Genomes and Genes
Affiliation: Lund University
- Lack of the cysteine protease inhibitor cystatin C promotes atherosclerosis in apolipoprotein E-deficient miceEva Bengtsson
Department of Clinical Sciences, Malmo University Hospital, Lund University, Sweden
Arterioscler Thromb Vasc Biol 25:2151-6. 2005..It is present in the normal artery wall but severely reduced in human atherosclerotic lesions...
- Cystatin C and cathepsins in cardiovascular diseaseEva Bengtsson
Department of Clinical Sciences, Experimental Cardiovascular Research Unit, Lund University, Malmo, Sweden
Front Biosci 13:5780-6. 2008..This article reviews possible roles of cystatin C and cathepsins in different processes and stages of the atherosclerotic disease...
- Absence of the protease inhibitor cystatin C in inflammatory cells results in larger plaque area in plaque regression of apoE-deficient miceEva Bengtsson
Department of Medicine, Section for Experimental Cardiovascular Research, Malmo University Hospital, Lund University, 205 02 Malmo, Sweden
Atherosclerosis 180:45-53. 2005..These observations suggest that leukocyte-specific expression of cystatin C is actively involved in matrix remodelling associated with plaque regression...
- Increased inflammation in atherosclerotic lesions of diabetic Akita-LDLr⁻/⁻ mice compared to nondiabetic LDLr⁻/⁻ miceDaniel Engelbertsen
Department of Clinical Sciences Malmo, Skane University Hospital, Lund University, CRC Entrance 72, 20502 Malmo, Sweden
Exp Diabetes Res 2012:176162. 2012..The Akita mouse has recently been adopted as a relevant model for microvascular complications of diabetes. Here we investigate the development of atherosclerosis and inflammation in vessels of Akita mice on LDLr⁻/⁻ background...
- Association between renin and atherosclerotic burden in subjects with and without type 2 diabetesIsabel Goncalves
Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
BMC Cardiovasc Disord 16:171. 2016..The aim of the present study was to determine if plasma renin levels are associated with the severity of vascular changes in subjects with and without T2D...
- Immune responses against aldehyde-modified laminin accelerate atherosclerosis in Apoe-/- micePontus Dunér
Department of Clinical Sciences, Malmo University Hospital, Lund University, Lund, Sweden
Atherosclerosis 212:457-65. 2010..Here we investigated the possible influence of immunity against a malondialdehyde (MDA)-modified form of the basement membrane protein laminin on atherosclerosis...
- High levels of cathepsin D and cystatin B are associated with increased risk of coronary eventsIsabel Goncalves
Experimental Cardiovascular Research Unit, Department of Clinical Sciences, Lund University, Malmo, Sweden Department of Cardiology, Skane University Hospital, Malmo, Sweden
Open Heart 3:e000353. 2016..Matrix metalloproteinases have been shown to be markers for cardiovascular disease whereas the members of the cathepsin protease family are less studied...
- High Plasma Levels of Galectin-3 Are Associated with Increased Risk for Stroke after Carotid EndarterectomyAndreas Edsfeldt
Department of Clinical Sciences Malmx00F6, Lund University, Lund, Sweden
Cerebrovasc Dis 41:199-203. 2016..The aim of this study was to investigate whether Gal-3 could be used as a marker to predict postoperative cerebrovascular ischemic events among patients who underwent carotid endarterectomy (CEA)...
- Increased aldehyde-modification of collagen type IV in symptomatic plaques--a possible cause of endothelial dysfunctionPontus Dunér
Experimental Cardiovascular Research Unit, Clinical Research Center, Department of Clinical Sciences, Lund University, Skane University Hospital, Malmo, Sweden Electronic address
Atherosclerosis 240:26-32. 2015..We have investigated if aldehyde-modification of collagen type IV, one of the major basement membrane components, in plaques is associated with cardiovascular events...
- Immunization of apoE-/- mice with aldehyde-modified fibronectin inhibits the development of atherosclerosisPontus Dunér
Department of Clinical Sciences, Skane University Hospital, Lund University, Malmo, Sweden
Cardiovasc Res 91:528-36. 2011..To determine the functional role of these immune responses in atherosclerosis, we performed studies in which apoE-deficient mice were immunized with MDA-modified fibronectin...
- Low Levels of IgM Antibodies against an Advanced Glycation Endproduct-Modified Apolipoprotein B100 Peptide Predict Cardiovascular Events in Nondiabetic SubjectsDaniel Engelbertsen
Department of Clinical Sciences, Malmo, Faculty of Medicine, Lund University, Skane University Hospital, 205 02 Malmo, Sweden and
J Immunol 195:3020-5. 2015..These data show that subjects with low levels of IgM recognizing MGO-modified p220 in apoB have an increased risk to develop cardiovascular events and that this association is present in nondiabetic subjects...
- Human Carotid Plaques With High Levels of Interleukin-16 Are Associated With Reduced Risk for Cardiovascular EventsCaitriona Grönberg
From the Department of Clinical Sciences C G, E B, G N F, M N, A P, L A, J N, I G, H B and Vascular Centre Malmö Lund G A, Skane University Hospital, Malmo, Lund University, Lund, Sweden
Stroke 46:2748-54. 2015....
- High plasma levels of heparin-binding epidermal growth factor are associated with a more stable plaque phenotype and reduced incidence of coronary eventsSara Rattik
From the Department of Clinical Sciences Malmö, Lund University, Malmo, Sweden S R, M W, H B, G N F, B H, E B, A s, A E, P D, H G, I G, J N Department of Cardiology Coronary diseases, Skane University Hospital, Malmo, Sweden A S, A E, I G and Department of Medical Sciences, Clinical Chemistry and Science for Life Laboratory, Uppsala University, Uppsala, Sweden A S
Arterioscler Thromb Vasc Biol 35:222-8. 2015....
- IL-25 inhibits atherosclerosis development in apolipoprotein E deficient micePolyxeni T Mantani
Department of Clinical Sciences, Skåne University Hospital Malmö, Lund University, Malmo, Sweden
PLoS ONE 10:e0117255. 2015..Recent studies have identified the novel innate lymphoid type 2 cells (ILC2s) as an IL-25 target cell population. The purpose of this study was to evaluate if IL-25 has any influence on atherosclerosis development in mice...
- Tumor necrosis factor-alpha does not mediate diabetes-induced vascular inflammation in miceJenny Nilsson-Ohman
Department of Clinical Sciences, Malmo University Hospital, Malmo, Sweden
Arterioscler Thromb Vasc Biol 29:1465-70. 2009..In the present study we evaluated the role of TNF alpha in streptozotocin (STZ)-induced diabetes on vascular inflammation in C57BL/6 wild-type and apoE-/- mice...
- Associations Between Macrophage Colony-Stimulating Factor and Monocyte Chemotactic Protein 1 in Plasma and First-Time Coronary Events: A Nested Case-Control StudyAlexandru Schiopu
Department of Clinical Sciences Malmo, Lund University, Sweden Cardiology Unit, Skane University Hospital, Malmo, Sweden
J Am Heart Assoc 5:. 2016..We investigated the associations between the plasma levels of growth factors and chemokines that regulate myeloid cell homeostasis and function and the risk of first-time acute coronary events in middle-aged persons...
- Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 DiabetesIsabel Goncalves
From the Department of Clinical Sciences Malmö, Lund University, Malmo, Sweden I G, E B, A E, P D, G N F, H B, G O, M P, J N Medical Research Institute, University of Dundee, Dundee, UK H M C, F K, H C L, F A, J B Institute of Biomedical and Clinical Science, Diabetes and Vascular Medicine, NIHR Exeter Clinical Research Facility and University of Exeter Medical School, Exeter, UK A C S, K A, F C, K G, D S Department of Clinical and Experimental Medicine A N, S P, E V and Department of Surgical, Medical, Molecular and Critical Area Pathology C P, M K, University of Pisa, Pisa, Italy and AstraZeneca
Arterioscler Thromb Vasc Biol 35:1723-31. 2015..The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a particular focus on type 2 diabetes mellitus...
- Atheroprotective effects of Alum are associated with capture of oxidized LDL antigens and activation of regulatory T cellsMaria Wigren
Department of Clinical Sciences, Entrance 72 91 12, Malmo University Hospital, 20502 Malmo, Sweden
Circ Res 104:e62-70. 2009....
- Inflammation and immunity in diabetic vascular complicationsJan Nilsson
Department of Clinical Sciences, Malmo University Hospital, Lund University, Sweden
Curr Opin Lipidol 19:519-24. 2008..The purpose of this review is to discuss possible mechanisms through which diabetes can contribute to a more aggressive atherosclerotic disease process with a particular focus on the role of innate and adaptive immunity...
- Induction of T helper 2 responses against human apolipoprotein B100 does not affect atherosclerosis in ApoE-/- miceDaniel Engelbertsen
Department of Clinical Sciences, Lund University, Malmo University Hospital, CRC 60 13, Jan Waldenströms gata 35, 20502 Malmo, Sweden
Cardiovasc Res 103:304-12. 2014..However, the role of antigen-specific T helper 2 (Th2) responses in atherosclerosis remains to be fully clarified...
- Dystrophin deficiency reduces atherosclerotic plaque development in ApoE-null miceAnnelie Shami
Department of Experimental Medical Science, Lund University, Lund, Sweden
Sci Rep 5:13904. 2015..The present study is the first to demonstrate a role for dystrophin in atherosclerosis and unexpectedly shows that this primarily involves immune cells. ..
- Inhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic miceAnna V Zetterqvist
Department of Clinical Sciences in Malmo, Lund University, Malmo, Sweden
PLoS ONE 8:e65020. 2014..Here we investigate whether NFAT activation may be a link between diabetes and atherogenesis...
- Elastin- and collagen-rich human carotid plaques have increased levels of the cysteine protease inhibitor cystatin CIsabel Goncalves
Department of Clinical Sciences, Experimental Cardiovascular Research Unit, Lund University, Malmo University Hospital, Malmo, Sweden
J Vasc Res 45:395-401. 2008..In this study we analyzed the associations between human carotid plaque cystatin C expression and the plaque content of collagen and elastin...
- Impaired fibrous repair: a possible contributor to atherosclerotic plaque vulnerability in patients with type II diabetesAndreas Edsfeldt
From the Experimental Cardiovascular Research Unit A E, I G, H G, M N, P D, E B, A P, M N, H B, J N and Department of Clinical Sciences I G M, M O M, O M, Clinical Research Center, Clinical Sciences, Lund University, Malmo, Sweden and Department of Cardiology Coronary Diseases, Skane University Hospital, Malmo, Sweden A E, I G, H G, A P, M N
Arterioscler Thromb Vasc Biol 34:2143-50. 2014..Inflammation has been proposed as the main cause for the high risk of atherosclerotic disease in DM II. In this study, we compared markers of inflammation and fibrous repair in plaques from subjects with and without DM II...
- The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchorEva Bengtsson
Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, SE 221 84 Lund, Sweden
J Biol Chem 277:15061-8. 2002..Based on the location of PRELP and its interaction with perlecan heparan sulfate chains and collagen, we propose a function of PRELP as a molecule anchoring basement membranes to the underlying connective tissue...
- Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout miceLena Brånén
Department of Medicine, University Hospital MAS, Experimental Cardiovascular Research, Wallenberg Laboratory, Ing 46, Plan 1, S 205 02 Malmo, Sweden
Arterioscler Thromb Vasc Biol 24:2137-42. 2004..The aim of the study was to evaluate the importance of TNF-alpha in atherogenesis...