Michael Ljungberg

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. doi request reprint MIRD Pamphlet No. 26: Joint EANM/MIRD Guidelines for Quantitative 177Lu SPECT Applied for Dosimetry of Radiopharmaceutical Therapy
    Michael Ljungberg
    Department of Medical Radiation Physics, Lund University, Lund, Sweden
    J Nucl Med 57:151-62. 2016
  2. doi request reprint The accuracy of absorbed dose estimates in tumours determined by quantitative SPECT: a Monte Carlo study
    Michael Ljungberg
    Department of Medical Radiation Physics, Clinical Sciences, Lund, Lund University, Lund, Sweden
    Acta Oncol 50:981-9. 2011
  3. doi request reprint 90Y Bremsstrahlung imaging for absorbed-dose assessment in high-dose radioimmunotherapy
    David Minarik
    Department of Medical Radiation Physics, Clinical Sciences, Lund University, Lund, Sweden
    J Nucl Med 51:1974-8. 2010
  4. doi request reprint Use of Monte Carlo simulations with a realistic rat phantom for examining the correlation between hematopoietic system response and red marrow absorbed dose in Brown Norway rats undergoing radionuclide therapy with (177)Lu- and (90)Y-BR96 mAbs
    Erik Larsson
    Department of Medical Radiation Physics, Clinical Sciences, Lund University, Lund, Sweden
    Med Phys 39:4434-43. 2012
  5. ncbi request reprint Evaluation of accuracy in activity calculations for the conjugate view method from Monte Carlo simulated scintillation camera images using experimental data in an anthropomorphic phantom
    Lena Jonsson
    Department of Medical Radiation Physics, Clinical Sciences Lund, Lund University, Lund, Sweden
    J Nucl Med 46:1679-86. 2005
  6. ncbi request reprint The LundADose method for planar image activity quantification and absorbed-dose assessment in radionuclide therapy
    Katarina Sjögreen
    Department of Medical Radiation Physics, Lund University, Lund, Sweden
    Cancer Biother Radiopharm 20:92-7. 2005
  7. doi request reprint Monte Carlo calculations of absorbed doses in tumours using a modified MOBY mouse phantom for pre-clinical dosimetry studies
    Erik Larsson
    Department of Medical Radiation Physics, Clinical Sciences Lund, Lund University, Sweden
    Acta Oncol 50:973-80. 2011
  8. ncbi request reprint Interdependence between measures of extent and severity of myocardial perfusion defects provided by automatic quantification programs
    Henrik Hussein El-Ali
    Department of Medical Radiation Physics, Clinical Sciences Lund, Lund University, Lund, Sweden
    Nucl Med Commun 26:1125-30. 2005
  9. ncbi request reprint Mouse S-factors based on Monte Carlo simulations in the anatomical realistic Moby phantom for internal dosimetry
    Erik Larsson
    Medical Radiation Physics, Department of Clinical Sciences, Lund, Lund University, Lund, Sweden
    Cancer Biother Radiopharm 22:438-42. 2007
  10. doi request reprint 177Lu-[DOTA0,Tyr3] octreotate therapy in patients with disseminated neuroendocrine tumors: Analysis of dosimetry with impact on future therapeutic strategy
    Michael Garkavij
    Department of Oncology, Lund University and Lund University Hospital, Lund, Sweden
    Cancer 116:1084-92. 2010

Detail Information

Publications29

  1. doi request reprint MIRD Pamphlet No. 26: Joint EANM/MIRD Guidelines for Quantitative 177Lu SPECT Applied for Dosimetry of Radiopharmaceutical Therapy
    Michael Ljungberg
    Department of Medical Radiation Physics, Lund University, Lund, Sweden
    J Nucl Med 57:151-62. 2016
    ..This paper focuses on (177)Lu (lutetium) and its application in radiopharmaceutical therapy. ..
  2. doi request reprint The accuracy of absorbed dose estimates in tumours determined by quantitative SPECT: a Monte Carlo study
    Michael Ljungberg
    Department of Medical Radiation Physics, Clinical Sciences, Lund, Lund University, Lund, Sweden
    Acta Oncol 50:981-9. 2011
    ..A question arises which dosimetry method is optimal given the limitations in reconstruction- and quantification procedures...
  3. doi request reprint 90Y Bremsstrahlung imaging for absorbed-dose assessment in high-dose radioimmunotherapy
    David Minarik
    Department of Medical Radiation Physics, Clinical Sciences, Lund University, Lund, Sweden
    J Nucl Med 51:1974-8. 2010
    ..This feasibility study demonstrates (90)Y quantitative bremsstrahlung imaging of patients undergoing high-dose myeloablative (90)Y-ibritumomab treatment...
  4. doi request reprint Use of Monte Carlo simulations with a realistic rat phantom for examining the correlation between hematopoietic system response and red marrow absorbed dose in Brown Norway rats undergoing radionuclide therapy with (177)Lu- and (90)Y-BR96 mAbs
    Erik Larsson
    Department of Medical Radiation Physics, Clinical Sciences, Lund University, Lund, Sweden
    Med Phys 39:4434-43. 2012
    ..The aim of this study was to develop an anatomically realistic dosimetry model for Brown Norway rats to calculate S factors for use in evaluating correlations between absorbed dose and biological effects in a preclinical therapy study...
  5. ncbi request reprint Evaluation of accuracy in activity calculations for the conjugate view method from Monte Carlo simulated scintillation camera images using experimental data in an anthropomorphic phantom
    Lena Jonsson
    Department of Medical Radiation Physics, Clinical Sciences Lund, Lund University, Lund, Sweden
    J Nucl Med 46:1679-86. 2005
    ..The aim of this study was to simulate patient scintillation camera images and from these evaluate the accuracy of 2 correction methods. The contribution from overlapping tissue activity was also calculated for some organs...
  6. ncbi request reprint The LundADose method for planar image activity quantification and absorbed-dose assessment in radionuclide therapy
    Katarina Sjögreen
    Department of Medical Radiation Physics, Lund University, Lund, Sweden
    Cancer Biother Radiopharm 20:92-7. 2005
    ..Evaluation of the whole-body activity quantification is performed for patients undergoing radioimmunotherapy by monoclonal antibodies labeled with (111)In or (90)Y...
  7. doi request reprint Monte Carlo calculations of absorbed doses in tumours using a modified MOBY mouse phantom for pre-clinical dosimetry studies
    Erik Larsson
    Department of Medical Radiation Physics, Clinical Sciences Lund, Lund University, Sweden
    Acta Oncol 50:973-80. 2011
    ..The aims of this study were to calculate S values of the mouse, and determine the absorbed dose contribution to and from subcutaneous tumours inoculated at four different locations...
  8. ncbi request reprint Interdependence between measures of extent and severity of myocardial perfusion defects provided by automatic quantification programs
    Henrik Hussein El-Ali
    Department of Medical Radiation Physics, Clinical Sciences Lund, Lund University, Lund, Sweden
    Nucl Med Commun 26:1125-30. 2005
    ....
  9. ncbi request reprint Mouse S-factors based on Monte Carlo simulations in the anatomical realistic Moby phantom for internal dosimetry
    Erik Larsson
    Medical Radiation Physics, Department of Clinical Sciences, Lund, Lund University, Lund, Sweden
    Cancer Biother Radiopharm 22:438-42. 2007
    ..The difference in results from the two Monte Carlo codes, EGS4 and MCNPX 2.6a, was also evaluated...
  10. doi request reprint 177Lu-[DOTA0,Tyr3] octreotate therapy in patients with disseminated neuroendocrine tumors: Analysis of dosimetry with impact on future therapeutic strategy
    Michael Garkavij
    Department of Oncology, Lund University and Lund University Hospital, Lund, Sweden
    Cancer 116:1084-92. 2010
    ..In commonly used dosimetry methods, planar imaging is used for determination of the residence time, whereas the kidney mass is determined from a computed tomography (CT) scan...
  11. ncbi request reprint A model that accounts for the interdependence of extent and severity in the automatic evaluation of myocardial defects
    Henrik Hussein El-Ali
    Department of Medical Radiation Physics, Clinical Sciences, Lund University, Sweden
    Nucl Med Commun 27:127-35. 2006
    ..This interdependence has been investigated in two commercially available analysis programs (AutoQUANT and 4D-MSPECT) using Monte Carlo-simulated SPECT data...
  12. doi request reprint Patient-specific whole-body attenuation correction maps from a CT system for conjugate-view-based activity quantification: method development and evaluation
    Katarina Sjögreen Gleisner
    Department of Medical Radiation Physics, Lund University, Lund, Sweden
    Cancer Biother Radiopharm 27:652-64. 2012
    ....
  13. ncbi request reprint A novel platform for radioimmunotherapy: extracorporeal depletion of biotinylated and 90Y-labeled rituximab in patients with refractory B-cell lymphoma
    Ola Linden
    Department of Oncology, Lund University Hospital, Lund, Sweden
    Cancer Biother Radiopharm 20:457-66. 2005
    ..No effects on patients' vital signs and no adverse effects on hematological or coagulation parameters was observed during the ECAT procedure. A dose-escalation study is initiated...
  14. ncbi request reprint Dosimetry calculations on a tissue level by using the MCNP4c2 Monte Carlo code
    Erik Larsson
    Department of Medical Radiation Physics, Lund University, Lund, Sweden
    Cancer Biother Radiopharm 20:85-91. 2005
    ..The aim of this study was to develop a MCNP4c2-code and to further refine the small-scale anatomy intestinal dosimetry model based on a EGS4-code developed by Jonsson et al.(1,2)..
  15. ncbi request reprint An activity quantification method based on registration of CT and whole-body scintillation camera images, with application to 131I
    Katarina Sjögreen
    Department of Radiation Physics, Jubileum Institute, University Hospital, Lund University, Sweden
    J Nucl Med 43:972-82. 2002
    ..This article presents a new method for conjugate view activity quantification for 131I-labeled monoclonal antibody distribution...
  16. ncbi request reprint 3D absorbed dose calculations based on SPECT: evaluation for 111-In/90-Y therapy using Monte Carlo simulations
    Michael Ljungberg
    Department of Radiation Physics, Lund University, Sweden
    Cancer Biother Radiopharm 18:99-107. 2003
    ..The proposed evaluation methodology may be used as a basis for future inter-comparison of different dosimetry calculation schemes...
  17. ncbi request reprint Crypt cell dosimetry for 99Tcm-sestamibi in a new small intestinal dosimetry model
    Lena Jonsson
    Department of Radiation Physics, The Jubileum Institute, Lund University, Lund University Hospital, Sweden
    Cancer Biother Radiopharm 18:217-23. 2003
    ....
  18. doi request reprint Uncertainty propagation for SPECT/CT-based renal dosimetry in (177)Lu peptide receptor radionuclide therapy
    Johan Gustafsson
    Department of Medical Radiation Physics, Clinical Sciences Lund, Lund University, S 221 85 Lund, Sweden
    Phys Med Biol 60:8329-46. 2015
    ..The most important sources of variability are the compensation for partial volume effects via a recovery coefficient and the gamma-camera calibration via the system sensitivity. ..
  19. doi request reprint Dynamic (99m)Tc-MAG3 renography: images for quality control obtained by combining pharmacokinetic modelling, an anthropomorphic computer phantom and Monte Carlo simulated scintillation camera imaging
    Gustav Brolin
    Department of Medical Radiation Physics, Lund University, Sweden
    Phys Med Biol 58:3145-61. 2013
    ..The obtained image data can be used to evaluate quantitative techniques and computer software in clinical renography...
  20. ncbi request reprint Absorbed dose distribution in glioma tumors in rat brain after therapeutic intratumoral injection of 201Tl-chloride
    Kaj Ljunggren
    Department of Medical Radiation Physics, Lund University, Sweden
    Cancer Biother Radiopharm 19:562-9. 2004
    ..The calculated total absorbed dose of 2-8 Gy in the tumor seems to be relativity low when considering the therapeutic effect that was seen. Further investigations, to determine the cause of the high therapeutic efficacy, are needed...
  21. pmc A 3-dimensional absorbed dose calculation method based on quantitative SPECT for radionuclide therapy: evaluation for (131)I using monte carlo simulation
    Michael Ljungberg
    Department of Radiation Physics, Jubileum Institute, Lund University, Sweden
    J Nucl Med 43:1101-9. 2002
    ..A general method is presented for patient-specific 3-dimensional absorbed dose calculations based on quantitative SPECT activity measurements...
  22. doi request reprint The accuracy of quantitative parameters in (99m) Tc-MAG3 dynamic renography: a national audit based on virtual image data
    Gustav Brolin
    Department of Medical Radiation Physics, Clinical Sciences Lund, Lund University, Lund, Sweden
    Clin Physiol Funct Imaging 36:146-54. 2016
    ....
  23. doi request reprint Pharmacokinetic digital phantoms for accuracy assessment of image-based dosimetry in (177)Lu-DOTATATE peptide receptor radionuclide therapy
    Gustav Brolin
    Department of Medical Radiation Physics, Clinical Sciences Lund, Lund University, Sweden
    Phys Med Biol 60:6131-49. 2015
    ..The phantoms are expected to be useful for further studies and optimisation of clinical dosimetry in (177)Lu PRRT. ..
  24. ncbi request reprint Comparison of 1- and 2-day protocols for myocardial SPECT: a Monte Carlo study
    H H El-Ali
    Department of Medical Radiation Physics, Clinical Sciences, Lund University, Lund, Sweden
    Clin Physiol Funct Imaging 25:189-95. 2005
    ..A problem when performing the two studies on 1 day is that the residual activity from the first study contributes to the activity measured in the second study...
  25. ncbi request reprint A new method to obtain transmission images for planar whole-body activity quantification
    David Minarik
    Department of Medical Radiation Physics, Clinical Sciences, Lund University, Lund, Sweden
    Cancer Biother Radiopharm 20:72-6. 2005
    ..We present a new method to measure whole-body transmission images using the X-ray unit on a single photon emission computed tomography/computed tomography (SPECT/CT) scintillation system...
  26. ncbi request reprint A dosimetry model for the small intestine incorporating intestinal wall activity and cross-doses
    Lena Jonsson
    Department of Radiation Physics, The Jubileum Institute, Lund University, Lund University Hospital, Lund, Sweden
    J Nucl Med 43:1657-64. 2002
    ..The aim of this investigation was to develop a general model for calculating the absorbed dose to the radiation-sensitive cells in the small intestinal mucosa from radionuclides located in the small intestinal wall or contents...
  27. doi request reprint Using Rose's metal alloy as a pinhole collimator material in preclinical small-animal imaging: a Monte Carlo evaluation
    Mikael Peterson
    Department of Medical Radiation Physics, Clinical Science, Lund University, Lund 221 85, Sweden
    Med Phys 42:1698-709. 2015
    ..Once cast, the piece can be machined with high precision. The aim of this study was to evaluate the imaging properties for Rose's metal and compare them with those of standard materials...
  28. doi request reprint Validation of an automated method to quantify stress-induced ischemia and infarction in rest-stress myocardial perfusion SPECT
    Helen Fransson
    Department of Clinical Physiology and Nuclear Medicine, Lund University, Lund University Hospital, 221 85, Lund, Sweden
    J Nucl Cardiol 21:503-18. 2014
    ..This article describes open access software for automated quantification in MPS of stress-induced ischemia and infarction and provides phantom and in vivo validation...
  29. ncbi request reprint Evaluation of parameters influencing S values in mouse dosimetry
    Cecilia Hindorf
    Department of Medical Radiation Physics, The Jubileum Institute, Lund University, SE 221 85 Lund, Sweden
    J Nucl Med 45:1960-5. 2004
    ..Reliable evaluation of therapeutic efficacy must be based on accurate dosimetry. This study was performed to evaluate the influence of the mass of organs, the shape of organs, and the distances between organs on S values for mice...