N Wierup

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas
    N Wierup
    Department of Physiological Sciences, Section of Neuroendocrine Cell Biology, Lund University, BMC F10, 22 184, Lund, Sweden
    Regul Pept 107:63-9. 2002
  2. ncbi Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet
    M Sörhede Winzell
    Department of Clinical Sciences, Lund, Division of Medicine, BMC, B11, Lund University, 221 84, Lund, Sweden
    Diabetologia 50:1453-62. 2007
  3. ncbi Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cells
    N Wierup
    Department of Physiological Science, Lund University, Lund, Sweden
    J Histochem Cytochem 52:301-10. 2004
  4. ncbi Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet
    M Fex
    Department of Experimental Medical Science, Division of Diabetes, Metabolism, and Endocrinology, Lund University, Lund, Sweden
    Diabetologia 50:74-83. 2007
  5. ncbi CART knock out mice have impaired insulin secretion and glucose intolerance, altered beta cell morphology and increased body weight
    N Wierup
    Department of Physiological Sciences, Lund University, Section for Neuroendocrine Cell Biology, BMC F10, 22 184, Lund, Sweden
    Regul Pept 129:203-11. 2005
  6. ncbi Cocaine- and amphetamine-regulated transcript (CART) is expressed in several islet cell types during rat development
    N Wierup
    Department of Physiological Sciences, Section of Neuroendocrine Cell Biology, Lund University, Lund, Sweden
    J Histochem Cytochem 52:169-77. 2004
  7. doi A low glycaemic diet improves oral glucose tolerance but has no effect on β-cell function in C57BL/6J mice
    U Andersson
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Diabetes Obes Metab 12:976-82. 2010
  8. ncbi Cocaine- and amphetamine-regulated transcript: distribution and function in rat gastrointestinal tract
    E Ekblad
    Department of Physiological Sciences, BMC F10, Lund University, Lund, Sweden
    Neurogastroenterol Motil 15:545-57. 2003
  9. ncbi CART-peptide immunoreactivity in enteric nerves in patients with Hirschsprung's disease
    A Gunnarsdottir
    Department of Pediatric Surgery, Lund University Hospital, Lund, Sweden
    Eur J Pediatr Surg 17:184-9. 2007
  10. ncbi Circulating levels of ghrelin in human fetuses
    N Wierup
    Eur J Endocrinol 150:405. 2004

Collaborators

Detail Information

Publications11

  1. ncbi The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas
    N Wierup
    Department of Physiological Sciences, Section of Neuroendocrine Cell Biology, Lund University, BMC F10, 22 184, Lund, Sweden
    Regul Pept 107:63-9. 2002
    ..Specimens from fetal to adult human pancreas and stomach were studied by immunocytochemistry, for ghrelin and islet hormones, and in situ hybridisation, for ghrelin mRNA...
  2. ncbi Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet
    M Sörhede Winzell
    Department of Clinical Sciences, Lund, Division of Medicine, BMC, B11, Lund University, 221 84, Lund, Sweden
    Diabetologia 50:1453-62. 2007
    ..Here, we investigated whether chronic treatment with a glucagon receptor antagonist (GRA) improves islet dysfunction in female mice on a high-fat diet (HFD)...
  3. ncbi Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cells
    N Wierup
    Department of Physiological Science, Lund University, Lund, Sweden
    J Histochem Cytochem 52:301-10. 2004
    ..We conclude that ghrelin is expressed in a novel developmentally regulated endocrine islet cell type in the rat pancreas and that ghrelin inhibits glucose-stimulated insulin secretion via a direct effect on the beta-cell...
  4. ncbi Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet
    M Fex
    Department of Experimental Medical Science, Division of Diabetes, Metabolism, and Endocrinology, Lund University, Lund, Sweden
    Diabetologia 50:74-83. 2007
    ..When this fails, type 2 diabetes ensues. Because mitochondria play a key role in beta cell pathophysiology, we tested the hypothesis that mitochondrial metabolism is critical for beta cell adaptation to insulin resistance...
  5. ncbi CART knock out mice have impaired insulin secretion and glucose intolerance, altered beta cell morphology and increased body weight
    N Wierup
    Department of Physiological Sciences, Lund University, Section for Neuroendocrine Cell Biology, BMC F10, 22 184, Lund, Sweden
    Regul Pept 129:203-11. 2005
    ..In addition, CART KO mice displayed increased body weight at the age of 40 weeks, without any difference in food intake. We conclude that CART is required for maintaining normal islet function in mice...
  6. ncbi Cocaine- and amphetamine-regulated transcript (CART) is expressed in several islet cell types during rat development
    N Wierup
    Department of Physiological Sciences, Section of Neuroendocrine Cell Biology, Lund University, Lund, Sweden
    J Histochem Cytochem 52:169-77. 2004
    ..We have demonstrated that CART is expressed in several islet cell types during rat development but is restricted to somatostatin cells and neurons in the adult rat...
  7. doi A low glycaemic diet improves oral glucose tolerance but has no effect on β-cell function in C57BL/6J mice
    U Andersson
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Diabetes Obes Metab 12:976-82. 2010
    ..Clinical studies have suggested a role for dietary glycaemic index (GI) in body weight regulation and diabetes risk. Here, we investigated the long-term metabolic effects of low and high glycaemic diets using the C57BL/6J mouse model...
  8. ncbi Cocaine- and amphetamine-regulated transcript: distribution and function in rat gastrointestinal tract
    E Ekblad
    Department of Physiological Sciences, BMC F10, Lund University, Lund, Sweden
    Neurogastroenterol Motil 15:545-57. 2003
    ..It may, moreover, be involved in intestinal adaptation, and an additional hormonal role is also possible...
  9. ncbi CART-peptide immunoreactivity in enteric nerves in patients with Hirschsprung's disease
    A Gunnarsdottir
    Department of Pediatric Surgery, Lund University Hospital, Lund, Sweden
    Eur J Pediatr Surg 17:184-9. 2007
    ....
  10. ncbi Circulating levels of ghrelin in human fetuses
    N Wierup
    Eur J Endocrinol 150:405. 2004
  11. pmc Human islet amyloid polypeptide transgenic mice: in vivo and ex vivo models for the role of hIAPP in type 2 diabetes mellitus
    J W M Höppener
    Division of Biomedical Genetics, Department of Metabolic and Endocrine Diseases, University Medical Center Utrecht, P O Box 85090, 3508 AB Utrecht, The Netherlands
    Exp Diabetes Res 2008:697035. 2008
    ..5% to 70%. This ex vivo system will allow a more rapid, convenient, and specific study of factors influencing islet amyloidosis as well as of therapeutic strategies to interfere with this pathological process...