Genomes and Genes
- Differential phosphorylation of Janus kinase 2, Stat5A and Stat5B in response to growth hormone in primary rat adipocytesM Ridderstrale
Department of Endocrinology, Lund University, Wallenberglaboratory, University Hospital Malmo, S 205 02 Malmo, Sweden
Mol Cell Endocrinol 183:49-54. 2001..We conclude that Stat5A is important for the diabetogenic actions of GH and that Jak2 still is the most probable candidate kinase for Stat5A in primary adipocytes...
- [A case report. Rosiglitazone treatment was highly effective yet had to be terminated]Martin Ridderstrale
Endokrinologiska kliniken, Universitetssjukhuset MAS, Malmo
Lakartidningen 99:407-10. 2002..4 to 5.3%. In spite of this dramatic effect on glucose homeostasis administration of the drug had to be discontinued due to critical congestive heart failure...
- FOXC2 mRNA Expression and a 5' untranslated region polymorphism of the gene are associated with insulin resistanceMartin Ridderstrale
Department of Endocrinology, Lund University, Wallenberg Laboratory, University Hospital Malmo, S 205 02 Malmo, Sweden
Diabetes 51:3554-60. 2002..03 vs. P = 0.7). Our data suggest that increased FOXC2 expression may protect against insulin resistance in human subjects and that genetic variability in the gene may influence features associated with the metabolic syndrome...
- Calpain 10 and type 2 diabetes: are we getting closer to an explanation?Martin Ridderstrale
Department of Clinical Sciences, Lund University, Wallenberg Laboratory, University Hospital MAS, S 205 02 Malmo, Sweden
Curr Opin Clin Nutr Metab Care 8:361-6. 2005..In this paper we give a general background on the genetic studies performed on CAPN10 to date, and review the most recent studies on the functional role of calpain 10...
- SOCS-3 is involved in the downregulation of the acute insulin-like effects of growth hormone in rat adipocytes by inhibition of Jak2/IRS-1 signalingM Ridderstrale
Department of Endocrinology, Lund University, Wallenberg Laboratory, University Hospital Malmo, Malmo, Sweden
Horm Metab Res 35:169-77. 2003....
- Signaling mechanism for the insulin-like effects of growth hormone--another example of a classical hormonal negative feedback loopMartin Ridderstrale
Department of Endocrinology, Lund University, University Hospital MAS, S 205 02 Malmo, Sweden
Curr Drug Targets Immune Endocr Metabol Disord 5:79-92. 2005....
- Role of the FOXC2 -512C>T polymorphism in type 2 diabetes: possible association with the dysmetabolic syndromeE Carlsson
Department of Endocrinology, Lund University, University Hospital MAS, Malmo, Sweden
Int J Obes (Lond) 29:268-74. 2005..Here, we addressed the potential role for FOXC2 as a candidate gene for type 2 diabetes and associated phenotypes...
- The hormone-sensitive lipase C-60G promoter polymorphism is associated with increased waist circumference in normal-weight subjectsE Carlsson
Department of Clinical Sciences, Diabetes and Endocrinology, Malmo University Hospital, Lund University, Sweden
Int J Obes (Lond) 30:1442-8. 2006..The aim of the present study was to investigate the role of the HSL gene promoter variant C-60G, a polymorphism which previously has been associated with reduced promoter activity in vitro, in obesity and type 2 diabetes...
- A polymorphism in the adiponectin gene influences adiponectin expression levels in visceral fat in obese subjectsJ Fredriksson
Department of Clinical Sciences Diabetes and Endocrinology, Malmo University Hospital, Lund University, Wallenberg Laboratory, Malmo, Sweden
Int J Obes (Lond) 30:226-32. 2006..Reduced serum adiponectin levels have been found in obesity and type 2 diabetes and variations in the adiponectin gene (APM1) have been associated with type 2 diabetes and features of the metabolic syndrome in different populations...
- Pro-opiomelanocortin gene is associated with serum leptin levels in lean but not in obese individualsE Suviolahti
Department of Endocrinology, Lund University, Malmo, Sweden
Int J Obes Relat Metab Disord 27:1204-11. 2003..We searched for monogenic obesity due to mutations in POMC and MC4R among morbidly obese Swedes and studied the association of POMC variants with BMI and serum leptin levels...
- Characterization of the human skeletal muscle glycogen synthase gene (GYS1) promoterJ Fredriksson
Malmo University Hospital, Malmo, Sweden
Eur J Clin Invest 34:113-21. 2004..Therefore we studied transcriptional regulation of the human skeletal muscle glycogen synthase gene (GYS1) and evaluated the effects of insulin and forskolin on the promoter activity...
- Obesity and cardiovascular risk factors in type 2 diabetes: results from the Swedish National Diabetes RegisterM Ridderstrale
Department of Clinical Sciences, Clinical Obesity, Lund University, Wallenberg Laboratory, University Hospital, Malmo, Sweden
J Intern Med 259:314-22. 2006..To compare obese with normal and overweight type 2 diabetic patients regarding body mass index (BMI) and cardiovascular risk factors, and to analyse changes in weight versus risk factors...
- Characterization of a naturally occurring mutation (L107I) in the HNF1 alpha (MODY3) geneC Cervin
Department of Endocrinology, Wallenberg Laboratory, Malmo University Hospital, Sweden
Diabetologia 45:1703-8. 2002..In this study we have examined the in vivo and in vitro effects of a mutation (L107I) outside the DNA binding and dimerization domains in the N terminal part of the HNF1 alpha gene...
- Increased risk of obesity associated with the variant allele of the PPARGC1A Gly482Ser polymorphism in physically inactive elderly menM Ridderstrale
Department of Clinical Sciences Clinical Obesity, Malmo University Hospital, Lund University, S 205 02 Malmo, Sweden
Diabetologia 49:496-500. 2006..Previous studies indicate that these risks depend on sex and environmental triggers such as age. The aim of the present study was to investigate the possible interactions between genotype and age and physical activity on risk of obesity...
- Six-minute walk test before and after a weight reduction program in obese subjectsMaja J Ekman
Department of Clinical Sciences, Clinical Obesity Research, Lund University, Skane University Hospital, Malmo, Malmo, Sweden
Obesity (Silver Spring) 21:E236-43. 2013..OBEJCTIVE: Weight loss and physical activity have shown favorable effects on risks associated with obesity. It is therefore of interest to evaluate exercise capacity and related co-morbidities in obese patients...