John Olov Jansson

Summary

Affiliation: Sahlgrenska University Hospital
Country: Sweden

Publications

  1. ncbi request reprint Effects of liver-derived insulin-like growth factor I on bone metabolism in mice
    Klara Sjögren
    RCEM, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    J Bone Miner Res 17:1977-87. 2002
  2. ncbi request reprint [Unexpected pharmacological effect resulted in discovery of ghrelin. A new hormone of significance for obesity research]
    John Olov Jansson
    Research Center for Endocrinology and Metabolism RCEM, Sahlgrenska akademin, Goteborg
    Lakartidningen 99:2140-1. 2002
  3. ncbi request reprint Leukemia inhibitory factor reduces body fat mass in ovariectomized mice
    John Olov Jansson
    Research Center for Endocrinology and Metabolism, University of Goteborg, Sweden
    Eur J Endocrinol 154:349-54. 2006
  4. ncbi request reprint On the site and mechanism of action of the anti-obesity effects of interleukin-6
    John Olov Jansson
    Division of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden
    Growth Horm IGF Res 13:S28-32. 2003
  5. ncbi request reprint Interleukin-6-deficient mice develop mature-onset obesity
    Ville Wallenius
    Research Center for Endocrinology and Metabolism, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden
    Nat Med 8:75-9. 2002
  6. pmc Liver-derived IGF-I regulates mean life span in mice
    Johan Svensson
    Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    PLoS ONE 6:e22640. 2011
  7. ncbi request reprint Interleukin-1 system gene polymorphisms are associated with fat mass in young men
    Louise Strandberg
    Institute of Neuroscience and Physiology Endocrinology, Sahlgrenska Academy, Goteborg University, P O Box 434, SE 405 30 Goteborg, Sweden
    J Clin Endocrinol Metab 91:2749-54. 2006
  8. ncbi request reprint Reduced exercise endurance in interleukin-6-deficient mice
    Jenny Fäldt
    Research Center for Endocrinology and Metabolism, Sahlgrenska University Hospital, Grona Straket 8, SE 413 45 Gothenburg, Sweden
    Endocrinology 145:2680-6. 2004
  9. ncbi request reprint Interleukin-6 levels in the central nervous system are negatively correlated with fat mass in overweight/obese subjects
    Kaj Stenlof
    Research Center for Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
    J Clin Endocrinol Metab 88:4379-83. 2003
  10. ncbi request reprint Intracerebroventricular interleukin-6 treatment decreases body fat in rats
    Kristina Wallenius
    Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    Biochem Biophys Res Commun 293:560-5. 2002

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Effects of liver-derived insulin-like growth factor I on bone metabolism in mice
    Klara Sjögren
    RCEM, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    J Bone Miner Res 17:1977-87. 2002
    ..In summary, liver-derived IGF-I exerts a small but significant effect on cortical periosteal bone growth and on adult axial skeletal growth while it is not required for the maintenance of the trabecular bone in adult mice...
  2. ncbi request reprint [Unexpected pharmacological effect resulted in discovery of ghrelin. A new hormone of significance for obesity research]
    John Olov Jansson
    Research Center for Endocrinology and Metabolism RCEM, Sahlgrenska akademin, Goteborg
    Lakartidningen 99:2140-1. 2002
  3. ncbi request reprint Leukemia inhibitory factor reduces body fat mass in ovariectomized mice
    John Olov Jansson
    Research Center for Endocrinology and Metabolism, University of Goteborg, Sweden
    Eur J Endocrinol 154:349-54. 2006
    ..LIF and other cytokines acting via the gp130 signal transducing receptor have been reported to decrease obesity. In the present study, we investigated whether LIF treatment can reduce obesity in OVX mice...
  4. ncbi request reprint On the site and mechanism of action of the anti-obesity effects of interleukin-6
    John Olov Jansson
    Division of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden
    Growth Horm IGF Res 13:S28-32. 2003
    ..Chronic ICV IL-6 treatment decreased body weight and fat mass in rodents. Administration of IL-6 may decrease fat mass in mice and rats by stimulating energy expenditure at the CNS level, possibly in the hypothalamus...
  5. ncbi request reprint Interleukin-6-deficient mice develop mature-onset obesity
    Ville Wallenius
    Research Center for Endocrinology and Metabolism, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden
    Nat Med 8:75-9. 2002
    ..Intracerebroventricular, but not intraperitoneal IL-6 treatment increased energy expenditure. In conclusion, centrally acting IL-6 exerts anti-obesity effects in rodents...
  6. pmc Liver-derived IGF-I regulates mean life span in mice
    Johan Svensson
    Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    PLoS ONE 6:e22640. 2011
    ..This study investigated whether specific deficiency of liver-derived, endocrine IGF-I is of importance for life span...
  7. ncbi request reprint Interleukin-1 system gene polymorphisms are associated with fat mass in young men
    Louise Strandberg
    Institute of Neuroscience and Physiology Endocrinology, Sahlgrenska Academy, Goteborg University, P O Box 434, SE 405 30 Goteborg, Sweden
    J Clin Endocrinol Metab 91:2749-54. 2006
    ..There is growing evidence for interactions between the regulation of body fat and the immune system. Studies of knockout mice indicate that IL-1 has an antiobesity effect...
  8. ncbi request reprint Reduced exercise endurance in interleukin-6-deficient mice
    Jenny Fäldt
    Research Center for Endocrinology and Metabolism, Sahlgrenska University Hospital, Grona Straket 8, SE 413 45 Gothenburg, Sweden
    Endocrinology 145:2680-6. 2004
    ..In summary, IL-6(-/-) mice have reduced endurance and energy expenditure during exercise, suggesting that IL-6 is necessary for normal exercise capacity...
  9. ncbi request reprint Interleukin-6 levels in the central nervous system are negatively correlated with fat mass in overweight/obese subjects
    Kaj Stenlof
    Research Center for Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
    J Clin Endocrinol Metab 88:4379-83. 2003
    ..CSF IL-6 may be locally produced rather than serum derived, and body fat-regulating regions in the central nervous system may be exposed to insufficient IL-6 levels in more severe obesity...
  10. ncbi request reprint Intracerebroventricular interleukin-6 treatment decreases body fat in rats
    Kristina Wallenius
    Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    Biochem Biophys Res Commun 293:560-5. 2002
    ..We conclude that centrally administered IL-6 can decrease body fat in rats without causing acute-phase reaction...
  11. ncbi request reprint A model for tissue-specific inducible insulin-like growth factor-I (IGF-I) inactivation to determine the physiological role of liver-derived IGF-I
    Klara Sjögren
    Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    Endocrine 19:249-56. 2002
    ..Furthermore, it regulates adult axial skeletal growth and cortical radial growth while it is not required for appendicular skeletal growth...
  12. ncbi request reprint Mature-onset obesity in interleukin-1 receptor I knockout mice
    Maria C Garcia
    Department of Physiology and Wallenberg Laboratory, Goteborg University, Medicinargatan 9A, Goteborg, Sweden
    Diabetes 55:1205-13. 2006
    ..In conclusion, lack of IL-1RI-mediated biological activity causes mature-onset obesity. This obese phenotype is preceded by decreased leptin sensitivity, fat utilization, and locomotor activity...
  13. ncbi request reprint Liver-derived insulin-like growth factor-I is involved in the regulation of blood pressure in mice
    Asa Tivesten
    Research Center for Endocrinology and Metabolism, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Endocrinology 143:4235-42. 2002
    ..In conclusion, our findings suggest that liver-derived IGF-I is involved in the regulation of BP in mice...
  14. doi request reprint Liver-derived IGF1 enhances the androgenic response in prostate
    Johan Svensson
    Division of Endocrinology, Department of Internal Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, Goteborg University, Grona Straket 8, SE 413 45 Goteborg, Sweden
    J Endocrinol 199:489-97. 2008
    ..These findings may explain, at least in part, the well-known clinical association between serum IGF1 levels and conditions with abnormal prostate growth...
  15. ncbi request reprint The therapeutic potential of interleukin-6 in treating obesity
    Kristina Wallenius
    Research Center for Endocrinology and Metabolism RCEM, Endocrine Division, Sahlgrenska University Hospital, Grona Straket 8, SE 413 45 Gothenburg, Sweden
    Expert Opin Biol Ther 3:1061-70. 2003
    ..Taken together, these data suggest that endogenous IL-6 has antiobesity effects and, therefore, it is possible that low endogenous IL-6 production contributes to obesity in humans...
  16. ncbi request reprint Reduced stress- and cold-induced increase in energy expenditure in interleukin-6-deficient mice
    Ingrid Wernstedt
    Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Gothenburg, Sweden
    Am J Physiol Regul Integr Comp Physiol 291:R551-7. 2006
    ..The present results indicate that endogenous IL-6 is of importance for stress- and cold-induced energy expenditure in mice...
  17. pmc Mice chronically fed high-fat diet have increased mortality and disturbed immune response in sepsis
    Louise Strandberg
    Institute of Neuroscience and Physiology Endocrinology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 4:e7605. 2009
    ..aureus). As there are few effective therapies for sepsis, increased basic knowledge about factors predisposing is needed...
  18. pmc Heparanase affects food intake and regulates energy balance in mice
    Linda Karlsson-Lindahl
    Institute of Neuroscience and Physiology Endocrinology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 7:e34313. 2012
    ..Our data indicate that heparanase acts as a negative modulator of AgRP signaling at MC4R, through cleavage of heparan sulfate chains presumably linked to syndecan-3...
  19. pmc Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca2+ influx in response to IL-6
    Fredrik Anesten
    Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Am J Physiol Regul Integr Comp Physiol 311:R115-23. 2016
    ..In summary, IL-6Rα is present on PPG neurons in the NTS, and IL-6 can stimulate these cells by increasing influx of Ca(2+) to the cytosol from the extracellular space. ..
  20. pmc Six Tissue Transcriptomics Reveals Specific Immune Suppression in Spleen by Dietary Polyunsaturated Fatty Acids
    Sara L Svahn
    Dept of Physiology, Institute of Neuroscience and Physiology, Gothenburg, Sweden
    PLoS ONE 11:e0155099. 2016
    ..Remarkably, dietary PUFA, but not saturated fat, prompted a specific regulation of immune related genes in the spleen, opening the possibility that PUFA can regulate immune function by influencing gene expression in this organ. ..
  21. pmc Dietary Omega-3 Fatty Acids Increase Survival and Decrease Bacterial Load in Mice Subjected to Staphylococcus aureus-Induced Sepsis
    Sara L Svahn
    Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburgy, Gothenburg, Sweden
    Infect Immun 84:1205-13. 2016
    ..aureus-induced sepsis compared with that in mice treated with vehicle. Dietary omega-3 fatty acids increase the survival of S. aureus-induced sepsis by reversing the deleterious effect of HFD-S on mouse survival...
  22. doi request reprint Edentulism associated with obesity: a study of four national surveys of 16 416 Swedes aged 55–84 years
    Tor Osterberg
    Department of Prosthetic Dentistry, The Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
    Acta Odontol Scand 68:360-7. 2010
    ..To investigate the association between edentulism and obesity in the Swedish population aged 55–84 years over a 22-year period as a result of changes in health and socio-economic factors...
  23. pmc Dietary polyunsaturated fatty acids increase survival and decrease bacterial load during septic Staphylococcus aureus infection and improve neutrophil function in mice
    Sara L Svahn
    Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Infect Immun 83:514-21. 2015
    ..aureus infection. Moreover, this diet increased the frequency and chemotaxis of neutrophils, key components of the immune response to S. aureus infections. ..
  24. pmc The androgen receptor confers protection against diet-induced atherosclerosis, obesity, and dyslipidemia in female mice
    Johan B Fagman
    Wallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Laboratory for Experimental Medicine and Endocrinology, Department of Experimental Medicine, Katholieke Universiteit Leuven, Leuven, Belgium Department of Physiology, Institute of Neuroscience and Physiology, and Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Nordic School of Public Health, Gothenburg, Sweden and Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    FASEB J 29:1540-50. 2015
    ..In conclusion, we demonstrate that the AR protects against diet-induced atherosclerosis in female mice and propose that this is mediated by modulation of body composition and lipid metabolism...
  25. doi request reprint IL6 and IL1B polymorphisms are associated with fat mass in older men: the MrOS Study Sweden
    Louise Strandberg
    Institute of Neuroscience and Physiology Endocrinology, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Obesity (Silver Spring) 16:710-3. 2008
    ..In conclusion, the IL-1 and IL-6 systems, shown to suppress mature-onset obesity in experimental animals, contain gene polymorphisms that are associated with fat, but not lean, mass in elderly men...
  26. pmc The role of liver-derived insulin-like growth factor-I
    Claes Ohlsson
    Division of Endocrinology, Institute of Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Endocr Rev 30:494-535. 2009
    ..All of the described multiple endocrine effects of liver-derived IGF-I should be considered in the development of possible novel treatment strategies aimed at increasing or reducing endocrine IGF-I activity...
  27. ncbi request reprint Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis
    John Olov Jansson
    J Appl Physiol 102:821; author reply 825. 2007
  28. ncbi request reprint A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population
    Anna Benrick
    Department of Neuroscience and Physiology, Goteborg University, Sweden
    Regul Pept 146:189-96. 2008
    ..The variant is also associated with decreased IL-6 responsiveness and could lead to a configuration change in the gp130 receptor...