Johannes Hulthe

Summary

Affiliation: Sahlgrenska University Hospital
Country: Sweden

Publications

  1. ncbi request reprint Monocytic expression of CD14 and CD18, circulating adhesion molecules and inflammatory markers in women with diabetes mellitus and impaired glucose tolerance
    L Fogelstrand
    Wallenberg Laboratory for Cardiovascular Research, Cardiovascular Institute, Sahlgrenska Academy at Goteborg University, Bruna Straket 16, 413 45 Goteborg, Sweden
    Diabetologia 47:1948-52. 2004
  2. ncbi request reprint Antibody titers against oxidized LDL are not elevated in patients with familial hypercholesterolemia
    J Hulthe
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    Arterioscler Thromb Vasc Biol 18:1203-11. 1998
  3. ncbi request reprint Antibodies to oxidized LDL in atherosclerosis development--clinical and animal studies
    Johannes Hulthe
    The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, Gothenburg 413 45, Sweden
    Clin Chim Acta 348:1-8. 2004
  4. ncbi request reprint Circulating ICAM-1 (intercellular cell-adhesion molecule 1) is associated with early stages of atherosclerosis development and with inflammatory cytokines in healthy 58-year-old men: the Atherosclerosis and Insulin Resistance (AIR) study
    Johannes Hulthe
    The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, S 413 45 Gothenburg, Sweden
    Clin Sci (Lond) 103:123-9. 2002
  5. ncbi request reprint Circulating oxidized LDL is associated with subclinical atherosclerosis development and inflammatory cytokines (AIR Study)
    Johannes Hulthe
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    Arterioscler Thromb Vasc Biol 22:1162-7. 2002
  6. ncbi request reprint Circulating oxidized LDL is associated with increased levels of cell-adhesion molecules in clinically healthy 58-year old men (AIR study)
    Johannes Hulthe
    The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Sahlgrenska Academy, Goteborg University, Gothenburg, Sweden
    Med Sci Monit 8:CR148-52. 2002
  7. ncbi request reprint Relationship between C-reactive protein and intima-media thickness in the carotid and femoral arteries and to antibodies against oxidized low-density lipoprotein in healthy men: the Atherosclerosis and Insulin Resistance (AIR) study
    J Hulthe
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, 413 45 Gothenburg, Sweden
    Clin Sci (Lond) 100:371-8. 2001
  8. ncbi request reprint Antibodies to oxidized LDL in relation to intima-media thickness in carotid and femoral arteries in 58-year-old subjectively clinically healthy men
    J Hulthe
    Wallenberg Laboratory for Cardiovascular Research, Department of Medicine, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    Arterioscler Thromb Vasc Biol 21:101-7. 2001
  9. ncbi request reprint LDL particle size in relation to intima-media thickness and plaque occurrence in the carotid and femoral arteries in patients with hypercholesterolaemia
    J Hulthe
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    J Intern Med 248:42-52. 2000
  10. ncbi request reprint The metabolic syndrome, LDL particle size, and atherosclerosis: the Atherosclerosis and Insulin Resistance (AIR) study
    J Hulthe
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    Arterioscler Thromb Vasc Biol 20:2140-7. 2000

Detail Information

Publications66

  1. ncbi request reprint Monocytic expression of CD14 and CD18, circulating adhesion molecules and inflammatory markers in women with diabetes mellitus and impaired glucose tolerance
    L Fogelstrand
    Wallenberg Laboratory for Cardiovascular Research, Cardiovascular Institute, Sahlgrenska Academy at Goteborg University, Bruna Straket 16, 413 45 Goteborg, Sweden
    Diabetologia 47:1948-52. 2004
    ..The aim of this study was to investigate levels of CD14 and the beta(2)-integrin subunits CD11b and CD18 on monocytes from women with diabetes or impaired glucose tolerance...
  2. ncbi request reprint Antibody titers against oxidized LDL are not elevated in patients with familial hypercholesterolemia
    J Hulthe
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    Arterioscler Thromb Vasc Biol 18:1203-11. 1998
    ..Taken together, these findings indicate that the relationship between the autoimmune response to Ox-LDL and the extent of atherosclerosis is more complex than previously anticipated...
  3. ncbi request reprint Antibodies to oxidized LDL in atherosclerosis development--clinical and animal studies
    Johannes Hulthe
    The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, Gothenburg 413 45, Sweden
    Clin Chim Acta 348:1-8. 2004
    ..Prospective and intervention studies, as well as mechanistic studies are clearly needed to elucidate the possible causal role of antibodies to oxLDL in man...
  4. ncbi request reprint Circulating ICAM-1 (intercellular cell-adhesion molecule 1) is associated with early stages of atherosclerosis development and with inflammatory cytokines in healthy 58-year-old men: the Atherosclerosis and Insulin Resistance (AIR) study
    Johannes Hulthe
    The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, S 413 45 Gothenburg, Sweden
    Clin Sci (Lond) 103:123-9. 2002
    ..Thus, in clinically healthy middle-aged men, levels of sICAM-1, but not of soluble VCAM-1 or E-selectin, were associated with both subclinical atherosclerosis and inflammatory variables...
  5. ncbi request reprint Circulating oxidized LDL is associated with subclinical atherosclerosis development and inflammatory cytokines (AIR Study)
    Johannes Hulthe
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    Arterioscler Thromb Vasc Biol 22:1162-7. 2002
    ....
  6. ncbi request reprint Circulating oxidized LDL is associated with increased levels of cell-adhesion molecules in clinically healthy 58-year old men (AIR study)
    Johannes Hulthe
    The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Sahlgrenska Academy, Goteborg University, Gothenburg, Sweden
    Med Sci Monit 8:CR148-52. 2002
    ..Furthermore, there are as yet no reports on the relationship between circulating ox-LDL and cell-adhesion molecules in vivo...
  7. ncbi request reprint Relationship between C-reactive protein and intima-media thickness in the carotid and femoral arteries and to antibodies against oxidized low-density lipoprotein in healthy men: the Atherosclerosis and Insulin Resistance (AIR) study
    J Hulthe
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, 413 45 Gothenburg, Sweden
    Clin Sci (Lond) 100:371-8. 2001
    ..CRP levels were independently related to abdominal obesity measured as WHR, smoking and antibody titres to Ox-LDL...
  8. ncbi request reprint Antibodies to oxidized LDL in relation to intima-media thickness in carotid and femoral arteries in 58-year-old subjectively clinically healthy men
    J Hulthe
    Wallenberg Laboratory for Cardiovascular Research, Department of Medicine, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    Arterioscler Thromb Vasc Biol 21:101-7. 2001
    ..However, these associations were not independent of other risk factors...
  9. ncbi request reprint LDL particle size in relation to intima-media thickness and plaque occurrence in the carotid and femoral arteries in patients with hypercholesterolaemia
    J Hulthe
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    J Intern Med 248:42-52. 2000
    ..LDL particle size was determined by subjecting serum to 2-16% polyacrylamide gradient gel electrophoresis...
  10. ncbi request reprint The metabolic syndrome, LDL particle size, and atherosclerosis: the Atherosclerosis and Insulin Resistance (AIR) study
    J Hulthe
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    Arterioscler Thromb Vasc Biol 20:2140-7. 2000
    ....
  11. ncbi request reprint Computerized measurement of LDL particle size in human serum. Reproducibility studies and evaluation of LDL particle size in relation to metabolic variables and the occurrence of atherosclerosis
    J Hulthe
    The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, Sweden
    Scand J Clin Lab Invest 59:649-61. 1999
    ....
  12. doi request reprint Echogenecity of the carotid intima-media complex is related to cardiovascular risk factors, dyslipidemia, oxidative stress and inflammation: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Jessika Andersson
    Department of Medicine, Uppsala University Hospital, 751 85 Uppsala, Sweden
    Atherosclerosis 204:612-8. 2009
    ..Our aim was therefore to investigate if intima-media echogenecity is related to cardiovascular risk factors, or to markers of inflammation and oxidation in an exploratory investigation...
  13. doi request reprint Baseline ICAM-1 and VCAM-1 are increased in initially healthy middle-aged men who develop cardiovascular disease during 6.6 years of follow-up
    Caroline Schmidt
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Angiology 60:108-14. 2009
    ..8, 95% CI = 1.8-4.3; and OR = 1.6, 95% CI = 1.1-2.5, respectively)...
  14. ncbi request reprint Circulating oxidized low-density lipoprotein is associated with echolucent plaques in the femoral artery independently of hsCRP in 61-year-old men
    Vilborg Sigurdardottir
    The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, S 413 45 Gothenburg, Sweden
    Atherosclerosis 190:187-93. 2007
    ....
  15. doi request reprint The carotid artery plaque size and echogenicity are related to different cardiovascular risk factors in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Jessika Andersson
    Department of Medicine, Uppsala University Hospital, 75185 Uppsala, Sweden
    Lipids 44:397-403. 2009
    ..These results suggest that plaque size and echogenicity are influenced by different risk factors...
  16. ncbi request reprint Plasma ghrelin, body fat, insulin resistance, and smoking in clinically healthy men: the atherosclerosis and insulin resistance study
    Bjorn Fagerberg
    Institute of Internal Medicine, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    Metabolism 52:1460-3. 2003
    ..The conclusion is that whole body insulin sensitivity was not associated with plasma ghrelin concentrations. Body fatness was the strongest determinant of circulating ghrelin. It was found that acute smoking may affect ghrelin levels...
  17. ncbi request reprint Low adipocyte-derived plasma protein adiponectin concentrations are associated with the metabolic syndrome and small dense low-density lipoprotein particles: atherosclerosis and insulin resistance study
    Johannes Hulthe
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    Metabolism 52:1612-4. 2003
    ..6). Because this was a cross-sectional study, no conclusions can be drawn about causality. This is the first population-based study in man demonstrating a relationship between small dense LDL particles and adiponectin...
  18. doi request reprint Gender specific associations between matrix metalloproteinases and inflammatory markers in post myocardial infarction patients
    Ann Samnegard
    Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Atherosclerosis 202:550-6. 2009
    ..In this study, we investigated the association between inflammatory markers and MMPs in men and women...
  19. ncbi request reprint C-reactive protein and e-selectin levels are related to vasodilation in resistance, but not conductance arteries in the elderly: the prospective investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, 751 85 Uppsala, Sweden
    Atherosclerosis 199:129-37. 2008
    ..The aim of the present study is to relate a wide range of inflammatory markers to vasoreactivity in both resistance and conductance arteries...
  20. doi request reprint Slightly elevated high-sensitivity C-reactive protein (hsCRP) concentrations are associated with carotid atherosclerosis in women with varying degrees of glucose tolerance
    Ulrica Prahl
    The Wallenberg Laboratory for Cardiovascular Research, and Center for Cardiovascular and Metabolic Research, University of Gothenburg, Gothenburg, Sweden
    Angiology 61:793-801. 2010
    ..0 mg/L were accompanied by elevated IMT in the carotid bulbs independently of other cardiovascular risk factors. Total plaque area was larger among women with plaques in the high hsCRP group versus the lower hsCRP group...
  21. ncbi request reprint Urokinase-type plasminogen activator receptor is associated with macrophages and plaque rupture in symptomatic carotid atherosclerosis
    Per Arne Svensson
    Center for Cardiovascular and Metabolic Research, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
    Int J Mol Med 22:459-64. 2008
    ..These findings support the hypothesis that UPAR is related to plaque rupture in symptomatic atherosclerotic lesions...
  22. ncbi request reprint Apolipoprotein B/apolipoprotein A-I in relation to the metabolic syndrome and change in carotid artery intima-media thickness during 3 years in middle-aged men
    Karin Wallenfeldt
    Institute of Internal Medicine, Sahlgrenska University Hospital, Gothenburg University, Gothenburg, Sweden
    Stroke 35:2248-52. 2004
    ..The aim was to examine whether apoB/apoA-I was associated with the metabolic syndrome (MetS) at baseline and also with the future change in carotid artery intima-media thickness (IMT)...
  23. ncbi request reprint Prevalence of diabetes and impaired glucose tolerance in 64-year-old Swedish women: experiences of using repeated oral glucose tolerance tests
    Gerhard Brohall
    Wallenberg Laboratory for Cardiovascular Research, Institute of Internal Medicine, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Diabetes Care 29:363-7. 2006
    ....
  24. ncbi request reprint Antiatherosclerotic effects of beta-blockers
    John Wikstrand
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    Am J Cardiol 91:25H-29H. 2003
    ..06 vs +0.03 mm; p = 0.011). Several factors may contribute to the mechanism of benefit in these trials, including reduced sympathetic activity, improved hemodynamic parameters, and direct effects on the vascular endothelium...
  25. ncbi request reprint Brachial artery intima-media thickness and echogenicity in relation to lipids and markers of oxidative stress in elderly subjects:--the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) Study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, Uppsala, Sweden
    Lipids 43:133-41. 2008
    ..Thus, both thickness and echogenicity of the brachial artery intima-media complex might be useful biomarkers in the future...
  26. ncbi request reprint The reciprocal association of adipocytokines with insulin resistance and C-reactive protein in clinically healthy men
    Carl Johan Behre
    Institute of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Metabolism 54:439-44. 2005
    ..001). In conclusion, this study in man showed that plasma adiponectin and TNF-alpha were independently and reversely associated with insulin resistance. C-reactive protein levels were related to TNF-alpha and obesity...
  27. doi request reprint C-reactive protein and tumor necrosis factor-alpha in relation to insulin-mediated glucose uptake, smoking and atherosclerosis
    Bjorn Fagerberg
    Institute of Medicine, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Scand J Clin Lab Invest 68:534-41. 2008
    ..To examine the hypothesis that serum concentration of C-reactive protein (CRP) is inversely associated with insulin sensitivity and obesity, and that this may by mediated by tumor necrosis factor-alpha (TNFalpha) and interleukin-6 (IL-6)...
  28. ncbi request reprint The metabolic syndrome, smoking, and antibodies to oxidized LDL in 58-year-old clinically healthy men
    B Fagerberg
    Department of Medicine, Sahlgrenska University Hospital, , Gothenburg, Sweden
    Nutr Metab Cardiovasc Dis 11:227-35. 2001
    ..Several of the factors in the metabolic syndrome were related to the IgG antibody titers to modified LDL. The high degree of intercorrelation among these factors makes it difficult to clarify the independent role of any specific factor...
  29. ncbi request reprint Plasma interleukin (IL)-18 concentrations is elevated in patients with previous myocardial infarction and related to severity of coronary atherosclerosis independently of C-reactive protein and IL-6
    Johannes Hulthe
    Discovery Medicine, AstraZeneca, Molndal, Sweden Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Gothenburg, Sweden
    Atherosclerosis 188:450-4. 2006
    ..Furthermore, the relationships between plasma IL-18 concentrations and coronary atherosclerosis, C-reactive protein (CRP), interleukin-6 (IL-6) and traditional cardiovascular risk factors were examined...
  30. ncbi request reprint Circulating estradiol is an independent predictor of progression of carotid artery intima-media thickness in middle-aged men
    Asa Tivesten
    Institute of Internal Medicine, The Wallenberg Laboratory for Cardiovascular Research, Bruna Straket 16, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    J Clin Endocrinol Metab 91:4433-7. 2006
    ..Estrogen treatment of men with prostate cancer is associated with increased cardiovascular morbidity and mortality; however, the role of endogenous estrogen levels for atherosclerotic disease in men is unknown...
  31. doi request reprint Adipose tissue is not an important source for matrix metalloproteinase-9 in the circulation
    Anders Gummesson
    Department of Molecular and Clinical Medicine, Center for Cardiovascular and Metabolic Research, The Sahlgrenska Academy at Gothenburg University, University of Gothenburg, Gothenburg, Sweden
    Scand J Clin Lab Invest 69:636-42. 2009
    ..The aim of this study was to evaluate the impact of AT on circulating MMP-9, and if the metabolic syndrome might have a modifying effect...
  32. ncbi request reprint Preclinical atherosclerosis and inflammation in 61-year-old men with newly diagnosed diabetes and established diabetes
    Vilborg Sigurdardottir
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    Diabetes Care 27:880-4. 2004
    ..The aim of this study was to investigate the occurrence of subclinical atherosclerosis and underlying mechanisms in men with newly diagnosed diabetes and established diabetes compared with healthy control subjects...
  33. ncbi request reprint Autoantibodies against oxidized low-density lipoprotein and C-reactive protein are associated with diabetes and myocardial infarction in women
    A Dotevall
    Section of Preventive Cardiology, Department of Medicine, SU/Ostra, Sahlgrenska University Hospital, , , Sweden
    Clin Sci (Lond) 101:523-31. 2001
    ..These findings might indicate a differentiated immune response against modified LDL, more pronounced inflammation and a more aggressive atherosclerotic process in women with diabetes...
  34. pmc Endotoxin-induced and vaccine-induced systemic inflammation both impair endothelium-dependent vasodilation, but not pulse wave reflection
    Lars Lind
    Department of Medicine, University Hospital, Uppsala, Sweden
    Vasc Health Risk Manag 8:447-53. 2012
    ..However, the vascular effects of these two mechanisms of inducing inflammation have not been compared in the same individuals...
  35. ncbi request reprint Intima-media thickness in cardiovascularly asymptomatic hypopituitary adults with growth hormone deficiency: relation to body mass index, gender, and other cardiovascular risk factors
    Maria Leonsson
    Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    Clin Endocrinol (Oxf) 57:751-9. 2002
    ..The aim of this study was to investigate intima-media thickness (IMT) in relation to cardiovascular risk factors in adults with GHD...
  36. ncbi request reprint Alcohol consumption, the metabolic syndrome and insulin resistance in 58-year-old clinically healthy men (AIR study)
    Daniel Goude
    Wallenberg Laboratory for Cardiovascular Research, SahlgrenskaUniversity Hospital, GöteborgUniversity, 413 45 Gothenburg, Sweden
    Clin Sci (Lond) 102:345-52. 2002
    ..To our knowledge, this is the first study to show an independent relationship between insulin sensitivity, as measured by the clamp technique, and alcohol intake...
  37. ncbi request reprint Serum adiponectin in a population sample of 64-year-old women in relation to glucose tolerance, family history of diabetes, autoimmunity, insulin sensitivity, C-peptide, and inflammation
    Carl Johan Behre
    Institute of Internal Medicine, Sahlgrenska University Hospital, Goteborg University, SE 413 45 Gothenburg, Sweden
    Metabolism 55:188-94. 2006
    ..Family history of diabetes was independently associated with hypoadiponectinemia. Autoimmune diabetic women did not have low adiponectin levels...
  38. ncbi request reprint The metabolic syndrome in middle-aged men according to different definitions and related changes in carotid artery intima-media thickness (IMT) during 3 years of follow-up
    K Wallenfeldt
    Institute of Internal Medicine, Sahlgrenska University Hospital, Gothenburg University, Gothenburg, Sweden
    J Intern Med 258:28-37. 2005
    ..To examine the occurrence over time of the metabolic syndrome (MetS) according to different definitions and the relation to change during follow-up in carotid artery intima-media thickness (IMT), measured by ultrasound...
  39. ncbi request reprint Effect of controlled release/extended release metoprolol on carotid intima-media thickness in patients with hypercholesterolemia: a 3-year randomized study
    Olov Wiklund
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital Sahlgrenska, Gothenburg, Sweden
    Stroke 33:572-7. 2002
    ....
  40. doi request reprint Interleukin-18 as a predictor of future events in patients with acute coronary syndromes
    Marianne Hartford
    Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy and Sahlgrenska University Hospital, Gothenburg, Sweden
    Arterioscler Thromb Vasc Biol 30:2039-46. 2010
    ..The aim of this study was to assess the short- and long-term prognostic significance of interleukin-18 (IL-18) levels in patients with acute coronary syndromes (ACS)...
  41. pmc Relationships between free radical levels during carotid endarterectomy and markers of arteriosclerotic disease
    Jagdish Gondalia
    Department of Urology, Sahlgrenska University Hospital, Goteborg, Sweden
    Int J Med Sci 4:124-30. 2007
    ..This study explores the relationships between markers for lesion progression in arteriosclerosis, production of radicals and clinical characteristics...
  42. ncbi request reprint Cell adhesion molecules and secretory type II phospholipase A2 in relation to carotid atherosclerosis in patients with hypercholesterolaemia
    O Wiklund
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, , Gothenburg, Sweden
    J Intern Med 249:441-9. 2001
    ..44, P < 0.001), which recently have been shown to predict coronary events. Finally, high sICAM-1 levels were associated with an atherogenic lipid profile including high triglyceride levels and low HDL levels...
  43. ncbi request reprint Insulin resistance and intima-media thickness in the carotid and femoral arteries of clinically healthy 58-year-old men. The Atherosclerosis and Insulin Resistance Study (AIR)
    L Bokemark
    Department of Medicine and Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg, Sweden
    J Intern Med 249:59-67. 2001
    ..To examine whether insulin resistance was associated with ultrasound-assessed measures of atherosclerosis in men with varying degrees of obesity...
  44. ncbi request reprint Non-stenotic echolucent ultrasound-assessed femoral artery plaques are predictive for future cardiovascular events in middle-aged men
    Caroline Schmidt
    The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, Sweden
    Atherosclerosis 181:125-30. 2005
    ..The aim of the present study was to examine the relationship between plaque occurrence, plaque size and plaque echogenicity, assessed by B-mode ultrasound, in the femoral artery and the development of clinical cardiovascular disease...
  45. doi request reprint Association between impaired glucose tolerance and carotid atherosclerosis: a study in 64-year-old women and a meta-analysis
    G Brohall
    Wallenberg Laboratory for Cardiovascular Research, Academy at Göteborg University, Sahlgrenska University Hospital, Gothenburg, Sweden
    Nutr Metab Cardiovasc Dis 19:327-33. 2009
    ..This study was designed to investigate if IGT is associated with subclinical atherosclerosis...
  46. doi request reprint Percentage white: a new feature for ultrasound classification of plaque echogenicity in carotid artery atherosclerosis
    Ulrica Prahl
    Wallenberg Laboratory for Cardiovascular Research, and Center for Cardiovascular and Metabolic Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Ultrasound Med Biol 36:218-26. 2010
    ..In conclusion, PW integrated within a SAMEE is a new feature for assessment of echogenicity in carotid plaques and shows excellent reproducibility and agreement with visual assessment...
  47. ncbi request reprint Endothelium-dependent flow-mediated vasodilatation, insulin resistance and the metabolic syndrome in 60-year-old men
    I Wendelhag
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, S 413 45 Gothenburg, Sweden
    J Intern Med 252:305-13. 2002
    ..To evaluate the endothelium-dependent flow-mediated vasodilatation (FMD) in the brachial artery and to study the relationship to insulin sensitivity and to the metabolic syndrome in 60-year-old clinically healthy men...
  48. ncbi request reprint Carotid and femoral atherosclerosis, cardiovascular risk factors and C-reactive protein in relation to smokeless tobacco use or smoking in 58-year-old men
    K Wallenfeldt
    Institute of Internal MedicineSahlgrenska University Hospital, Gothenburg University, Sweden
    J Intern Med 250:492-501. 2001
    ..e. the metabolic syndrome. The inhaled smoke from the combustion of tobacco seems to be an important aetiological factor in the atherosclerotic process...
  49. ncbi request reprint Circulating oxidized low-density lipoprotein (LDL) is associated with risk factors of the metabolic syndrome and LDL size in clinically healthy 58-year-old men (AIR study)
    V Sigurdardottir
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    J Intern Med 252:440-7. 2002
    ..The aim of this study was to test this concept by examining the association between circulating ox-LDL, LDL-particle size, and the metabolic syndrome...
  50. doi request reprint Circulating matrix metalloproteinase 9 levels in relation to sampling methods, femoral and carotid atherosclerosis
    F J Olson
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Intern Med 263:626-35. 2008
    ..To examine preanalytical sources of variability in MMP-9 concentrations related to sampling procedures...
  51. doi request reprint Circulating oxidized LDL is associated with the occurrence of echolucent plaques in the carotid artery in 61-year-old men
    V Sigurdardottir
    The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    Scand J Clin Lab Invest 68:292-7. 2008
    ....
  52. ncbi request reprint Are serum adiponectin concentrations in a population sample of 64-year-old Caucasian women with varying glucose tolerance associated with ultrasound-assessed atherosclerosis?
    C J Behre
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg, Sweden
    J Intern Med 260:238-44. 2006
    ..To examine whether serum adiponectin concentrations were associated with subclinical atherosclerosis assessed as intima media thickness (IMT) in the carotid arteries in Caucasian women with varying degrees of glucose tolerance...
  53. ncbi request reprint Antibodies to oxidized LDL in relation to carotid atherosclerosis, cell adhesion molecules, and phospholipase A(2)
    J Hulthe
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, Gothenburg
    Arterioscler Thromb Vasc Biol 21:269-74. 2001
    ..The pattern, however, is complex, and the role of the immune response may differ in different patient groups as well as at different stages of the disease...
  54. ncbi request reprint Circulating soluble CD44 is higher among women than men and is not associated with cardiovascular risk factors or subclinical atherosclerosis
    Sara Sjoberg
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at Goteborg University, 413 45 Goteborg, Sweden
    Metabolism 54:139-41. 2005
    ..Women had higher levels of circulating sCD44 than men. There were no associations between sCD44 and cardiovascular risk factors or subclinical atherosclerosis...
  55. ncbi request reprint Identification of genes predominantly expressed in human macrophages
    Per Arne Svensson
    Department of Internal Medicine, Research Centre for Endocrinology and Metabolism, Vita straket 12, Sahlgrenska Academy, Goteborg University, S 41345 Goteborg, Sweden
    Atherosclerosis 177:287-90. 2004
    ..Identification of novel macrophage specific genes may increase our understanding of the role of this cell in different diseases...
  56. ncbi request reprint Low-density lipoprotein particle size, insulin resistance, and proinsulin in a population sample of 58-year-old men
    B Fagerberg
    Institute of Internal Medicine, Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, , Sweden
    Metabolism 50:120-4. 2001
    ..Serum proinsulin was more directly related to LDL particle size than insulin...
  57. ncbi request reprint Increased Interleukin-6 levels in pituitary-deficient patients are independently related to their carotid intima-media thickness
    M Leonsson
    Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    Clin Endocrinol (Oxf) 59:242-50. 2003
    ..We investigated peripheral inflammatory and fibrinolytic markers and their associations with arterial intima-media thickness (IMT) in GHD...
  58. ncbi request reprint Oxidized low-density lipoprotein in plasma is a prognostic marker of subclinical atherosclerosis development in clinically healthy men
    K Wallenfeldt
    Institute of Internal Medicine, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    J Intern Med 256:413-20. 2004
    ..To investigate the association between plasma oxidized low-density lipoprotein (OxLDL) and the progress of clinically silent atherosclerosis, as measured by ultrasound in the carotid arteries...
  59. ncbi request reprint apoB/apoA-I ratio is related to femoral artery plaques and is predictive for future cardiovascular events in healthy men
    C Schmidt
    The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at Goteborg University, Gothenburg, Sweden
    Atherosclerosis 189:178-85. 2006
    ..6 years of follow-up. A further aim was to investigate the concentrations of apoB, apoA-I and the apoB/apoA-I ratio to the association of plaque occurrence in the carotid and femoral arteries...
  60. ncbi request reprint Vasodilation and visceral fat in elderly subjects: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, Uppsala, Sweden
    Atherosclerosis 194:e64-71. 2007
    ..In the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study, we related VAT and other obesity indices to endothelium-dependent vasodilation in both capacitance and resistance arteries...
  61. ncbi request reprint Multiple risk factor intervention reduces cardiovascular risk in hypertensive patients with echolucent plaques in the carotid artery
    C Schmidt
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, Sweden
    J Intern Med 253:430-8. 2003
    ....
  62. ncbi request reprint Methodological aspects of measuring oxidized low density lipoproteins in human serum and plasma
    J Perman
    The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    Scand J Clin Lab Invest 64:753-5. 2004
  63. ncbi request reprint Clinically unrecognized myocardial infarction detected at MR imaging may not be associated with atherosclerosis
    Charlotte Ebeling Barbier
    Department of Radiology, Uppsala University Hospital, 751 85 Uppsala, Sweden
    Radiology 245:103-10. 2007
    ....
  64. ncbi request reprint Endothelial function, CRP and oxidative stress in chronic kidney disease
    Margus Annuk
    Department of Medical Sciences, Uppsala University, Uppsala Sweden
    J Nephrol 18:721-6. 2005
    ..Our aim was to investigate the relationship between high sensitivity C-reactive protein (CRP), endothelium dependent vasodilation (EDV) and oxidative stress markers in patients with CKD K/DOQI stage 3-5...
  65. ncbi request reprint Tooth loss is related to the presence of metabolic syndrome and inflammation in elderly subjects: a prospective study of the vasculature in Uppsala seniors (PIVUS)
    Anders Holmlund
    Department of Periodontology, The Gävle County Hospital, Sweden
    Oral Health Prev Dent 5:125-30. 2007
    ..To investigate how the number of remaining teeth relates to the presence of metabolic syndrome (MetS) and markers of inflammation...
  66. ncbi request reprint A proteomic study of the apolipoproteins in LDL subclasses in patients with the metabolic syndrome and type 2 diabetes
    Pia Davidsson
    AstraZeneca R and D Molndal, Molndal, Sweden
    J Lipid Res 46:1999-2006. 2005
    ....