Li Ming Gan

Summary

Affiliation: Sahlgrenska University Hospital
Country: Sweden

Publications

  1. ncbi request reprint Haemodynamically significant plaque formation and regional endothelial dysfunction in cholesterol-fed ApoE-/- mice
    Maria E Johansson
    Department of Physiology, Institute of Physiology and Pharmacology, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Clin Sci (Lond) 108:531-8. 2005
  2. ncbi request reprint Non-invasive real-time imaging of atherosclerosis in mice using ultrasound biomicroscopy
    Li Ming Gan
    Department of Physiology, Institute of Physiology and Pharmacology, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Atherosclerosis 190:313-20. 2007
  3. doi request reprint Adenosine induces dilation of epicardial coronary arteries in mice: relationship between coronary flow velocity reserve and coronary flow reserve in vivo using transthoracic echocardiography
    Johannes Wikström
    Department of Neuroscience and Physiology, Institute of Physiology, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Ultrasound Med Biol 34:1053-62. 2008
  4. ncbi request reprint Non-invasive imaging of coronary arteries in living mice using high-resolution echocardiography
    Li Ming Gan
    Department of Clinical Physiology, Cardiovascular Institute, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Scand Cardiovasc J 38:121-6. 2004
  5. ncbi request reprint Voluntary physical exercise-induced vascular effects in spontaneously hypertensive rats
    Ulrika Hägg
    Department of Physiology, Institute of Physiology and Pharmacology, Goteborg University, Goteborg, Sweden
    Clin Sci (Lond) 107:571-81. 2004
  6. ncbi request reprint Endothelial dysfunction in growth hormone transgenic mice
    Irene J Andersson
    Department of Physiology, Institute of Physiology and Pharmacology, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Clin Sci (Lond) 110:217-25. 2006
  7. ncbi request reprint Proximal to middle left coronary artery flow velocity ratio, as assessed using color Doppler echocardiography, predicts coronary artery atherosclerosis in mice
    Julia Grönros
    Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Goteborg University, Sweden
    Arterioscler Thromb Vasc Biol 26:1126-31. 2006
  8. ncbi request reprint Voluntary physical exercise and coronary flow velocity reserve: a transthoracic colour Doppler echocardiography study in spontaneously hypertensive rats
    Ulrika Hägg
    Department of Physiology, Institute of Physiology and Pharmacology, Goteborg University, Goteborg, Sweden
    Clin Sci (Lond) 109:325-34. 2005
  9. ncbi request reprint Angiotensin II, type 2 receptor is not involved in the angiotensin II-mediated pro-atherogenic process in ApoE-/- mice
    Maria E Johansson
    Department of Physiology, Institute of Physiology and Pharmacology, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    J Hypertens 23:1541-9. 2005
  10. ncbi request reprint Physical exercise capacity is associated with coronary and peripheral vascular function in healthy young adults
    Ulrika Hägg
    Institute of Physiology and Pharmacology, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Am J Physiol Heart Circ Physiol 289:H1627-34. 2005

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Haemodynamically significant plaque formation and regional endothelial dysfunction in cholesterol-fed ApoE-/- mice
    Maria E Johansson
    Department of Physiology, Institute of Physiology and Pharmacology, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Clin Sci (Lond) 108:531-8. 2005
    ..This phenomenon is associated with impaired NO-dependent vasodilation in vessel segments known to be prone to atherosclerosis...
  2. ncbi request reprint Non-invasive real-time imaging of atherosclerosis in mice using ultrasound biomicroscopy
    Li Ming Gan
    Department of Physiology, Institute of Physiology and Pharmacology, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Atherosclerosis 190:313-20. 2007
    ..106+/-0.108 mm at 32 weeks of age to 0.256+/-0.345 mm at 35 weeks of age (p=0.0002). In conclusion, this novel imaging protocol provides us with a non-invasive, accurate and inexpensive way to follow lesion progression in mice in vivo...
  3. doi request reprint Adenosine induces dilation of epicardial coronary arteries in mice: relationship between coronary flow velocity reserve and coronary flow reserve in vivo using transthoracic echocardiography
    Johannes Wikström
    Department of Neuroscience and Physiology, Institute of Physiology, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Ultrasound Med Biol 34:1053-62. 2008
    ..Therefore, the CFVR protocol will probably work well in most settings...
  4. ncbi request reprint Non-invasive imaging of coronary arteries in living mice using high-resolution echocardiography
    Li Ming Gan
    Department of Clinical Physiology, Cardiovascular Institute, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Scand Cardiovasc J 38:121-6. 2004
    ..In vivo mouse coronary artery circulation is still largely unknown. We demonstrate here in vivo coronary flow velocity profiles in anesthesized mice using a novel high-resolution ultrasound technique...
  5. ncbi request reprint Voluntary physical exercise-induced vascular effects in spontaneously hypertensive rats
    Ulrika Hägg
    Department of Physiology, Institute of Physiology and Pharmacology, Goteborg University, Goteborg, Sweden
    Clin Sci (Lond) 107:571-81. 2004
    ..Increased vascular compliance and antioxidative capacity may contribute to the atheroprotective effects associated with physical exercise in conduit vessels...
  6. ncbi request reprint Endothelial dysfunction in growth hormone transgenic mice
    Irene J Andersson
    Department of Physiology, Institute of Physiology and Pharmacology, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Clin Sci (Lond) 110:217-25. 2006
    ....
  7. ncbi request reprint Proximal to middle left coronary artery flow velocity ratio, as assessed using color Doppler echocardiography, predicts coronary artery atherosclerosis in mice
    Julia Grönros
    Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Goteborg University, Sweden
    Arterioscler Thromb Vasc Biol 26:1126-31. 2006
    ..We aimed to establish a completely noninvasive technique to assess coronary artery atherosclerosis in living mice using proximal to middle left coronary artery (LCA) velocity ratio as assessed with color Doppler echocardiography (CDE)...
  8. ncbi request reprint Voluntary physical exercise and coronary flow velocity reserve: a transthoracic colour Doppler echocardiography study in spontaneously hypertensive rats
    Ulrika Hägg
    Department of Physiology, Institute of Physiology and Pharmacology, Goteborg University, Goteborg, Sweden
    Clin Sci (Lond) 109:325-34. 2005
    ..09; P<0.01), whereas eNOS expression was unchanged. In conclusion, CFVR in rats can be non-invasively assessed using CDE with high feasibility. Physical exercise is associated with improved CFVR and antioxidative capacity in SHR...
  9. ncbi request reprint Angiotensin II, type 2 receptor is not involved in the angiotensin II-mediated pro-atherogenic process in ApoE-/- mice
    Maria E Johansson
    Department of Physiology, Institute of Physiology and Pharmacology, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    J Hypertens 23:1541-9. 2005
    ..To confirm and further explore this possibility, we studied the effect of AT2 receptor antagonism on Ang II-accelerated atherosclerosis...
  10. ncbi request reprint Physical exercise capacity is associated with coronary and peripheral vascular function in healthy young adults
    Ulrika Hägg
    Institute of Physiology and Pharmacology, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Am J Physiol Heart Circ Physiol 289:H1627-34. 2005
    ..High exercise capacity due to a physically active lifestyle is associated with high coronary and peripheral artery function, indicating an early protective role of physical exercise for cardiovascular health...
  11. ncbi request reprint Amplitude and velocity of mitral annulus motion in rabbits
    Li Ming Gan
    Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden
    Echocardiography 21:313-7. 2004
    ..The main aims of the present study were to investigate the feasibility of these techniques in rabbits and to investigate age-related changes concerning these variables...
  12. ncbi request reprint Increased atherosclerotic lesion area in apoE deficient mice overexpressing bovine growth hormone
    Irene J Andersson
    Department of Physiology, Goteborg University, Goteborg, Sweden
    Atherosclerosis 188:331-40. 2006
    ..The mechanisms could be direct effects of GH on cellular processes in the vessel wall or the result of concomitant processes such as hypertension or a general inflammatory state...
  13. doi request reprint High-resolution radial artery intima-media thickness and cardiovascular risk factors in patients with suspected coronary artery disease--comparison with common carotid artery intima-media thickness
    Charlotte Eklund
    Department of Clinical Physiology, Sahlgrenska University Hospital, S 41345 Gothenburg, Sweden
    Atherosclerosis 221:118-23. 2012
    ....
  14. ncbi request reprint Gene expression profile and aortic vessel distensibility in voluntarily exercised spontaneously hypertensive rats: potential role of heat shock proteins
    Ulrika Hägg
    Department of Physiology, Institute of Physiology and Pharmacology, Goteborg University, Sweden
    Physiol Genomics 22:319-26. 2005
    ..In conclusion, voluntary exercise leads to improved vessel wall distensibility and reduced gene expression of heat shock protein 60 and 70, which may indicate decreased oxidative stress in the aortic vascular wall...
  15. pmc Muscle sympathetic nerve activity is related to a surrogate marker of endothelial function in healthy individuals
    Yrsa Bergmann Sverrisdottir
    Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 5:e9257. 2010
    ..The aim of this study was to investigate whether directly recorded sympathetic vasoconstrictor outflow is related to a surrogate marker of endothelial function in healthy individuals...
  16. doi request reprint Obese children show increased intimal wall thickness and decreased pulse wave velocity
    Frida Dangardt
    Department of Molecular and Clinical Medicine, Clinical Physiology, Sahlgrenska University Hospital, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Clin Physiol Funct Imaging 28:287-93. 2008
    ....
  17. ncbi request reprint Functional and morphologic imaging of coronary atherosclerosis in living mice using high-resolution color Doppler echocardiography and ultrasound biomicroscopy
    Johannes Wikström
    Department of Physiology, Institute of Physiology and Pharmacology, The Sahlgrenska Academy, Goteborg University, Sweden
    J Am Coll Cardiol 46:720-7. 2005
    ..This study aimed to establish non-invasive methods of assessing coronary artery morphology in normal and atherosclerotic mice in vivo...
  18. doi request reprint Sex differences in peripheral artery intima, media and intima media thickness in children and adolescents
    Walter Osika
    Department of Metabolism and Cardiovascular Research Clinical Physiology, Sahlgrenska University Hospital, Goteborg, Sweden
    Atherosclerosis 203:172-7. 2009
    ..We wanted to test whether there is already a difference between the sexes in childhood for IT, MT and intima media thickness (IMT) in the radial and dorsal pedal arteries...
  19. ncbi request reprint Blood pressure is the major driving force for plaque formation in aortic-constricted ApoE-/- mice
    Maria E Johansson
    Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    J Hypertens 24:2001-8. 2006
    ..Using an aortic constriction model in mice, we studied whether the increase in pressure or the activation of the renin-angiotensin system (RAS) and its main receptors is the main driving force for plaque progression...
  20. doi request reprint Effects of social isolation and environmental enrichment on atherosclerosis in ApoE-/- mice
    Evelina Bernberg
    Department of Molecular and Clinical Medicine Clinical Physiology, Institute of Medicine, The Sahlgrenska Academy, Götenborg University, Goteborg, Sweden
    Stress 11:381-9. 2008
    ..Reduction in plasma G-CSF levels may hamper endothelial regeneration in the atherosclerotic process. While environmental enrichment did not affect atherosclerosis, social isolation accelerated atherosclerosis...
  21. pmc Coronary flow reserve from mouse to man--from mechanistic understanding to future interventions
    Li Ming Gan
    Department of Molecular and Clinical Medicine, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Goteborg, Sweden
    J Cardiovasc Transl Res 6:715-28. 2013
    ....
  22. ncbi request reprint Intraluminal pressure modulates eicosanoid enzyme expression in vascular endothelium of intact human conduit vessels at physiological levels of shear stress
    Roya Doroudi
    Clinical Experimental Research Laboratory, Heart and Lung Institute, Sahlgrenska University Hospital Ostra, Goteborg University, S 416 85 Goteborg, Sweden
    J Hypertens 20:63-70. 2002
    ..We investigated whether intraluminal pressure modulates gene and protein expression of key eicosanoid enzymes in intact human conduit vessels and/or release of their vasoactive metabolites...
  23. ncbi request reprint Platelet-derived growth factor B retention is essential for development of normal structure and function of conduit vessels and capillaries
    Henrik C Nystrom
    Institute of Physiology and Pharmacology, Department of Physiology, Goteborg University, and RCEM and Wallenberg Laboratory, Sahlgrenska University Hospital, Sweden
    Cardiovasc Res 71:557-65. 2006
    ..We used the PDGF-B retention motif knockout mouse (RetKO) to study the effects of retention motif deletion on development of micro- and macrovascular structure and function...
  24. ncbi request reprint Imaging of atherosclerosis in WHHL rabbits using high-resolution ultrasound
    Robert Wetterholm
    Department of Clinical Physiology, Sahlgrenska University Hospital, Goteborg, Sweden
    Ultrasound Med Biol 33:720-6. 2007
    ..0002). We conclude that transthoracic ultrasound of aortic arch IMT in WHHL rabbits is a reliable and feasible technique for studies of plaque progression and the evaluation of interventions...
  25. doi request reprint Carotid artery longitudinal displacement predicts 1-year cardiovascular outcome in patients with suspected coronary artery disease
    Sara Svedlund
    Department of Clinical Physiology, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Arterioscler Thromb Vasc Biol 31:1668-74. 2011
    ..This study aimed to investigate clinical correlates and the possible predictive value of tLoD for cardiovascular outcome...
  26. doi request reprint Omega-3 fatty acid supplementation improves vascular function and reduces inflammation in obese adolescents
    Frida Dangardt
    Department of Clinical Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Atherosclerosis 212:580-5. 2010
    ..We wanted to assess whether n-3 supplementation increases the serum n-3 PUFA concentration, improves vascular function and morphology, and lowers inflammation in obese adolescents...
  27. ncbi request reprint A short period of apnoea causes a marked increase in coronary flow velocity: a transthoracic pulsed wave Doppler study
    Li Ming Gan
    Department of Clinical Physiology, Sahlgrenska University Hospital, Goteborg, Sweden
    Clin Physiol Funct Imaging 25:148-51. 2005
    ....
  28. ncbi request reprint A technique to estimate the rate of whole body nitric oxide formation in conscious mice
    Anna Wickman
    Department of Physiology, Sahlgrenska Academy, Goteborg University, PO Box 432, S 405 30, Goteborg, Sweden
    Nitric Oxide 9:77-85. 2003
    ..We have established a technique to estimate the total rate of nitric oxide (NO) formation in mice, based on inhalation of a stable oxygen isotope (18O(2)). Changes of NO production with age were also studied...
  29. ncbi request reprint Epidermal growth factor levels are related to diastolic blood pressure and carotid artery stiffness
    Ulf Lundstam
    Department of Physiology, Institute of Physiology and Pharmacology, The Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
    Scand Cardiovasc J 41:308-12. 2007
    ..The epidermal growth factor (EGF) is believed to be involved in vascular remodelling. EGF receptors are expressed in human atherosclerotic tissue...
  30. doi request reprint Ticagrelor enhances adenosine-induced coronary vasodilatory responses in humans
    Ann Wittfeldt
    Department of Clinical and Molecular Medicine, Institution of Medicine, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    J Am Coll Cardiol 61:723-7. 2013
    ..This study was undertaken to determine if ticagrelor augments adenosine-induced coronary blood flow and the sensation of dyspnea in human subjects...
  31. doi request reprint Protein disulfide isomerase increases in myocardial endothelial cells in mice exposed to chronic hypoxia: a stimulatory role in angiogenesis
    Fei Tian
    Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory, University of Gothenburg, SE 413 45 Goteborg, Sweden
    Am J Physiol Heart Circ Physiol 297:H1078-86. 2009
    ..The increased PDI expression in endothelial cells may be a novel mechanism to protect the myocardium against myocardial ischemic diseases...
  32. ncbi request reprint High-salt diet combined with elevated angiotensin II accelerates atherosclerosis in apolipoprotein E-deficient mice
    Maria E Johansson
    Department of Molecular and Clinical Medicine, Clinical Physiology, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    J Hypertens 27:41-7. 2009
    ..We hypothesized that a high-salt diet plays a critical role in subjects whose renin-angiotensin systems cannot adjust to variable salt intake, rendering them more susceptible to atherosclerosis...
  33. ncbi request reprint Increasing peripheral artery intima thickness from childhood to seniority
    Walter Osika
    Department of Clinical Physiology, Sahlgrenska University Hospital Sahlgrenska, SE 413 45 Goteborg, Sweden
    Arterioscler Thromb Vasc Biol 27:671-6. 2007
    ..Using new, very high-resolution ultrasound biomicroscopy, we examined the thickness of artificial layers of silicone and intima thickness (IT) of radial and anterior tibial arteries in healthy subjects and in patients with vascular disease...
  34. doi request reprint Radial artery intima-media thickness predicts major cardiovascular events in patients with suspected coronary artery disease
    Charlotte Eklund
    Department of Clinical Physiology, Sahlgrenska University Hospital, S 41345 Gothenburg, Sweden Department of Molecular and Clinical Medicine Clinical Physiology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, S 41345 Gothenburg, Sweden
    Eur Heart J Cardiovasc Imaging 15:769-75. 2014
    ..Recently, using very high-resolution ultrasound, we showed rIMT can be imaged with great precision and is related to various cardiovascular risk factors...
  35. doi request reprint Longitudinal common carotid artery wall motion is associated with plaque burden in man and mouse
    Sara Svedlund
    The Department of Clinical Physiology, Sahlgrenska University Hospital, Sweden
    Atherosclerosis 217:120-4. 2011
    ..Velocity vector imaging can be used to assess longitudinal common carotid artery (CCA) wall movement (tLoD) in man. To deepen our mechanistic understanding, we aimed to adapt this technique to atherosclerotic prone mice models...
  36. pmc Longitudinal wall motion of the common carotid artery can be assessed by velocity vector imaging
    Sara Svedlund
    The Department of Clinical Physiology, Sahlgrenska University Hospital, Goteborg, Sweden
    Clin Physiol Funct Imaging 31:32-8. 2011
    ..VVI is a highly feasible technique in assessing longitudinal CCA wall motion, which may be of potential relevance as a novel vascular biomarker...
  37. pmc Endothelial function in a mouse model of myeloperoxidase deficiency
    Veronika Golubinskaya
    Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, P O Box 432, 405 30 Gothenburg, Sweden
    Biomed Res Int 2014:128046. 2014
    ..These data suggest that mature MPO-deficient mice do not show enhanced endothelial function compared to wild-type mice, even when provoked with LPS treatment. The EDHF response appears to be reduced in MPO deficiency. ..
  38. doi request reprint Evaluation of new automated gated-SPECT and echocardiographic methods for calculating left ventricular volumes and ejection fraction
    Peter Gjertsson
    Department of Clinical Physiology, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Int J Cardiol 136:171-7. 2009
    ..AutoEF software is a new automated method for quantifying echocardiograms (Tomtec research arena). The aim of the study was to compare these new methods with standard methods...