Gunilla Nordin Fredrikson

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi request reprint Identification of immune responses against aldehyde-modified peptide sequences in apoB associated with cardiovascular disease
    Gunilla Nordin Fredrikson
    Department of Medicine, Malmo University Hospital, Lund University, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 23:872-8. 2003
  2. ncbi request reprint Inhibition of atherosclerosis in apoE-null mice by immunization with apoB-100 peptide sequences
    Gunilla Nordin Fredrikson
    Department of Medicine, Malmo University Hospital, Lund University, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 23:879-84. 2003
  3. ncbi request reprint Recombinant human antibodies against aldehyde-modified apolipoprotein B-100 peptide sequences inhibit atherosclerosis
    Alexandru Schiopu
    Department of Medicine, Malmo University Hospital, Lund University, Malmo, Sweden
    Circulation 110:2047-52. 2004
  4. ncbi request reprint Atheroprotective immunization with MDA-modified apo B-100 peptide sequences is associated with activation of Th2 specific antibody expression
    Gunilla Nordin Fredrikson
    Department of Medicine, Lund University, Wallenberg Labortatory 1st floor, Malmo University Hospital, 205 02 Malmo, Sweden
    Autoimmunity 38:171-9. 2005
  5. ncbi request reprint Identification of autoantibodies in human plasma recognizing an apoB-100 LDL receptor binding site peptide
    Gunilla Nordin Fredrikson
    Department of Clinical Sciences, Malmo University Hospital, Lund University, Malmo, Sweden
    J Lipid Res 47:2049-54. 2006
  6. ncbi request reprint Association between IgM against an aldehyde-modified peptide in apolipoprotein B-100 and progression of carotid disease
    Gunilla Nordin Fredrikson
    Department of Clinical Sciences, Malmo University Hospital, Lund University, Malmo, Sweden
    Stroke 38:1495-500. 2007
  7. ncbi request reprint Autoimmune responses against the apo B-100 LDL receptor-binding site protect against arterial accumulation of lipids in LDL receptor deficient mice
    Gunilla Nordin Fredrikson
    Department of Biomedical Laboratory Science, Malmo University Hospital, Lund University, S 205 02 Malmo, Sweden
    Autoimmunity 40:122-30. 2007
  8. doi request reprint Treatment with apo B peptide vaccines inhibits atherosclerosis in human apo B-100 transgenic mice without inducing an increase in peptide-specific antibodies
    G N Fredrikson
    Department of Clinical Sciences, Malmo University Hospital, Lund University, Lund, Sweden
    J Intern Med 264:563-70. 2008
  9. doi request reprint FcgammaRIIB inhibits the development of atherosclerosis in low-density lipoprotein receptor-deficient mice
    Ming Zhao
    Department of Clinical Sciences, Malmo University Hospital, Lund University, S 205 02 Malmo, Sweden
    J Immunol 184:2253-60. 2010
  10. doi request reprint Immunization of apoE-/- mice with aldehyde-modified fibronectin inhibits the development of atherosclerosis
    Pontus Dunér
    Department of Clinical Sciences, Skane University Hospital, Lund University, Malmo, Sweden
    Cardiovasc Res 91:528-36. 2011

Detail Information

Publications55

  1. ncbi request reprint Identification of immune responses against aldehyde-modified peptide sequences in apoB associated with cardiovascular disease
    Gunilla Nordin Fredrikson
    Department of Medicine, Malmo University Hospital, Lund University, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 23:872-8. 2003
    ..Atherosclerosis is associated with an immune response against oxidized LDL, which modulates the progression of the disease process...
  2. ncbi request reprint Inhibition of atherosclerosis in apoE-null mice by immunization with apoB-100 peptide sequences
    Gunilla Nordin Fredrikson
    Department of Medicine, Malmo University Hospital, Lund University, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 23:879-84. 2003
    ..Immunization of animals with oxidized LDL results in reduction of atherosclerosis, suggesting an atheroprotective effect of this immune response...
  3. ncbi request reprint Recombinant human antibodies against aldehyde-modified apolipoprotein B-100 peptide sequences inhibit atherosclerosis
    Alexandru Schiopu
    Department of Medicine, Malmo University Hospital, Lund University, Malmo, Sweden
    Circulation 110:2047-52. 2004
    ..Aldehyde-modified peptide sequences in apolipoprotein B-100 (apoB-100) are major targets for these immune responses...
  4. ncbi request reprint Atheroprotective immunization with MDA-modified apo B-100 peptide sequences is associated with activation of Th2 specific antibody expression
    Gunilla Nordin Fredrikson
    Department of Medicine, Lund University, Wallenberg Labortatory 1st floor, Malmo University Hospital, 205 02 Malmo, Sweden
    Autoimmunity 38:171-9. 2005
    ..The objective of this study was to evaluate if immunization with MDA-modified human apo B-100 fragments is associated with a shift in the Th1/Th2 balance...
  5. ncbi request reprint Identification of autoantibodies in human plasma recognizing an apoB-100 LDL receptor binding site peptide
    Gunilla Nordin Fredrikson
    Department of Clinical Sciences, Malmo University Hospital, Lund University, Malmo, Sweden
    J Lipid Res 47:2049-54. 2006
    ..Their association with plasma oxidized LDL suggests that they have been generated in response to breakdown products of LDL oxidation, but their influence on cholesterol metabolism and the development of atherosclerosis appears limited...
  6. ncbi request reprint Association between IgM against an aldehyde-modified peptide in apolipoprotein B-100 and progression of carotid disease
    Gunilla Nordin Fredrikson
    Department of Clinical Sciences, Malmo University Hospital, Lund University, Malmo, Sweden
    Stroke 38:1495-500. 2007
    ....
  7. ncbi request reprint Autoimmune responses against the apo B-100 LDL receptor-binding site protect against arterial accumulation of lipids in LDL receptor deficient mice
    Gunilla Nordin Fredrikson
    Department of Biomedical Laboratory Science, Malmo University Hospital, Lund University, S 205 02 Malmo, Sweden
    Autoimmunity 40:122-30. 2007
    ..The aim of the present study was to determine physiological effects of induction of immune responses against the apo B-100 LDL receptor-binding site in mice deficient for the LDL receptor...
  8. doi request reprint Treatment with apo B peptide vaccines inhibits atherosclerosis in human apo B-100 transgenic mice without inducing an increase in peptide-specific antibodies
    G N Fredrikson
    Department of Clinical Sciences, Malmo University Hospital, Lund University, Lund, Sweden
    J Intern Med 264:563-70. 2008
    ....
  9. doi request reprint FcgammaRIIB inhibits the development of atherosclerosis in low-density lipoprotein receptor-deficient mice
    Ming Zhao
    Department of Clinical Sciences, Malmo University Hospital, Lund University, S 205 02 Malmo, Sweden
    J Immunol 184:2253-60. 2010
    ..In addition, they indicate that absence of the inhibiting IgG receptor cause disease, depending on an imbalance of activating and inhibiting immune cells...
  10. doi request reprint Immunization of apoE-/- mice with aldehyde-modified fibronectin inhibits the development of atherosclerosis
    Pontus Dunér
    Department of Clinical Sciences, Skane University Hospital, Lund University, Malmo, Sweden
    Cardiovasc Res 91:528-36. 2011
    ..To determine the functional role of these immune responses in atherosclerosis, we performed studies in which apoE-deficient mice were immunized with MDA-modified fibronectin...
  11. ncbi request reprint Inhibition of injury-induced arterial remodelling and carotid atherosclerosis by recombinant human antibodies against aldehyde-modified apoB-100
    Asa Ström
    Department of Experimental Medical Science, Lund University, BMC, C12, SE 22184 Lund, Sweden
    Atherosclerosis 190:298-305. 2007
    ..In the present study we investigated the effect of antibodies against aldehyde-modified apolipoprotein B-100 (apoB-100), a component of oxidized LDL, on atherosclerosis and response to arterial injury in mice...
  12. pmc Nuclear factor of activated T cells regulates osteopontin expression in arterial smooth muscle in response to diabetes-induced hyperglycemia
    Lisa M Nilsson-Berglund
    Department of Clinical Sciences in Malmo, Lund University, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 30:218-24. 2010
    ..Here, we sought to determine whether hyperglycemia activates NFAT in vivo and whether this leads to vascular complications...
  13. doi request reprint Immune responses against aldehyde-modified laminin accelerate atherosclerosis in Apoe-/- mice
    Pontus Dunér
    Department of Clinical Sciences, Malmo University Hospital, Lund University, Lund, Sweden
    Atherosclerosis 212:457-65. 2010
    ..Here we investigated the possible influence of immunity against a malondialdehyde (MDA)-modified form of the basement membrane protein laminin on atherosclerosis...
  14. ncbi request reprint Recombinant antibodies to an oxidized low-density lipoprotein epitope induce rapid regression of atherosclerosis in apobec-1(-/-)/low-density lipoprotein receptor(-/-) mice
    Alexandru Schiopu
    Department of Clinical Sciences, Malmo University Hospital, Lund University, Malmo, Sweden
    J Am Coll Cardiol 50:2313-8. 2007
    ....
  15. ncbi request reprint Autoantibody against the amino acid sequence 661-680 in apo B-100 is associated with decreased carotid stenosis and cardiovascular events
    Gunilla Nordin Fredrikson
    Department of Clinical Sciences, Malmo University Hospital, Lund University, Sweden
    Atherosclerosis 194:e188-92. 2007
    ..Our findings support the notion that the p45 sequence of apo B-100 is a potential target for immunomodulatory treatment of atherosclerosis in humans...
  16. pmc TAP1-deficiency does not alter atherosclerosis development in Apoe-/- mice
    Daniel Kolbus
    Department of Clinical Sciences, Skåne University Hospital Malmö, Lund University, Malmo, Sweden
    PLoS ONE 7:e33932. 2012
    ..In conclusion, Apoe(-/-)Tap1(-/-) mice develop atherosclerosis equal to Apoe(-/-) mice, indicating a minor role for CD8(+) T cells and TAP1-dependent antigen presentation in the disease process...
  17. doi request reprint Circulating CD40+ and CD86+ B cell subsets demonstrate opposing associations with risk of stroke
    Polyxeni T Mantani
    From the Department of Clinical Sciences, Skåne University Hospital Malmö, Lund University, Malmo, Sweden P T M, I L, L A, R A, B H, H B, J N, G N F and Faculty of Health and Society, Malmo University, Malmo, Sweden G N F
    Arterioscler Thromb Vasc Biol 34:211-8. 2014
    ..In this study, we assessed the association of 2 different B cell subsets, CD19(+)CD40(+) and CD19(+)CD86(+) B cells, with risk for development of acute cardiovascular events...
  18. pmc Mobilization of regulatory T cells in response to carotid injury does not influence subsequent neointima formation
    Amit Saxena
    Department of Clinical Sciences Malmo, Lund University, Lund, Sweden
    PLoS ONE 7:e51556. 2012
    ..T cells have been attributed an important role in modulating repair responses following vascular injury. The aim of this study was to investigate the role of different T cell subsets in this context...
  19. ncbi request reprint Humoral immune response against defined oxidized low-density lipoprotein antigens reflects structure and disease activity of carotid plaques
    Isabel Goncalves
    Department of Medicine, Lund University, Wallenberg Laboratory, University Hospital MAS, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 25:1250-5. 2005
    ....
  20. doi request reprint Activator protein-1 in carotid plaques is related to cerebrovascular symptoms and cholesteryl ester content
    Isabel Goncalves
    Department of Clinical Sciences, Clinical Research Center, Lund University, Malmo, Sweden
    Cardiovasc Pathol 20:36-43. 2011
    ..The aim of this study was to determine whether transcription factor activator protein-1 activity in carotid plaques is related to symptoms, lipid accumulation, or extracellular matrix composition...
  21. doi request reprint Elastin- and collagen-rich human carotid plaques have increased levels of the cysteine protease inhibitor cystatin C
    Isabel Goncalves
    Department of Clinical Sciences, Experimental Cardiovascular Research Unit, Lund University, Malmo University Hospital, Malmo, Sweden
    J Vasc Res 45:395-401. 2008
    ..In this study we analyzed the associations between human carotid plaque cystatin C expression and the plaque content of collagen and elastin...
  22. doi request reprint Tumor necrosis factor-alpha does not mediate diabetes-induced vascular inflammation in mice
    Jenny Nilsson-Ohman
    Department of Clinical Sciences, Malmo University Hospital, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 29:1465-70. 2009
    ..In the present study we evaluated the role of TNF alpha in streptozotocin (STZ)-induced diabetes on vascular inflammation in C57BL/6 wild-type and apoE-/- mice...
  23. pmc Association between renin and atherosclerotic burden in subjects with and without type 2 diabetes
    Isabel Goncalves
    Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
    BMC Cardiovasc Disord 16:171. 2016
    ..The aim of the present study was to determine if plasma renin levels are associated with the severity of vascular changes in subjects with and without T2D...
  24. ncbi request reprint Involvement of the CD1d-natural killer T cell pathway in neointima formation after vascular injury
    Asa Ström
    Department of Experimental Medicine, Lund University, Sweden
    Circ Res 101:e83-9. 2007
    ..The results suggest that presentation of lipid antigens through the CD1d-natural killer T cell pathway modulates vascular repair responses...
  25. doi request reprint Identification of the target for therapeutic recombinant anti-apoB-100 peptide antibodies in human atherosclerotic lesions
    Isabel Goncalves
    Department of Clinical Sciences, Lund University, Sweden
    Atherosclerosis 205:96-100. 2009
    ....
  26. pmc IL-25 inhibits atherosclerosis development in apolipoprotein E deficient mice
    Polyxeni T Mantani
    Department of Clinical Sciences, Skåne University Hospital Malmö, Lund University, Malmo, Sweden
    PLoS ONE 10:e0117255. 2015
    ..Recent studies have identified the novel innate lymphoid type 2 cells (ILC2s) as an IL-25 target cell population. The purpose of this study was to evaluate if IL-25 has any influence on atherosclerosis development in mice...
  27. doi request reprint Emerging biomarkers and intervention targets for immune-modulation of atherosclerosis - a review of the experimental evidence
    Harry Bjorkbacka
    Department of Clinical Sciences, Skåne University Hospital Malmö, Lund University, Sweden
    Atherosclerosis 227:9-17. 2013
    ..It is therefore critical that more attention is given to the characterization and evaluation of immune biomarkers for cardiovascular risk...
  28. doi request reprint Low levels of circulating CD4+FoxP3+ T cells are associated with an increased risk for development of myocardial infarction but not for stroke
    Maria Wigren
    Department of Clinical Sciences, Entrance 72, 60 13, Malmo University Hospital, 20502 Malmo, Sweden
    Arterioscler Thromb Vasc Biol 32:2000-4. 2012
    ..The aim of the present study was to determine whether circulating Tregs predict the development of acute cardiovascular events in humans...
  29. pmc High levels of cathepsin D and cystatin B are associated with increased risk of coronary events
    Isabel Goncalves
    Experimental Cardiovascular Research Unit, Department of Clinical Sciences, Lund University, Malmo, Sweden Department of Cardiology, Skane University Hospital, Malmo, Sweden
    Open Heart 3:e000353. 2016
    ..Matrix metalloproteinases have been shown to be markers for cardiovascular disease whereas the members of the cathepsin protease family are less studied...
  30. doi request reprint Apolipoprotein B-100 Antibody Interaction With Atherosclerotic Plaque Inflammation and Repair Processes
    Giuseppe Asciutto
    From the Department of Clinical Sciences Malmö, Lund University, Malmo, Sweden
    Stroke 47:1140-3. 2016
    ..This study investigated the association between p45 IgG autoantibodies and plaque inflammation in subjects with advanced cardiovascular disease...
  31. doi request reprint High Plasma Levels of Galectin-3 Are Associated with Increased Risk for Stroke after Carotid Endarterectomy
    Andreas Edsfeldt
    Department of Clinical Sciences Malmx00F6, Lund University, Lund, Sweden
    Cerebrovasc Dis 41:199-203. 2016
    ..The aim of this study was to investigate whether Gal-3 could be used as a marker to predict postoperative cerebrovascular ischemic events among patients who underwent carotid endarterectomy (CEA)...
  32. doi request reprint High plasma levels of heparin-binding epidermal growth factor are associated with a more stable plaque phenotype and reduced incidence of coronary events
    Sara Rattik
    From the Department of Clinical Sciences Malmö, Lund University, Malmo, Sweden S R, M W, H B, G N F, B H, E B, A s, A E, P D, H G, I G, J N Department of Cardiology Coronary diseases, Skane University Hospital, Malmo, Sweden A S, A E, I G and Department of Medical Sciences, Clinical Chemistry and Science for Life Laboratory, Uppsala University, Uppsala, Sweden A S
    Arterioscler Thromb Vasc Biol 35:222-8. 2015
    ....
  33. doi request reprint Apolipoprotein B100 autoimmunity and atherosclerosis - disease mechanisms and therapeutic potential
    Jan Nilsson
    Department of Clinical Sciences Malmo, Skane University Hospital, Lund University, Sweden
    Curr Opin Lipidol 23:422-8. 2012
    ..This review will discuss recent developments in the mechanistic understanding of apo B100 autoimmunity and approaches taken to use this knowledge for development of novel therapies...
  34. doi request reprint Endarterectomy patients with elevated levels of circulating IL-16 have fewer cardiovascular events during follow-up
    Caitriona Grönberg
    Department of Clinical Sciences, Skane University Hospital, Lund University, Malmo, Sweden Electronic address
    Cytokine 85:137-9. 2016
    ..In the present study we aimed to determine whether high circulating levels of IL-16 also are associated with a decreased risk of CV events after CEA...
  35. doi request reprint Low Levels of Apolipoprotein B-100 Autoantibodies Are Associated With Increased Risk of Coronary Events
    Harry Bjorkbacka
    From the Department of Clinical Sciences, Skåne University Hospital Malmö, Lund University, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 36:765-71. 2016
    ..The present study investigated associations between autoantibodies against the apolipoprotein B-100 peptides p45 and p210, respectively, and risk of incident cardiovascular disease in a large population-based cohort...
  36. doi request reprint Low Levels of IgM Antibodies against an Advanced Glycation Endproduct-Modified Apolipoprotein B100 Peptide Predict Cardiovascular Events in Nondiabetic Subjects
    Daniel Engelbertsen
    Department of Clinical Sciences, Malmo, Faculty of Medicine, Lund University, Skane University Hospital, 205 02 Malmo, Sweden and
    J Immunol 195:3020-5. 2015
    ..These data show that subjects with low levels of IgM recognizing MGO-modified p220 in apoB have an increased risk to develop cardiovascular events and that this association is present in nondiabetic subjects...
  37. doi request reprint Human Carotid Plaques With High Levels of Interleukin-16 Are Associated With Reduced Risk for Cardiovascular Events
    Caitriona Grönberg
    From the Department of Clinical Sciences C G, E B, G N F, M N, A P, L A, J N, I G, H B and Vascular Centre Malmö Lund G A, Skane University Hospital, Malmo, Lund University, Lund, Sweden
    Stroke 46:2748-54. 2015
    ....
  38. doi request reprint Atheroprotective effects of Alum are associated with capture of oxidized LDL antigens and activation of regulatory T cells
    Maria Wigren
    Department of Clinical Sciences, Entrance 72 91 12, Malmo University Hospital, 20502 Malmo, Sweden
    Circ Res 104:e62-70. 2009
    ....
  39. ncbi request reprint Association between diet, lifestyle, metabolic cardiovascular risk factors, and plasma C-reactive protein levels
    Gunilla Nordin Fredrikson
    Department of Medicine, Malmo University Hospital, S 205 02 Malmo, Sweden
    Metabolism 53:1436-42. 2004
    ..These observations suggest that CRP levels are only marginally associated with individual dietary and lifestyle factors. Surprisingly, a higher intake of fat tended to be associated with lower CRP values among women...
  40. ncbi request reprint Elastin and calcium rather than collagen or lipid content are associated with echogenicity of human carotid plaques
    Isabel Goncalves
    Department of Medicine, Wallenberg Laboratory, University of Lund, Entrance 46, 1st Floor, Malmo University Hospital, SE 20502 Malmo, Sweden
    Stroke 35:2795-800. 2004
    ..This is the first study to relate echogenicity to plaque composition analyzed biochemically...
  41. ncbi request reprint Inhibitory effect on arterial injury-induced neointimal formation by adoptive B-cell transfer in Rag-1 knockout mice
    Paul Dimayuga
    Experimental Cardiovascular Research, Department of Medicine, Lund University, University Hospital MAS, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 22:644-9. 2002
    ..05). Injured carotid arteries from reconstituted Rag-1 KO mice had detectable IgM and IgG, indicating viable transfer of B cells. The results suggest that B cells modulate the response to arterial injury...
  42. pmc Associations Between Macrophage Colony-Stimulating Factor and Monocyte Chemotactic Protein 1 in Plasma and First-Time Coronary Events: A Nested Case-Control Study
    Alexandru Schiopu
    Department of Clinical Sciences Malmo, Lund University, Sweden Cardiology Unit, Skane University Hospital, Malmo, Sweden
    J Am Heart Assoc 5:. 2016
    ..We investigated the associations between the plasma levels of growth factors and chemokines that regulate myeloid cell homeostasis and function and the risk of first-time acute coronary events in middle-aged persons...
  43. doi request reprint Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes
    Isabel Goncalves
    From the Department of Clinical Sciences Malmö, Lund University, Malmo, Sweden I G, E B, A E, P D, G N F, H B, G O, M P, J N Medical Research Institute, University of Dundee, Dundee, UK H M C, F K, H C L, F A, J B Institute of Biomedical and Clinical Science, Diabetes and Vascular Medicine, NIHR Exeter Clinical Research Facility and University of Exeter Medical School, Exeter, UK A C S, K A, F C, K G, D S Department of Clinical and Experimental Medicine A N, S P, E V and Department of Surgical, Medical, Molecular and Critical Area Pathology C P, M K, University of Pisa, Pisa, Italy and AstraZeneca
    Arterioscler Thromb Vasc Biol 35:1723-31. 2015
    ..The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a particular focus on type 2 diabetes mellitus...
  44. pmc CD8+ T cell activation predominate early immune responses to hypercholesterolemia in Apoe⁻(/)⁻ mice
    Daniel Kolbus
    Department of Clinical Sciences, Skåne University Hospital Malmö, Lund University, Sweden
    BMC Immunol 11:58. 2010
    ..In the present study we assessed immune responses to hypercholesterolemia induced by feeding Apoe-/- mice a high-fat diet for 4 or 8 weeks...
  45. doi request reprint Inflammation and immunity in diabetic vascular complications
    Jan Nilsson
    Department of Clinical Sciences, Malmo University Hospital, Lund University, Sweden
    Curr Opin Lipidol 19:519-24. 2008
    ..The purpose of this review is to discuss possible mechanisms through which diabetes can contribute to a more aggressive atherosclerotic disease process with a particular focus on the role of innate and adaptive immunity...
  46. ncbi request reprint Very low density lipoprotein potentiates tumor necrosis factor-alpha expression in macrophages
    Maria M Stollenwerk
    Department of Medicine, Lund University, Wallenberg Laboratory, Malmo University Hospital, SE 20502 Malmo, Sweden
    Atherosclerosis 179:247-54. 2005
    ..These findings suggest that triacylglycerol-rich lipoproteins are involved in inflammatory processes associated with atherosclerosis...
  47. ncbi request reprint Atherosclerosis
    Jan Nilsson
    Department of Medicine, Malmo University Hospital, Lund University, Sweden
    Autoimmunity 37:351-5. 2004
  48. pmc Antibodies against gonadotropin-releasing hormone (GnRH) in patients with diabetes mellitus is associated with lower body weight and autonomic neuropathy
    Kerstin Berntorp
    Department of Clinical Sciences, Division of Endocrinology, Skane University Hospital, Malmo, Lund University, Lund, Sweden
    BMC Res Notes 6:329. 2013
    ..The aim of the present study was to scrutinize patients with diabetes mellitus with regard to the presence of GnRH antibodies, and to examine associations between antibodies and clinical findings...
  49. doi request reprint Gonadotropin-releasing hormone analog buserelin causes neuronal loss in rat gastrointestinal tract
    Elin Sand
    Department of Experimental Medical Sciences, Neurogastroenterology Unit, Lund University, BMC B11, 22184, Lund, Sweden
    Cell Tissue Res 351:521-34. 2013
    ..The present findings suggest that enteric neurodegenerative effects of GnRH analog treatment in man can be mimicked in rat. However, in contrast to man, no production of GnRH auto-antibodies has been noted in rat...
  50. ncbi request reprint Depletion of enteric gonadotropin-releasing hormone is found in a few patients suffering from severe gastrointestinal dysmotility
    Oskar Hammar
    Department of Clinical Sciences, Section of Gastroenterology and Hepatology, Skane University Hospital, Lund University, Malmo, Sweden
    Scand J Gastroenterol 47:1165-73. 2012
    ..The aim of this study was to examine the expression of GnRH in ENS and antibodies against GnRH in serum, in a dysmotility patient cohort of southern Sweden...
  51. doi request reprint Probiotic therapy to men with incipient arteriosclerosis initiates increased bacterial diversity in colon: a randomized controlled trial
    Caroline Karlsson
    Food Hygiene, Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden
    Atherosclerosis 208:228-33. 2010
    ..This study aimed to clarify the microbial change in the intestinal microbiota in patients, with cardiovascular disease, consuming a drink with high numbers of live Lactobacillus plantarum...
  52. ncbi request reprint T cell modulation of intimal thickening after vascular injury: the bimodal role of IFN-gamma in immune deficiency
    Paul C Dimayuga
    Atherosclerosis Research Center, Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, David Geffen School of Medicine, UCLA, Los Angeles, California, USA
    Arterioscler Thromb Vasc Biol 25:2528-34. 2005
    ..The mechanisms involved are not well defined. We investigated the role of T cells and IFN-gamma in the response to injury in normal and immune-deficient Rag-1KO mice...
  53. ncbi request reprint [A vaccine for protection against atherosclerosis. Oxidized LDL plays a major role in the immunologic defence]
    Jan Nilsson
    Institutionen för medicin, kirurgi och ortopedi, Universitetssjukhuset MAS, Malmo, Lunds universitet
    Lakartidningen 101:1700-1, 1704-5. 2004
  54. ncbi request reprint Immunization using an Apo B-100 related epitope reduces atherosclerosis and plaque inflammation in hypercholesterolemic apo E (-/-) mice
    Kuang Yuh Chyu
    Atherosclerosis Research Center, Division of Cardiology, Department of Medicine and Burns and Allen Research Institute, Cedars Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Biochem Biophys Res Commun 338:1982-9. 2005
    ..Such acquired immunity and athero-protective effect appears to be mediated by splenocytes. These data demonstrate the feasibility of peptide based immunomodulating therapy for atherosclerosis...