history of the GPCR superfamily...
  11. ncbi Classification, Nomenclature, and Structural Aspects of Adhesion GPCRs
    Arunkumar Krishnan
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Biomedical Center, 593, Uppsala, 75 124, Sweden
    Handb Exp Pharmacol 234:15-41. 2016
    ..Of note, we systematically describe the structural domains in the ECD of aGPCR subfamilies and highlight their role in aGPCR-protein interactions...
  12. doi The role of G protein-coupled receptors in the early evolution of neurotransmission and the nervous system
    Arunkumar Krishnan
    Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, Box 593, 751 24, Uppsala, Sweden
    J Exp Biol 218:562-71. 2015
    ....