Olga Göransson

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi request reprint Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation
    Olga Göransson
    University of Dundee, MRC Protein Phosphorylation Unit, James Black Centre, Dow Street, Dundee, DD1 5EH, Scotland, UK
    J Cell Sci 119:4059-70. 2006
  2. ncbi request reprint 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK
    Abdallah K Al-Hakim
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 118:5661-73. 2005
  3. pmc LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    Jose M Lizcano
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 23:833-43. 2004
  4. ncbi request reprint Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR
    Kei Sakamoto
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Scotland, UK
    Am J Physiol Endocrinol Metab 287:E310-7. 2004
  5. doi request reprint Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake
    Charlotte J Green
    Division of Molecular Physiology, James Black Centre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 283:27653-67. 2008
  6. pmc Regulation of AMP-activated protein kinase by cAMP in adipocytes: roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis
    Bilal Omar
    Lund University, Biomedical Center, C11 Department of Experimental Medical Science, 221 84 Lund, Sweden
    Cell Signal 21:760-6. 2009
  7. doi request reprint Rose hip exerts antidiabetic effects via a mechanism involving downregulation of the hepatic lipogenic program
    Ulrika Andersson
    Division of Diabetes, Metabolism and Endocrinology, Department of Experimental Medical Sciences, Lund University, Lund, Sweden
    Am J Physiol Endocrinol Metab 300:E111-21. 2011
  8. pmc The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver
    Kashyap Patel
    1 MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK 2
    Nat Commun 5:4535. 2014

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation
    Olga Göransson
    University of Dundee, MRC Protein Phosphorylation Unit, James Black Centre, Dow Street, Dundee, DD1 5EH, Scotland, UK
    J Cell Sci 119:4059-70. 2006
    ..Collectively, these results indicate that 14-3-3 binding to MARK isoforms is mediated by multiple phosphorylation sites, and serves to anchor MARK isoforms in the cytoplasm...
  2. ncbi request reprint 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK
    Abdallah K Al-Hakim
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 118:5661-73. 2005
    ..To our knowledge, this study provides the first example of 14-3-3 binding directly to the T-loop of a protein kinase and influencing its catalytic activity and cellular localization...
  3. pmc LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    Jose M Lizcano
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 23:833-43. 2004
    ..Between them, these kinases may mediate the physiological effects of LKB1, including its tumour suppressor function...
  4. ncbi request reprint Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR
    Kei Sakamoto
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Scotland, UK
    Am J Physiol Endocrinol Metab 287:E310-7. 2004
    ..They also suggest that the effects of excercise, phenformin, and AICAR on metabolic processes in muscle may be mediated through activation of AMPK rather than activation of LKB1 or the AMPK-related kinases...
  5. doi request reprint Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake
    Charlotte J Green
    Division of Molecular Physiology, James Black Centre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 283:27653-67. 2008
    ....
  6. pmc Regulation of AMP-activated protein kinase by cAMP in adipocytes: roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis
    Bilal Omar
    Lund University, Biomedical Center, C11 Department of Experimental Medical Science, 221 84 Lund, Sweden
    Cell Signal 21:760-6. 2009
    ..Taken together, these data suggest that PDE3B and PDE4 regulate cAMP pools that affect the activation/phosphorylation state of AMPK and that the effects of cyclic AMP on AMPK involve Epac1, PKA and lipolysis...
  7. doi request reprint Rose hip exerts antidiabetic effects via a mechanism involving downregulation of the hepatic lipogenic program
    Ulrika Andersson
    Division of Diabetes, Metabolism and Endocrinology, Department of Experimental Medical Sciences, Lund University, Lund, Sweden
    Am J Physiol Endocrinol Metab 300:E111-21. 2011
    ....
  8. pmc The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver
    Kashyap Patel
    1 MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK 2
    Nat Commun 5:4535. 2014
    ..Collectively, we demonstrate that the LKB1-SIK pathway functions as a key gluconeogenic gatekeeper in the liver. ..