Henrik Sjovall

Summary

Affiliation: Sahlgrenska University Hospital
Country: Sweden

Publications

  1. ncbi request reprint Pharmacokinetic study of esomeprazole in patients with hepatic impairment
    Henrik Sjovall
    Sahlgrenska University Hospital, Goteborg, Sweden
    Eur J Gastroenterol Hepatol 14:491-6. 2002
  2. doi request reprint Meaningful or redundant complexity - mechanisms behind cyclic changes in gastroduodenal pH in the fasting state
    H Sjovall
    Department of Internal Medicine, University of Gothenburg, Sweden
    Acta Physiol (Oxf) 201:127-31. 2011
  3. pmc Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis
    Malin E V Johansson
    Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden
    Gut 63:281-91. 2014
  4. pmc Carbachol-induced colonic mucus formation requires transport via NKCC1, K⁺ channels and CFTR
    Jenny K Gustafsson
    Department of Medical Biochemistry, University of Gothenburg, Medicinaregatan 9A, Box 440, Gothenburg, 405 30, Sweden
    Pflugers Arch 467:1403-15. 2015
  5. pmc Proteomic mucin profiling for the identification of cystic precursors of pancreatic cancer
    Karolina S Jabbar
    Affiliations of authors Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden KSJ, GCH Department of Gastroenterology and Hepatology KSJ, HS, RS and Department of Surgery AGH, Sahlgrenska University Hospital, Gothenburg, Sweden Division of Pathology, Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden CV
    J Natl Cancer Inst 106:djt439. 2014
  6. ncbi request reprint Normal or increased bile acid uptake in isolated mucosa from patients with bile acid malabsorption
    Antal Bajor
    Division of Gastroenterology, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Eur J Gastroenterol Hepatol 18:397-403. 2006
  7. pmc Transcriptome signatures in Helicobacter pylori-infected mucosa identifies acidic mammalian chitinase loss as a corpus atrophy marker
    Intawat Nookaew
    Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    BMC Med Genomics 6:41. 2013
  8. pmc Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis
    Ulf A Wenzel
    Department of Microbiology and Immunology and the Mucosal Immunobiology and Vaccine Center MIVAC, Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 9:e100217. 2014
  9. pmc Dynamic changes in mucus thickness and ion secretion during Citrobacter rodentium infection and clearance
    Jenny K Gustafsson
    Department of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 8:e84430. 2013
  10. ncbi request reprint Small intestinal motility disturbances and bacterial overgrowth in patients with liver cirrhosis and portal hypertension
    Steingerdur Anna Gunnarsdottir
    Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Goteborg, Sweden
    Am J Gastroenterol 98:1362-70. 2003

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Pharmacokinetic study of esomeprazole in patients with hepatic impairment
    Henrik Sjovall
    Sahlgrenska University Hospital, Goteborg, Sweden
    Eur J Gastroenterol Hepatol 14:491-6. 2002
    ..To evaluate the pharmacokinetics and safety of esomeprazole (Nexium), the S-isomer of omeprazole, after repeated oral dosing in patients with hepatic impairment...
  2. doi request reprint Meaningful or redundant complexity - mechanisms behind cyclic changes in gastroduodenal pH in the fasting state
    H Sjovall
    Department of Internal Medicine, University of Gothenburg, Sweden
    Acta Physiol (Oxf) 201:127-31. 2011
    ..Possible physiological and pathophysiological implications of this complex system, in particular the role of the gastric mucus layer in antral Helicobacter infection, will be discussed...
  3. pmc Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis
    Malin E V Johansson
    Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden
    Gut 63:281-91. 2014
    ..Do humans have a similar inner mucus layer and are defects in this mucus layer a common denominator for spontaneous colitis in mice models and ulcerative colitis (UC)?..
  4. pmc Carbachol-induced colonic mucus formation requires transport via NKCC1, K⁺ channels and CFTR
    Jenny K Gustafsson
    Department of Medical Biochemistry, University of Gothenburg, Medicinaregatan 9A, Box 440, Gothenburg, 405 30, Sweden
    Pflugers Arch 467:1403-15. 2015
    ..In conclusion, these findings suggest that colonic epithelial transport regulates mucus formation by affecting both exocytosis and expansion of the mucin molecules. ..
  5. pmc Proteomic mucin profiling for the identification of cystic precursors of pancreatic cancer
    Karolina S Jabbar
    Affiliations of authors Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden KSJ, GCH Department of Gastroenterology and Hepatology KSJ, HS, RS and Department of Surgery AGH, Sahlgrenska University Hospital, Gothenburg, Sweden Division of Pathology, Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden CV
    J Natl Cancer Inst 106:djt439. 2014
    ..Better diagnostic tools are required for patients to benefit from this development...
  6. ncbi request reprint Normal or increased bile acid uptake in isolated mucosa from patients with bile acid malabsorption
    Antal Bajor
    Division of Gastroenterology, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Eur J Gastroenterol Hepatol 18:397-403. 2006
    ..Bile acid malabsorption as reflected by an abnormal Se-labelled homocholic acid-taurine (SeHCAT) test is associated with diarrhoea, but the mechanisms and cause-and-effect relations are unclear...
  7. pmc Transcriptome signatures in Helicobacter pylori-infected mucosa identifies acidic mammalian chitinase loss as a corpus atrophy marker
    Intawat Nookaew
    Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    BMC Med Genomics 6:41. 2013
    ..We aimed to increase understanding of the molecular details of atrophy by performing a global transcriptome analysis of stomach tissue...
  8. pmc Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis
    Ulf A Wenzel
    Department of Microbiology and Immunology and the Mucosal Immunobiology and Vaccine Center MIVAC, Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 9:e100217. 2014
    ..Alterations in the immune compartment due to intestinal bacterial breach in mice lacking the colon mucus barrier have not been characterized and correlated to active UC...
  9. pmc Dynamic changes in mucus thickness and ion secretion during Citrobacter rodentium infection and clearance
    Jenny K Gustafsson
    Department of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 8:e84430. 2013
    ..In conclusion, mucus and ion secretion are dynamically altered during the C. rodentium infection cycle. ..
  10. ncbi request reprint Small intestinal motility disturbances and bacterial overgrowth in patients with liver cirrhosis and portal hypertension
    Steingerdur Anna Gunnarsdottir
    Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Goteborg, Sweden
    Am J Gastroenterol 98:1362-70. 2003
    ..Our aim was to explore the relationship between motility abnormalities, portal hypertension, and SIBO...
  11. doi request reprint The importance of a person-centered approach in diagnostic workups of patients with irritable bowel syndrome: a qualitative study
    Gisela Ringström
    Gisela Ringstrom, PhD, RN, is Head Nurse, Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy and University of Gothenburg Centre for Person Centered Care GPCC, University of Gothenburg, Gothenburg, Sweden Henrik Sjovall, PhD, MD, is Professor, Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy and University of Gothenburg Centre for Person Centered Care GPCC, University of Gothenburg, Gothenburg, Sweden Magnus Simrén, PhD, MD, is Professor, Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy and University of Gothenburg Centre for Person Centered Care GPCC, University of Gothenburg, Gothenburg, Sweden Eva Jakobsson Ung, PhD, RN, is Senior Lecturer and Associate Professor, Institute of Health and Care Sciences, Sahlgrenska Academy and University of Gothenburg Centre of Person Centered Care GPCC, University of Gothenburg, Gothenburg, Sweden
    Gastroenterol Nurs 36:443-51. 2013
    ..Validation of IBS experience surfaced in the data implying that in such context, patients with IBS appear to find personal solutions to cope with everyday experiences and enhance autonomy. ..
  12. doi request reprint An Antibody Against Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) Dampens Proinflammatory Cytokine Secretion by Lamina Propria Cells from Patients with IBD
    Siggeir F Brynjolfsson
    Department of Microbiology and Immunology, Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Novo Nordisk Research Center, Seattle, USA and Novo Nordisk A S, Måløv, Denmark
    Inflamm Bowel Dis 22:1803-11. 2016
    ..Here, the ability of an anti-TREM-1 antibody to dampen the release of proinflammatory cytokines by colon lamina propria cells (LPCs) from patients with IBD was investigated and correlated with PGLYRP-1 levels...
  13. ncbi request reprint Effects of nicotinic receptor blockade on the colonic mucosal response to luminal bile acids in anaesthetized rats
    Ying Sun
    Department of Physiology, University of Goteborg, Goteborg, Sweden
    Acta Physiol Scand 178:251-60. 2003
    ..To test the hypothesis that nicotinic receptor mechanisms mediate the effects of bile acids on the colonic mucosa...
  14. pmc The gastrointestinal mucus system in health and disease
    Malin E V Johansson
    Department of Medical Biochemistry, The Sahlgrenska Academy, University of Gothenburg, Box 440, 405 30, Gothenburg, Sweden
    Nat Rev Gastroenterol Hepatol 10:352-61. 2013
    ..When bacteria reach the epithelial surface, the immune system is activated and inflammation is triggered. This mechanism might occur in some types of ulcerative colitis...
  15. doi request reprint How patients with long-term experience of living with irritable bowel syndrome manage illness in daily life: a qualitative study
    Eva Jakobsson Ung
    aInstitute of Health and Care Sciences bDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine cCentre for Person Centred Care GPCC, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Eur J Gastroenterol Hepatol 25:1478-83. 2013
    ..The aim of this study was to explore how patients with long-term experience of living with IBS perceive their situation and manage illness in daily life...
  16. doi request reprint Immune responses against Helicobacter pylori in gastric cancer patients and in risk groups for gastric cancer
    Jenni Adamsson
    Department of Microbiology and Immunology, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
    Helicobacter 18:73-82. 2013
    ..pylori may be associated with risk of gastric cancer (GC) development. To search for potential immunologic markers for GC, we analyzed antibody responses against H. pylori in risk groups of cancer development...
  17. ncbi request reprint Abnormal levels of neuropeptide Y and peptide YY in the colon in irritable bowel syndrome
    Magnus Simren
    Section of Gastroenterology, Department of Internal Medicine, Sahlgrenska University Hosptial, Goteborg, Sweden
    Eur J Gastroenterol Hepatol 15:55-62. 2003
    ..To assess the levels of gut peptides involved in gastrointestinal motor, secretory and sensory function in colonic biopsies in irritable bowel syndrome (IBS) patients and healthy controls...
  18. doi request reprint T-cell activation in patients with irritable bowel syndrome
    Lena Ohman
    Department of Internal Medicine, Institute of Medicine, The Sahlgren s Academy, University of Gothenburg, Gothenburg, Sweden
    Am J Gastroenterol 104:1205-12. 2009
    ..Irritable bowel syndrome (IBS) has been found to be associated with low-grade immune activation in a subset of patients. We therefore investigated blood and colonic T-cell activity in IBS patients...