A Bjorklund

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi Incorporation of mouse neural progenitors transplanted into the rat embryonic forebrain is developmentally regulated and dependent on regional and adhesive properties
    M Olsson
    Wallenberg Neuroscience Center, Department of Physiology and Neuroscience, University of Lund, Sweden
    Eur J Neurosci 10:71-85. 1998
  2. ncbi Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle
    C Rosenblad
    Department of Physiology and Neuroscience, Wallenberg Neuroscience Center, Lund University, Sweden
    Eur J Neurosci 11:1554-66. 1999
  3. ncbi Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model
    C Rosenblad
    Wallenberg Neuroscience Center, Department of Physiology, Lund University, Solvegatan 17, Lund, S 223 62, Sweden
    Exp Neurol 161:503-16. 2000
  4. ncbi Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model
    A Bjorklund
    Wallenberg Neuroscience Center, Section of Neurobiology, Lund University, Solvegatan 17, S 22362, Lund, Sweden
    Brain Res 886:82-98. 2000
  5. ncbi Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat
    D Kirik
    Department of Physiology and Neuroscience, Lund University, Solvegatan 17, Lund, 223 62, Sweden
    Exp Neurol 152:259-77. 1998
  6. ncbi Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system
    D Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of Neurobiology, Lund University, 223 62 Lund, Sweden
    J Neurosci 20:4686-700. 2000
  7. ncbi Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor
    D Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Solvegatan 17, 223 62 Lund, Sweden
    Eur J Neurosci 12:3871-82. 2000
  8. doi Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons
    M Decressac
    Wallenberg Neuroscience Center, Department of Experimental Medical Sciences, Lund University, BMC A11, Lund 22184, Sweden
    Neurobiol Dis 45:939-53. 2012
  9. ncbi In utero gene transfer reveals survival effects of nerve growth factor on rat brain cholinergic neurones during development
    A Martinez-Serrano
    Department of Physiology and Neuroscience, Wallenberg Neuroscience Center, University of Lund, Sweden
    Eur J Neurosci 10:263-71. 1998
  10. ncbi Dopamine neurons grafted unilaterally to the nucleus accumbens affect drug-induced circling and locomotion
    P Brundin
    Department of Medical Cell Research, University of Lund, Sweden
    Exp Brain Res 69:183-94. 1987

Detail Information

Publications26

  1. ncbi Incorporation of mouse neural progenitors transplanted into the rat embryonic forebrain is developmentally regulated and dependent on regional and adhesive properties
    M Olsson
    Wallenberg Neuroscience Center, Department of Physiology and Neuroscience, University of Lund, Sweden
    Eur J Neurosci 10:71-85. 1998
    ....
  2. ncbi Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle
    C Rosenblad
    Department of Physiology and Neuroscience, Wallenberg Neuroscience Center, Lund University, Sweden
    Eur J Neurosci 11:1554-66. 1999
    ..The lower efficacy of NTN after IS, and particularly ICV, administration may be explained by the poor solubility and diffusion properties at neutral pH...
  3. ncbi Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model
    C Rosenblad
    Wallenberg Neuroscience Center, Department of Physiology, Lund University, Solvegatan 17, Lund, S 223 62, Sweden
    Exp Neurol 161:503-16. 2000
    ..We conclude that functional recovery in the partial lesion model depends not only on preservation of the nigral cell bodies, but more critically on the ability of GDNF to promote significant reinnervation of the denervated striatum...
  4. ncbi Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model
    A Bjorklund
    Wallenberg Neuroscience Center, Section of Neurobiology, Lund University, Solvegatan 17, S 22362, Lund, Sweden
    Brain Res 886:82-98. 2000
    ....
  5. ncbi Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat
    D Kirik
    Department of Physiology and Neuroscience, Lund University, Solvegatan 17, Lund, 223 62, Sweden
    Exp Neurol 152:259-77. 1998
    ....
  6. ncbi Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system
    D Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of Neurobiology, Lund University, 223 62 Lund, Sweden
    J Neurosci 20:4686-700. 2000
    ..GDNF transgene expression was maintained at high levels throughout this period. These results provide evidence that rAAV is a highly efficient vector system for long-term expression of therapeutic proteins in the nigrostriatal system...
  7. ncbi Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor
    D Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Solvegatan 17, 223 62 Lund, Sweden
    Eur J Neurosci 12:3871-82. 2000
    ....
  8. doi Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons
    M Decressac
    Wallenberg Neuroscience Center, Department of Experimental Medical Sciences, Lund University, BMC A11, Lund 22184, Sweden
    Neurobiol Dis 45:939-53. 2012
    ..This model provides new interesting possibilities for studies of stage-specific pathologic mechanisms and identification of targets for disease-modifying therapeutic interventions linked to early or late stages of the disease...
  9. ncbi In utero gene transfer reveals survival effects of nerve growth factor on rat brain cholinergic neurones during development
    A Martinez-Serrano
    Department of Physiology and Neuroscience, Wallenberg Neuroscience Center, University of Lund, Sweden
    Eur J Neurosci 10:263-71. 1998
    ..The present results suggest that overexpression of NGF during development may promote the survival of distinct populations of central cholinergic neurones into adulthood...
  10. ncbi Dopamine neurons grafted unilaterally to the nucleus accumbens affect drug-induced circling and locomotion
    P Brundin
    Department of Medical Cell Research, University of Lund, Sweden
    Exp Brain Res 69:183-94. 1987
    ....
  11. ncbi Growth and functional efficacy of intrastriatal nigral transplants depend on the extent of nigrostriatal degeneration
    D Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, 22184, Lund, Sweden
    J Neurosci 21:2889-96. 2001
    ..These data have implications for the optimal use of fetal nigral transplants in Parkinson patients in different stages of the disease...
  12. pmc Ex vivo nerve growth factor gene transfer to the basal forebrain in presymptomatic middle-aged rats prevents the development of cholinergic neuron atrophy and cognitive impairment during aging
    A Martinez-Serrano
    Wallenberg Neuroscience Center, University of Lund, Solvegatan 17, S 223 62 Lund, Sweden
    Proc Natl Acad Sci U S A 95:1858-63. 1998
    ....
  13. doi Comparison of the behavioural and histological characteristics of the 6-OHDA and α-synuclein rat models of Parkinson's disease
    M Decressac
    Wallenberg Neuroscience Center, Department of Experimental Medical Sciences, Lund University, BMC A11, Lund 22184, Sweden
    Exp Neurol 235:306-15. 2012
    ..This study suggests that the AAV-α-syn model replicates the human pathology more closely than either of the other two 6-OHDA lesion models...
  14. ncbi Delayed infusion of GDNF promotes recovery of motor function in the partial lesion model of Parkinson's disease
    D Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, BMC A11, 221 84 Lund, Sweden
    Eur J Neurosci 13:1589-99. 2001
    ....
  15. ncbi Injury induced c-Jun expression and phosphorylation in the dopaminergic nigral neurons of the rat: correlation with neuronal death and modulation by glial-cell-line-derived neurotrophic factor
    E Vaudano
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Solvegatan 17, S 223 62 Lund, Sweden
    Eur J Neurosci 13:1-14. 2001
    ..We conclude that c-Jun induction and phosphorylation may be involved in the cellular events leading to death of nigral dopaminergic neurons in vivo and that this response can be modulated by glial-cell-line-derived-neurotrophic factor...
  16. ncbi Conditionally immortalized neural progenitor cell lines integrate and differentiate after grafting to the adult rat striatum. A combined autoradiographic and electron microscopic study
    C Lundberg
    Wallenberg Neurocenter, Department of Physiology and Neuroscience, University of Lund, Sweden
    Brain Res 737:295-300. 1996
    ..The ability of the cells to become fully integrated with the resident glial population suggests that they will be highly useful as vehicles for intracerebral transgene expression in ex vivo gene transfer...
  17. ncbi Intracerebral xenografts of dopamine neurons: the role of immunosuppression and the blood-brain barrier
    P Brundin
    Department of Medical Cell Research, University of Lund, Sweden
    Exp Brain Res 75:195-207. 1989
    ..Temporary CyA treatment, even exceeding the time it takes for the blood-brain barrier to reform after transplantation surgery, is thus not sufficient to reliably support long term survival of xenografted dopamine neurons...
  18. ncbi Basic characteristics of noradrenaline release in the hippocampus of intact and 6-hydroxydopamine-lesioned rats as studied by in vivo microdialysis
    P Kalén
    Department of Medical Cell Research, University of Lund, Sweden
    Brain Res 474:374-9. 1988
    ..These results support the conclusion that the extracellular NA levels recovered in the dialysis perfusates are neuronally derived and can be used as an index of noradrenergic synaptic activity in the brain...
  19. ncbi Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2
    E Andersson
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A11, Sweden
    Development 133:507-16. 2006
    ....
  20. ncbi Amelioration of spatial navigation and short-term memory deficits by grafts of foetal basal forebrain tissue placed into the hippocampus and cortex of rats with selective cholinergic lesions
    G Leanza
    Wallenberg Neuroscience Center, Lund University, Sweden
    Eur J Neurosci 10:2353-70. 1998
    ....
  21. ncbi Chimeric stem cells
    A Bjorklund
    Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    Trends Mol Med 7:144-6. 2001
    ..There have been many commentaries on all of these issues in prominent journals and newspapers over recent months. In this article, we take a critical look at new data that underpin the last of these claims: the chimeric stem cell...
  22. ncbi L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA
    M A Cenci
    Wallenberg Neuroscience Center, Institute of Physiology and Neuroscience, University of Lund, 223 62 Lund, Sweden
    Eur J Neurosci 10:2694-706. 1998
    ..Due to its treatment-dependent expression, and strong correlation with the associated dyskinetic symptoms, striatal PDyn mRNA, in particular, may play a role in the mechanisms of behavioural sensitization brought about by the drug...
  23. ncbi Neural grafting in a rat model of Huntington's disease: striosomal-like organization of striatal grafts as revealed by acetylcholinesterase histochemistry, immunocytochemistry and receptor autoradiography
    O Isacson
    Department of Histology, University of Lund, Sweden
    Neuroscience 22:481-97. 1987
    ..abstract truncated at 400 words)..
  24. ncbi Host afferents into intrastriatal transplants of fetal ventral mesencephalon
    G Doucet
    Department of Medical Cell Research, University of Lund, Sweden
    Exp Neurol 106:1-19. 1989
    ..Intrastriatal injections of PHA-L or DARPP-32 immunocytochemistry indicated that the deep portions of the nigral grafts were entirely devoid of host striatal afferents.(ABSTRACT TRUNCATED AT 400 WORDS)..
  25. ncbi Behaviour-dependent changes in acetylcholine release in normal and graft-reinnervated hippocampus: evidence for host regulation of grafted cholinergic neurons
    O G Nilsson
    Department of Medical Cell Research, University of Lund, Sweden
    Neuroscience 49:33-44. 1992
    ....
  26. ncbi In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin
    C Rosenblad
    Wallenberg Neuroscience Center, Lund University, Solvegatan 17, Lund, S 223 62, Sweden
    Mol Cell Neurosci 15:199-214. 2000
    ..We conclude that NBN/ART, similarly to GDNF, is a potent neuroprotective factor for the nigrostriatal DA neurons in vivo...