Elena Jazin

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. doi request reprint Sex differences in molecular neuroscience: from fruit flies to humans
    Elena Jazin
    Department of Genetics and Development, Evolutionary Biology Centre, Uppsala University, SE 75236, Sweden
    Nat Rev Neurosci 11:9-17. 2010
  2. doi request reprint Support for schizophrenia susceptibility locus on chromosome 2q detected in a Swedish isolate using a dense map of microsatellites and SNPs
    Karolina Aberg
    Department of Evolution, Genomics and Systematics, Uppsala University, Uppsala, Sweden
    Am J Med Genet B Neuropsychiatr Genet 147:1238-44. 2008
  3. pmc Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia
    Karolina Aberg
    Department of Evolution, Genomics and Systematics, Uppsala University, SE 75236 Uppsala, Sweden
    Proc Natl Acad Sci U S A 103:7482-7. 2006
  4. pmc Inflammation-related genes up-regulated in schizophrenia brains
    Peter Saetre
    Department of Development and Genetics, Uppsala University, Sweden
    BMC Psychiatry 7:46. 2007
  5. ncbi request reprint Human QKI, a new candidate gene for schizophrenia involved in myelination
    Karolina Aberg
    Department of Evolution, Genomics and Systematics, Uppsala University, Norbyvagen 18D, 752 36 Uppsala, Sweden
    Am J Med Genet B Neuropsychiatr Genet 141:84-90. 2006
  6. pmc Abundance of female-biased and paucity of male-biased somatically expressed genes on the mouse X-chromosome
    Björn Reinius
    Department of Organismal Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    BMC Genomics 13:607. 2012
  7. doi request reprint RNA-binding protein QKI regulates Glial fibrillary acidic protein expression in human astrocytes
    Katarzyna J Radomska
    Department of Evolution and Development, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Hum Mol Genet 22:1373-82. 2013
  8. pmc Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse
    Björn Reinius
    Department of Evolution and Development, EBC, Uppsala University, Sweden
    BMC Genomics 11:614. 2010
  9. pmc QKI-7 regulates expression of interferon-related genes in human astrocyte glioma cells
    Lin Jiang
    Department of Development and Genetics, Uppsala University, Uppsala, Sweden
    PLoS ONE 5:. 2010
  10. ncbi request reprint From wild wolf to domestic dog: gene expression changes in the brain
    Peter Saetre
    Department of Evolution, Genomics and Systematics, Uppsala University, Norbyvagen 18D, S 752 36 Uppsala, Sweden
    Brain Res Mol Brain Res 126:198-206. 2004

Collaborators

Detail Information

Publications21

  1. doi request reprint Sex differences in molecular neuroscience: from fruit flies to humans
    Elena Jazin
    Department of Genetics and Development, Evolutionary Biology Centre, Uppsala University, SE 75236, Sweden
    Nat Rev Neurosci 11:9-17. 2010
    ..The overriding conclusion is that, as for neuroscience in general, molecular neuroscience has to take into account potential sex influences that might modify signalling pathways...
  2. doi request reprint Support for schizophrenia susceptibility locus on chromosome 2q detected in a Swedish isolate using a dense map of microsatellites and SNPs
    Karolina Aberg
    Department of Evolution, Genomics and Systematics, Uppsala University, Uppsala, Sweden
    Am J Med Genet B Neuropsychiatr Genet 147:1238-44. 2008
    ..Haplotype sharing in families helped to delimit the detected regions that potentially are susceptibility loci for schizophrenia...
  3. pmc Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia
    Karolina Aberg
    Department of Evolution, Genomics and Systematics, Uppsala University, SE 75236 Uppsala, Sweden
    Proc Natl Acad Sci U S A 103:7482-7. 2006
    ..Moreover, we hypothesize that previously observed decreased activity of myelin-related genes in schizophrenia might be caused by disturbed QKI splicing...
  4. pmc Inflammation-related genes up-regulated in schizophrenia brains
    Peter Saetre
    Department of Development and Genetics, Uppsala University, Sweden
    BMC Psychiatry 7:46. 2007
    ..However, disentangling disease effects from alterations caused by medication is a challenging task. The main goal of this study is to find transcriptional alterations in schizophrenia that are independent of neuroleptic treatment...
  5. ncbi request reprint Human QKI, a new candidate gene for schizophrenia involved in myelination
    Karolina Aberg
    Department of Evolution, Genomics and Systematics, Uppsala University, Norbyvagen 18D, 752 36 Uppsala, Sweden
    Am J Med Genet B Neuropsychiatr Genet 141:84-90. 2006
    ..Taken together, we propose QKI as a possible target for functional studies related to the role of myelination in schizophrenia...
  6. pmc Abundance of female-biased and paucity of male-biased somatically expressed genes on the mouse X-chromosome
    Björn Reinius
    Department of Organismal Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    BMC Genomics 13:607. 2012
    ..We performed a large-scale sex-bias expression analysis of genes on the X-chromosome in six different somatic tissues from mouse...
  7. doi request reprint RNA-binding protein QKI regulates Glial fibrillary acidic protein expression in human astrocytes
    Katarzyna J Radomska
    Department of Evolution and Development, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Hum Mol Genet 22:1373-82. 2013
    ..Our findings for QKI, together with its well-known role in myelination, suggest that QKI is a hub regulator of glia function in humans...
  8. pmc Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse
    Björn Reinius
    Department of Evolution and Development, EBC, Uppsala University, Sweden
    BMC Genomics 11:614. 2010
    ....
  9. pmc QKI-7 regulates expression of interferon-related genes in human astrocyte glioma cells
    Lin Jiang
    Department of Development and Genetics, Uppsala University, Uppsala, Sweden
    PLoS ONE 5:. 2010
    ..This gene was shown to be essential for myelination in oligodendrocytes. QKI is also highly expressed in astrocytes, but its function in these cells is not known...
  10. ncbi request reprint From wild wolf to domestic dog: gene expression changes in the brain
    Peter Saetre
    Department of Evolution, Genomics and Systematics, Uppsala University, Norbyvagen 18D, S 752 36 Uppsala, Sweden
    Brain Res Mol Brain Res 126:198-206. 2004
    ..Instead, they may provide a common mechanism for rapid adaptive changes during speciation, particularly in cases that present strong selective pressures on behavioral characters...
  11. ncbi request reprint Serotonin receptor 2C (HTR2C) and schizophrenia: examination of possible medication and genetic influences on expression levels
    Anja Castensson
    Department of Evolution, Genomics and Systematics, Evolutionary Biology Centre EBC, Uppsala University, Uppsala, Sweden
    Am J Med Genet B Neuropsychiatr Genet 134:84-9. 2005
    ..The disease related changes in HTR2C expression are not related to the promoter variants typed in our sample, but could be due to other regulatory variants or trans-acting factors...
  12. pmc Gene Expression of Quaking in Sporadic Alzheimer's Disease Patients is Both Upregulated and Related to Expression Levels of Genes Involved in Amyloid Plaque and Neurofibrillary Tangle Formation
    Bryn Farnsworth
    Department of Evolution and Development, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    J Alzheimers Dis 53:209-19. 2016
    ..Overall, these results implicate a possible role of QKI in AD, although the exact mechanism by which this occurs remains to be uncovered. ..
  13. pmc Spatial sexual dimorphism of X and Y homolog gene expression in the human central nervous system during early male development
    Martin M Johansson
    Department of Organismal Biology, EBC, Uppsala University, Uppsala, Sweden
    Biol Sex Differ 7:5. 2016
    ..PCDH11Y and NLGN4Y are of special interest because they belong to gene families involved in cell fate determination and formation of dendrites and axon...
  14. pmc Reduced expression of TAC1, PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain
    Julia Lindberg
    Evolutionary Biology Centre, Department of Evolution, Genomics and Systematics, Uppsala University, Norbyvagen 18D, Uppsala, Sweden
    BMC Neurosci 8:34. 2007
    ..However, little is known about molecular alterations downstream of the hypocretin signals...
  15. ncbi request reprint Genome-wide prediction of human VNTRs
    Karl Näslund
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, S 751 85, Uppsala, Sweden
    Genomics 85:24-35. 2005
    ..Contrary to previous results, VNTRs appear to be widespread and abundant throughout the human genome, with an estimated density of 9.1 VNTRs/Mb...
  16. pmc Selection for tameness modulates the expression of heme related genes in silver foxes
    Julia Lindberg
    Department of Evolution, Genomics and Systematics, Uppsala University, Norbyvagen 18D, S 752 36 Uppsala, Sweden
    Behav Brain Funct 3:18. 2007
    ..Unexpectedly, many of the genes showing evidence of differential expression between groups were related to hemoproteins...
  17. pmc Microarray Analysis of Copy Number Variants on the Human Y Chromosome Reveals Novel and Frequent Duplications Overrepresented in Specific Haplogroups
    Martin M Johansson
    Department of Organismal Biology, EBC, Uppsala University, Uppsala, Sweden
    PLoS ONE 10:e0137223. 2015
    ..This chromosome should not be forgotten, not only for its well-known relevance in male fertility, but also for its involvement in clinical phenotypes such as cancers, heart failure and sex specific effects on brain and behaviour...
  18. pmc Characterization and Expression of the Zebrafish qki Paralogs
    Katarzyna J Radomska
    Department of Evolution and Development, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    PLoS ONE 11:e0146155. 2016
    ..Therefore, we suggest the zebrafish could be used to study the separate functions of qki genes during embryonic development. ..
  19. pmc Haloperidol changes mRNA expression of a QKI splice variant in human astrocytoma cells
    Lin Jiang
    Department of Development and Genetics, Uppsala University, Sweden
    BMC Pharmacol 9:6. 2009
    ..Messenger RNA expression levels of splice variants QKI-5, QKI-6 and QKI-7 were measured by Real-Time PCR...
  20. pmc An evolutionarily conserved sexual signature in the primate brain
    Björn Reinius
    Department of Development and Genetics, Uppsala University, Uppsala, Sweden
    PLoS Genet 4:e1000100. 2008
    ..Genes within sexual expression profiles may underlie important functional differences between the sexes, with possible importance during primate evolution...
  21. ncbi request reprint Decrease of serotonin receptor 2C in schizophrenia brains identified by high-resolution mRNA expression analysis
    Anja Castensson
    Department of Evolutionary Biology, Uppsala University, Uppsala, Sweden
    Biol Psychiatry 54:1212-21. 2003
    ..We measured messenger RNA expression levels of 16 candidate genes in brain samples from 55 schizophrenia patients and 55 controls. This is the largest sample so far used to identify genes differentially expressed in schizophrenia brains...