Yun Chen

Summary

Affiliation: Lundberg Laboratory for Cancer Research
Country: Sweden

Publications

  1. ncbi request reprint Neonatal losartan treatment suppresses renal expression of molecules involved in cell-cell and cell-matrix interactions
    Yun Chen
    Department of Physiology, University of Gothenburg, Gothenburg, Sweden
    J Am Soc Nephrol 15:1232-43. 2004
  2. ncbi request reprint Perturbed medullary tubulogenesis in neonatal rat exposed to renin-angiotensin system inhibition
    Daina Lasaitiene
    Department of Physiology, Institute of Physiology and Pharmacology, University of Gothenburg, Box 432, S 405 30 Gothenburg, Sweden
    Nephrol Dial Transplant 18:2534-41. 2003
  3. pmc Increased rate of arterial stiffening with obesity in adolescents: a five-year follow-up study
    Frida Dangardt
    Department of Molecular and Clinical Medicine, Clinical Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 8:e57454. 2013
  4. doi request reprint High levels of soluble intercellular adhesion molecule-1, insulin resistance and saturated fatty acids are associated with endothelial dysfunction in healthy adolescents
    Yun Chen
    Department of Molecular and Clinical Medicine Clinical Physiology, The Sahlgrenska Academy and University Hospital, University of Gothenburg, SE 41345 Gothenburg, Sweden
    Atherosclerosis 211:638-42. 2010
  5. ncbi request reprint Growth hormone aggravates renal abnormalities induced by neonatal enalapril treatment
    Annika B M Nilsson
    Department of Physiology, University of Gothenburg, 405 30 Gothenburg, Sweden
    Pediatr Nephrol 18:878-86. 2003
  6. ncbi request reprint Neonatal ACE inhibition in rats interferes with lung development
    Daina Lasaitiene
    Department of Physiology, University of Gothenburg, Gothenburg, Sweden
    Clin Physiol Funct Imaging 24:65-8. 2004
  7. doi request reprint Age- and sex-related differences in vascular function and vascular response to mental stress. Longitudinal and cross-sectional studies in a cohort of healthy children and adolescents
    Yun Chen
    Department of Molecular and Clinical Medicine Clinical Physiology, The Sahlgrenska Academy and University Hospital, University of Gothenburg, SE 41345 Gothenburg, Sweden
    Atherosclerosis 220:269-74. 2012
  8. ncbi request reprint Further insights into the role of angiotensin II in kidney development
    Daina Lasaitiene
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, University of Gothenburg, Sweden
    Clin Physiol Funct Imaging 26:197-204. 2006
  9. ncbi request reprint Neonatal RAS inhibition changes the phenotype of the developing thick ascending limb of Henle
    Daina Lasaitiene
    Dept of Physiology, Institute of Physiology and Pharmacology, Univ of Gothenburg, Box 432, S 405 30 Gothenburg, Sweden
    Am J Physiol Renal Physiol 286:F1144-53. 2004
  10. ncbi request reprint Tubular mitochondrial alterations in neonatal rats subjected to RAS inhibition
    Daina Lasaitiene
    Dept of Clinical Physiology, Univ of Gothenburg, S 413 45 Gothenburg, Sweden
    Am J Physiol Renal Physiol 290:F1260-9. 2006

Collaborators

  • Daina Lasaitiene
  • Frida Dangardt
  • Li Ming Gan
  • Li Li
  • Ying Fu
  • Walter Osika
  • Britt G Gabrielsson
  • Ulf Nilsson
  • Masato Yano
  • Wei Li
  • Gregor S Guron
  • Jun Li
  • Sheng Hong Tseng
  • Hong Shiee Lai
  • Jin Cherng Chen
  • Wen Fang Dou
  • Ylva K Magnusson
  • Yu Zhou
  • Shuangjin Cui
  • Weiwei Qin
  • Peter Friberg
  • Yen Hao Su
  • Swei Ming Lin
  • Lan Zheng
  • Wei Jao Chen
  • Hsin Yi Huang
  • King Jen Chang
  • Chia Kang Chen
  • Annika B M Nilsson
  • David Vaudry
  • Zhe Liu
  • Jakob Malm
  • Jing Dong
  • Lian Fen Zhang
  • Ren Lai
  • Zheng hong Xu
  • Jian Jin
  • Jian Yong Lei
  • Peter Sjovall
  • Xu Wang
  • Yu Qin Zhang
  • Xiao Yang Zhi
  • Fang Feng
  • Han Liu
  • Zunjian Zhang
  • Na Wang
  • Fengguo Xu
  • Ming Ma
  • Yuan Tian
  • Hsiu Chuan Wu
  • Po Huang Lee
  • Chee Jen Chang
  • Chiung Nien Chen
  • Wen Hsi Lin
  • Xiang Xia
  • Yu Zhai
  • Po Yin Lin
  • Xiao heng Shen
  • Chan Xing Yuan
  • Xue Mei Tang
  • Ying Wang
  • Chih Hsien Wang
  • Niels Marcussen
  • Linda Bönquist
  • Abdel G Elkahloun
  • Jing Pian Peng
  • Carol Hamelink
  • Aurélia Ravni
  • Lee E Eiden
  • Ying Yang

Detail Information

Publications32

  1. ncbi request reprint Neonatal losartan treatment suppresses renal expression of molecules involved in cell-cell and cell-matrix interactions
    Yun Chen
    Department of Physiology, University of Gothenburg, Gothenburg, Sweden
    J Am Soc Nephrol 15:1232-43. 2004
    ..Moreover, regulation of the expression of leukocyte type 12-lipoxygenase and alpha-smooth muscle actin by the renin-angiotensin system in the immature kidney adds new knowledge toward the understanding of renal vascular development...
  2. ncbi request reprint Perturbed medullary tubulogenesis in neonatal rat exposed to renin-angiotensin system inhibition
    Daina Lasaitiene
    Department of Physiology, Institute of Physiology and Pharmacology, University of Gothenburg, Box 432, S 405 30 Gothenburg, Sweden
    Nephrol Dial Transplant 18:2534-41. 2003
    ..Additionally, medullary expression of E-cadherin, a marker for tubular formation, was investigated in ACE-inhibited rats...
  3. pmc Increased rate of arterial stiffening with obesity in adolescents: a five-year follow-up study
    Frida Dangardt
    Department of Molecular and Clinical Medicine, Clinical Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 8:e57454. 2013
    ..Changes in arterial stiffness measured as pulse wave velocity (PWV) and vascular morphology of the radial (RA) and dorsal pedal arteries (DPA) were examined in obese adolescents compared to lean subjects in a 5-year follow-up study...
  4. doi request reprint High levels of soluble intercellular adhesion molecule-1, insulin resistance and saturated fatty acids are associated with endothelial dysfunction in healthy adolescents
    Yun Chen
    Department of Molecular and Clinical Medicine Clinical Physiology, The Sahlgrenska Academy and University Hospital, University of Gothenburg, SE 41345 Gothenburg, Sweden
    Atherosclerosis 211:638-42. 2010
    ..As the determinants of endothelial function in childhood are unknown, we investigated the influence of cardiovascular risk factors on endothelial function in a cohort of healthy adolescents...
  5. ncbi request reprint Growth hormone aggravates renal abnormalities induced by neonatal enalapril treatment
    Annika B M Nilsson
    Department of Physiology, University of Gothenburg, 405 30 Gothenburg, Sweden
    Pediatr Nephrol 18:878-86. 2003
    ..These findings indicate that GH and IGF-I have different roles in the renin-angiotensin system-mediated kidney development...
  6. ncbi request reprint Neonatal ACE inhibition in rats interferes with lung development
    Daina Lasaitiene
    Department of Physiology, University of Gothenburg, Gothenburg, Sweden
    Clin Physiol Funct Imaging 24:65-8. 2004
    ..Our results suggest that early postnatal ACE inhibition in rats interferes with lung development...
  7. doi request reprint Age- and sex-related differences in vascular function and vascular response to mental stress. Longitudinal and cross-sectional studies in a cohort of healthy children and adolescents
    Yun Chen
    Department of Molecular and Clinical Medicine Clinical Physiology, The Sahlgrenska Academy and University Hospital, University of Gothenburg, SE 41345 Gothenburg, Sweden
    Atherosclerosis 220:269-74. 2012
    ..In this study, we performed longitudinal and cross-sectional studies in healthy children and adolescents to investigate age- and sex-related differences in vascular functions and vascular response to mental stress...
  8. ncbi request reprint Further insights into the role of angiotensin II in kidney development
    Daina Lasaitiene
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, University of Gothenburg, Sweden
    Clin Physiol Funct Imaging 26:197-204. 2006
    ..In addition, the investigations linking the perinatal development of RAS inhibition-induced renal dysmorphology and establishment of adult blood pressure are discussed...
  9. ncbi request reprint Neonatal RAS inhibition changes the phenotype of the developing thick ascending limb of Henle
    Daina Lasaitiene
    Dept of Physiology, Institute of Physiology and Pharmacology, Univ of Gothenburg, Box 432, S 405 30 Gothenburg, Sweden
    Am J Physiol Renal Physiol 286:F1144-53. 2004
    ..We conclude that neonatal losartan treatment causes significant changes in the phenotype of the developing TALH in the rat...
  10. ncbi request reprint Tubular mitochondrial alterations in neonatal rats subjected to RAS inhibition
    Daina Lasaitiene
    Dept of Clinical Physiology, Univ of Gothenburg, S 413 45 Gothenburg, Sweden
    Am J Physiol Renal Physiol 290:F1260-9. 2006
    ....
  11. pmc Characterization of VCAM-1-binding peptide-functionalized quantum dots for molecular imaging of inflamed endothelium
    Yun Chen
    Department of Molecular and Clinical Medicine Clinical Physiology, The Sahlgrenska Academy and University Hospital, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 8:e83805. 2013
    ..We anticipate that the specific interaction between VQDs and VCAM-1 and the blue-shift of the QD fluorescence peak can be very useful for VCAM-1 detection in vivo. ..
  12. doi request reprint Omega-3 fatty acid supplementation improves vascular function and reduces inflammation in obese adolescents
    Frida Dangardt
    Department of Clinical Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Atherosclerosis 212:580-5. 2010
    ..We wanted to assess whether n-3 supplementation increases the serum n-3 PUFA concentration, improves vascular function and morphology, and lowers inflammation in obese adolescents...
  13. doi request reprint TOF-SIMS analysis of lipid accumulation in the skeletal muscle of ob/ob mice
    Ylva K Magnusson
    Department of Molecular and Clinical Medicine Clinical Physiology, The Sahlgrenska Academy and University Hospital, University of Gothenburg, Gothenburg, Sweden
    Obesity (Silver Spring) 16:2745-53. 2008
    ..Imaging TOF-SIMS together with PCA of TOF-SIMS spectra is a promising tool for studying skeletal muscle lipid accumulation associated with obesity...
  14. ncbi request reprint Quantitative gene expression analysis by cDNA microarray during liver regeneration after partial hepatectomy in rats
    Hong Shiee Lai
    Departments of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, No 7 Chung Shan South Road, Taipei, Taiwan
    Surg Today 35:396-403. 2005
    ..It is speculated that genetic regulation plays an important role during liver regeneration. We conducted this study to analyze quantitative gene expression during liver regeneration after partial hepatectomy...
  15. doi request reprint Expression, purification, and characterization of recombinant human serum albumin fusion protein with two human glucagon-like peptide-1 mutants in Pichia pastoris
    Wen Fang Dou
    The Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, PR China
    Protein Expr Purif 61:45-9. 2008
    ..The result showed that the terminal biological half-time of the protein was about 54.2 h which is 650-fold longer than that of GLP-1. The pharmacokinetic analysis of the protein suggests its promising application in clinical medicine...
  16. doi request reprint Description of Sinobacter flavus gen. nov., sp. nov., and proposal of Sinobacteraceae fam. nov
    Yu Zhou
    Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing, Jiangsu 210095, PR China
    Int J Syst Evol Microbiol 58:184-9. 2008
    ..nov., sp. nov. is proposed. The type strain is CW-KD 4(T) (=DSM 18980(T)=KCTC 12881(T)=CCTCC AB 206145(T)). In addition, a new family, Sinobacteraceae fam. nov., is proposed to house the genus Sinobacter gen. nov...
  17. pmc Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5
    Yun Chen
    Division of Surgical Oncology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, The Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA
    Blood 111:1217-26. 2008
    ..From these data, we conclude that miR-130a is a regulator of the angiogenic phenotype of vascular ECs largely through its ability to modulate the expression of GAX and HOXA5...
  18. ncbi request reprint Celecoxib increased expression of 14-3-3sigma and induced apoptosis of glioma cells
    Jin Cherng Chen
    Department of Surgery, Buddhist Tzu Chi Dalin General Hospital, 2, Ming Shen Road, Dalin, Chia Yi, ROC
    Anticancer Res 27:2547-54. 2007
    ..Celecoxib, a cyclooxygenase-2 inhibitor, has been found to inhibit the proliferation of several kinds of cancer cells; however, the effects of celecoxib on glioma cells are not clear...
  19. ncbi request reprint Development and validation of liquid chromatography-tandem mass spectrometric method for simultaneous determination of fosinopril and its active metabolite fosinoprilat in human plasma
    Shuangjin Cui
    Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China
    J Chromatogr B Analyt Technol Biomed Life Sci 854:143-51. 2007
    ..The validated method was successfully applied to reveal the pharmacokinetic properties of fosinopril and fosinoprilat after oral administration...
  20. ncbi request reprint Rapid quantification of lisinopril in human plasma by liquid chromatography/tandem mass spectrometry
    Weiwei Qin
    Key Laboratory of Drug Quality Control and Pharmacovigilance China Pharmaceutical University, Ministry of Education, Nanjing 210009, People s Republic of China
    Biomed Chromatogr 21:415-21. 2007
    ..The validated LC-MS/MS method has been successfully applied to a preliminary pharmacokinetic study of lisinopril in Chinese healthy male volunteers...
  21. ncbi request reprint [Progress of gene therapy for erectile dysfunction]
    Yun Chen
    Department of Urology, Drum Tower Hospital Affiliated to Nanjing University Medical College, Nanjing, Jiangsu 210008, China
    Zhonghua Nan Ke Xue 12:1016-20. 2006
    ..This review aims to examine the experimental efforts in recent years and tries to give a brief introduction to the new approaches in the field of ED researches...
  22. ncbi request reprint [Expression of TTF-1 in thyroid tumors originating from follicular epithelium and its correlation with expression of RET, galectin-3 and mucin-1 genes]
    Yun Chen
    Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Zhonghua Yi Xue Za Zhi 82:257-61. 2002
    ....
  23. pmc Analysis of the PC12 cell transcriptome after differentiation with pituitary adenylate cyclase-activating polypeptide (PACAP)
    David Vaudry
    Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, NIH, Bethesda, Maryland, USA
    J Neurochem 83:1272-84. 2002
    ..Thirteen of these are candidates for mediating ERK-dependent neurite outgrowth, and 47 are possibly involved in the ERK-independent growth arrest induced by PACAP...
  24. ncbi request reprint Effects of octreotide on epidermal growth factor receptor, tissue plasminogen activator, and plasminogen activator inhibitor during intraperitoneal adhesion formation
    Hong Shiee Lai
    Department of Surgery, National Taiwan University Hospital, Taipei
    J Gastroenterol 38:555-60. 2003
    ..The aim of the present study was to investigate whether epidermal growth factor receptor (EGF-R), tissue plasminogen activator (tPA), and plasminogen activator inhibitor (PAI) are involved in this process...
  25. ncbi request reprint Activation of c-Jun N-terminal kinase 1 and caspase 3 in the tamoxifen-induced apoptosis of rat glioma cells
    Sheng Hong Tseng
    Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, 7 Chung Shan S Road, Taipei, Taiwan
    J Cancer Res Clin Oncol 130:285-93. 2004
    ..The mechanisms of the antitumor effects of tamoxifen upon gliomas are still unclear. In this study, we investigated the role of c-Jun N-terminal kinase-1 (JNK1) and caspase 3 in the tamoxifen-induced apoptosis of rat glioma cells...
  26. ncbi request reprint Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats
    Sheng Hong Tseng
    Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Clin Cancer Res 10:2190-202. 2004
    ..We wanted to investigate the antitumor effects and effect on angiogenesis of resveratrol in rat RT-2 gliomas...
  27. ncbi request reprint [Effect of Baisuifang Granule on cognitive malfunction after cerebral infarction]
    Lan Zheng
    Department of Traditional Chinese Medicine, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    Zhong Xi Yi Jie He Xue Bao 2:258-61. 2004
    ..To explore the mechanism of Baisuifang Granule in treating cognitive malfunction after cerebral infarction...
  28. ncbi request reprint Induction of apoptosis and cell cycle arrest in glioma cells by GL331 (a topoisomerase II inhibitor)
    Yun Chen
    Department of Surgery, Far Eastern Memorial Hospital, 21, Sec 2, Nan Ya South Road, Pan Chiao, Taipei 220, Taiwan
    Anticancer Res 25:4203-8. 2005
    ..GL331 is a topoisomerase II inhibitor and, in this study, the effects of GL331 upon rat C6 glioma cells were investigated...
  29. ncbi request reprint Overexpression of the regulator of G-protein signalling protein enhances ABA-mediated inhibition of root elongation and drought tolerance in Arabidopsis
    Yun Chen
    College of Bioscience and Biotechnology, Key Laboratory of Crop Genetics and Physiology of Jiangsu Province, Yangzhou University, People s Republic of China
    J Exp Bot 57:2101-10. 2006
    ....
  30. ncbi request reprint GL331, a topoisomerase II inhibitor, induces radiosensitization of human glioma cells
    Yun Chen
    Department of Surgery, Far Eastern Memorial Hospital, 21, Sec 2, Nan Ya South Road, Pan Chiao, Taipei 220, Taiwan, ROC
    Anticancer Res 26:2149-56. 2006
    ..GL331 is a topoisomerase II inhibitor and its effects on cultured human T98G glioma cells were investigated in this study. The effects of combined GL331 and radiation treatment on human T98G glioma cells were also examined...
  31. ncbi request reprint Differential expression of neurotrophins in penises of streptozotocin-induced diabetic rats
    Yun Chen
    Department of Urology, Affiliated Drum Tower Hospital, Nanjing University, School of Medicine, Nanjing 210008, China
    J Androl 28:306-12. 2007
    ..The lesion of the retrograde axonal transport of the nerves caused by hyperglycemia may be related to this phenomenon...
  32. ncbi request reprint The effect on MHC class II expression and apoptosis in placenta by IFNgamma administration
    Zhe Liu
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy Sciences, Beijing 100080, People s Republic of China
    Contraception 65:177-84. 2002
    ..The results suggested that IFNgamma exerted its deleterious effect on pregnancy by inducing apoptosis in trophoblasts and by reducing the production of progesterone...