Samar Basu

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. ncbi request reprint Novel cyclooxygenase-catalyzed bioactive prostaglandin F2alpha from physiology to new principles in inflammation
    Samar Basu
    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Uppsala Science Park, Uppsala, Sweden
    Med Res Rev 27:435-68. 2007
  2. ncbi request reprint Increased rate of lipid peroxidation and protein carbonylation in experimental diabetic pregnancy
    J Cederberg
    Department of Medical Cell Biology, Uppsala University, Sweden
    Diabetologia 44:766-74. 2001
  3. ncbi request reprint Antithrombin administration during experimental cardiopulmonary resuscitation
    Jakob Johansson
    Department of Surgical Sciences, Anaesthesiology and Intensive Care, Uppsala University Hospital, Uppsala S 751 85, Sweden
    Resuscitation 62:71-8. 2004
  4. ncbi request reprint Maintaining nitric oxide-induced airway relaxation with superoxide dismutase
    Claus G Krenn
    Department of Medical Sciences, Clinical Physiology, Uppsala University, SE 751 85 Uppsala, Sweden
    Nitric Oxide 16:419-24. 2007
  5. doi request reprint Effects of dietary fat modification on oxidative stress and inflammatory markers in the LIPGENE study
    Helena Petersson
    Department of Public Health and Caring Sciences Clinical Nutrition and Metabolism, Uppsala University, Uppsala Science Park, 75185 Uppsala, Sweden
    Br J Nutr 104:1357-62. 2010
  6. ncbi request reprint F2-isoprostane induced prostaglandin formation in the rabbit
    Samar Basu
    Uppsala University, Section of Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala Science Park, Uppsala SE 751 85, Sweden
    Free Radic Res 40:273-7. 2006
  7. ncbi request reprint Type 1 diabetes is associated with increased cyclooxygenase- and cytokine-mediated inflammation
    Samar Basu
    Section of Geriatrics and Clinical Nutrition Research, Faculty of Medicine, Uppsala University, P O Box 609, SE 751 25 Uppsala, Sweden
    Diabetes Care 28:1371-5. 2005
  8. ncbi request reprint Biomarkers of free radical injury during spinal cord ischemia
    S Basu
    Section of Geriatrics, Faculty of Medicine, Uppsala University, P O Box 69, SE 751 25 Uppsala, Sweden
    FEBS Lett 508:36-8. 2001
  9. doi request reprint Propofol mitigates systemic oxidative injury during experimental cardiopulmonary cerebral resuscitation
    Samar Basu
    Oxidative Stress and Inflammation SB, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Uppsala, Sweden
    Prostaglandins Leukot Essent Fatty Acids 84:123-30. 2011
  10. ncbi request reprint Factors regulating isoprostane formation in vivo
    Samar Basu
    Section of Geriatrics and Clinical Nutrition Research, Faculty of Medicine, Uppsala University, Uppsala, Sweden
    Antioxid Redox Signal 7:221-35. 2005

Detail Information

Publications126 found, 100 shown here

  1. ncbi request reprint Novel cyclooxygenase-catalyzed bioactive prostaglandin F2alpha from physiology to new principles in inflammation
    Samar Basu
    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Uppsala Science Park, Uppsala, Sweden
    Med Res Rev 27:435-68. 2007
    ..This review addresses multiple aspects of PGF2alpha in addition to its emerging role in physiology to inflammation...
  2. ncbi request reprint Increased rate of lipid peroxidation and protein carbonylation in experimental diabetic pregnancy
    J Cederberg
    Department of Medical Cell Biology, Uppsala University, Sweden
    Diabetologia 44:766-74. 2001
    ..CONCLUSIONS/INTERPRETATION: In diabetic pregnancy, both diabetes and pregnancy are promoting oxygen radical damage. Fetal oxidative stress markers do not clearly reflect fetal morphology...
  3. ncbi request reprint Antithrombin administration during experimental cardiopulmonary resuscitation
    Jakob Johansson
    Department of Surgical Sciences, Anaesthesiology and Intensive Care, Uppsala University Hospital, Uppsala S 751 85, Sweden
    Resuscitation 62:71-8. 2004
    ..To determine whether antithrombin (AT) administration during cardiopulmonary resuscitation (CPR) increased cerebral circulation and reduced reperfusion injury...
  4. ncbi request reprint Maintaining nitric oxide-induced airway relaxation with superoxide dismutase
    Claus G Krenn
    Department of Medical Sciences, Clinical Physiology, Uppsala University, SE 751 85 Uppsala, Sweden
    Nitric Oxide 16:419-24. 2007
    ..In this study, hypothesizing that the impaired efficiency of iNO was caused by release of reactive oxygen radicals, we examined the effect of the radical scavenging enzyme superoxide dismutase (SOD)...
  5. doi request reprint Effects of dietary fat modification on oxidative stress and inflammatory markers in the LIPGENE study
    Helena Petersson
    Department of Public Health and Caring Sciences Clinical Nutrition and Metabolism, Uppsala University, Uppsala Science Park, 75185 Uppsala, Sweden
    Br J Nutr 104:1357-62. 2010
    ..In conclusion, a 12-week dietary fat modification did not affect the investigated markers of oxidative stress and inflammation among subjects with the MetS in the LIPGENE study...
  6. ncbi request reprint F2-isoprostane induced prostaglandin formation in the rabbit
    Samar Basu
    Uppsala University, Section of Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala Science Park, Uppsala SE 751 85, Sweden
    Free Radic Res 40:273-7. 2006
    ....
  7. ncbi request reprint Type 1 diabetes is associated with increased cyclooxygenase- and cytokine-mediated inflammation
    Samar Basu
    Section of Geriatrics and Clinical Nutrition Research, Faculty of Medicine, Uppsala University, P O Box 609, SE 751 25 Uppsala, Sweden
    Diabetes Care 28:1371-5. 2005
    ..The extent of involvement of cyclooxygenase (COX)-mediated inflammation in type 1 diabetes is unknown, and the association between the COX- and cytokine-mediated inflammatory responses in type 1 diabetes is not fully understood...
  8. ncbi request reprint Biomarkers of free radical injury during spinal cord ischemia
    S Basu
    Section of Geriatrics, Faculty of Medicine, Uppsala University, P O Box 69, SE 751 25 Uppsala, Sweden
    FEBS Lett 508:36-8. 2001
    ..Thus, free radical mediated and cyclooxygenase catalysed products of arachidonic acid are increased during spinal cord ischemia as a consequence of oxidative injury and inflammation...
  9. doi request reprint Propofol mitigates systemic oxidative injury during experimental cardiopulmonary cerebral resuscitation
    Samar Basu
    Oxidative Stress and Inflammation SB, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Uppsala, Sweden
    Prostaglandins Leukot Essent Fatty Acids 84:123-30. 2011
    ..Propofol significantly reduced an ROSC-mediated oxidative stress in the brain...
  10. ncbi request reprint Factors regulating isoprostane formation in vivo
    Samar Basu
    Section of Geriatrics and Clinical Nutrition Research, Faculty of Medicine, Uppsala University, Uppsala, Sweden
    Antioxid Redox Signal 7:221-35. 2005
    ..Selected aspects of issues related to isoprostane formation and metabolism in vivo will be examined herein...
  11. ncbi request reprint Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients
    Samar Basu
    Section of Geriatrics and Clinical Nutrition Research, Department of Public Health, Faculty of Medicine, Uppsala University, Box 609, SE 751 25 Uppsala, Sweden
    Toxicology 189:113-27. 2003
    ..Antioxidant nutrients have been shown to affect both the formation of isoprostanes and prostaglandin metabolite but the therapeutic values and exact mechanisms of action remain unclear...
  12. ncbi request reprint Evidence for time-dependent maximum increase of free radical damage and eicosanoid formation in the brain as related to duration of cardiac arrest and cardio-pulmonary resuscitation
    Samar Basu
    Department of Public Health Geriatrics and Clinical Nutrition Research, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Free Radic Res 37:251-6. 2003
    ..In contrast, the greatest increase of 15-keto-dihydro-PGF2alpha was observed in the 13 min group (VF8 min + CPR5 min). Thus, a time-dependent cerebral oxidative injury occurs in conjunction which cardiac arrest and CPR...
  13. ncbi request reprint Time course and attenuation of ischaemia-reperfusion induced oxidative injury by propofol in human renal transplantation
    Samar Basu
    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Uppsala, Sweden
    Redox Rep 12:195-202. 2007
    ..Furthermore, propofol a well-known anaesthetic, counteracted oxidative stress by lowering the formation of a major F(2)-isoprostane...
  14. doi request reprint Bioactive eicosanoids: role of prostaglandin F(2α) and F₂-isoprostanes in inflammation and oxidative stress related pathology
    Samar Basu
    Oxidative Stress and Inflammation, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Uppsala, Sweden
    Mol Cells 30:383-91. 2010
    ....
  15. doi request reprint F2-isoprostanes in human health and diseases: from molecular mechanisms to clinical implications
    Samar Basu
    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Uppsala, Sweden
    Antioxid Redox Signal 10:1405-34. 2008
    ....
  16. ncbi request reprint Isoprostanes: novel bioactive products of lipid peroxidation
    Samar Basu
    Section of Geriatrics and Clinical Nutrition Research, Faculty of Medicine, Uppsala University, Box 609, SE 751 25 Uppsala, Sweden
    Free Radic Res 38:105-22. 2004
    ....
  17. doi request reprint Fatty acid oxidation and isoprostanes: oxidative strain and oxidative stress
    Samar Basu
    Oxidative Stress and Inflammation, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Prostaglandins Leukot Essent Fatty Acids 82:219-25. 2010
    ..Measurement of F(2)-isoprostanes in body fluids could offer a unique analytical opportunity to study the role of free radicals in physiology and pathophysiology in order to comprehend both oxidative strain and oxidative stress...
  18. pmc Inflammation, oxidative stress, glomerular filtration rate, and albuminuria in elderly men: a cross-sectional study
    Elisabet Nerpin
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, SE 751 85, Uppsala, Sweden
    BMC Res Notes 5:537. 2012
    ....
  19. doi request reprint Systemic tocopherols and F2-isoprostanes and the risk of Alzheimer's disease and dementia: a prospective population-based study
    Johan Sundelöf
    Department of Public Health and Caring Sciences Geriatrics, Faculty of Medicine, Uppsala University, Uppsala, Sweden
    J Alzheimers Dis 18:71-8. 2009
    ..In conclusion, systemic serum alpha- and gamma-tocopherol and urinary F2-isoprostane levels are not associated with the future risk of AD or dementia and do not seem to be useful predictors of clinical AD or dementia...
  20. ncbi request reprint Neuro- and cardioprotective effects of blockade of nitric oxide action by administration of methylene blue
    Lars Wiklund
    Department of Surgical Sciences, Uppsala University Hospital, SE 75185 Uppsala, Sweden
    Ann N Y Acad Sci 1122:231-44. 2007
    ..The last two effects are recorded as less increase in plasma concentrations of astroglial protein S-100beta, as well as troponin I and creatine kinase isoenzyme MB, respectively...
  21. ncbi request reprint Serum selenium predicts levels of F2-isoprostanes and prostaglandin F2alpha in a 27 year follow-up study of Swedish men
    Johanna Helmersson
    Clinical Nutrition Research Geriatrics, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Uppsala, Sweden
    Free Radic Res 39:763-70. 2005
    ..The associations between Se, oxidative stress and inflammation, respectively, might be related to the proposed cardiovascular protective property of Se...
  22. ncbi request reprint Glycaemic status in relation to oxidative stress and inflammation in well-controlled type 2 diabetes subjects
    Elisabet Rytter
    Clinical Nutrition and Metabolism, Department of Public Health and Caring Science, Uppsala University, Uppsala, Sweden
    Br J Nutr 101:1423-6. 2009
    ..This could be due to the fact that none of these biomarkers biosynthesises via similar pathways or simultaneously owing to their diverse nature and origin...
  23. ncbi request reprint Metabolic effects of conjugated linoleic acid in humans: the Swedish experience
    Ulf Riserus
    Unit for Clinical Nutrition Research, Department of Public Health and Caring Sciences, University of Uppsala, Uppsala, Sweden
    Am J Clin Nutr 79:1146S-1148S. 2004
    ..In addition, CLA markedly elevated lipid peroxidation. Thus, the metabolic effects of CLA in humans seem complex, and further studies, especially of specific isomers and of longer duration, are needed...
  24. doi request reprint Enhanced prostaglandin F2α formation in human pregnancy and the effect of increased oily fish intake: results from the Salmon in Pregnancy Study
    Johanna Helmersson-Karlqvist
    Clinical Chemistry, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Prostaglandins Leukot Essent Fatty Acids 86:35-8. 2012
    ..Oily fish intervention altered fatty acid concentrations but did not affect urinary 15-keto-dihydro-PGF(2α) concentrations in pregnant women...
  25. doi request reprint Use of multiple biomarkers to improve the prediction of death from cardiovascular causes
    Bjorn Zethelius
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    N Engl J Med 358:2107-16. 2008
    ..The incremental usefulness of adding multiple biomarkers from different disease pathways for predicting the risk of death from cardiovascular causes has not, to our knowledge, been evaluated among the elderly...
  26. pmc Serum cathepsin S is associated with decreased insulin sensitivity and the development of type 2 diabetes in a community-based cohort of elderly men
    Elisabeth Jobs
    Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala, Sweden
    Diabetes Care 36:163-5. 2013
    ..To investigate associations between serum cathepsin S, impaired insulin sensitivity, defective insulin secretion, and diabetes risk in a community-based sample of elderly men without diabetes...
  27. doi request reprint Cerebral effects of hyperglycemia in experimental cardiac arrest
    Fredrik Lennmyr
    Department of Surgical Sciences, Section of Anesthesiology and Intensive Care, Section of Cardiothoracic Surgery and Anesthesiology, Uppsala University Hospital, Uppsala, Sweden
    Crit Care Med 38:1726-32. 2010
    ..To investigate the effects of cardiac arrest on cerebral perfusion and oxidative stress during hyperglycemia and normoglycemia...
  28. doi request reprint Supplementation with a combination of antioxidants does not affect glycaemic control, oxidative stress or inflammation in type 2 diabetes subjects
    Elisabet Rytter
    Oxidative Stress and Inflammation, Department of Public Health and Caring Science, Uppsala University, Uppsala, Sweden
    Free Radic Res 44:1445-53. 2010
    ....
  29. ncbi request reprint Association of type 2 diabetes with cyclooxygenase-mediated inflammation and oxidative stress in an elderly population
    Johanna Helmersson
    Section of Geriatrics and Clinical Nutrition Research, Uppsala University, Uppsala, Sweden
    Circulation 109:1729-34. 2004
    ..Involvement of cyclooxygenase (COX)-mediated inflammation in type 2 diabetes has not been studied, and the association between cytokine-mediated inflammation and diabetes is not fully clarified...
  30. ncbi request reprint Antioxidant intake, oxidative stress and inflammation among immigrant women from the Middle East living in Sweden: associations with cardiovascular risk factors
    Achraf Daryani
    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, 751 85 Uppsala, Sweden
    Nutr Metab Cardiovasc Dis 17:748-56. 2007
    ..We also investigated relationships between F(2)-isoprostanes, CRP and cardiovascular risk factors...
  31. ncbi request reprint Antithrombin reduction after experimental cardiopulmonary resuscitation
    Jakob Johansson
    Department of Surgical Sciences Anesthesiology and Intensive Care, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Resuscitation 59:235-42. 2003
    ..To determine whether activation of coagulation and inflammation during cardiac arrest results in a reduction of antithrombin (AT) and an increase in thrombin-antithrombin (TAT) complex during reperfusion...
  32. ncbi request reprint Conjugated linoleic acid increased C-reactive protein in human subjects
    Annika Smedman
    Unit for Clinical Nutrition Research, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Br J Nutr 94:791-5. 2005
    ..CLA supplementation increased levels of C-reactive protein (P=0.003) compared with the control group. However, no changes in TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1 were detected...
  33. ncbi request reprint Low-grade albuminuria and the incidence of heart failure in a community-based cohort of elderly men
    Erik Ingelsson
    Section of Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, Uppsala, Sweden
    Eur Heart J 28:1739-45. 2007
    ..To investigate associations of urinary albumin excretion rate (UAER) and heart failure (HF) incidence in a community-based sample...
  34. ncbi request reprint Cardio-cerebral and metabolic effects of methylene blue in hypertonic sodium lactate during experimental cardiopulmonary resuscitation
    Adriana Miclescu
    Department of Surgical Sciences Anaesthesiology, Faculty of Medicine, Uppsala University, S 751 85 Uppsala, Sweden
    Resuscitation 75:88-97. 2007
    ..As MB precipitates in hypertonic sodium chloride, an alternative mixture of methylene blue in hypertonic sodium lactate (MBL) was developed and investigated during and after cardiopulmonary resuscitation (CPR)...
  35. doi request reprint The combined contribution of albuminuria and glomerular filtration rate to the prediction of cardiovascular mortality in elderly men
    Elisabet Nerpin
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
    Nephrol Dial Transplant 26:2820-7. 2011
    ..Yet, data on whether the combined addition of albuminuria and estimated glomerular filtration rate (eGFR) improves cardiovascular risk prediction in individuals without CVD in the community is scarce...
  36. ncbi request reprint Whole-grain foods do not affect insulin sensitivity or markers of lipid peroxidation and inflammation in healthy, moderately overweight subjects
    Agneta Andersson
    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    J Nutr 137:1401-7. 2007
    ....
  37. doi request reprint Neuroprotective effects of 17β-estradiol after hypovolemic cardiac arrest in immature piglets: the role of nitric oxide and peroxidation
    Egidijus Semenas
    Department of Surgical Sciences Anesthesiology and Intensive Care, Faculty of Medicine, Uppsala University Hospital, Uppsala, Sweden
    Shock 36:30-7. 2011
    ..In conclusion, in our immature piglet model of hypovolemic cardiac arrest, E₂ downregulates iNOS and nNOS expression and results in decreased blood-brain-barrier permeability disruption and smaller neuronal injury...
  38. ncbi request reprint Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men
    Ulf Riserus
    Clinical Nutrition Research Unit, Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Box 609, 75125 Uppsala, Sweden
    Am J Clin Nutr 80:279-83. 2004
    ..Because c9,t11 CLA is the predominant CLA isomer in foods and is included in dietary weight-loss products, it is important to conduct randomized controlled studies that use c9,t11 CLA preparations...
  39. ncbi request reprint Acute elevations of medium- and long-chain fatty acid have different impacts on endothelium-dependent vasodilation in humans
    Peter Steer
    Department of Medical Sciences Internal Medicine, University Hospital, SE 751 85 Uppsala, Sweden
    Lipids 38:15-9. 2003
    ..05). In conclusion, an acute elevation of LCFA attenuated EDV, whereas an elevation of both MCFA and LCFA did not influence EDV. Thus, FA composition seems to be of importance for EDV in healthy humans...
  40. ncbi request reprint Active smoking and a history of smoking are associated with enhanced prostaglandin F(2alpha), interleukin-6 and F2-isoprostane formation in elderly men
    J Helmersson
    Sections of Geriatrics and Clinical Nutrition Research, Department of Public Health and Caring Sciences, Uppsala University, Sweden
    Atherosclerosis 181:201-7. 2005
    ..Subclinical COX- and cytokine-mediated inflammation and oxidative stress are ongoing processes not only in active smokers but also in former smokers which may contribute to the accelerated atherosclerosis associated with smoking...
  41. ncbi request reprint Increased cortical cerebral blood flow by continuous infusion of adrenaline (epinephrine) during experimental cardiopulmonary resuscitation
    Jakob Johansson
    Department of Surgical Sciences Anaesthesiology and Intensive Care, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Resuscitation 57:299-307. 2003
    ....
  42. ncbi request reprint The effect of a mixed meal on endothelium-dependent vasodilation is dependent on fat content in healthy humans
    Peter Steer
    Department of Medical Sciences Internal Medicine, University Hospital, SE 751 85 Uppsala, Sweden
    Clin Sci (Lond) 105:81-7. 2003
    ..Our findings indicate that a dietary fat content of 20 E% or less might be beneficial to endothelial vasodilatory function...
  43. doi request reprint Involvement of inflammation in normal pregnancy
    Maria Palm
    Department of Women s and Children s Health, Obstetrics and Gynecology Uppsala University, Uppsala, Sweden
    Acta Obstet Gynecol Scand 92:601-5. 2013
    ..These results suggest that mild but significant inflammatory activity is involved in the development of normal pregnancy, which might have important physiological roles...
  44. doi request reprint Associations between oxidative parameters in pregnancy and birth anthropometry in a cohort of women and children in rural Bangladesh: the MINIMat-cohort
    Emma Lindström
    International Maternal and Child Health, Department of Women s and Children s Health, Uppsala University, Sweden
    Free Radic Res 46:253-64. 2012
    ..In conclusion, a higher level of lipid peroxidation in early (but not late) pregnancy was associated with a favourable larger birth size suggesting that timing of lipid peroxidation is of importance...
  45. doi request reprint Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial
    Helena Bjermo
    Department of Public Health, Uppsala University, Uppsala, Sweden
    Am J Clin Nutr 95:1003-12. 2012
    ..Replacing SFAs with vegetable PUFAs has cardiometabolic benefits, but the effects on liver fat are unknown. Increased dietary n-6 PUFAs have, however, also been proposed to promote inflammation-a yet unproven theory...
  46. doi request reprint Biomarkers of oxidative stress in overweight men are not influenced by a combination of antioxidants
    Elisabet Rytter
    Oxidative Stress and Inflammation, Department of Public Health and Caring Science, Faculty of Medicine, Uppsala University, Sweden
    Free Radic Res 44:522-8. 2010
    ..The absence of antioxidant supplement effect might possibly be explained by the chosen study group having a normal level of oxidative stress, duration of the intervention and/or doses of antioxidants...
  47. doi request reprint Systemic inflammation and the risk of Alzheimer's disease and dementia: a prospective population-based study
    Johan Sundelöf
    Department of Public Health and Caring Sciences Geriatrics, Faculty of Medicine, Uppsala University, Uppsala, Sweden
    J Alzheimers Dis 18:79-87. 2009
    ..In conclusion, Serum IL-6, hsCRP, SAA, and PGF2alpha levels are not associated with the risk of AD. High serum IL-6 levels may be associated with increased risk of non-AD dementia...
  48. doi request reprint F2-isoprostane, inflammation, cardiac function and oxygenation in the endotoxaemic pig
    Miklos Lipcsey
    Section of Anaesthesiology and Intensive Care, Department of Surgical Sciences, Uppsala University Hospital, 751 85 Uppsala, Sweden
    Prostaglandins Leukot Essent Fatty Acids 78:209-17. 2008
    ..Furthermore, formation of these eicosanoids on endotoxin-mediated alterations in pulmonary hypertension, oxygen delivery and oxygen utilisation seems to be independent of the administered endotoxin dose...
  49. ncbi request reprint Serum fatty acid composition and indices of stearoyl-CoA desaturase activity are associated with systemic inflammation: longitudinal analyses in middle-aged men
    Helena Petersson
    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, 751 85 Uppsala, Sweden
    Br J Nutr 99:1186-9. 2008
    ....
  50. ncbi request reprint Ropivacaine may have advantages compared to bupivacaine in porcine endotoxemic shock
    Diana K Mutschler
    Department of Surgical Sciences, Anaesthesia and Intensive Care, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Ups J Med Sci 111:189-99. 2006
    ..Ropivacaine displays pathophysiological advantages compared to bupivacaine in septic shock, which may be explained by improved tissue perfusion by ropivacaine...
  51. ncbi request reprint Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein: a potential link to fatty acid-induced insulin resistance
    Ulf Riserus
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
    Circulation 106:1925-9. 2002
    ..The aim of the present study was to examine whether CLA has isomer-specific effects on oxidative stress or inflammatory biomarkers and to investigate the relationship between these factors and induced insulin resistance...
  52. ncbi request reprint Apolipoprotein A1 is a stronger prognostic marker than are HDL and LDL cholesterol for cardiovascular disease and mortality in elderly men
    Gösta Florvall
    Section of Clinical Chemistry, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    J Gerontol A Biol Sci Med Sci 61:1262-6. 2006
    ..Serum ApoA1 is a better risk marker than are ApoB, ApoB/ApoA1 ratio, HDL-C, and LDL-C for cardiovascular disease and mortality in elderly men...
  53. ncbi request reprint Circulatory arrest as a model for studies of global ischemic injury and neuroprotection
    Lars Wiklund
    Department of Surgical Sciences Anesthesiology and Intensive Care Medicine, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Ann N Y Acad Sci 1053:205-19. 2005
    ..These observations suggest that our model can be used to explore neuroprotective effects of potential therapeutic agents...
  54. ncbi request reprint Methylene blue added to a hypertonic-hyperoncotic solution increases short-term survival in experimental cardiac arrest
    Adriana Miclescu
    Department of Surgical Sciences Anesthesiology and Intensive Care, Uppsala University Hospital, Uppsala, Sweden
    Crit Care Med 34:2806-13. 2006
    ..Effects of MB in cardiac arrest and cardiopulmonary resuscitation were investigated...
  55. doi request reprint Association between serum cathepsin S and mortality in older adults
    Elisabeth Jobs
    Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala, Sweden
    JAMA 306:1113-21. 2011
    ..However, prospective data concerning a potential association between circulating cathepsin S levels and mortality are lacking...
  56. doi request reprint F(2)-isoprostanes, tocopherols and normal pregnancy
    Maria Palm
    Department of Women s and Children s Health, Obstetrics and Gynecology, Uppsala University, Uppsala, Sweden
    Free Radic Res 43:546-52. 2009
    ..Lipid-adjusted alpha- and gamma-tocopherol levels decreased with advancing gestational age. This longitudinal study suggests that mild oxidative stress is involved in normal human pregnancy...
  57. ncbi request reprint Isomer-specific effects of conjugated linoleic acid on lipid peroxidation in humans: regulation by alpha-tocopherol and cyclo-oxygenase-2 inhibitor
    Annika Smedman
    Unit for Clinical Nutrition Research, Department for Public Health and Caring Sciences Geriatrics, Uppsala University, PO Box 609, S 751 25 Uppsala, Sweden
    Clin Sci (Lond) 106:67-73. 2004
    ..The CLA-induced production of PGF2alpha metabolites is probably partially mediated by COX-2. Levels of the induced lipid peroxidation may be dependent on the isomeric property of CLA...
  58. doi request reprint Allergen-induced formation of F2-isoprostanes in a murine asthma model identifies oxidative stress in acute airway inflammation in vivo
    Sofia Jonasson
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    Prostaglandins Leukot Essent Fatty Acids 80:1-7. 2009
    ..This study showed an accumulation of F(2)-isoprostanes in acute airway inflammation and a markedly increased tissue damage caused by oxidative stress in an ongoing inflammation...
  59. doi request reprint Does increased intake of salmon increase markers of oxidative stress in pregnant women? The salmon in pregnancy study
    Cruz E García-Rodríguez
    Oxidative Stress and Inflammation, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Uppsala, Sweden
    Antioxid Redox Signal 15:2819-23. 2011
    ..Thus, increased intake of salmon during pregnancy does not increase oxidative stress, as judged by the markers of oxidative damage to lipids and DNA measured herein...
  60. doi request reprint A longitudinal study of plasma levels of soluble fms-like tyrosine kinase 1 (sFlt1), placental growth factor (PlGF), sFlt1: PlGF ratio and vascular endothelial growth factor (VEGF-A) in normal pregnancy
    Maria Palm
    Department of Women s and Children s Health, Obstetrics and Gynecology, Uppsala University, Uppsala, Sweden
    Acta Obstet Gynecol Scand 90:1244-51. 2011
    ..To describe plasma levels of angiogenic (PlGF, VEGF-A) and anti-angiogenic (sFlt1) factors as well as the sFlt1:PlGF ratio throughout normal pregnancy and postpartum...
  61. ncbi request reprint Dietary (n-3) fatty acids reduce plasma F2-isoprostanes but not prostaglandin F2alpha in healthy humans
    Cecilia Nälsén
    The KANWU Study Group at Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Sweden
    J Nutr 136:1222-8. 2006
    ..We conclude that supplementation with (n-3) fatty acids decreases nonenzymatic free radical-catalyzed isoprostane formation, but does not affect cyclooxygenase-mediated prostaglandin formation...
  62. doi request reprint Regulatory factors of basal F(2)-isoprostane formation: population, age, gender and smoking habits in humans
    Samar Basu
    Oxidative Stress and Inflammation, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Uppsala Science Park, and Center of Excellence Inflammation, Uppsala University Hospital, Uppsala, Sweden
    Free Radic Res 43:85-91. 2009
    ..There is a difference in F(2)-isoprostane levels in vivo between countries. Smoking, age and gender affect isoprostane formation and should be taken into consideration in clinical studies of oxidative stress...
  63. pmc Effects of prenatal micronutrient and early food supplementation on metabolic status of the offspring at 4.5 years of age. The MINIMat randomized trial in rural Bangladesh
    Eva Charlotte Ekström
    International Maternal and Child Health, Women s and Children s Health, Uppsala University, Uppsala, Sweden
    Int J Epidemiol 45:1656-1667. 2016
    ..Fetal nutritional insults may alter the later metabolic phenotype. We hypothesized that early timing of prenatal food supplementation and multiple micronutrient supplementation (MMS) would favourably influence childhood metabolic phenotype...
  64. doi request reprint Insulin-like growth factor binding protein-1 (IGFBP-1) during normal pregnancy
    Anders Larsson
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    Gynecol Endocrinol 29:129-32. 2013
    ..To be able to evaluate IGFBP-1 values during pregnancy it is important to establish normal values in pregnant women...
  65. ncbi request reprint Endothelial vasodilatory function is predicted by circulating apolipoprotein B and HDL in healthy humans
    Peter Steer
    Departments of Medical Sciences Internal Medicine, University Hospital, SE 751 85 Uppsala, Sweden
    Lipids 37:1135-40. 2002
    ....
  66. doi request reprint Interstitial F(2)-isoprostane 8-iso-PGF(2α) as a biomarker of oxidative stress after severe human traumatic brain injury
    Fredrik Clausen
    Department of Neuroscience, Uppsala University, Uppsala University Hospital, Uppsala, Sweden
    J Neurotrauma 29:766-75. 2012
    ..Our results support a close relationship between oxidative stress and excitotoxicity following human TBI. MD-8-iso-PGF(2α) in combination with MD-glycerol may be useful biomarkers of oxidative stress in the neurointensive care setting...
  67. ncbi request reprint Prostaglandin F(2alpha) metabolite and F(2)-isoprostane excretion rates in migraine
    Johanna Helmersson
    Section of Geriatrics, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Box 609, SE 751 25 Uppsala, Sweden
    Clin Sci (Lond) 102:39-43. 2002
    ..Our results indicate, however, a lower level of oxidative stress in pre-menopausal compared with post-menopausal women...
  68. ncbi request reprint Cyclooxygenase-mediated prostaglandin F2alpha is decreased in an elderly population treated with low-dose aspirin
    J Helmersson
    Section of Clinical Nutrition Research, Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Kålsängsgränd 10D, P O Box 609, SE 751 25 Uppsala, Sweden
    Prostaglandins Leukot Essent Fatty Acids 72:227-33. 2005
    ..This observation suggests a possible COX-mediated anti-inflammatory effect of low-dose aspirin, which should be further confirmed by intervention studies...
  69. ncbi request reprint Hemocue urine albumin point-of-care test shows strong agreement with the results obtained with a large nephelometer
    Gösta Florvall
    Section of Clinical Chemistry, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Diabetes Care 29:422-3. 2006
  70. ncbi request reprint Effects of mechanical ventilation on platelet microparticles in bronchoalveolar lavage fluid
    Diana K Mutschler
    Department of Surgical Sciences, Faculty of Medicine, Uppsala University Hospital, Sweden
    Thromb Res 108:215-20. 2002
    ..We evaluated the presence of these PMPs and two prostaglandin-derived metabolites in bronchoalveolar lavage fluid (BALF) regarding their possible relation to MV...
  71. ncbi request reprint Both cyclooxygenase- and cytokine-mediated inflammation are associated with carotid intima-media thickness
    M Wohlin
    Department of Public Health and Caring Sciences Geriatrics and Clinical Nutrition, Faculty of Medicine, Uppsala University, Uppsala Science Park, SE 751 85 Uppsala, Sweden
    Cytokine 38:130-6. 2007
    ..It is unknown if various modes of inflammation (cyclooxygenase [COX]-mediated, cytokine-mediated), oxidative stress and anti-oxidants are independently related to CCA-IMT...
  72. ncbi request reprint Apolipoprotein E epsilon4 genotype is independently associated with increased intima-media thickness in a recessive pattern
    M Wohlin
    Department of Public Health and Caring Sciences Geriatrics and Clinical Nutrition, Faculty of Medicine, Uppsala University, Uppsala Science Park, 751 85, Uppsala, Sweden
    Lipids 42:451-6. 2007
    ....
  73. doi request reprint Serum and dietary beta-carotene and alpha-tocopherol and incidence of type 2 diabetes mellitus in a community-based study of Swedish men: report from the Uppsala Longitudinal Study of Adult Men (ULSAM) study
    J Arnlov
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala Science Park, Uppsala, Sweden
    Diabetologia 52:97-105. 2009
    ..To investigate the association of serum concentrations and dietary intake of beta-carotene and alpha-tocopherol with type 2 diabetes incidence...
  74. ncbi request reprint Development of a novel biomarker of free radical damage in reperfusion injury after cardiac arrest
    S Basu
    Department of Geriatrics, Faculty of Medicine, Uppsala University, P O Box 609, SE 751 25, Uppsala, Sweden
    FEBS Lett 470:1-6. 2000
    ..Thus, 8-iso-PGF(2alpha) and 15-keto-dihydro-PGF(2alpha) measurements in jugular bulb plasma may be used as biomarkers for quantification of free radical catalyzed oxidative brain injury and inflammatory response in reperfusion injury...
  75. ncbi request reprint Oxidative injury and survival during endotoxemia
    S Basu
    Department of Geriatrics, Faculty of Medicine, Uppsala University, Sweden
    FEBS Lett 438:159-60. 1998
    ..Free radical dependent oxidative injury following endotoxin induced inflammation may be the major cause of organ failure and increased mortality...
  76. pmc Serum cystatin C and the risk of Alzheimer disease in elderly men
    J Sundelof
    Uppsala University, Department of Public Health Geriatrics, Uppsala Science Park, Uppsala, Sweden
    Neurology 71:1072-9. 2008
    ..Multiple lines of research suggest that increased cystatin C activity in the brain protects against the development of Alzheimer disease (AD)...
  77. ncbi request reprint Cardiac and vascular structure and function are related to lipid peroxidation and metabolism
    Peter Steer
    Department of Medical Sciences Internal Medicine, University Hospital, Uppsala, Sweden
    Lipids 37:231-6. 2002
    ....
  78. pmc Microalbuminuria measured by three different methods, blood pressure and cardiovascular risk factors in elderly Swedish males
    Gösta Florvall
    Section of Clinical Chemistry, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Anal Chem Insights 3:69-74. 2008
    ..The good correlation between the studied urine albumin measurements show that all three methods can be used for monitoring urine albumin excretion...
  79. doi request reprint Reference values for alpha1-acid glycoprotein, alpha1-antitrypsin, albumin, haptoglobin, C-reactive protein, IgA, IgG and IgM during pregnancy
    Anders Larsson
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    Acta Obstet Gynecol Scand 87:1084-8. 2008
    ..A laboratory test result from a pregnant woman should be compared with pregnancy-specific reference intervals...
  80. ncbi request reprint Retinol palmitate counteracts oxidative injury during experimental septic shock
    S Basu
    Section of Geriatrics, Faculty of Medicine, Uppsala University, Box 609, SE 751 25 Uppsala, Sweden
    Ann Acad Med Singapore 30:265-9. 2001
    ....
  81. ncbi request reprint Propofol (Diprivan-EDTA) counteracts oxidative injury and deterioration of the arterial oxygen tension during experimental septic shock
    S Basu
    Department of Geriatrics and Clinical Nutrition Research, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Resuscitation 50:341-8. 2001
    ..CONCLUSIONS: Propofol reduced endotoxin-induced free radical mediated and cyclooxygenase catalysed lipid peroxidation significantly. The implication is that propofol counteracts endotoxin-induced deterioration of PaO(2)...
  82. ncbi request reprint Differences in cerebral reperfusion and oxidative injury after cardiac arrest in pigs
    X L Liu
    Departments of Anaesthesiology and Intensive Care and Public Health Geriatrics, Uppsala University Hospital, Uppsala, Sweden
    Acta Anaesthesiol Scand 47:958-67. 2003
    ....
  83. ncbi request reprint Intra-day variation of in vivo prostaglandin F2alpha formation in healthy subjects
    Johanna Helmersson
    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Uppsala Science Park, SE 751 85 Uppsala, Sweden
    Prostaglandins Other Lipid Mediat 80:93-9. 2006
    ..Single morning urine samples can be used as an alternative to 24-h urine collections for quantification of PGF(2alpha) formation to simplify the sampling regime in larger clinical studies...
  84. ncbi request reprint CLA and body weight regulation in humans
    Ulf Riserus
    Unit for Clinical Nutrition Research, Department of Public Health and Caring Sciences, University of Uppsala, Uppsala, Sweden
    Lipids 38:133-7. 2003
    ..In addition, CLA markedly elevated lipid peroxidation. Thus, the metabolic effects of CLA in humans seem complex; further studies, especially of isomer-specific effects and for longer time periods, are warranted...
  85. ncbi request reprint Increased serum cystatin C is associated with increased mortality in elderly men
    A Larsson
    Section of Clinical Chemistry, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Scand J Clin Lab Invest 65:301-5. 2005
    ..The cystatin C values were significantly correlated with overall mortality (p=0.013). Mortality was three times higher in the highest cystatin C quintile in relation to the lowest quintile...
  86. ncbi request reprint Metabolism of 8-iso-prostaglandin F2alpha
    S Basu
    Department of Geriatrics, Faculty of Medicine, Uppsala University, Sweden
    FEBS Lett 428:32-6. 1998
    ..Thus, 8-iso-PGF2alpha metabolises in the rabbit mainly to several degraded polar metabolites through dehydrogenation at C-15, reduction of delta13-double bond and beta-oxidation, and excretes efficiently into the urine...
  87. pmc Raised levels of F(2)-isoprostanes and prostaglandin F(2alpha) in different rheumatic diseases
    S Basu
    Sections of Geriatrics and Clinical Nutrition Research, Faculty of Medicine, Uppsala University, Box 609, SE 751 25 Uppsala, Sweden
    Ann Rheum Dis 60:627-31. 2001
    ..To evaluate oxidative injury and inflammatory status in various rheumatic diseases by measuring the levels of isoprostanes and prostaglandins in serum and synovial fluid...
  88. ncbi request reprint F(2)-isoprostane and prostaglandin F(2 alpha)metabolite excretion rate and day to day variation in healthy humans
    J Helmersson
    Unit of Clinical Nutrition Research, Uppsala University, Sweden
    Prostaglandins Leukot Essent Fatty Acids 65:99-102. 2001
    ....
  89. ncbi request reprint Association between oxidative stress and bone mineral density
    S Basu
    Sections of Geriatrics and Clinical Nutrition Research, Uppsala University Hospital, S 751 25 Uppsala, Sweden
    Biochem Biophys Res Commun 288:275-9. 2001
    ..Our findings establish a biochemical link between increased oxidative stress and reduced bone density and provide a rational for further studies investigating the role of pro- and antioxidants in osteoporosis...
  90. ncbi request reprint Vitamin E in relation to lipid peroxidation in experimental septic shock
    S Basu
    Department of Geriatrics Clinical Nutrition Research, Faculty of Medicine, Uppsala University, Sweden
    Prostaglandins Leukot Essent Fatty Acids 62:195-9. 2000
    ....
  91. ncbi request reprint A diet containing rapeseed oil-based fats does not increase lipid peroxidation in humans when compared to a diet rich in saturated fatty acids
    E Sodergren
    Section for Geriatrics Clinical Nutrition Research, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Eur J Clin Nutr 55:922-31. 2001
    ....
  92. doi request reprint Pittsburgh compound-B and Alzheimer's disease biomarkers in CSF, plasma and urine: An exploratory study
    M Degerman Gunnarsson
    Department of Public Health Geriatrics, Uppsala University, Sweden
    Dement Geriatr Cogn Disord 29:204-12. 2010
    ....
  93. ncbi request reprint Microdialysis-evaluated myocardial cyclooxygenase-mediated inflammation and early circulatory depression in porcine endotoxemia
    D K Mutschler
    Department of Surgical Sciences, Institute of Anesthesiology and Critical Care, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Crit Care Med 31:1780-5. 2003
    ..To evaluate the early myocardial biochemical inflammatory response with the microdialysis technique during porcine endotoxemia and to simultaneously monitor systemic hemodynamics...
  94. ncbi request reprint Conjugated linoleic acid induces lipid peroxidation in humans
    S Basu
    Section of Geriatrics Clinical Nutrition Research, Faculty of Medicine, Uppsala University, Box 609, SE 751 25, Uppsala, Sweden
    FEBS Lett 468:33-6. 2000
    ..Thus, CLA may induce both non-enzymatic and enzymatic lipid peroxidation in vivo. Further studies of the mechanism behind, and the possible consequences of, the increased lipid peroxidation after CLA supplementation are urgently needed...
  95. ncbi request reprint Oxidative stress and antioxidant status in type 1 diabetes mellitus
    J Vessby
    Section for Clinical Nutrition Research, Department of Public and Caring Sciences, Uppsala University, Uppsala, Sweden
    J Intern Med 251:69-76. 2002
    ....
  96. ncbi request reprint Oxidative injury induced cyclooxygenase activation in experimental hepatotoxicity
    S Basu
    Department of Geriatrics, Faculty of Medicine, Uppsala University, Uppsala, S 751 25, Sweden
    Biochem Biophys Res Commun 254:764-7. 1999
    ..Cyclooxygenase-dependent inflammatory response through PGF2alpha formation in CCl4-induced hepatotoxicity may possibly be a secondary effect to oxidative injury and a conceivable link between inflammatory response and oxidative injury...
  97. ncbi request reprint Neurological outcome after experimental cardiopulmonary resuscitation: a result of delayed and potentially treatable neuronal injury?
    X L Liu
    Department of Surgical Sciences Anaesthesiology and Intensive Care, Uppsala University Hospital, Uppsala, Sweden
    Acta Anaesthesiol Scand 46:537-46. 2002
    ..Free radical scavenger alpha-phenyl-N-tert-butyl-nitrone (PBN) and cyclosporine-A (CsA) alleviate neuronal damage after global ischemia. Combining these treatments, we investigated neurological outcome after experimental cardiac arrest...
  98. ncbi request reprint Oxidative stress and changes in alpha- and gamma-tocopherol levels during coronary artery bypass grafting
    A T Ulus
    Sections of Geriatrics and Clinical Nutrition Research, Faculty of Medicine, Uppsala University, Uppsala, Sweden
    Ann N Y Acad Sci 1031:352-6. 2004
    ..These findings suggest that an increased free radical-induced oxidative stress together with a gradual appearance of antioxidative defense system during and after CPB...
  99. doi request reprint Sex differences in cerebral injury after severe haemorrhage and ventricular fibrillation in pigs
    E Semenas
    Department of Surgical Sciences Anesthesiology and Intensive Care, Faculty of Medicine, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Acta Anaesthesiol Scand 54:343-53. 2010
    ..The hypothesis was that cerebral injury is less extensive in female animals, and that this difference is independent of sexual hormones or choice of resuscitative fluid...
  100. ncbi request reprint Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity
    S Basu
    Sections of Geriatrics and Clinical Nutrition Research, Faculty of Medicine, Uppsala University, Box 609, SE 751 25 Uppsala, Sweden
    Clin Sci (Lond) 99:511-6. 2000
    ..Thus CLA may induce both non-enzymic and enzymic lipid peroxidation in vivo in middle-aged men with abdominal obesity, without any side effects. The consequences of the increased lipid peroxidation after CLA supplementation are unknown...
  101. ncbi request reprint N-acetylcysteine attenuates kidney injury in rats subjected to renal ischaemia-reperfusion
    Nicoletta Nitescu
    Department of Anaesthesiology and Intensive Care, Institute of Surgical Sciences, The Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Nephrol Dial Transplant 21:1240-7. 2006
    ..The aim of the present study is to examine the effects of N-acetylcysteine (NAC), a thiol-containing anti-oxidant, on renal function and morphology, and biomarkers of oxidative stress, in rats subjected to renal ischaemia-reperfusion (IR)...