E L Lane

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi request reprint The impact of graft size on the development of dyskinesia following intrastriatal grafting of embryonic dopamine neurons in the rat
    E L Lane
    Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Neurobiol Dis 22:334-45. 2006
  2. doi request reprint Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease
    E L Lane
    Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sweden
    Neurobiol Dis 32:220-8. 2008
  3. doi request reprint Priming for L-DOPA-induced abnormal involuntary movements increases the severity of amphetamine-induced dyskinesia in grafted rats
    E L Lane
    Neuronal Survival Unit, Department of Experimental Medical Science, Lund, Sweden
    Exp Neurol 219:355-8. 2009
  4. ncbi request reprint Dopamine uptake inhibitor-induced rotation in 6-hydroxydopamine-lesioned rats involves both D1 and D2 receptors but is modulated through 5-hydroxytryptamine and noradrenaline receptors
    E L Lane
    GKT School of Biomedical Sciences, Hodgkin Building, Guy s Campus, London SE1 1UL, United Kingdom
    J Pharmacol Exp Ther 312:1124-31. 2005
  5. ncbi request reprint Repeated administration of the monoamine reuptake inhibitor BTS 74 398 induces ipsilateral circling in the 6-hydroxydopamine lesioned rat without sensitizing motor behaviours
    E L Lane
    Neurodegenerative Disease Research Centre, GKT School of Biomedical Sciences, King s College, London SE1 1UL, UK
    Eur J Neurosci 21:179-86. 2005
  6. ncbi request reprint Does contraversive circling in the 6-OHDA-lesioned rat indicate an ability to induce motor complications as well as therapeutic effects in Parkinson's disease?
    E L Lane
    Neurodegenerative Disease Research Centre, GKT School of Biomedical Sciences, King s College, London, UK
    Exp Neurol 197:284-90. 2006
  7. doi request reprint Striatal output markers do not alter in response to circling behaviour in 6-OHDA lesioned rats produced by acute or chronic administration of the monoamine uptake inhibitor BTS 74 398
    E L Lane
    Neurodegenerative Disease Research Centre, School of Health and Biomedical Sciences, King s College, London, UK
    J Neural Transm 115:423-9. 2008

Collaborators

Detail Information

Publications7

  1. ncbi request reprint The impact of graft size on the development of dyskinesia following intrastriatal grafting of embryonic dopamine neurons in the rat
    E L Lane
    Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Neurobiol Dis 22:334-45. 2006
    ..In conclusion, robust and reproducible AIMs were evoked in rats with large grafts by blockade of monoamine reuptake. These AIMs may provide a new tool for assessing dyskinetic effects of neural grafting...
  2. doi request reprint Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease
    E L Lane
    Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sweden
    Neurobiol Dis 32:220-8. 2008
    ..These results indicate that an inflammatory response in and around grafted dopaminergic neurons is not sufficient to evoke dyskinetic behaviors in experimental models of PD...
  3. doi request reprint Priming for L-DOPA-induced abnormal involuntary movements increases the severity of amphetamine-induced dyskinesia in grafted rats
    E L Lane
    Neuronal Survival Unit, Department of Experimental Medical Science, Lund, Sweden
    Exp Neurol 219:355-8. 2009
    ....
  4. ncbi request reprint Dopamine uptake inhibitor-induced rotation in 6-hydroxydopamine-lesioned rats involves both D1 and D2 receptors but is modulated through 5-hydroxytryptamine and noradrenaline receptors
    E L Lane
    GKT School of Biomedical Sciences, Hodgkin Building, Guy s Campus, London SE1 1UL, United Kingdom
    J Pharmacol Exp Ther 312:1124-31. 2005
    ..However, the mechanism of this interaction is complex, involving opposing effects of noradrenaline and 5-HT agonism and antagonism...
  5. ncbi request reprint Repeated administration of the monoamine reuptake inhibitor BTS 74 398 induces ipsilateral circling in the 6-hydroxydopamine lesioned rat without sensitizing motor behaviours
    E L Lane
    Neurodegenerative Disease Research Centre, GKT School of Biomedical Sciences, King s College, London SE1 1UL, UK
    Eur J Neurosci 21:179-86. 2005
    ..The lack of such changes following repeated BTS 74 398 treatment suggests that it may be an effective antiparkinsonian therapy that is unlikely to produce involuntary movements...
  6. ncbi request reprint Does contraversive circling in the 6-OHDA-lesioned rat indicate an ability to induce motor complications as well as therapeutic effects in Parkinson's disease?
    E L Lane
    Neurodegenerative Disease Research Centre, GKT School of Biomedical Sciences, King s College, London, UK
    Exp Neurol 197:284-90. 2006
    ....
  7. doi request reprint Striatal output markers do not alter in response to circling behaviour in 6-OHDA lesioned rats produced by acute or chronic administration of the monoamine uptake inhibitor BTS 74 398
    E L Lane
    Neurodegenerative Disease Research Centre, School of Health and Biomedical Sciences, King s College, London, UK
    J Neural Transm 115:423-9. 2008
    ..An action in another area of the brain appears likely and may explain the subsequent failure of BTS 74 398 and related compounds to exert anti-parkinsonian actions in man...