Kai M Eggers

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. ncbi Diagnostic value of serial measurement of cardiac markers in patients with chest pain: limited value of adding myoglobin to troponin I for exclusion of myocardial infarction
    Kai Marten Eggers
    Department of Cardiology, Cardiothoracic Center, University Hospital, Uppsala, Sweden
    Am Heart J 148:574-81. 2004
  2. doi Pathophysiologic mechanisms of persistent cardiac troponin I elevation in stabilized patients after an episode of acute coronary syndrome
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital, Uppsala, Sweden
    Am Heart J 156:588-94. 2008
  3. ncbi Persistent cardiac troponin I elevation in stabilized patients after an episode of acute coronary syndrome predicts long-term mortality
    Kai M Eggers
    Department of Medical Sciences, Cardiology, University Hospital Uppsala, S 751 85 Uppsala, Sweden
    Circulation 116:1907-14. 2007
  4. ncbi Risk prediction in chest pain patients by biochemical markers including estimates of renal function
    Kai M Eggers
    Department of Medical Sciences, Cardiology, University Hospital Uppsala, S 751 85 Uppsala, Sweden
    Int J Cardiol 128:207-13. 2008
  5. ncbi Artificial neural network algorithms for early diagnosis of acute myocardial infarction and prediction of infarct size in chest pain patients
    Kai M Eggers
    Department of Medical Sciences, Cardiology, University Hospital Uppsala, S 751 85 Uppsala, Sweden
    Int J Cardiol 114:366-74. 2007
  6. ncbi Combining different biochemical markers of myocardial ischemia does not improve risk stratification in chest pain patients compared to troponin I alone
    Kai M Eggers
    Department of Cardiology, University Hospital, Uppsala, Sweden
    Coron Artery Dis 16:315-9. 2005
  7. ncbi Risk prediction in patients with chest pain: early assessment by the combination of troponin I results and electrocardiographic findings
    Kai M Eggers
    Department of Cardiology, University Hospital, Uppsala, Sweden
    Coron Artery Dis 16:181-9. 2005
  8. doi Improving long-term risk prediction in patients with acute chest pain: the Global Registry of Acute Coronary Events (GRACE) risk score is enhanced by selected nonnecrosis biomarkers
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital and Uppsala Clinical Research Center, Uppsala, Sweden
    Am Heart J 160:88-94. 2010
  9. pmc Growth-differentiation factor-15 for early risk stratification in patients with acute chest pain
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital, Uppsala, Sweden
    Eur Heart J 29:2327-35. 2008
  10. doi Unrecognized myocardial scars detected by delayed-enhanced MRI are associated with increased levels of NT-proBNP
    Raquel Espregueira Themudo
    Department of ORKI, Section of Radiology, Uppsala University Hospital, Sweden
    Coron Artery Dis 22:158-64. 2011

Detail Information

Publications39

  1. ncbi Diagnostic value of serial measurement of cardiac markers in patients with chest pain: limited value of adding myoglobin to troponin I for exclusion of myocardial infarction
    Kai Marten Eggers
    Department of Cardiology, Cardiothoracic Center, University Hospital, Uppsala, Sweden
    Am Heart J 148:574-81. 2004
    ..Despite improved laboratory assays for cardiac markers and a revised standard for definition of myocardial infarction (AMI), early detection of coronary ischemia in unselected patients with chest pain remains a difficult challenge...
  2. doi Pathophysiologic mechanisms of persistent cardiac troponin I elevation in stabilized patients after an episode of acute coronary syndrome
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital, Uppsala, Sweden
    Am Heart J 156:588-94. 2008
    ..We now have studied the associations of persistently elevated cTnI levels to cardiac performance, inflammation, coagulation, coronary status, and treatment strategy in these patients...
  3. ncbi Persistent cardiac troponin I elevation in stabilized patients after an episode of acute coronary syndrome predicts long-term mortality
    Kai M Eggers
    Department of Medical Sciences, Cardiology, University Hospital Uppsala, S 751 85 Uppsala, Sweden
    Circulation 116:1907-14. 2007
    ..However, the prevalence and prognostic importance of persistent troponin elevation in stabilized patients after an episode of non-ST-elevation acute coronary syndrome are unknown and were therefore assessed in this study...
  4. ncbi Risk prediction in chest pain patients by biochemical markers including estimates of renal function
    Kai M Eggers
    Department of Medical Sciences, Cardiology, University Hospital Uppsala, S 751 85 Uppsala, Sweden
    Int J Cardiol 128:207-13. 2008
    ..Early risk stratification of patients with chest pain may be improved by combining cardiac Troponin I (cTnI) results and ECG findings with markers of left-ventricular dysfunction, inflammation or renal function...
  5. ncbi Artificial neural network algorithms for early diagnosis of acute myocardial infarction and prediction of infarct size in chest pain patients
    Kai M Eggers
    Department of Medical Sciences, Cardiology, University Hospital Uppsala, S 751 85 Uppsala, Sweden
    Int J Cardiol 114:366-74. 2007
    ..To prospectively validate artificial neural network (ANN)-algorithms for early diagnosis of myocardial infarction (AMI) and prediction of 'major infarct' size in patients with chest pain and without ECG changes diagnostic for AMI...
  6. ncbi Combining different biochemical markers of myocardial ischemia does not improve risk stratification in chest pain patients compared to troponin I alone
    Kai M Eggers
    Department of Cardiology, University Hospital, Uppsala, Sweden
    Coron Artery Dis 16:315-9. 2005
    ..A multimarker strategy applying results of early measurements of different biochemical markers of cardiac necrosis in combination may improve risk prediction in chest pain patients...
  7. ncbi Risk prediction in patients with chest pain: early assessment by the combination of troponin I results and electrocardiographic findings
    Kai M Eggers
    Department of Cardiology, University Hospital, Uppsala, Sweden
    Coron Artery Dis 16:181-9. 2005
    ..To evaluate the prognostic value of point of care troponin I (TnI) results in combination with findings from the admission electrocardiogram (ECG) in patients with chest pain...
  8. doi Improving long-term risk prediction in patients with acute chest pain: the Global Registry of Acute Coronary Events (GRACE) risk score is enhanced by selected nonnecrosis biomarkers
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital and Uppsala Clinical Research Center, Uppsala, Sweden
    Am Heart J 160:88-94. 2010
    ..However, there is limited knowledge regarding the utility of this score for long-term risk prediction in unselected patients with acute chest pain and whether it might be improved by the integration of nonnecrosis biomarkers...
  9. pmc Growth-differentiation factor-15 for early risk stratification in patients with acute chest pain
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital, Uppsala, Sweden
    Eur Heart J 29:2327-35. 2008
    ..We explored the usefulness of GDF-15 for early risk stratification in 479 unselected patients with acute chest pain...
  10. doi Unrecognized myocardial scars detected by delayed-enhanced MRI are associated with increased levels of NT-proBNP
    Raquel Espregueira Themudo
    Department of ORKI, Section of Radiology, Uppsala University Hospital, Sweden
    Coron Artery Dis 22:158-64. 2011
    ..The second aim was to compare whether the TnI levels differed in those two groups...
  11. doi Prognostic value of biomarkers during and after non-ST-segment elevation acute coronary syndrome
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital and Uppsala Clinical Research Centre, Uppsala, Sweden
    J Am Coll Cardiol 54:357-64. 2009
    ..The aim of this study was to assess risk prediction by different biomarkers in patients with an ongoing non-ST-segment elevation acute coronary syndrome (NSTE-ACS) and after clinical stabilization...
  12. pmc GDF-15 for prognostication of cardiovascular and cancer morbidity and mortality in men
    Lars Wallentin
    Uppsala Clinical Research Center UCR and Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    PLoS ONE 8:e78797. 2013
    ..001). In conclusion, in elderly men, GDF-15 improves prognostication of both cardiovascular, cancer mortality and morbidity beyond established risk factors and biomarkers of cardiac, renal dysfunction and inflammation. ..
  13. doi Growth-differentiation factor-15 for long-term risk prediction in patients stabilized after an episode of non-ST-segment-elevation acute coronary syndrome
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital and Uppsala Clinical Research Center, Uppsala, Sweden
    Circ Cardiovasc Genet 3:88-96. 2010
    ..This study assessed the time course and the long-term prognostic relevance of GDF-15 levels measured repetitively in patients with non-ST-segment-elevation acute coronary syndrome during 6 months after the acute event...
  14. doi Cardiac troponin I levels measured with a high-sensitive assay increase over time and are strong predictors of mortality in an elderly population
    Kai M Eggers
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    J Am Coll Cardiol 61:1906-13. 2013
    ..This study sought to assess changes in troponin levels, underlying conditions, and the prognostic implications in elderly subjects from the community...
  15. doi Prognostic usefulness of the change in N-terminal pro B-type natriuretic peptide levels to predict mortality in a single community cohort aged ≥ 70 years
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden
    Am J Cardiol 111:131-6. 2013
    ....
  16. doi Clinical implications of the change of cardiac troponin I levels in patients with acute chest pain - an evaluation with respect to the Universal Definition of Myocardial Infarction
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital, Sweden
    Clin Chim Acta 412:91-7. 2011
    ..We sought to evaluate the clinical implications of the relative change of cardiac troponin I (cTnI) levels with respect to the Universal Definition in patients with acute chest pain...
  17. doi A novel approach to cardiac troponins to improve the diagnostic work-up in chest pain patients
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden
    Crit Pathw Cardiol 11:199-205. 2012
    ..This could facilitate the early diagnostic work-up of chest pain patients, thereby improving patient flow and reducing overcrowding in healthcare facilities...
  18. doi Myeloperoxidase is not useful for the early assessment of patients with chest pain
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital and Uppsala Clinical Research Center, Uppsala, Sweden
    Clin Biochem 43:240-5. 2010
    ..Myeloperoxidase (MPO) has been listed as a potentially useful risk marker in acute coronary syndrome. However, its clinical utility in patients with acute chest pain is not yet defined...
  19. doi Value of cardiac troponin I cutoff concentrations below the 99th percentile for clinical decision-making
    Kai M Eggers
    Department of Medical Sciences, Uppsala University Hospital, Sweden
    Clin Chem 55:85-92. 2009
    ....
  20. doi Evaluation of Temporal Changes in Cardiovascular Biomarker Concentrations Improves Risk Prediction in an Elderly Population from the Community
    Kai M Eggers
    Department of Medical Sciences and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
    Clin Chem 62:485-93. 2016
    ..We investigated the prognostic utility of a panel of novel CV biomarkers including biomarker changes over time...
  21. doi High-sensitive cardiac troponin T and its relations to cardiovascular risk factors, morbidity, and mortality in elderly men
    Kai M Eggers
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden Electronic address
    Am Heart J 166:541-8. 2013
    ..Cardiac troponin is emerging as risk indicator in community-dwelling populations. In this study, we investigated the associations of cardiac troponin T (cTnT) to cardiovascular (CV) disease and outcome in elderly men...
  22. doi Factors influencing the 99th percentile of cardiac troponin I evaluated in community-dwelling individuals at 70 and 75 years of age
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University, S 751 85 Uppsala, Sweden
    Clin Chem 59:1068-73. 2013
    ..We aimed to investigate the effects of sex, prevalent cardiovascular disease (CVD), and aging on the 99th percentile of cardiac troponin I (cTnI)...
  23. doi Short- and long-term individual variation in cardiac troponin in patients with stable coronary artery disease
    Anna M Nordenskjöld
    Department of Cardiology, Orebro University Hospital, Orebro, Sweden
    Clin Chem 59:401-9. 2013
    ..Therefore, we studied the individual variation of cardiac troponin in patients with symptoms of stable coronary artery disease...
  24. doi Relations of growth-differentiation factor-15 to biomarkers reflecting vascular pathologies in a population-based sample of elderly subjects
    Kai M Eggers
    Department of Medical Sciences Cardiology and Clinical Chemistry and Clinical Research Center, Uppsala University, Uppsala, Sweden
    Scand J Clin Lab Invest 72:45-51. 2012
    ..GDF-15 is commonly related to cardiovascular risk factors, inflammatory activity and cardiac abnormalities. However, it is not clear whether it might be an indicator of vascular pathologies as well...
  25. doi B-type natriuretic peptides and their relation to cardiovascular structure and function in a population-based sample of subjects aged 70 years
    Kai M Eggers
    Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala, Sweden
    Am J Cardiol 103:1032-8. 2009
    ....
  26. doi Will the universal definition of myocardial infarction criteria result in an overdiagnosis of myocardial infarction?
    Kai M Eggers
    Department of Medical Sciences, Uppsala University Hospital, Sweden
    Am J Cardiol 103:588-91. 2009
    ..In conclusion, our results emphasized the importance of a significant change in cardiac troponin to avoid misdiagnosis of AMI...
  27. doi High-sensitive cardiac troponin T outperforms novel diagnostic biomarkers in patients with acute chest pain
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden
    Clin Chim Acta 413:1135-40. 2012
    ..However, the information obtained from hs-cTnT levels might be improved when combined with results of other biomarkers of myocardial injury...
  28. doi Prevalence and pathophysiological mechanisms of elevated cardiac troponin I levels in a population-based sample of elderly subjects
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Eur Heart J 29:2252-8. 2008
    ....
  29. pmc Unrecognized Myocardial Infarction Assessed by Cardiac Magnetic Resonance Imaging--Prognostic Implications
    Anna M Nordenskjöld
    Department of Cardiology, Faculty of Health, Orebro University, Orebro, Sweden
    PLoS ONE 11:e0148803. 2016
    ..The aims of this study were to determine the prognostic implication of UMI in patients with stable suspected coronary artery disease (CAD) and to investigate the associations of UMI with the presence of CAD...
  30. doi Mid-regional pro-atrial natriuretic peptide levels in the elderly: clinical and prognostic implications, and comparison to B-type natriuretic peptides
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden
    Clin Chim Acta 419:62-6. 2013
    ..However, there are only sparse data on its clinical value relative to the B-type natriuretic peptides in the general population...
  31. doi Short- and long-term individual variation in NT-proBNP levels in patients with stable coronary artery disease
    Anna M Nordenskjöld
    Department of Cardiology, Orebro University Hospital, Orebro, Sweden
    Clin Chim Acta 422:15-20. 2013
    ..The aim of the study was to evaluate the short- and long-term individual variation of NT-proBNP in patients with stable coronary artery disease...
  32. doi Cardiac troponin I levels in patients with non-ST-elevation acute coronary syndrome-the importance of gender
    Kai M Eggers
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden Electronic address
    Am Heart J 168:317-324.e1. 2014
    ..However, studies investigating the distribution and prognostic implications of high-sensitivity troponin levels in men and women separately are currently lacking...
  33. doi Prognostic implications of changes in cardiac troponin I levels in patients with non-ST elevation acute coronary syndrome
    Kai M Eggers
    Cardiology Unit, Department of Medical Sciences, Faculty of Medicine, Uppsala University, Uppsala, Sweden and
    Biomarkers 18:668-72. 2013
    ..Information is limited on the prognostic implications of cardiac troponin I (cTnI) changes during the first days of non-ST elevation acute coronary syndrome (NSTE-ACS)...
  34. doi Consequences of implementing a cardiac troponin assay with improved sensitivity at Swedish coronary care units: an analysis from the SWEDEHEART registry
    Kai M Eggers
    Department of Medical Sciences, Uppsala University, S 751 85 Uppsala, Sweden
    Eur Heart J 37:2417-24. 2016
    ..However, data on the clinical consequences of the implementation of such assays are limited...
  35. doi An algorithm for rule-in and rule-out of acute myocardial infarction using a novel troponin I assay
    Bertil Lindahl
    Department of Medical Sciences and Uppsala Clinical Research Center, Uppsala, University, Uppsala, Sweden
    Heart . 2016
    ..To derive and validate a hybrid algorithm for rule-out and rule-in of acute myocardial infarction based on measurements at presentation and after 2 hours with a novel cardiac troponin I (cTnI) assay...
  36. doi Two-hour diagnostic algorithms for early assessment of patients with acute chest pain--Implications of lowering the cardiac troponin I cut-off to the 97.5th percentile
    Kai M Eggers
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden Electronic address
    Clin Chim Acta 445:19-24. 2015
    ..We therefore, aimed to investigate the utility of 2-hour algorithms using the high-sensitivity cardiac troponin I (hs-cTnI) 97.5th percentile as cut-off which corresponds to the standard URL for most biomarkers...
  37. doi Utility of B-type natriuretic peptides and cardiac troponins for population screening regarding cardiac abnormalities
    Kai M Eggers
    Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Pathology 44:129-38. 2012
    ..This review focuses on the utility of the B-type natriuretic peptides (NP) and the cardiac troponins (cTns) for this purpose...
  38. doi ST2 and mortality in non-ST-segment elevation acute coronary syndrome
    Kai M Eggers
    Department of Medical Sciences, Uppsala University, Sweden
    Am Heart J 159:788-94. 2010
    ....
  39. doi High-sensitive troponin T and I are related to invasive hemodynamic data and mortality in patients with left-ventricular dysfunction and precapillary pulmonary hypertension
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden
    Clin Chim Acta 412:1582-8. 2011
    ....