Cecilia Hegardt

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi Changes in polyamine metabolism during glucocorticoid-induced programmed cell death in mouse thymus
    C Hegardt
    Department of Animal Physiology, Lund University, Lund, Sweden
    Cell Biol Int 24:871-80. 2000
  2. ncbi Different roles of spermine in glucocorticoid- and Fas-induced apoptosis
    C Hegardt
    Department of Animal Physiology, Lund University, Lund, SE 223 62, Sweden
    Exp Cell Res 266:333-41. 2001
  3. ncbi Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N(1),N(11)-diethylnorspermine
    Cecilia Hegardt
    Department of Animal Physiology, Lund University, Sweden
    Eur J Biochem 269:1033-9. 2002
  4. doi Numb protein expression correlates with a basal-like phenotype and cancer stem cell markers in primary breast cancer
    Karin Rennstam
    Department of Oncology, Clinical Sciences, Lund University, Barngatan 2B, 221 85, Lund, Sweden
    Breast Cancer Res Treat 122:315-24. 2010
  5. ncbi The retinoblastoma gene undergoes rearrangements in BRCA1-deficient basal-like breast cancer
    Goran Jonsson
    Department of Oncology, CREATE Health Strategic Center for Translational Cancer Research, Lund University, Skåne Department of Oncology, Skane University Hospital, Lund, Sweden
    Cancer Res 72:4028-36. 2012
  6. doi Characterisation of amplification patterns and target genes at chromosome 11q13 in CCND1-amplified sporadic and familial breast tumours
    Karolina Holm
    Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    Breast Cancer Res Treat 133:583-94. 2012
  7. pmc CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers
    Eleonor Olsson
    Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    BMC Cancer 11:418. 2011
  8. pmc Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns
    Karolina Holm
    Department of Oncology, Clinical Sciences, Lund University, Barngatan 2B, Lund, Sweden
    Breast Cancer Res 12:R36. 2010
  9. doi Effect of polyamine deficiency on proteins involved in Okazaki fragment maturation
    Veronica M Johansson
    Department of Cell and Organism Biology, Lund University, Helgonavagen 3B, SE 223 62 Lund, Sweden
    Cell Biol Int 32:1467-77. 2008
  10. doi Molecular mechanisms underlying N1, N11-diethylnorspermine-induced apoptosis in a human breast cancer cell line
    C Martina Holst
    Department of Cell and Organism Biology, Lund University, Lund, Sweden
    Anticancer Drugs 19:871-83. 2008

Collaborators

Detail Information

Publications24

  1. ncbi Changes in polyamine metabolism during glucocorticoid-induced programmed cell death in mouse thymus
    C Hegardt
    Department of Animal Physiology, Lund University, Lund, Sweden
    Cell Biol Int 24:871-80. 2000
    ..Presumably the complexity of this in vivo system masks changes in the spermidine and spermine pools that were expected in relation to the increased SSAT activity and decreased AdoMetDC activity...
  2. ncbi Different roles of spermine in glucocorticoid- and Fas-induced apoptosis
    C Hegardt
    Department of Animal Physiology, Lund University, Lund, SE 223 62, Sweden
    Exp Cell Res 266:333-41. 2001
    ..The fact that spermine inhibited caspase activation only in the thymocytes implies that spermine inhibited dexamethasone-induced apoptosis upstream of caspase-9 activation...
  3. ncbi Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N(1),N(11)-diethylnorspermine
    Cecilia Hegardt
    Department of Animal Physiology, Lund University, Sweden
    Eur J Biochem 269:1033-9. 2002
    ..The results are discussed in the light of the L56Br-C1 cells containing mutated BRCA1 and p53, two genes involved in DNA repair...
  4. doi Numb protein expression correlates with a basal-like phenotype and cancer stem cell markers in primary breast cancer
    Karin Rennstam
    Department of Oncology, Clinical Sciences, Lund University, Barngatan 2B, 221 85, Lund, Sweden
    Breast Cancer Res Treat 122:315-24. 2010
    ..01). Taken together, our results indicate that loss of Numb expression is a marker of tumor aggressiveness, potentially linked to BRCA1 status and a cancer stem cell phenotype in primary breast cancer...
  5. ncbi The retinoblastoma gene undergoes rearrangements in BRCA1-deficient basal-like breast cancer
    Goran Jonsson
    Department of Oncology, CREATE Health Strategic Center for Translational Cancer Research, Lund University, Skåne Department of Oncology, Skane University Hospital, Lund, Sweden
    Cancer Res 72:4028-36. 2012
    ..Together, our findings show the existence of genetic heterogeneity within the basal-like breast cancer subtype that is based upon BRCA1 status...
  6. doi Characterisation of amplification patterns and target genes at chromosome 11q13 in CCND1-amplified sporadic and familial breast tumours
    Karolina Holm
    Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    Breast Cancer Res Treat 133:583-94. 2012
    ..Amplification was equally prevalent in familial and sporadic tumours, but strikingly rare in BRCA1- and BRCA2-mutated tumours. We conclude that 11q13 includes many potential target genes in addition to CCND1...
  7. pmc CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers
    Eleonor Olsson
    Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    BMC Cancer 11:418. 2011
    ..We aimed to investigate potential associations between alternatively spliced isoforms of CD44 and CSCs as well as to various breast cancer biomarkers and molecular subtypes...
  8. pmc Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns
    Karolina Holm
    Department of Oncology, Clinical Sciences, Lund University, Barngatan 2B, Lund, Sweden
    Breast Cancer Res 12:R36. 2010
    ..Each subtype has a characteristic expression pattern suggested to partly depend on cellular origin. We aimed to investigate whether the molecular subtypes also display distinct methylation profiles...
  9. doi Effect of polyamine deficiency on proteins involved in Okazaki fragment maturation
    Veronica M Johansson
    Department of Cell and Organism Biology, Lund University, Helgonavagen 3B, SE 223 62 Lund, Sweden
    Cell Biol Int 32:1467-77. 2008
    ..DENSPM treatment affects the cellular distribution of FEN1 in L56Br-C1 cells, but not in MCF-7 cells, implying that FEN1 is affected by or involved in DENSPM-induced apoptosis...
  10. doi Molecular mechanisms underlying N1, N11-diethylnorspermine-induced apoptosis in a human breast cancer cell line
    C Martina Holst
    Department of Cell and Organism Biology, Lund University, Lund, Sweden
    Anticancer Drugs 19:871-83. 2008
    ..The results also indicate that it should be possible to find molecular markers for sensitivity to DENSPM that could be used in the clinic to predict sensitivity to a polyamine analogue...
  11. doi Identification of subtypes in human epidermal growth factor receptor 2--positive breast cancer reveals a gene signature prognostic of outcome
    Johan Staaf
    Department of Oncology, CREATE Health Strategic Center for TranslationalCancer Research, Lund University, Lund, Sweden
    J Clin Oncol 28:1813-20. 2010
    ....
  12. doi Different cell cycle kinetic effects of N1,N11-diethylnorspermine-induced polyamine depletion in four human breast cancer cell lines
    Louise Myhre
    Department of Cell and Organism Biology, Lund University, Lund, Sweden
    Anticancer Drugs 19:359-68. 2008
    ..The two cell lines that were most sensitive to DENSPM treatment belong to the basal-like subtype of breast cancer and they were deficient with respect to p53, BRCA1, and RB1...
  13. pmc The CD44+/CD24- phenotype is enriched in basal-like breast tumors
    Gabriella Honeth
    Department of Oncology, Clinical Sciences, Lund University, Barngatan 2B, SE 221 85 Lund, Sweden
    Breast Cancer Res 10:R53. 2008
    ..We have explored the prevalence of cells with different CD44/CD24 phenotypes within breast cancer subtypes...
  14. doi Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypes
    Karolina Holm
    Department of Oncology, Clinical Sciences, Lund University, Skane University Hospital, SE 221 85 Lund, Sweden
    Mol Oncol 6:494-506. 2012
    ..Our observation that increased expression of EZH2 does not necessarily correlate with increased abundance of H3K27me3 supports the idea that EZH2 can have effects beyond epigenetic silencing of target genes in breast cancer...
  15. doi Reduction of the putative CD44+CD24- breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047
    Helena Cirenajwis
    Department of Biology, Division of Cell and Organism, Lund University, Lund, Sweden
    Anticancer Drugs 21:897-906. 2010
    ..Our findings indicate that treatment with PG11047 targeted the CSC population by interfering with several stem cell-related properties, such as self-renewal, differentiation, motility and the mesenchymal phenotype...
  16. doi The antiproliferative effect of dietary fiber phenolic compounds ferulic acid and p-coumaric acid on the cell cycle of Caco-2 cells
    Birgit Janicke
    Food Technology, Lund Institute of Technology, Lund University, Lund, Sweden
    Nutr Cancer 63:611-22. 2011
    ..Taken together, the changes found can partly explain the effects of FA or p-CA treatment on cell cycle progression, specifically in the S phase by FA and G(2)/M phase by p-CA treatment...
  17. pmc Breast cancer stem cell selectivity of synthetic nanomolar-active salinomycin analogs
    Xiaoli Huang
    Department of Biology, Lund University, Lund, Sweden
    BMC Cancer 16:145. 2016
    ..Herein we specifically investigate the CSC selectivity of the most active member in each class of C20-O-acylated analogs as well as a C1-methyl ester analog incapable of charge-neutral metal ion transport...
  18. doi Semisynthesis of SY-1 for investigation of breast cancer stem cell selectivity of C-ring-modified salinomycin analogues
    Xiaoli Huang
    Department of Biology, Lund University, 221 00 Lund, Sweden
    ACS Chem Biol 9:1587-94. 2014
    ....
  19. ncbi Spermine prevents cytochrome c release in glucocorticoid-induced apoptosis in mouse thymocytes
    Cecilia Hegardt
    Department of Cell and Organism Biology, Lund University, Helgonavagen 3B, SE 223 62 Lund, Sweden
    Cell Biol Int 27:115-21. 2003
    ..Thus, the spermine-induced inhibition of cytochrome c release confers a survival advantage on thymocytes...
  20. doi Structure-Activity Relationships in Salinomycin: Cytotoxicity and Phenotype Selectivity of Semi-synthetic Derivatives
    Björn Borgström
    Centre for Analysis and Synthesis, Lund University, Box 124, 22100, Lund, Sweden
    Chemistry . 2016
    ....
  21. doi Stem cell biomarker ALDH1A1 in breast cancer shows an association with prognosis and clinicopathological variables that is highly cut-off dependent
    Martin Sjöström
    Department of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden
    J Clin Pathol 68:1012-9. 2015
    ....
  22. doi Synthetic modification of salinomycin: selective O-acylation and biological evaluation
    Björn Borgström
    Centre for Analysis and Synthesis, Department of Chemistry, Lund University, Box 124, 221 00 Lund, Sweden
    Chem Commun (Camb) 49:9944-6. 2013
    ..An evaluation of the dose-response effects of the resulting library on breast cancer cell lines shows that acylation of the C20 hydroxyl can be used to improve IC50 values down to one fifth that of salinomycin. ..
  23. ncbi Induction of apoptotic cell death by putrescine
    Koichi Takao
    Department of Experimental Medical Science, Lund University, S 22184 Lund, Sweden
    Int J Biochem Cell Biol 38:621-8. 2006
    ..In conclusion, deregulation of polyamine homeostasis may negatively affect cell proliferation and eventually lead to cell death by apoptosis if putrescine levels become too high...
  24. ncbi Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma
    Sofia K Gruvberger-Saal
    Department of Oncology and Theoretical Physics, Lund University, Lund, Sweden
    Clin Cancer Res 13:1987-94. 2007
    ..The aim of the present study was to elucidate the biology and prognostic role of the second ER, ERbeta, in patients treated with adjuvant tamoxifen...