Jan Nilsson

Summary

Country: Sweden

Publications

  1. ncbi Ultrasound in Lund--three world premieres
    Jan Nilsson
    Department of Medicine, University Hospital MAS, Lund University, Malmo, Sweden
    Clin Physiol Funct Imaging 24:137-40. 2004
  2. ncbi Atherosclerosis
    Jan Nilsson
    Department of Medicine, Malmo University Hospital, Lund University, Sweden
    Autoimmunity 37:351-5. 2004
  3. ncbi [A vaccine for protection against atherosclerosis. Oxidized LDL plays a major role in the immunologic defence]
    Jan Nilsson
    Institutionen för medicin, kirurgi och ortopedi, Universitetssjukhuset MAS, Malmo, Lunds universitet
    Lakartidningen 101:1700-1, 1704-5. 2004
  4. ncbi Immunomodulation of atherosclerosis: implications for vaccine development
    Jan Nilsson
    Department of Medicine, Malmo University Hospital, Lund University, Sweden
    Arterioscler Thromb Vasc Biol 25:18-28. 2005
  5. doi FcgammaRIIB inhibits the development of atherosclerosis in low-density lipoprotein receptor-deficient mice
    Ming Zhao
    Department of Clinical Sciences, Malmo University Hospital, Lund University, S 205 02 Malmo, Sweden
    J Immunol 184:2253-60. 2010
  6. ncbi Lack of the cysteine protease inhibitor cystatin C promotes atherosclerosis in apolipoprotein E-deficient mice
    Eva Bengtsson
    Department of Clinical Sciences, Malmo University Hospital, Lund University, Sweden
    Arterioscler Thromb Vasc Biol 25:2151-6. 2005
  7. pmc A high diet quality is associated with lower incidence of cardiovascular events in the Malmö diet and cancer cohort
    Joanna Hlebowicz
    Center for Emergency, Skane University Hospital, Malmo, Sweden
    PLoS ONE 8:e71095. 2013
  8. doi Scoring models of a diet quality index and the predictive capability of mortality in a population-based cohort of Swedish men and women
    Isabel Drake
    Department of Clinical Sciences in Malmo, Lund University, Malmo, Sweden
    Public Health Nutr 16:468-78. 2013
  9. pmc Increased inflammation in atherosclerotic lesions of diabetic Akita-LDLr⁻/⁻ mice compared to nondiabetic LDLr⁻/⁻ mice
    Daniel Engelbertsen
    Department of Clinical Sciences Malmo, Skane University Hospital, Lund University, CRC Entrance 72, 20502 Malmo, Sweden
    Exp Diabetes Res 2012:176162. 2012
  10. doi Immunization of apoE-/- mice with aldehyde-modified fibronectin inhibits the development of atherosclerosis
    Pontus Dunér
    Department of Clinical Sciences, Skane University Hospital, Lund University, Malmo, Sweden
    Cardiovasc Res 91:528-36. 2011

Detail Information

Publications109 found, 100 shown here

  1. ncbi Ultrasound in Lund--three world premieres
    Jan Nilsson
    Department of Medicine, University Hospital MAS, Lund University, Malmo, Sweden
    Clin Physiol Funct Imaging 24:137-40. 2004
  2. ncbi Atherosclerosis
    Jan Nilsson
    Department of Medicine, Malmo University Hospital, Lund University, Sweden
    Autoimmunity 37:351-5. 2004
  3. ncbi [A vaccine for protection against atherosclerosis. Oxidized LDL plays a major role in the immunologic defence]
    Jan Nilsson
    Institutionen för medicin, kirurgi och ortopedi, Universitetssjukhuset MAS, Malmo, Lunds universitet
    Lakartidningen 101:1700-1, 1704-5. 2004
  4. ncbi Immunomodulation of atherosclerosis: implications for vaccine development
    Jan Nilsson
    Department of Medicine, Malmo University Hospital, Lund University, Sweden
    Arterioscler Thromb Vasc Biol 25:18-28. 2005
    ..In this review, we summarize recent experimental studies using immunomodulatory approaches for treatment of atherosclerosis...
  5. doi FcgammaRIIB inhibits the development of atherosclerosis in low-density lipoprotein receptor-deficient mice
    Ming Zhao
    Department of Clinical Sciences, Malmo University Hospital, Lund University, S 205 02 Malmo, Sweden
    J Immunol 184:2253-60. 2010
    ..In addition, they indicate that absence of the inhibiting IgG receptor cause disease, depending on an imbalance of activating and inhibiting immune cells...
  6. ncbi Lack of the cysteine protease inhibitor cystatin C promotes atherosclerosis in apolipoprotein E-deficient mice
    Eva Bengtsson
    Department of Clinical Sciences, Malmo University Hospital, Lund University, Sweden
    Arterioscler Thromb Vasc Biol 25:2151-6. 2005
    ..It is present in the normal artery wall but severely reduced in human atherosclerotic lesions...
  7. pmc A high diet quality is associated with lower incidence of cardiovascular events in the Malmö diet and cancer cohort
    Joanna Hlebowicz
    Center for Emergency, Skane University Hospital, Malmo, Sweden
    PLoS ONE 8:e71095. 2013
    ..To investigate if diet quality is related to incidence of cardiovascular (CV) events...
  8. doi Scoring models of a diet quality index and the predictive capability of mortality in a population-based cohort of Swedish men and women
    Isabel Drake
    Department of Clinical Sciences in Malmo, Lund University, Malmo, Sweden
    Public Health Nutr 16:468-78. 2013
    ..To examine how different scoring models for a diet quality index influence associations with mortality outcomes...
  9. pmc Increased inflammation in atherosclerotic lesions of diabetic Akita-LDLr⁻/⁻ mice compared to nondiabetic LDLr⁻/⁻ mice
    Daniel Engelbertsen
    Department of Clinical Sciences Malmo, Skane University Hospital, Lund University, CRC Entrance 72, 20502 Malmo, Sweden
    Exp Diabetes Res 2012:176162. 2012
    ..The Akita mouse has recently been adopted as a relevant model for microvascular complications of diabetes. Here we investigate the development of atherosclerosis and inflammation in vessels of Akita mice on LDLr⁻/⁻ background...
  10. doi Immunization of apoE-/- mice with aldehyde-modified fibronectin inhibits the development of atherosclerosis
    Pontus Dunér
    Department of Clinical Sciences, Skane University Hospital, Lund University, Malmo, Sweden
    Cardiovasc Res 91:528-36. 2011
    ..To determine the functional role of these immune responses in atherosclerosis, we performed studies in which apoE-deficient mice were immunized with MDA-modified fibronectin...
  11. ncbi Recombinant human antibodies against aldehyde-modified apolipoprotein B-100 peptide sequences inhibit atherosclerosis
    Alexandru Schiopu
    Department of Medicine, Malmo University Hospital, Lund University, Malmo, Sweden
    Circulation 110:2047-52. 2004
    ..Aldehyde-modified peptide sequences in apolipoprotein B-100 (apoB-100) are major targets for these immune responses...
  12. doi Immunization with cationized BSA inhibits progression of disease in ApoBec-1/LDL receptor deficient mice with manifest atherosclerosis
    Daniel Kolbus
    Department of Clinical Sciences, Skane University Hospital in Malmö, Lund University, Sweden
    Immunobiology 216:663-9. 2011
    ..This was associated with development of a more stable plaque phenotype and reduced atherosclerosis progression...
  13. ncbi Association between IgM against an aldehyde-modified peptide in apolipoprotein B-100 and progression of carotid disease
    Gunilla Nordin Fredrikson
    Department of Clinical Sciences, Malmo University Hospital, Lund University, Malmo, Sweden
    Stroke 38:1495-500. 2007
    ....
  14. doi T-helper 2 immunity is associated with reduced risk of myocardial infarction and stroke
    Daniel Engelbertsen
    Department of Clinical Sciences, Lund University, Malmo University Hospital, Sweden
    Arterioscler Thromb Vasc Biol 33:637-44. 2013
    ..Here, we investigated associations between Th1 and Th2 cells, carotid intima-media thickness, and cardiovascular risk...
  15. pmc Nuclear factor of activated T cells regulates osteopontin expression in arterial smooth muscle in response to diabetes-induced hyperglycemia
    Lisa M Nilsson-Berglund
    Department of Clinical Sciences in Malmo, Lund University, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 30:218-24. 2010
    ..Here, we sought to determine whether hyperglycemia activates NFAT in vivo and whether this leads to vascular complications...
  16. doi Circulating CD40+ and CD86+ B cell subsets demonstrate opposing associations with risk of stroke
    Polyxeni T Mantani
    From the Department of Clinical Sciences, Skåne University Hospital Malmö, Lund University, Malmo, Sweden P T M, I L, L A, R A, B H, H B, J N, G N F and Faculty of Health and Society, Malmo University, Malmo, Sweden G N F
    Arterioscler Thromb Vasc Biol 34:211-8. 2014
    ..In this study, we assessed the association of 2 different B cell subsets, CD19(+)CD40(+) and CD19(+)CD86(+) B cells, with risk for development of acute cardiovascular events...
  17. doi Plasma S100A8/A9 correlates with blood neutrophil counts, traditional risk factors, and cardiovascular disease in middle-aged healthy individuals
    Ovidiu S Cotoi
    From the Department of Cellular and Molecular Biology, University of Medicine and Pharmacy of Tirgu Mures, Tirgu Mures, Romania O S C and Department of Clinical Sciences, Lund University P D, N K, B H, J N, H B, A S and Cardiology Clinic A S, Skåne University Hospital Malmö, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 34:202-10. 2014
    ..S100A8/A9 has previously been linked to atherogenesis and cardiovascular (CV) disease. We investigated whether S100A8, A9, and A8/A9 correlate with carotid artery disease and CV risk in apparently healthy individuals...
  18. ncbi Inhibition of atherosclerosis in apoE-null mice by immunization with apoB-100 peptide sequences
    Gunilla Nordin Fredrikson
    Department of Medicine, Malmo University Hospital, Lund University, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 23:879-84. 2003
    ..Immunization of animals with oxidized LDL results in reduction of atherosclerosis, suggesting an atheroprotective effect of this immune response...
  19. ncbi Autoimmune responses against the apo B-100 LDL receptor-binding site protect against arterial accumulation of lipids in LDL receptor deficient mice
    Gunilla Nordin Fredrikson
    Department of Biomedical Laboratory Science, Malmo University Hospital, Lund University, S 205 02 Malmo, Sweden
    Autoimmunity 40:122-30. 2007
    ..The aim of the present study was to determine physiological effects of induction of immune responses against the apo B-100 LDL receptor-binding site in mice deficient for the LDL receptor...
  20. ncbi Identification of autoantibodies in human plasma recognizing an apoB-100 LDL receptor binding site peptide
    Gunilla Nordin Fredrikson
    Department of Clinical Sciences, Malmo University Hospital, Lund University, Malmo, Sweden
    J Lipid Res 47:2049-54. 2006
    ..Their association with plasma oxidized LDL suggests that they have been generated in response to breakdown products of LDL oxidation, but their influence on cholesterol metabolism and the development of atherosclerosis appears limited...
  21. doi Elastin- and collagen-rich human carotid plaques have increased levels of the cysteine protease inhibitor cystatin C
    Isabel Goncalves
    Department of Clinical Sciences, Experimental Cardiovascular Research Unit, Lund University, Malmo University Hospital, Malmo, Sweden
    J Vasc Res 45:395-401. 2008
    ..In this study we analyzed the associations between human carotid plaque cystatin C expression and the plaque content of collagen and elastin...
  22. doi Fibromodulin deficiency reduces low-density lipoprotein accumulation in atherosclerotic plaques in apolipoprotein E-null mice
    Annelie Shami
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Arterioscler Thromb Vasc Biol 33:354-61. 2013
    ..The aim of this study was to analyze how an altered collagen structure affects development of atherosclerotic plaques...
  23. ncbi Elastin and calcium rather than collagen or lipid content are associated with echogenicity of human carotid plaques
    Isabel Goncalves
    Department of Medicine, Wallenberg Laboratory, University of Lund, Entrance 46, 1st Floor, Malmo University Hospital, SE 20502 Malmo, Sweden
    Stroke 35:2795-800. 2004
    ..This is the first study to relate echogenicity to plaque composition analyzed biochemically...
  24. doi Tumor necrosis factor-alpha does not mediate diabetes-induced vascular inflammation in mice
    Jenny Nilsson-Ohman
    Department of Clinical Sciences, Malmo University Hospital, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 29:1465-70. 2009
    ..In the present study we evaluated the role of TNF alpha in streptozotocin (STZ)-induced diabetes on vascular inflammation in C57BL/6 wild-type and apoE-/- mice...
  25. doi Immune responses against aldehyde-modified laminin accelerate atherosclerosis in Apoe-/- mice
    Pontus Dunér
    Department of Clinical Sciences, Malmo University Hospital, Lund University, Lund, Sweden
    Atherosclerosis 212:457-65. 2010
    ..Here we investigated the possible influence of immunity against a malondialdehyde (MDA)-modified form of the basement membrane protein laminin on atherosclerosis...
  26. ncbi Oxidized LDL antibodies in treatment and risk assessment of atherosclerosis and associated cardiovascular disease
    Jan Nilsson
    Department of Clinical Sciences, CRC Entrance 72 91 12, Malmo University Hospital, S 20502 Malmo, Sweden
    Curr Pharm Des 13:1021-30. 2007
    ..There is also evidence antibodies against oxidized LDL could also be used for imaging atherosclerosis...
  27. pmc TAP1-deficiency does not alter atherosclerosis development in Apoe-/- mice
    Daniel Kolbus
    Department of Clinical Sciences, Skåne University Hospital Malmö, Lund University, Malmo, Sweden
    PLoS ONE 7:e33932. 2012
    ..In conclusion, Apoe(-/-)Tap1(-/-) mice develop atherosclerosis equal to Apoe(-/-) mice, indicating a minor role for CD8(+) T cells and TAP1-dependent antigen presentation in the disease process...
  28. ncbi Atheroprotective immunization with MDA-modified apo B-100 peptide sequences is associated with activation of Th2 specific antibody expression
    Gunilla Nordin Fredrikson
    Department of Medicine, Lund University, Wallenberg Labortatory 1st floor, Malmo University Hospital, 205 02 Malmo, Sweden
    Autoimmunity 38:171-9. 2005
    ..The objective of this study was to evaluate if immunization with MDA-modified human apo B-100 fragments is associated with a shift in the Th1/Th2 balance...
  29. pmc Mobilization of regulatory T cells in response to carotid injury does not influence subsequent neointima formation
    Amit Saxena
    Department of Clinical Sciences Malmo, Lund University, Lund, Sweden
    PLoS ONE 7:e51556. 2012
    ..T cells have been attributed an important role in modulating repair responses following vascular injury. The aim of this study was to investigate the role of different T cell subsets in this context...
  30. doi Evidence supporting a key role of Lp-PLA2-generated lysophosphatidylcholine in human atherosclerotic plaque inflammation
    Isabel Goncalves
    Experimental Cardiovascular Research Group, Clinical Research Center, Clinical Sciences, Lund University, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 32:1505-12. 2012
    ..Lp-PLA2 hydrolyzes low-density lipoprotein-oxidized phospholipids generating lysoPCs. According to in vitro studies, lysoPCs are proinflammatory but the association between their generation and plaque inflammation remains unknown...
  31. ncbi Recombinant antibodies to an oxidized low-density lipoprotein epitope induce rapid regression of atherosclerosis in apobec-1(-/-)/low-density lipoprotein receptor(-/-) mice
    Alexandru Schiopu
    Department of Clinical Sciences, Malmo University Hospital, Lund University, Malmo, Sweden
    J Am Coll Cardiol 50:2313-8. 2007
    ....
  32. ncbi Very low-density lipoprotein induces interleukin-1beta expression in macrophages
    Maria M Stollenwerk
    Department of Clinical Sciences, Lund University, Sweden
    Biochem Biophys Res Commun 335:603-8. 2005
    ..In conclusion, VLDL induces IL-1beta mRNA expression, caspase-1 activation, and IL-1beta release from macrophages, suggesting that VLDL can promote inflammation in atherosclerotic lesions...
  33. ncbi Absence of the protease inhibitor cystatin C in inflammatory cells results in larger plaque area in plaque regression of apoE-deficient mice
    Eva Bengtsson
    Department of Medicine, Section for Experimental Cardiovascular Research, Malmo University Hospital, Lund University, 205 02 Malmo, Sweden
    Atherosclerosis 180:45-53. 2005
    ..These observations suggest that leukocyte-specific expression of cystatin C is actively involved in matrix remodelling associated with plaque regression...
  34. doi Identification of the target for therapeutic recombinant anti-apoB-100 peptide antibodies in human atherosclerotic lesions
    Isabel Goncalves
    Department of Clinical Sciences, Lund University, Sweden
    Atherosclerosis 205:96-100. 2009
    ....
  35. doi Atheroprotective effects of Alum are associated with capture of oxidized LDL antigens and activation of regulatory T cells
    Maria Wigren
    Department of Clinical Sciences, Entrance 72 91 12, Malmo University Hospital, 20502 Malmo, Sweden
    Circ Res 104:e62-70. 2009
    ....
  36. doi Activator protein-1 in carotid plaques is related to cerebrovascular symptoms and cholesteryl ester content
    Isabel Goncalves
    Department of Clinical Sciences, Clinical Research Center, Lund University, Malmo, Sweden
    Cardiovasc Pathol 20:36-43. 2011
    ..The aim of this study was to determine whether transcription factor activator protein-1 activity in carotid plaques is related to symptoms, lipid accumulation, or extracellular matrix composition...
  37. ncbi Autoantibody against the amino acid sequence 661-680 in apo B-100 is associated with decreased carotid stenosis and cardiovascular events
    Gunilla Nordin Fredrikson
    Department of Clinical Sciences, Malmo University Hospital, Lund University, Sweden
    Atherosclerosis 194:e188-92. 2007
    ..Our findings support the notion that the p45 sequence of apo B-100 is a potential target for immunomodulatory treatment of atherosclerosis in humans...
  38. doi High disaccharide intake associates with atherogenic lipoprotein profile
    Emily Sonestedt
    Department of Clinical Sciences Malmo, Lund University, SE 205 02 Malmo, Sweden
    Br J Nutr 107:1062-9. 2012
    ..The present findings indicate that the ALP may be improved by a low intake of disaccharides, and moderate intakes of protein and alcohol...
  39. doi Low levels of circulating CD4+FoxP3+ T cells are associated with an increased risk for development of myocardial infarction but not for stroke
    Maria Wigren
    Department of Clinical Sciences, Entrance 72, 60 13, Malmo University Hospital, 20502 Malmo, Sweden
    Arterioscler Thromb Vasc Biol 32:2000-4. 2012
    ..The aim of the present study was to determine whether circulating Tregs predict the development of acute cardiovascular events in humans...
  40. doi The vascular repair process after injury of the carotid artery is regulated by IL-1RI and MyD88 signalling
    Amit Saxena
    Department of Experimental Medicine, Lund University, Lund, Sweden
    Cardiovasc Res 91:350-7. 2011
    ..The aim of this study was to determine whether innate immune signalling influences the vascular repair process in response to mechanical injury of arteries in mice...
  41. ncbi Inhibition of injury-induced arterial remodelling and carotid atherosclerosis by recombinant human antibodies against aldehyde-modified apoB-100
    Asa Ström
    Department of Experimental Medical Science, Lund University, BMC, C12, SE 22184 Lund, Sweden
    Atherosclerosis 190:298-305. 2007
    ..In the present study we investigated the effect of antibodies against aldehyde-modified apolipoprotein B-100 (apoB-100), a component of oxidized LDL, on atherosclerosis and response to arterial injury in mice...
  42. ncbi Humoral immune response against defined oxidized low-density lipoprotein antigens reflects structure and disease activity of carotid plaques
    Isabel Goncalves
    Department of Medicine, Lund University, Wallenberg Laboratory, University Hospital MAS, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 25:1250-5. 2005
    ....
  43. ncbi Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice
    Lena Brånén
    Department of Medicine, University Hospital MAS, Experimental Cardiovascular Research, Wallenberg Laboratory, Ing 46, Plan 1, S 205 02 Malmo, Sweden
    Arterioscler Thromb Vasc Biol 24:2137-42. 2004
    ..The aim of the study was to evaluate the importance of TNF-alpha in atherogenesis...
  44. ncbi Identification of immune responses against aldehyde-modified peptide sequences in apoB associated with cardiovascular disease
    Gunilla Nordin Fredrikson
    Department of Medicine, Malmo University Hospital, Lund University, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 23:872-8. 2003
    ..Atherosclerosis is associated with an immune response against oxidized LDL, which modulates the progression of the disease process...
  45. pmc Association between renin and atherosclerotic burden in subjects with and without type 2 diabetes
    Isabel Goncalves
    Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
    BMC Cardiovasc Disord 16:171. 2016
    ..The aim of the present study was to determine if plasma renin levels are associated with the severity of vascular changes in subjects with and without T2D...
  46. ncbi Involvement of the CD1d-natural killer T cell pathway in neointima formation after vascular injury
    Asa Ström
    Department of Experimental Medicine, Lund University, Sweden
    Circ Res 101:e83-9. 2007
    ..The results suggest that presentation of lipid antigens through the CD1d-natural killer T cell pathway modulates vascular repair responses...
  47. doi Elevated CD14++CD16- monocytes predict cardiovascular events
    Katarina E Berg
    Department of Clinical Sciences, Skåne University Hospital Malmö, Lund University, Malmo, Sweden
    Circ Cardiovasc Genet 5:122-31. 2012
    ..Although monocytes in peripheral blood are no longer considered to be a homogeneous population, associations between distinct monocyte subsets and cardiovascular disease have not been highlighted in large epidemiological studies...
  48. pmc Interleukin-1beta and tumour necrosis factor-alpha impede neutral lipid turnover in macrophage-derived foam cells
    Jenny Persson
    Department of Clinical Sciences Malmo, Clinical Research Center, UMAS, Lund University, Sweden
    BMC Immunol 9:70. 2008
    ....
  49. doi Apolipoprotein B-100 Antibody Interaction With Atherosclerotic Plaque Inflammation and Repair Processes
    Giuseppe Asciutto
    From the Department of Clinical Sciences Malmö, Lund University, Malmo, Sweden
    Stroke 47:1140-3. 2016
    ..This study investigated the association between p45 IgG autoantibodies and plaque inflammation in subjects with advanced cardiovascular disease...
  50. doi Human Carotid Plaques With High Levels of Interleukin-16 Are Associated With Reduced Risk for Cardiovascular Events
    Caitriona Grönberg
    From the Department of Clinical Sciences C G, E B, G N F, M N, A P, L A, J N, I G, H B and Vascular Centre Malmö Lund G A, Skane University Hospital, Malmo, Lund University, Lund, Sweden
    Stroke 46:2748-54. 2015
    ....
  51. doi High plasma levels of heparin-binding epidermal growth factor are associated with a more stable plaque phenotype and reduced incidence of coronary events
    Sara Rattik
    From the Department of Clinical Sciences Malmö, Lund University, Malmo, Sweden S R, M W, H B, G N F, B H, E B, A s, A E, P D, H G, I G, J N Department of Cardiology Coronary diseases, Skane University Hospital, Malmo, Sweden A S, A E, I G and Department of Medical Sciences, Clinical Chemistry and Science for Life Laboratory, Uppsala University, Uppsala, Sweden A S
    Arterioscler Thromb Vasc Biol 35:222-8. 2015
    ....
  52. pmc IL-25 inhibits atherosclerosis development in apolipoprotein E deficient mice
    Polyxeni T Mantani
    Department of Clinical Sciences, Skåne University Hospital Malmö, Lund University, Malmo, Sweden
    PLoS ONE 10:e0117255. 2015
    ..Recent studies have identified the novel innate lymphoid type 2 cells (ILC2s) as an IL-25 target cell population. The purpose of this study was to evaluate if IL-25 has any influence on atherosclerosis development in mice...
  53. doi Emerging biomarkers and intervention targets for immune-modulation of atherosclerosis - a review of the experimental evidence
    Harry Bjorkbacka
    Department of Clinical Sciences, Skåne University Hospital Malmö, Lund University, Sweden
    Atherosclerosis 227:9-17. 2013
    ..It is therefore critical that more attention is given to the characterization and evaluation of immune biomarkers for cardiovascular risk...
  54. doi Apolipoprotein B100 autoimmunity and atherosclerosis - disease mechanisms and therapeutic potential
    Jan Nilsson
    Department of Clinical Sciences Malmo, Skane University Hospital, Lund University, Sweden
    Curr Opin Lipidol 23:422-8. 2012
    ..This review will discuss recent developments in the mechanistic understanding of apo B100 autoimmunity and approaches taken to use this knowledge for development of novel therapies...
  55. doi Lymphocytes in atherosclerosis
    Maria Wigren
    Department of Clinical Sciences Malmo, Lund University, Sweden
    Clin Chim Acta 413:1562-8. 2012
    ..The elucidation of role of immune system in atherosclerosis has revealed new targets for intervention and both vaccines and antibody-based therapies are presently in or due to enter clinical testing...
  56. pmc Vascular cellular adhesion molecule-1 (VCAM-1) expression in mice retinal vessels is affected by both hyperglycemia and hyperlipidemia
    Carin Gustavsson
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    PLoS ONE 5:e12699. 2010
    ..Here we investigated the impact of diabetes and dyslipidemia on VCAM-1 expression in mouse retinal vessels, as well as the potential role of tumor necrosis factor-α (TNFα)...
  57. ncbi Cystatin C and cathepsins in cardiovascular disease
    Eva Bengtsson
    Department of Clinical Sciences, Experimental Cardiovascular Research Unit, Lund University, Malmo, Sweden
    Front Biosci 13:5780-6. 2008
    ..This article reviews possible roles of cystatin C and cathepsins in different processes and stages of the atherosclerotic disease...
  58. doi Plasma variation and reproducibility of oxidized LDL-cholesterol and low-grade inflammation biomarkers among participants of the Malmö Diet and Cancer cohort
    Joana Alves Dias
    a Department of Clinical Sciences in Malmö, Clinical Research Centre CRC, Lund University, Lund, Sweden
    Biomarkers 21:562-71. 2016
    ..Large epidemiological studies often collect non-fasting samples, although the reliability of biomarkers may be uncertain...
  59. doi Sphingolipids Contribute to Human Atherosclerotic Plaque Inflammation
    Andreas Edsfeldt
    From the Experimental Cardiovascular Research Unit, Clinical Research Centre, Clinical Sciences Malmö, Lund University, Malmo, Sweden A E, P D, G A, H G, M N, A F P, J N, I G Vascular Centre Malmö Lund, Skåne, University Hospital, Malmo, Sweden G A Department of Cardiology, Skane University Hospital, Lund Malmö, Sweden A E, H G, A F P, I G Department of Molecular and Clinical Medicine Wallenberg Laboratory, Sahlgrenska University Hospital University, Gothenburg, Sweden M S, J B Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Solna, Sweden R M F and Department of Clinical Sciences Malmö, Clinical Research Center, Lund University, Malmo, Sweden I G M, Sezione di Anatomia e Istologia
    Arterioscler Thromb Vasc Biol 36:1132-40. 2016
    ..The aim of this study was to assess plaque levels of sphingolipids and investigate their potential association with and contribution to plaque vulnerability...
  60. pmc High levels of cathepsin D and cystatin B are associated with increased risk of coronary events
    Isabel Goncalves
    Experimental Cardiovascular Research Unit, Department of Clinical Sciences, Lund University, Malmo, Sweden Department of Cardiology, Skane University Hospital, Malmo, Sweden
    Open Heart 3:e000353. 2016
    ..Matrix metalloproteinases have been shown to be markers for cardiovascular disease whereas the members of the cathepsin protease family are less studied...
  61. pmc Low elastin content of carotid plaques is associated with increased risk of ipsilateral stroke
    Giuseppe Asciutto
    Vascular Centre Malmö Lund, Skane University Hospital, Malmo, Sweden
    PLoS ONE 10:e0121086. 2015
    ..The aim of the present study was to investigate if the content of elastin, collagen and of the matrix metalloproteinase (MMP) -1, -3, -9 and -12 in plaques removed at surgery can be associated with the occurrence of ipsilateral symptoms...
  62. doi High Plasma Levels of Galectin-3 Are Associated with Increased Risk for Stroke after Carotid Endarterectomy
    Andreas Edsfeldt
    Department of Clinical Sciences Malmx00F6, Lund University, Lund, Sweden
    Cerebrovasc Dis 41:199-203. 2016
    ..The aim of this study was to investigate whether Gal-3 could be used as a marker to predict postoperative cerebrovascular ischemic events among patients who underwent carotid endarterectomy (CEA)...
  63. doi Increased aldehyde-modification of collagen type IV in symptomatic plaques--a possible cause of endothelial dysfunction
    Pontus Dunér
    Experimental Cardiovascular Research Unit, Clinical Research Center, Department of Clinical Sciences, Lund University, Skane University Hospital, Malmo, Sweden Electronic address
    Atherosclerosis 240:26-32. 2015
    ..We have investigated if aldehyde-modification of collagen type IV, one of the major basement membrane components, in plaques is associated with cardiovascular events...
  64. doi Impaired fibrous repair: a possible contributor to atherosclerotic plaque vulnerability in patients with type II diabetes
    Andreas Edsfeldt
    From the Experimental Cardiovascular Research Unit A E, I G, H G, M N, P D, E B, A P, M N, H B, J N and Department of Clinical Sciences I G M, M O M, O M, Clinical Research Center, Clinical Sciences, Lund University, Malmo, Sweden and Department of Cardiology Coronary Diseases, Skane University Hospital, Malmo, Sweden A E, I G, H G, A P, M N
    Arterioscler Thromb Vasc Biol 34:2143-50. 2014
    ..Inflammation has been proposed as the main cause for the high risk of atherosclerotic disease in DM II. In this study, we compared markers of inflammation and fibrous repair in plaques from subjects with and without DM II...
  65. doi Intranasal immunization with an apolipoprotein B-100 fusion protein induces antigen-specific regulatory T cells and reduces atherosclerosis
    Roland Klingenberg
    Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 30:946-52. 2010
    ..The objective of this study was to develop an atheroprotective vaccine by targeting a peptide of the LDL protein constituent apolipoprotein B-100 (apoB-100) to the nasal mucosa to induce a protective mucosal immune response...
  66. doi Regulatory T cells and the control of modified lipoprotein autoimmunity-driven atherosclerosis
    Jan Nilsson
    Department of Clinical Sciences, Malmo University Hospital, Lund University, 205 02 Malmo, Sweden
    Trends Cardiovasc Med 19:272-6. 2009
    ....
  67. doi Short communication: Dating components of human atherosclerotic plaques
    Isabel Goncalves
    Departments of Clinical Sciences Malmö, Malmo University Hospital, Malmo, Sweden
    Circ Res 106:1174-7. 2010
    ..Experimental studies have shown that mechanisms to repair vulnerable lesions exist, but the rate of remodeling of human plaque tissue has not been studied...
  68. doi Vaccines against atherosclerosis
    Jan Nilsson
    Department of Clinical Sciences, Malmo University Hospital, Lund University, SE 205 02 Malmo, Sweden
    Expert Rev Vaccines 12:311-21. 2013
    ..A first generation of atherosclerosis vaccines based on peptides derived from apoB100 and heat shock proteins have demonstrated promising results in animal studies and are now approaching clinical testing...
  69. doi Identification of a danger-associated peptide from apolipoprotein B100 (ApoBDS-1) that triggers innate proatherogenic responses
    Daniel F J Ketelhuth
    Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Stockholm, Sweden
    Circulation 124:2433-43, 1-7. 2011
    ..In this study, we analyzed the proinflammatory activity of ApoB100 peptides in atherosclerosis...
  70. ncbi Simvastatin stimulates macrophage interleukin-1beta secretion through an isoprenylation-dependent mechanism
    Marie W Lindholm
    Experimental Cardiovascular Research, Department of Clinical Science, Malmo, Faculty of Medicine, Lund University, CRC, UMAS Ing 72, 20502 Malmo, Sweden
    Vascul Pharmacol 46:91-6. 2007
    ..These data suggest an isoprenylation-dependent negative-feedback loop for macrophage IL-1beta secretion that is inhibited by statin treatment...
  71. ncbi Very low density lipoprotein potentiates tumor necrosis factor-alpha expression in macrophages
    Maria M Stollenwerk
    Department of Medicine, Lund University, Wallenberg Laboratory, Malmo University Hospital, SE 20502 Malmo, Sweden
    Atherosclerosis 179:247-54. 2005
    ..These findings suggest that triacylglycerol-rich lipoproteins are involved in inflammatory processes associated with atherosclerosis...
  72. pmc Inhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic mice
    Anna V Zetterqvist
    Department of Clinical Sciences in Malmo, Lund University, Malmo, Sweden
    PLoS ONE 8:e65020. 2014
    ..Here we investigate whether NFAT activation may be a link between diabetes and atherogenesis...
  73. ncbi Association between diet, lifestyle, metabolic cardiovascular risk factors, and plasma C-reactive protein levels
    Gunilla Nordin Fredrikson
    Department of Medicine, Malmo University Hospital, S 205 02 Malmo, Sweden
    Metabolism 53:1436-42. 2004
    ..These observations suggest that CRP levels are only marginally associated with individual dietary and lifestyle factors. Surprisingly, a higher intake of fat tended to be associated with lower CRP values among women...
  74. doi Inflammation and immunity in diabetic vascular complications
    Jan Nilsson
    Department of Clinical Sciences, Malmo University Hospital, Lund University, Sweden
    Curr Opin Lipidol 19:519-24. 2008
    ..The purpose of this review is to discuss possible mechanisms through which diabetes can contribute to a more aggressive atherosclerotic disease process with a particular focus on the role of innate and adaptive immunity...
  75. doi Development of a diet quality index assessing adherence to the Swedish nutrition recommendations and dietary guidelines in the Malmö Diet and Cancer cohort
    Isabel Drake
    Department of Clinical Sciences in Malmo, Lund University, Skane University Hospital, Malmo, Sweden
    Public Health Nutr 14:835-45. 2011
    ..To develop a diet quality index (DQI) that assesses adherence to the Swedish nutrition recommendations (SNR) and the Swedish dietary guidelines (SDG)...
  76. ncbi Low density lipoprotein stimulation of human macrophage proteoglycan secretion
    Marie Wickström Lindholm
    Department of Medicine, Lund University, Wallenberg Laboratory Plan 1, UMAS Ing 46, 20502 Malmo, Sweden
    Biochem Biophys Res Commun 328:455-60. 2005
    ..These observations suggest that native LDL stimulate macrophages to secrete a chondroitin sulfate-rich proteoglycan moiety likely to have high capacity for vascular extracellular trapping of apolipoprotein B-containing lipoproteins...
  77. doi High plasma concentrations of autoantibodies against native peptide 210 of apoB-100 are related to less coronary atherosclerosis and lower risk of myocardial infarction
    Per Sjogren
    Department of Medicine, Atherosclerosis Research Unit, Solna Karolinska Institutet, Stockholm, Sweden
    Eur Heart J 29:2218-26. 2008
    ..We examined whether antibodies against peptides 45 and 210 of apoB-100 are related to myocardial infarction (MI) and severity of coronary atherosclerosis...
  78. pmc CD8+ T cell activation predominate early immune responses to hypercholesterolemia in Apoe⁻(/)⁻ mice
    Daniel Kolbus
    Department of Clinical Sciences, Skåne University Hospital Malmö, Lund University, Sweden
    BMC Immunol 11:58. 2010
    ..In the present study we assessed immune responses to hypercholesterolemia induced by feeding Apoe-/- mice a high-fat diet for 4 or 8 weeks...
  79. ncbi Perilipin and adipophilin expression in lipid loaded macrophages
    Jenny Persson
    Experimental Cardiovascular Research, Department of Clinical Sciences Malmo, Lund University, Clinical Research Centre 91 12, UMAS Ing 72, 205 02 Malmo, Sweden
    Biochem Biophys Res Commun 363:1020-6. 2007
    ..This protein expression pattern may hinder lipid turnover in macrophage foam cells, thereby increasing lipid content of atherosclerotic plaques...
  80. doi Nanomolar concentrations of lysophosphatidylcholine recruit monocytes and induce pro-inflammatory cytokine production in macrophages
    Katarina E Olofsson
    Department of Clinical Sciences, Experimental Cardiovascular Research, CRC Lund University, Building 91 12, Malmo University Hospital, Entrance 72, SE 205 02 Malmo, Sweden
    Biochem Biophys Res Commun 370:348-52. 2008
    ..Our findings demonstrate two peaks of LPC-induced pro-inflammatory activity, one in the nM and one in the muM range, and indicate that the latter may involve a stress response to lipid cytotoxicity...
  81. doi Cardiovascular and cancer mortality in very elderly post-myocardial infarction patients receiving statin treatment
    Klas Gränsbo
    Department of Clinical Sciences, Malmo University Hospital, Malmo, Sweden Lund University, Lund, Sweden
    J Am Coll Cardiol 55:1362-9. 2010
    ..The purpose of this study was to determine whether statin treatment is effective and safe in very elderly (80 years and older) acute myocardial infarction (AMI) patients...
  82. ncbi Insulin-like growth factor II plays a central role in atherosclerosis in a mouse model
    Silvio Zaina
    Experimental Cardiovascular Research, Wallenberg Laboratory, Department of Medicine, University of Lund, Malmo General Hospital, 205 02 Malmo, Sweden
    J Biol Chem 277:4505-11. 2002
    ..These observations provide the first direct evidence for an atherogenic activity of insulin-like growth factor II in vivo...
  83. doi Ceylon cinnamon does not affect postprandial plasma glucose or insulin in subjects with impaired glucose tolerance
    Jennie Wickenberg
    Center for Emergency, Skane University Hospital, Lund University, Malmo, Sweden
    Br J Nutr 107:1845-9. 2012
    ..cassia by C. zeylanicum or the use of aqueous extracts of C. cassia to lower coumarin exposure. However, the positive effects seen with C. cassia in subjects with poor glycaemic control would then be lost...
  84. pmc Decreased inducibility of TNF expression in lipid-loaded macrophages
    Mikko P S Ares
    Lund University, Wallenberg Laboratory, University Hospital MAS, S 20502 Malmo, Sweden
    BMC Immunol 3:13. 2002
    ..We studied the effects of lipid loading on the regulation of TNF expression in human monocyte-derived macrophages...
  85. doi Vaccination against atherosclerosis? Induction of atheroprotective immunity
    Goran K Hansson
    Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital L8 03, Stockholm, 17176, Sweden
    Semin Immunopathol 31:95-101. 2009
    ..This review summarizes our current understanding of the role immunity in atherosclerosis and outlines strategies for antigen-specific prevention of this disease...
  86. ncbi Linoleic acid-stimulated vascular adhesion molecule-1 expression in endothelial cells depends on nuclear factor-kappaB activation
    Wolfgang Dichtl
    Wallenberg Laboratory, Department of Medicine, Malmo University Hospital, Lund University, Lund, Sweden
    Metabolism 51:327-33. 2002
    ..These findings suggest that diets rich in linoleic acid may be proinflammatory and thus atherogenic by activating vascular endothelial cells...
  87. ncbi Changes related to age and cerebrovascular symptoms in the extracellular matrix of human carotid plaques
    Isabel Goncalves
    Department of Medicine, Lund University, Wallenberg Laboratory, University Hospital MAS, S 20502 Malmo, Sweden
    Stroke 34:616-22. 2003
    ..The purpose of the present study was to compare the matrix composition of human carotid plaques from symptomatic patients with those obtained from patients without symptoms. Furthermore, matrix changes related to age were studied...
  88. ncbi Inhibitory effect on arterial injury-induced neointimal formation by adoptive B-cell transfer in Rag-1 knockout mice
    Paul Dimayuga
    Experimental Cardiovascular Research, Department of Medicine, Lund University, University Hospital MAS, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 22:644-9. 2002
    ..05). Injured carotid arteries from reconstituted Rag-1 KO mice had detectable IgM and IgG, indicating viable transfer of B cells. The results suggest that B cells modulate the response to arterial injury...
  89. ncbi Will autoantibodies help to determine severity and progression of atherosclerosis?
    Jan Nilsson
    Curr Opin Lipidol 15:499-503. 2004
  90. ncbi Insulin-like growth factor II and its receptors in atherosclerosis and in conditions predisposing to atherosclerosis
    Silvio Zaina
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    Curr Opin Lipidol 14:483-9. 2003
    ..Here we discuss experimental evidence pointing to insulin-like growth factor II and its receptors as important players in cardiovascular diseases...
  91. ncbi Autoantibodies against modified low-density lipoproteins in coronary artery disease
    Per Tornvall
    Department of Cardiology, Karolinska Hospital, Karolinska Institute, S 17176 Stockholm, Sweden
    Atherosclerosis 167:347-53. 2003
    ..To evaluate the importance of different autoantibodies against modified low-density lipoprotein (LDL) in patients with coronary artery disease (CAD)...
  92. ncbi Shortened life span, bradycardia, and hypotension in mice with targeted expression of an Igf2 transgene in smooth muscle cells
    Silvio Zaina
    Department of Medicine Experimental Cardiovascular Research, University of Lund, Malmo General Hospital, 205 02 Malmo, Sweden
    Endocrinology 144:2695-703. 2003
    ..These observations are discussed in the light of the proposed therapeutic use of IGF2 in human cardiac diseases...
  93. ncbi HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells
    Wolfgang Dichtl
    Department of Internal Medicine, Division of Cardiology, Leopold Franzens University Innsbruck, Austria
    Arterioscler Thromb Vasc Biol 23:58-63. 2003
    ..The aim of this study was to characterize the effects of statins on the activation of transcription factors known to regulate inflammation and cell proliferation/differentiation...
  94. ncbi Timing affects the efficacy of LDL immunization on atherosclerotic lesions in apo E (-/-) mice
    Kuang Yuh Chyu
    Atherosclerosis Research Center, Division of Cardiology, Department of Medicine and Burns and Allen Research Institute, Cedars Sinai Medical Center and UCLA School of Medicine, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Atherosclerosis 176:27-35. 2004
    ..However, whether the timing of immunization affects its efficacy is not known. In this study, we evaluated the influence of timing of immunization on the athero-protective effects of LDL immunization in apo E (-/-) mice...
  95. ncbi Immunotherapy for atherosclerosis: an emerging paradigm
    Prediman K Shah
    Atherosclerosis Research Center, Division of Cardiology, Cedars Sinai Medical Center, Los Angeles, California, USA
    Rev Cardiovasc Med 5:194-203. 2004
    ..Suppression of proatherogenic immune responses and activation of antiatherogenic immune responses promise to emerge as novel strategies for the prevention and treatment of atherosclerotic vascular disease...
  96. doi Autoantibodies against modified apolipoprotein B-100 in relation to low-density lipoprotein size and the metabolic syndrome in otherwise healthy men
    Per Sjogren
    Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
    Metabolism 57:362-6. 2008
    ..07). We conclude that subjects with a predominance of small dense LDL particles have elevated concentrations of IgG(45) in the circulation, which reflect an activated immune response to a specific epitope of modified apo B-100...
  97. ncbi Immunization using an Apo B-100 related epitope reduces atherosclerosis and plaque inflammation in hypercholesterolemic apo E (-/-) mice
    Kuang Yuh Chyu
    Atherosclerosis Research Center, Division of Cardiology, Department of Medicine and Burns and Allen Research Institute, Cedars Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Biochem Biophys Res Commun 338:1982-9. 2005
    ..Such acquired immunity and athero-protective effect appears to be mediated by splenocytes. These data demonstrate the feasibility of peptide based immunomodulating therapy for atherosclerosis...
  98. ncbi Antibodies against oxidized low-density lipoprotein for the treatment of vulnerable plaques
    Jan Nilsson
    Biolnvent International AB, Lund, Sweden
    Curr Opin Investig Drugs 7:815-9. 2006
    ..Patients that may benefit front antibody treatment are most likely to be high-risk individuals in which conventional treatments, including lipid-lowering statins, do not provide sufficient protection...
  99. ncbi T cell modulation of intimal thickening after vascular injury: the bimodal role of IFN-gamma in immune deficiency
    Paul C Dimayuga
    Atherosclerosis Research Center, Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, David Geffen School of Medicine, UCLA, Los Angeles, California, USA
    Arterioscler Thromb Vasc Biol 25:2528-34. 2005
    ..The mechanisms involved are not well defined. We investigated the role of T cells and IFN-gamma in the response to injury in normal and immune-deficient Rag-1KO mice...
  100. ncbi Immunomodulation of atherosclerosis with a vaccine
    Prediman K Shah
    Division of Cardiology and Atherosclerosis Research Center, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Nat Clin Pract Cardiovasc Med 2:639-46. 2005
    ..In this review, we discuss the possible immunologic mechanisms by which vaccines against atherosclerosis might work and the ways in which such treatment might be most effectively administered...
  101. ncbi Regulating protective immunity in atherosclerosis
    Jan Nilsson
    Circ Res 96:395-7. 2005