M A Cenci
Affiliation: Lund University
- Transcription factors involved in the pathogenesis of L-DOPA-induced dyskinesia in a rat model of Parkinson's diseaseM A Cenci
Department of Physiological Sciences, Lund University, Lund, Sweden
Amino Acids 23:105-9. 2002..Antisense-mediated knockdown of CREB (cyclic AMP response-element binding proteins) has however no effect. Our results identify fosB as a potential target for adjunctive antiparkinsonian therapies...
- Persistent changes in striatal gene expression induced by long-term L-DOPA treatment in a rat model of Parkinson's diseaseJ E Westin
Department of Physiological Sciences, Section of Neurobiology, Lund University, Wallenberg Neuroscience Centre, BMC A11, S-221 84 Lund, Sweden
Eur J Neurosci 14:1171-6. 2001....
- Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's diseaseE L Lane
Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sweden
Neurobiol Dis 32:220-8. 2008..These results indicate that an inflammatory response in and around grafted dopaminergic neurons is not sufficient to evoke dyskinetic behaviors in experimental models of PD...
- Priming for L-DOPA-induced abnormal involuntary movements increases the severity of amphetamine-induced dyskinesia in grafted ratsE L Lane
Neuronal Survival Unit, Department of Experimental Medical Science, Lund, Sweden
Exp Neurol 219:355-8. 2009....
- cAMP response element-binding protein is required for dopamine-dependent gene expression in the intact but not the dopamine-denervated striatumM Andersson
Department of Physiological Sciences, Neurobiology Division, Lund University, Wallenberg Neuroscience Centre, 221 84 Lund, Sweden
J Neurosci 21:9930-43. 2001..Moreover, our results reveal an unexpected alteration of nuclear signaling mechanisms in the parkinsonian striatum treated with l-DOPA, where AP-1 transcription factors appear to supersede CREB in the activation of CRE-containing genes...
- Alterations in cortical and basal ganglia levels of opioid receptor binding in a rat model of l-DOPA-induced dyskinesiaP A Johansson
Department of Physiological Sciences, Neurobiology Division, Wallenberg Neuroscience Centre, University of Lund, , Lund, S-223 62, Sweden
Neurobiol Dis 8:220-39. 2001....
- The impact of graft size on the development of dyskinesia following intrastriatal grafting of embryonic dopamine neurons in the ratE L Lane
Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden
Neurobiol Dis 22:334-45. 2006..In conclusion, robust and reproducible AIMs were evoked in rats with large grafts by blockade of monoamine reuptake. These AIMs may provide a new tool for assessing dyskinetic effects of neural grafting...
- Putaminal upregulation of FosB/ΔFosB-like immunoreactivity in Parkinson's disease patients with dyskinesiaH S Lindgren
Lund University, Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Sciences, Lund, Sweden
J Parkinsons Dis 1:347-57. 2011..The present findings support the hypothesis of an involvement of ΔFosB-related transcription factors in the molecular mechanisms of L-DOPA-induced dyskinesia. ..
- Cellular and behavioural effects of the adenosine A2a receptor antagonist KW-6002 in a rat model of l-DOPA-induced dyskinesiaM Lundblad
Department of Physiological Sciences, Wallenberg Neuroscience Centre, Neurobiology Division, Lund, Sweden
J Neurochem 84:1398-410. 2003..Cotreatment with KW-6002 and L-DOPA potentiates the therapeutic effect but not the dyskinesiogenic potential of the latter drug...
- Expression pattern of JunD after acute or chronic L-DOPA treatment: comparison with deltaFosBB Valastro
Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, BMC F11, Lund 221 84, Sweden
Neuroscience 144:198-207. 2007..The upregulation of deltaFosB protein, but not JunD, is likely to reflect an increased stability of the deltaFosB proteins without ongoing enhanced transcription of the encoding genes...
- Role of striatal L-DOPA in the production of dyskinesia in 6-hydroxydopamine lesioned ratsManolo Carta
Department of Exp Medical Science, Basal Ganglia Pathophysiology Unit, Lund University, Lund, Sweden
J Neurochem 96:1718-27. 2006..Individual differences in the central bioavailability of L-DOPA may provide a clue to the varying susceptibility to dyskinesia in Parkinson's disease...
- Regulation of neuropeptide mRNA expression in the basal ganglia by intrastriatal and intranigral transplants in the rat Parkinson modelC Winkler
Lund University, Wallenberg Neuroscience Center, Department of Physiological Sciences, BMC A11, S 22184 Sweden
Neuroscience 118:1063-77. 2003..A full reconstruction of the nigrostriatal pathway or, alternatively, modulation of basal ganglia function by grafting in non-striatal regions may be required to further improve the functional outcome in the DA-denervated brain...
- A model of L-DOPA-induced dyskinesia in 6-hydroxydopamine lesioned mice: relation to motor and cellular parameters of nigrostriatal functionM Lundblad
Department of Physiological Sciences, Neurobiology Division, Wallenberg Neuroscience Centre, Lund University, S 223 62 Lund, Sweden
Neurobiol Dis 16:110-23. 2004..The mouse model of L-DOPA-induced dyskinesia will provide a useful tool to study the molecular determinants of this movement disorder in transgenic mice strains...
- Advances in understanding L-DOPA-induced dyskinesiaM A Cenci
Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, S 221 84 Lund, Sweden
Curr Opin Neurobiol 17:665-71. 2007..Further research on L-DOPA-induced dyskinesia will contribute to a deeper understanding of the functional interplay between neurotransmitters and neuromodulators in the motor circuits of the basal ganglia...
- Current options and future possibilities for the treatment of dyskinesia and motor fluctuations in Parkinson's diseaseM A Cenci
Basal Ganglia Pathophysiology Unit, Dept Experimental Medical Science, Lund University, Sweden
CNS Neurol Disord Drug Targets 10:670-84. 2011....
- L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNAM A Cenci
Wallenberg Neuroscience Center, Institute of Physiology and Neuroscience, University of Lund, 223 62 Lund, Sweden
Eur J Neurosci 10:2694-706. 1998..Due to its treatment-dependent expression, and strong correlation with the associated dyskinetic symptoms, striatal PDyn mRNA, in particular, may play a role in the mechanisms of behavioural sensitization brought about by the drug...
- Time course of striatal DeltaFosB-like immunoreactivity and prodynorphin mRNA levels after discontinuation of chronic dopaminomimetic treatmentM Andersson
Department of Physiological Sciences, Neurobiology Division, Lund University, Wallenberg Neuroscience Center, BMC A11, Sweden
Eur J Neurosci 17:661-6. 2003..In the dopamine-denervated striatum, these proteins may exert sustained effects on the expression of their target genes long after discontinuation of L-DOPA pharmacotherapy...
- NLX-112, a novel 5-HT1A receptor agonist for the treatment of L-DOPA-induced dyskinesia: Behavioral and neurochemical profile in ratH Iderberg
Basal Ganglia Pathophysiology Unit, Dept of Experimental Medical Sciences, Lund University, Sweden
Exp Neurol 271:335-50. 2015....
- Effects of pulsatile L-DOPA treatment in the double lesion rat model of striatonigral degeneration (multiple system atrophy)N Stefanova
Department of Neurology, University Hospital of Innsbruck, Innsbruck, Austria
Neurobiol Dis 15:630-9. 2004....
- Pharmacological validation of a mouse model of l-DOPA-induced dyskinesiaM Lundblad
Wallenberg Neuroscience Centre, Section of Basal Ganglia Pathophysiology, BMC A11, S 221 84 Lund, Sweden
Exp Neurol 194:66-75. 2005..The present data indicate that the mouse AIMs are indeed a functional equivalent of l-DOPA-induced dyskinesia...