Genomes and Genes
Affiliation: Lund University
- TNK2 preserves epidermal growth factor receptor expression on the cell surface and enhances migration and invasion of human breast cancer cellsJillian Howlin
Cell and Experimental Pathology, Lund University, Department of Laboratory Medicine, Clinical Research Centre, Ent 72, Bldg 91, fl 11, Malmo University Hospital, S 205 02 Malmo, Sweden
Breast Cancer Res 10:R36. 2008....
- A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasionVeronika Jenei
Department of Laboratory Medicine, Lund University, Clinical Research Centre, Malmo University Hospital, SE 20502 Malmo, Sweden
Proc Natl Acad Sci U S A 106:19473-8. 2009..The Box5 peptide directly inhibits Wnt5a signaling, representing an approach to anti-metastatic therapy for otherwise rapidly progressive melanoma, and for other Wnt5a-stimulated invasive cancers...
- Genome-Wide DNA Methylation Analysis in Melanoma Reveals the Importance of CpG Methylation in MITF RegulationMartin Lauss
1 Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Lund, Sweden 2 CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden
J Invest Dermatol 135:1820-8. 2015..The discovery that the activity of the master regulator of pigmentation, MITF, and its downstream targets may be regulated by hypermethylation has significant implications for understanding the development and evolvement of melanoma. ..
- Wnt-5a-induced phosphorylation of DARPP-32 inhibits breast cancer cell migration in a CREB-dependent mannerChristian Hansen
Experimental Pathology, Department of Laboratory Medicine, Lund University, CRC, 205 02 Malmo, Sweden
J Biol Chem 284:27533-43. 2009....
- Loss of CITED1, an MITF regulator, drives a phenotype switch in vitro and can predict clinical outcome in primary melanoma tumoursJillian Howlin
Division of Oncology Pathology, Lund University Cancer Center Medicon Village, Scheelev gen, Lund, Sweden Cell and Experimental Pathology, Department of Laboratory Medicine Malm, Lund University, Sweden
Peerj 3:e788. 2015..We hypothesize that CITED1 acts a regulator of MITF, functioning to maintain MITF levels in a range compatible with tumourigenesis...
- Molecular and genetic diversity in the metastatic process of melanomaKatja Harbst
Department of Oncology, Clinical Sciences, Lund University, Sweden CREATE Health Strategic Centre for Clinical Cancer Research, Lund University, Sweden
J Pathol 233:39-50. 2014....
- Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypesKarolina Holm
Department of Oncology, Clinical Sciences, Lund University, Skane University Hospital, SE 221 85 Lund, Sweden
Mol Oncol 6:494-506. 2012..Our observation that increased expression of EZH2 does not necessarily correlate with increased abundance of H3K27me3 supports the idea that EZH2 can have effects beyond epigenetic silencing of target genes in breast cancer...
- The WNT-5a derived peptide, Foxy-5, possesses dual properties that impair progression of ERalpha negative breast cancerCaroline E Ford
Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
Cell Cycle 8:1838-42. 2009....
- Amphiregulin: role in mammary gland development and breast cancerJean McBryan
School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
J Mammary Gland Biol Neoplasia 13:159-69. 2008..Here we summarise our current understanding of amphiregulin's contribution to mammary gland development and breast cancer progression...