Nils P Hailer

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. pmc High metal ion levels after use of the ASR™ device correlate with development of pseudotumors and T cell activation
    Nils P Hailer
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Uppland, 75591, Sweden
    Clin Orthop Relat Res 472:953-61. 2014
  2. pmc Dual-mobility cups for revision due to instability are associated with a low rate of re-revisions due to dislocation: 228 patients from the Swedish Hip Arthroplasty Register
    Nils P Hailer
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 83:566-71. 2012
  3. pmc The risk of revision due to dislocation after total hip arthroplasty depends on surgical approach, femoral head size, sex, and primary diagnosis. An analysis of 78,098 operations in the Swedish Hip Arthroplasty Register
    Nils P Hailer
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 83:442-8. 2012
  4. pmc Elevation of circulating HLA DR(+) CD8(+) T-cells and correlation with chromium and cobalt concentrations 6 years after metal-on-metal hip arthroplasty
    Nils P Hailer
    Department of Orthopedics, Institute of Surgical Sciences, Uppsala University Hospital, Sweden
    Acta Orthop 82:6-12. 2011
  5. ncbi request reprint Compartment syndrome of the calf following total knee arthroplasty--a case report of a highly unusual complication
    Nils P Hailer
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, SE 751 85, Sweden
    Acta Orthop 78:293-5. 2007
  6. doi request reprint Immunosuppression after traumatic or ischemic CNS damage: it is neuroprotective and illuminates the role of microglial cells
    Nils P Hailer
    Department of Orthopaedics, Institute for Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Prog Neurobiol 84:211-33. 2008
  7. pmc Uncemented and cemented primary total hip arthroplasty in the Swedish Hip Arthroplasty Register
    Nils P Hailer
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 81:34-41. 2010
  8. pmc Effects of hydroxyapatite coating of cups used in hip revision arthroplasty
    Stergios Lazarinis
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 83:427-35. 2012
  9. pmc Effects of hydroxyapatite coating on survival of an uncemented femoral stem. A Swedish Hip Arthroplasty Register study on 4,772 hips
    Stergios Lazarinis
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 82:399-404. 2011
  10. pmc Increased risk of revision of acetabular cups coated with hydroxyapatite
    Stergios Lazarinis
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 81:53-9. 2010

Collaborators

Detail Information

Publications25

  1. pmc High metal ion levels after use of the ASR™ device correlate with development of pseudotumors and T cell activation
    Nils P Hailer
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Uppland, 75591, Sweden
    Clin Orthop Relat Res 472:953-61. 2014
    ..A direct association of increased cobalt and chromium concentrations with the development of pseudotumors has not been established...
  2. pmc Dual-mobility cups for revision due to instability are associated with a low rate of re-revisions due to dislocation: 228 patients from the Swedish Hip Arthroplasty Register
    Nils P Hailer
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 83:566-71. 2012
    ..We hypothesized that the use of dual-mobility cups would reduce the risk of re-revision due to dislocation after revision THA...
  3. pmc The risk of revision due to dislocation after total hip arthroplasty depends on surgical approach, femoral head size, sex, and primary diagnosis. An analysis of 78,098 operations in the Swedish Hip Arthroplasty Register
    Nils P Hailer
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 83:442-8. 2012
    ....
  4. pmc Elevation of circulating HLA DR(+) CD8(+) T-cells and correlation with chromium and cobalt concentrations 6 years after metal-on-metal hip arthroplasty
    Nils P Hailer
    Department of Orthopedics, Institute of Surgical Sciences, Uppsala University Hospital, Sweden
    Acta Orthop 82:6-12. 2011
    ..We hypothesized that changes in lymphocyte subpopulations would be associated with elevated metal ion concentrations...
  5. ncbi request reprint Compartment syndrome of the calf following total knee arthroplasty--a case report of a highly unusual complication
    Nils P Hailer
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, SE 751 85, Sweden
    Acta Orthop 78:293-5. 2007
  6. doi request reprint Immunosuppression after traumatic or ischemic CNS damage: it is neuroprotective and illuminates the role of microglial cells
    Nils P Hailer
    Department of Orthopaedics, Institute for Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Prog Neurobiol 84:211-33. 2008
    ..Further experiments with more specific agents or genetic approaches that specifically inhibit microglial cells are needed in order to fully answer the question of whether microglial activation is "good or bad"...
  7. pmc Uncemented and cemented primary total hip arthroplasty in the Swedish Hip Arthroplasty Register
    Nils P Hailer
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 81:34-41. 2010
    ..We therefore analyzed implant survival of cemented and uncemented THA, and whether the modes of failure differ between the two methods of fixation...
  8. pmc Effects of hydroxyapatite coating of cups used in hip revision arthroplasty
    Stergios Lazarinis
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 83:427-35. 2012
    ..Coating of acetabular revision implants with hydroxyapatite (HA) has been proposed to improve ingrowth and stability. We investigated whether HA coating of revision cups can reduce the risk of any subsequent re-revision...
  9. pmc Effects of hydroxyapatite coating on survival of an uncemented femoral stem. A Swedish Hip Arthroplasty Register study on 4,772 hips
    Stergios Lazarinis
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 82:399-404. 2011
    ..However, the evidence behind the use of HA coating on femoral stems is ambiguous. We investigated survival of an uncemented, tapered titanium femoral stem that was available either with or without HA coating (Bi-Metric)...
  10. pmc Increased risk of revision of acetabular cups coated with hydroxyapatite
    Stergios Lazarinis
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 81:53-9. 2010
    ..Hydroxyapatite (HA) is the main inorganic component of bone, and HA coating is widely used on acetabular cups in hip arthroplasty. It has been suggested that this surface finish improves cup survival...
  11. pmc Increased Long-Term Cardiovascular Risk After Total Hip Arthroplasty: A Nationwide Cohort Study
    Max Gordon
    From the Department of Clinical Sciences at Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden MG, AR, SA, TE, As, OS Department of Orthopedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden AG, NH Swedish Hip Arthroplasty Register, Registercentrum VGR, Gothenburg, Sweden or, GG Department of Orthopedics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden or, GG and Harris Orthopedic Laboratory, Massachusetts General Hospital and Harvard Medical School OR, Boston, MA
    Medicine (Baltimore) 95:e2662. 2016
    ..08 (95% CI 1.06-1.11).Patients with surgically treated osteoarthritis of the hip have an increased risk of cardiovascular morbidity and mortality many years after the operation when compared with controls...
  12. doi request reprint Bone loss around a stable, partly threaded hydroxyapatite-coated cup: a prospective cohort study using RSA and DXA
    Stergios Lazarinis
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala Sweden
    Hip Int 24:155-66. 2014
    ..We hypothesised that this cup provides good primary stability and improves preservation of periprosthetic bone mineral density (BMD)...
  13. pmc A prospective cohort study on the short collum femoris-preserving (CFP) stem using RSA and DXA. Primary stability but no prevention of proximal bone loss in 27 patients followed for 2 years
    Stergios Lazarinis
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 84:32-9. 2013
    ..Short femoral stems have been introduced in total hip arthroplasty in order to save proximal bone stock. We hypothesized that a short stem preserves periprosthetic bone mineral density (BMD) and provides good primary stability...
  14. doi request reprint Total Hip Arthroplasty in 6690 Patients with Inflammatory Arthritis: Effect of Medical Comorbidities and Age on Early Mortality
    Rudiger J Weiss
    From the Department of Molecular Medicine and Surgery, Section of Orthopedics and Sports Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm Swedish Hip Arthroplasty Register, and Institute of Clinical Sciences, Department of Orthopedics, Sahlgrenska University Hospital, Gothenburg Department of Orthopedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden R J Weiss, MD PhD, Department of Molecular Medicine and Surgery, Section of Orthopaedics and Sports Medicine, Karolinska Institutet, Karolinska University Hospital, and Swedish Hip Arthroplasty Register, Department of Orthopedics, Sahlgrenska University Hospital G Garellick, MD, PhD, Swedish Hip Arthroplasty Register, Department of Orthopedics, and Institute of Clinical Sciences, Sahlgrenska University Hospital J Kärrholm, MD, PhD, Swedish Hip Arthroplasty Register, Department of Orthopedics, and Institute of Clinical Sciences, Sahlgrenska University Hospital N P Hailer, MD, Swedish Hip Arthroplasty Register, Department of Orthopedics, Sahlgrenska University Hospital, and Department of Orthopedics, Institute of Surgical Sciences, Uppsala University Hospital
    J Rheumatol 43:1320-7. 2016
    ..We analyzed early mortality after total hip arthroplasty (THA) in patients with inflammatory arthritis (IA), adjusting for medical comorbidities and socioeconomic background...
  15. pmc Early mortality and morbidity after total hip arthroplasty in patients with femoral neck fracture
    Nils P Hailer
    a Department of Orthopedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala
    Acta Orthop 87:560-566. 2016
    ....
  16. doi request reprint Implant survival and outcome after rotating-hinge total knee revision arthroplasty: a minimum 6-year follow-up
    Asgeir Gudnason
    Department of Orthopaedics, Institute for Surgical Sciences, Uppsala University Hospital, 751 85 Uppsala, Sweden
    Arch Orthop Trauma Surg 131:1601-7. 2011
    ..Data on long-time survival and clinical function of rotating hinge knee prostheses used in revision total knee arthroplasty (TKA) are scarce...
  17. pmc Early postoperative mortality after simultaneous or staged bilateral primary total hip arthroplasty: an observational register study from the Swedish Hip Arthroplasty Register
    Anne Garland
    Department of Orthopaedics, Visby Hospital, Visby, Sweden
    BMC Musculoskelet Disord 16:77. 2015
    ..It is unclear whether mortality risks differ between simultaneous bilateral THA and staged bilateral THA. We investigated mortality after simultaneous THA compared with staged bilateral THA in the largest cohort hitherto reported...
  18. ncbi request reprint All-Polyethylene Versus Metal-Backed Tibial Components-An Analysis of 27,733 Cruciate-Retaining Total Knee Replacements from the Swedish Knee Arthroplasty Register
    Asgeir Gudnason
    Department of Orthopedics, Institute of Surgical Sciences, Uppsala University Hospital, SE 751 85, Uppsala, Sweden E mail address
    J Bone Joint Surg Am 96:994-999. 2014
    ..We hypothesized that there would be no difference in the ten-year survival rate between all-polyethylene and metal-backed tibial components of a specific design in a large nationwide cohort...
  19. pmc Are porous tantalum cups superior to conventional reinforcement rings?
    Anders Brüggemann
    a Department of Orthopedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop . 2016
    ..We conclude that TM cups are a valuable treatment option in acetabular revision surgery, but the reasons underlying dislocations after the use of TM cups must be analyzed further...
  20. pmc Hydroxyapatite coating does not improve uncemented stem survival after total hip arthroplasty!
    Nils P Hailer
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 86:18-25. 2015
    ..We therefore investigated different uncemented stem brands, with and without HA coating, regarding early and long-term survival...
  21. ncbi request reprint Interleukin-1beta exacerbates and interleukin-1 receptor antagonist attenuates neuronal injury and microglial activation after excitotoxic damage in organotypic hippocampal slice cultures
    Nils P Hailer
    Dr Senckenbergische Anatomie, Institute of Anatomy 2, Johann Wolfgang Goethe University, D 60590 Frankfurt am Main, Federal Republic of Germany
    Eur J Neurosci 21:2347-60. 2005
    ....
  22. ncbi request reprint Characterisation of transverse slice culture preparations of postnatal rat spinal cord: preservation of defined neuronal populations
    Stavros I Stavridis
    University Hospital for Orthopaedic Surgery Friedrichsheim, Johann Wolfgang Goethe University, Frankfurt am Main, 60528 Federal Republic of Germany
    Histochem Cell Biol 123:377-92. 2005
    ..In summary, SCSC undergo degenerative changes, but they contain defined neuronal populations, the cytoarchitecture is partially preserved and the glial reaction is limited...
  23. ncbi request reprint Clodronate inhibits the secretion of proinflammatory cytokines and NO by isolated microglial cells and reduces the number of proliferating glial cells in excitotoxically injured organotypic hippocampal slice cultures
    Faramarz Dehghani
    Institute of Anatomy II, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Exp Neurol 189:241-51. 2004
    ..Furthermore, clodronate inhibits microglial secretion of proinflammatory cytokines and NO. Clodronate could therefore prove to be a useful tool in the investigation of interactions between damaged neurons and microglial cells...
  24. ncbi request reprint The immunosuppressant mycophenolate mofetil attenuates neuronal damage after excitotoxic injury in hippocampal slice cultures
    Faramarz Dehghani
    Institute of Anatomy, Hospital of the Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Federal Republic of Germany
    Eur J Neurosci 18:1061-72. 2003
    ..In conclusion, MMF inhibits proliferation and activation of microglia and astrocytes and protects neurons after excitotoxic injury...
  25. ncbi request reprint Interleukin-4, interleukin-10, and interleukin-1-receptor antagonist but not transforming growth factor-beta induce ramification and reduce adhesion molecule expression of rat microglial cells
    Florentina Wirjatijasa
    University Hospital for Orthopaedic Surgery Friedrichsheim, Frankfurt, Germany
    J Neurosci Res 68:579-87. 2002
    ..TGF-beta has no modulating effects. Importantly, unidentified astrocytic factors that are not identical with IL-4, IL-10, or TGF-beta possess strong immunomodulatory properties...