Lund University

Summary

Organization: Lund University
Country: Sweden

Top Publications

  1. ncbi Satellite cells of dorsal root ganglia are multipotential glial precursors
    Asa Fex Svenningsen
    The Montreal Neurological Institute of McGill University, 3801 University Street, Montreal, Quebec H3A 2B4
    Neuron Glia Biol 1:85-93. 2004
  2. ncbi Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cells
    N Wierup
    Department of Physiological Science, Lund University, Lund, Sweden
    J Histochem Cytochem 52:301-10. 2004
  3. ncbi Neuronal differentiation following transplantation of expanded mouse neurosphere cultures derived from different embryonic forebrain regions
    Cecilia Eriksson
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Lund, Sweden
    Exp Neurol 184:615-35. 2003
  4. ncbi Smooth, slow and smart muscle motors
    Anders Arner
    Department of Physiological Sciences, Medical Faculty, Lund University, BMC F11, Tornavagen 10, SE 221 84 Lund, Sweden
    J Muscle Res Cell Motil 24:165-73. 2003
  5. ncbi Cocaine- and amphetamine-regulated transcript: distribution and function in rat gastrointestinal tract
    E Ekblad
    Department of Physiological Sciences, BMC F10, Lund University, Lund, Sweden
    Neurogastroenterol Motil 15:545-57. 2003
  6. ncbi Inhibition of Rho kinase decreases hydraulic and protein microvascular permeability in cat skeletal muscle
    C Lundblad
    Department of Physiological Sciences, University of Lund, Sweden
    Microvasc Res 66:126-33. 2003
  7. ncbi A transplantation study of expanded human embryonic forebrain precursors: evidence for selection of a specific progenitor population
    Malin Parmar
    Wallenberg Neuroscience Center, BMC A11, Section of Neurobiology, Lund University, SE 221 84 Lund, Sweden
    Mol Cell Neurosci 23:531-43. 2003
  8. ncbi Developmental learning in a pain-related system: evidence for a cross-modality mechanism
    Alexandra Waldenström
    Section of Neurophysiology, Department for Physiological Sciences, Lund University, S 221 84 Lund, Sweden
    J Neurosci 23:7719-25. 2003
  9. ncbi Parallel fiber receptive fields: a key to understanding cerebellar operation and learning
    Carl Fredrik Ekerot
    Department of Physiological Sciences, Section for Neurophysiology, Lund University, Sweden
    Cerebellum 2:101-9. 2003
  10. ncbi Optimized reporter gene assays based on a synthetic multifunctional promoter and a secreted luciferase
    Knut Kotarsky
    Division of Molecular Neurobiology, Wallenberg Neuroscience Center, Lund University, Sweden
    Anal Biochem 316:208-15. 2003

Scientific Experts

Detail Information

Publications62

  1. ncbi Satellite cells of dorsal root ganglia are multipotential glial precursors
    Asa Fex Svenningsen
    The Montreal Neurological Institute of McGill University, 3801 University Street, Montreal, Quebec H3A 2B4
    Neuron Glia Biol 1:85-93. 2004
    ..In sum, it appears that glial fate might be determined over and above the CNS/PNS dichotomy. Last, we suggest that primordial ensheathing cells form the original cell population in which the myelination program first evolved...
  2. ncbi Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cells
    N Wierup
    Department of Physiological Science, Lund University, Lund, Sweden
    J Histochem Cytochem 52:301-10. 2004
    ..We conclude that ghrelin is expressed in a novel developmentally regulated endocrine islet cell type in the rat pancreas and that ghrelin inhibits glucose-stimulated insulin secretion via a direct effect on the beta-cell...
  3. ncbi Neuronal differentiation following transplantation of expanded mouse neurosphere cultures derived from different embryonic forebrain regions
    Cecilia Eriksson
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Lund, Sweden
    Exp Neurol 184:615-35. 2003
    ....
  4. ncbi Smooth, slow and smart muscle motors
    Anders Arner
    Department of Physiological Sciences, Medical Faculty, Lund University, BMC F11, Tornavagen 10, SE 221 84 Lund, Sweden
    J Muscle Res Cell Motil 24:165-73. 2003
    ..Non-muscle myosin has been shown to have a contractile function in some smooth muscle tissues and recent data on the kinetic properties of non-muscle myosin filaments in smooth muscle tissue are described...
  5. ncbi Cocaine- and amphetamine-regulated transcript: distribution and function in rat gastrointestinal tract
    E Ekblad
    Department of Physiological Sciences, BMC F10, Lund University, Lund, Sweden
    Neurogastroenterol Motil 15:545-57. 2003
    ..It may, moreover, be involved in intestinal adaptation, and an additional hormonal role is also possible...
  6. ncbi Inhibition of Rho kinase decreases hydraulic and protein microvascular permeability in cat skeletal muscle
    C Lundblad
    Department of Physiological Sciences, University of Lund, Sweden
    Microvasc Res 66:126-33. 2003
    ..We conclude that hydraulic and protein microvascular permeability increase by Rho kinase activation, and that Rho kinase is involved in regulation of microvascular permeability...
  7. ncbi A transplantation study of expanded human embryonic forebrain precursors: evidence for selection of a specific progenitor population
    Malin Parmar
    Wallenberg Neuroscience Center, BMC A11, Section of Neurobiology, Lund University, SE 221 84 Lund, Sweden
    Mol Cell Neurosci 23:531-43. 2003
    ..However, the human LGE cells do not migrate or undergo region-specific differentiation when placed outside the SVZ and RMS...
  8. ncbi Developmental learning in a pain-related system: evidence for a cross-modality mechanism
    Alexandra Waldenström
    Section of Neurophysiology, Department for Physiological Sciences, Lund University, S 221 84 Lund, Sweden
    J Neurosci 23:7719-25. 2003
    ..These findings provide a key to the puzzle of how pain-related systems can be functionally adapted through experience despite the rare occurrence of noxious input during early life...
  9. ncbi Parallel fiber receptive fields: a key to understanding cerebellar operation and learning
    Carl Fredrik Ekerot
    Department of Physiological Sciences, Section for Neurophysiology, Lund University, Sweden
    Cerebellum 2:101-9. 2003
    ..The present review, which focuses on the C3 zone of the cerebellar anterior lobe, will present and discuss recent data of the cutaneous PF input to Purkinje cells, interneurons and Golgi cells as well as novel forms of PF plasticity...
  10. ncbi Optimized reporter gene assays based on a synthetic multifunctional promoter and a secreted luciferase
    Knut Kotarsky
    Division of Molecular Neurobiology, Wallenberg Neuroscience Center, Lund University, Sweden
    Anal Biochem 316:208-15. 2003
    ..This procedure economizes cell handling and at the same time increases assay quality and sensitivity..
  11. ncbi Mechanisms of exocytosis in insulin-secreting B-cells and glucagon-secreting A-cells
    Sebastian Barg
    Department of Physiological Sciences, Molecular and Cellular Physiology, Lund University, Solvegatan 19, BMC F11, S 221 84 Lund, Sweden
    Pharmacol Toxicol 92:3-13. 2003
    ....
  12. ncbi Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids
    Niclas E Nilsson
    Division of Molecular Neurobiology, Wallenberg Neuroscience Center, BMC A12, SE 221 84 Lund, Sweden
    Biochem Biophys Res Commun 303:1047-52. 2003
    ..We suggest the designation FFA(2)R to this second receptor activated by free fatty acids. The first-described FFAR, now named FFA(1)R, is activated by medium- to long-chain free fatty acids...
  13. ncbi Modular organisation and spinal somatosensory imprinting
    Jens Schouenborg
    Department of Physiological Sciences, Lund University, Tornavagen 10, BMC F10, 221 84, Lund, Sweden
    Brain Res Brain Res Rev 40:80-91. 2002
    ..These findings and their implications for the understanding of higher motor functions as well as clinical aspects will be discussed...
  14. ncbi Animal models of neurological deficits: how relevant is the rat?
    M Angela Cenci
    Wallenberg Neuroscience Centre, Neurobiology Division, University of Lund, BMC A11, S 221 84 Lund, Sweden
    Nat Rev Neurosci 3:574-9. 2002
    ..Studies in rodents that emphasize careful behavioural analysis should continue to be developed as effective and inexpensive models that complement studies in primates...
  15. ncbi Properties of an adult spinal sensorimotor circuit shaped through early postnatal experience
    Per Petersson
    Section for Neurophysiology, Department of Physiological, University of Lund, Sweden
    J Neurophysiol 92:280-8. 2004
    ..It is suggested that after normal postnatal experience-dependent adaptation, the number of connections from a given skin site onto the reflex encoding interneurons is a major determinant of the difference in gain...
  16. ncbi Transvascular passage of macromolecules into the peritoneal cavity of normo- and hypothermic rats in vivo: active or passive transport?
    Bert Inge Rosengren
    Department of Nephrology and Department of Physiological Sciences, Lund University, Lund, Sweden
    J Vasc Res 41:123-30. 2004
    ..In conclusion, the good correlation of predicted to calculated changes suggests that the overall transendothelial macromolecular passage in vivo occurs passively, and not due to active processes...
  17. ncbi Vasopeptidase inhibition with omapatrilat increases fluid and protein microvascular permeability in cat skeletal muscle
    Johan Persson
    Department of Physiological Sciences, University of Lund and University Hospital of Lund, Lund, Sweden
    J Hypertens 22:637-44. 2004
    ....
  18. ncbi Different basal levels of CaMKII phosphorylated at Thr286/287 at nociceptive and low-threshold primary afferent synapses
    Max Larsson
    Department of Experimental Medical Science, Division of Neuroscience, Lund University, BMC F10, SE 221 84 Lund, Sweden
    Eur J Neurosci 21:2445-58. 2005
    ..Furthermore, pCaMKII appears to be differentially regulated between high- and low-threshold primary afferent synapses, possibly reflecting different susceptibility to synaptic plasticity between these afferent pathways...
  19. ncbi Lentiviral gene delivery of GDNF into the striatum of R6/2 Huntington mice fails to attenuate behavioral and neuropathological changes
    Natalija Popovic
    Section for Neuronal Survival, Division of Neurobiology, Department of Physiological Sciences, Wallenberg Neuroscience Center, Lund University, BMC A10, Sweden
    Exp Neurol 193:65-74. 2005
    ..Further studies are, however, needed to investigate if GDNF given at earlier time points is beneficial...
  20. ncbi Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat beta-cells
    Patrick E MacDonald
    Section of Diabetes, Metabolism and Endocrinology, Lund University, Lund, Sweden
    Diabetes 54:736-43. 2005
    ..Our observations support a role for beta-cell SLMVs in a synaptic-like function of rapid intra-islet signaling...
  21. ncbi Learning in sensorimotor circuits
    Jens Schouenborg
    University of Lund, Section for Neurophysiology, Department of Physiological Sciences, BMC F10, 221 84 Lund, Sweden
    Curr Opin Neurobiol 14:693-7. 2004
    ..This experience-dependent signal adapts the circuitry in the sensorimotor module to the body anatomy and biomechanics...
  22. ncbi Acute peritoneal dialysis in rats results in a marked reduction of interstitial colloid osmotic pressure
    Bert Inge Rosengren
    Department of Nephrology, University Hospital of Lund, S 221 85 Lund, Sweden
    J Am Soc Nephrol 15:3111-6. 2004
    ..It is speculated that the increase in peritoneal hydrostatic pressure after PD causes an increase in interstitial tissue volume, with primarily a dilution of interstitial colloids...
  23. pmc Bradykinin specificity and signaling at GPR100 and B2 kinin receptors
    L M Fredrik Leeb-Lundberg
    Department of Physiological Sciences, Lund University, SE 22184 Lund, Sweden
    Br J Pharmacol 143:931-2. 2004
  24. ncbi The permeability-reducing effects of prostacyclin and inhibition of Rho kinase do not counteract endotoxin-induced increase in permeability in cat skeletal muscle
    Cornelia Lundblad
    Department of Physiology, University of Lund, Sweden
    Microvasc Res 68:286-94. 2004
    ..We conclude that cAMP stimulation and Rho kinase inhibition reduce permeability by other pathways and mechanisms than those by which permeability is increased during endotoxemia...
  25. pmc Incidence of "quasi-ditags" in catalogs generated by Serial Analysis of Gene Expression (SAGE)
    Sergey V Anisimov
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, 221 84 Lund, Sweden
    BMC Bioinformatics 5:152. 2004
    ..The analysis of SAGE libraries relies on the identification of ditags from sequencing files; however, the software used to examine SAGE libraries cannot distinguish between authentic versus false ditags ("quasi-ditags")...
  26. ncbi Allergen exposure of mouse airways evokes remodeling of both bronchi and large pulmonary vessels
    Kristina Rydell Törmänen
    Department of Physiological Sciences, BMC F10, Lund University, 221 84 Lund, Sweden
    Am J Respir Crit Care Med 171:19-25. 2005
    ..The significance of this finding with respect to occurrence in disease, pathophysiologic importance, and involved mechanisms warrants further investigation...
  27. ncbi Genetic aspects of melatonin biology
    Sergey V Anisimov
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Lund, Sweden
    Rev Neurosci 15:209-30. 2004
    ....
  28. ncbi Stem cell therapy for Parkinson's disease: where do we stand?
    Laurent Roybon
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, BMC A10, 22184 Lund, Sweden
    Cell Tissue Res 318:261-73. 2004
    ....
  29. ncbi A mouse model for evaluation of capillary perfusion, microvascular permeability, cortical blood flow, and cortical edema in the traumatized brain
    C Lundblad
    Department of Physiological Sciences, University of Lund and Lund University Hospital, Lund, Sweden
    J Neurotrauma 21:741-53. 2004
    ..The CCI in mouse is likely to be a useful tool to elucidate mechanisms involved in hemodynamic alterations following brain trauma...
  30. pmc GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin
    Matthias Braun
    Department of Physiological Sciences, BMC B11, SE 221 84 Lund, Sweden
    J Physiol 559:397-409. 2004
    ..These data indicate that GABA released from beta-cells functions as an autocrine inhibitor of insulin secretion in pancreatic islets and that the effect is principally due to direct suppression of exocytosis...
  31. ncbi Reciprocal bidirectional plasticity of parallel fiber receptive fields in cerebellar Purkinje cells and their afferent interneurons
    Henrik Jörntell
    Department of Physiological Sciences, Section for Neurophysiology, Lund University, The Biomedical Center F10, Tornavagen 10, SE 221 84, Sweden
    Neuron 34:797-806. 2002
    ..These properties, and the fact the mossy fiber receptive fields were unchanged, suggest that the receptive field changes were due to bidirectional PF synaptic plasticity in Purkinje cells and interneurons...
  32. pmc Common principles of sensory encoding in spinal reflex modules and cerebellar climbing fibres
    Martin Garwicz
    Section for Neurophysiology, Department of Physiological Sciences, Lund University, Sweden
    J Physiol 540:1061-9. 2002
    ..This suggests that an individual climbing fibre signals cutaneous sensory events reflecting activity of a single muscle conditional upon the functional state of the muscle itself and that of functionally related muscles...
  33. ncbi Patterns of cell death and dopaminergic neuron survival in intrastriatal nigral grafts
    M Emgard
    Department of Physiological Sciences, Lund University, Sweden
    Exp Neurol 160:279-88. 1999
    ....
  34. ncbi Short-lasting conditioned stimulus applied to the middle cerebellar peduncle elicits delayed conditioned eye blink responses in the decerebrate ferret
    P Svensson
    Section for Neurophysiology, Department of Physiological Sciences, Lund, Sweden
    Eur J Neurosci 11:4333-40. 1999
    ..It is suggested that neurons maintaining such activity are located in the cerebellum, either the cortex alone or the cortex and the deep nuclei...
  35. ncbi Developmental tuning in a spinal nociceptive system: effects of neonatal spinalization
    A Levinsson
    Department of Physiological Sciences, Section for Neurophysiology, Lund University, S 223 62 Lund, Sweden
    J Neurosci 19:10397-403. 1999
    ..It is concluded that withdrawal reflexes do not become functionally adapted in rats spinalized at birth. These findings suggest a critical role for supraspinal systems in the postnatal tuning of spinal nociceptive systems...
  36. ncbi Discordant xenografts: different outcome after mouse and rat neural tissue transplantation to guinea-pigs
    L C Larsson
    Department of Physiological Sciences, Wallenberg Neuroscience Center, Lund University, Sweden
    Brain Res Bull 49:367-76. 1999
    ..The factors responsible for the divergent graft outcomes between the two combinations might provide clues on how to manipulate xenogeneic tissue to increase survival rates in the future...
  37. pmc Kinetics of contraction in depolarized smooth muscle from guinea-pig taenia coli after photodestruction of nifedipine
    U Malmqvist
    Department of Physiology and Neuroscience, University of Lund, Sweden
    J Physiol 519:213-21. 1999
    ..The delay was similar at low and high extracellular [CaCl2] indicating that buffering by superficial sarcoplasmatic reticulum does not introduce a delay in force development following activation of Ca2+ channels in this muscle...
  38. pmc Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity
    O Hansson
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Solvegatan 17, S 223 62 Lund, Sweden
    Proc Natl Acad Sci U S A 96:8727-32. 1999
    ..We propose that the presence of exon 1 of the mutant HD gene induces profound changes in striatal neurons that render these cells resistant to excessive NMDA receptor activation...
  39. ncbi Role of prostacyclin and nitric oxide in regulation of basal microvascular hydraulic permeability in cat skeletal muscle
    A D Möller
    Department of Physiological Sciences, University and University Hospital of Lund, Sweden
    J Vasc Res 36:245-52. 1999
    ..Physiological beta2 stimulation has no effect on basal hydraulic permeability. The permeability-reducing effects of prostacyclin and NO are additive. NO, but not prostacyclin, is involved in regulation of basal vascular tone...
  40. ncbi Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle
    C Rosenblad
    Department of Physiology and Neuroscience, Wallenberg Neuroscience Center, Lund University, Sweden
    Eur J Neurosci 11:1554-66. 1999
    ..The lower efficacy of NTN after IS, and particularly ICV, administration may be explained by the poor solubility and diffusion properties at neutral pH...
  41. ncbi Evidence that neuroepithelial endocrine cells control the spontaneous tone in guinea pig tracheal preparations
    S Skogvall
    Department of Physiology and Neuroscience, Lund University, S 223 62 Lund, Sweden
    J Appl Physiol (1985) 86:789-98. 1999
    ..The results also suggest that the regulation by the NEE cells involves the release of powerful relaxing and contracting factors from the epithelium...
  42. ncbi Properties of electrolyte-filled glass microelectrodes: an experimental study
    C Fåhraeus
    Department of Physiology and Neuroscience, University of Lund, Sweden
    J Neurosci Methods 78:15-28. 1997
    ..Together, the observed electrode properties are consistent with the electrode electrolyte's solute and solvent turnover being governed by electro-osmotic as well as by electrodiffusion laws...
  43. ncbi Sagittal zonal organization of climbing fibre input to the cerebellar anterior lobe of the ferret
    M Garwicz
    Department of Physiology and Neuroscience, Sölveg, Lund, Sweden
    Exp Brain Res 117:389-98. 1997
    ..The findings thus provide evidence of cross-species generality of cerebellar sagittal organization...
  44. pmc Bilateral disruption of conditioned responses after unilateral blockade of cerebellar output in the decerebrate ferret
    M Ivarsson
    Department of Physiology and Neuroscience, Lund University, Sweden
    J Physiol 502:189-201. 1997
    ....
  45. pmc Developmental adaptation of withdrawal reflexes to early alteration of peripheral innervation in the rat
    H Holmberg
    Department of Physiology and Neuroscience, University of Lund, Sweden
    J Physiol 495:399-409. 1996
    ..An experience-dependent mechanism is suggested to be instrumental in adapting the reflex connectivity to the peripheral innervation...
  46. ncbi Alteration of PACAP distribution and PACAP receptor binding in the rat sensory nervous system following sciatic nerve transection
    H Jongsma
    Department of Physiological Sciences, Section for Neuroendocrine Cell Biology, Bldg EA 5, Lund University Hospital, S 221 85, Lund, Sweden
    Brain Res 853:186-96. 2000
    ..Very few DRG nerve cell bodies contained PAC(1) mRNA. The findings are consistent with a role for PACAP both in nociception and regeneration...
  47. ncbi In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin
    C Rosenblad
    Wallenberg Neuroscience Center, Lund University, Solvegatan 17, Lund, S 223 62, Sweden
    Mol Cell Neurosci 15:199-214. 2000
    ..We conclude that NBN/ART, similarly to GDNF, is a potent neuroprotective factor for the nigrostriatal DA neurons in vivo...
  48. ncbi Oxidative stress, mitochondrial permeability transition and activation of caspases in calcium ionophore A23187-induced death of cultured striatal neurons
    A Petersen
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Department of Physiological Sciences, Solvegatan 17, S 223 62, Lund, Sweden
    Brain Res 857:20-9. 2000
    ..These results suggest that oxidative stress, opening of the mitochondrial permeability transition pore and activation of caspases are important steps in A23187-induced cell death...
  49. ncbi Stem cells: hype or hope?
    Gesine Paul
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, BMC A10, 221 84 Lund, Sweden
    Drug Discov Today 7:295-302. 2002
    ..The new options raise several fundamental ethical issues. This review gives an overview of the scientific basis underlying the hope generated by stem cell research and discusses current ethical and funding regulations...
  50. ncbi Sulfonylurea-mediated stimulation of insulin exocytosis via an ATP-sensitive K+ channel-independent action
    Erik Renstrom
    Department of Molecular and Cellular Physiology, Institute of Physiology, Lund University, Lund, Sweden
    Diabetes 51:S33-6. 2002
    ..Here we discuss the possibility that modulation of granule ClC-3 channels represents the mechanism whereby sulfonylureas directly potentiate the beta-cell exocytotic machinery...
  51. ncbi Lung tissue eosinophils may be cleared through luminal entry rather than apoptosis: effects of steroid treatment
    L Uller
    Department of Physiological Sciences, University Hospital, Lund, Sweden
    Am J Respir Crit Care Med 164:1948-56. 2001
    ....
  52. ncbi Porcine neural xenografts in rats and mice: donor tissue development and characteristics of rejection
    L C Larsson
    Section for Neuronal Survival, Department of Physiological Sciences, Wallenburg Neuroscience Center, Lund University, SE 221 84 Lund, Sweden
    Exp Neurol 172:100-14. 2001
    ..CD8(+) lymphocytes and microglia cells are most likely important effector cells in the late, cyclosporin A-resistant rejection process...
  53. ncbi Enhanced survival of porcine neural xenografts in mice lacking CD1d1, but no effect of NK1.1 depletion
    L C Larsson
    Wallenberg Neuroscience Center, Lund University, Sweden
    Cell Transplant 10:295-304. 2001
    ..1+ cells do not seem to be important mediators of the rejection of discordant cellular neural xenografts. However, our results suggest that the antigen-presenting molecule CD1d1 may be involved in the rejection process...
  54. ncbi An imaging system for monitoring receptive field dynamics
    P Petersson
    Section of Neurophysiology, Department of Physiological Sciences, University of Lund, Solvegatan 19, 223 62 Lund, Sweden
    J Neurosci Methods 104:123-31. 2001
    ..The large number of stimulation and registration sites that can be monitored in parallel permits detailed network analysis of synaptic sets, corresponding to 'connection weights' between individual neurones...
  55. ncbi Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model
    A Bjorklund
    Wallenberg Neuroscience Center, Section of Neurobiology, Lund University, Solvegatan 17, S 22362, Lund, Sweden
    Brain Res 886:82-98. 2000
    ....
  56. ncbi Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor
    D Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Solvegatan 17, 223 62 Lund, Sweden
    Eur J Neurosci 12:3871-82. 2000
    ....
  57. ncbi Low-dose prostacyclin in treatment of severe brain trauma evaluated with microdialysis and jugular bulb oxygen measurements
    P O Grande
    Department of Anaesthesia and Intensive Care, University Hospital of Lund, Sweden
    Acta Anaesthesiol Scand 44:886-94. 2000
    ....
  58. ncbi Increased survival of embryonic nigral neurons when grafted to hypothermic rats
    J Karlsson
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Sweden
    Neuroreport 11:1665-8. 2000
    ..These findings may be of importance for clinical neural transplantation trials which are in need of procedures that improve transplant survival...
  59. ncbi Cell replacement therapies for central nervous system disorders
    A Bjorklund
    The authors are at the Wallenberg Neuroscience Center, Lund University, Solvegatan 17, S 223 62 Lund, Sweden
    Nat Neurosci 3:537-44. 2000
    ..Clinical trials in Parkinson's disease suggest that similar approaches may also work in the diseased human brain. But how realistic is it that cell replacement can be developed into effective clinical therapy?..
  60. ncbi Intrastriatal ventral mesencephalic xenografts of porcine tissue in rats: immune responses and functional effects
    L C Larsson
    Department of Physiological Sciences, Wallenberg Neuroscience Center, Lund University, Sweden
    Cell Transplant 9:261-72. 2000
    ..However, to achieve stable graft survival in discordant xenogeneic combinations, an appropriate immunosuppressive treatment or donor tissue modifications are needed...
  61. ncbi Transient expression of a functional serotonin transporter in Merkel cells during late gestation and early postnatal rat development
    S R Hansson
    Unit on Molecular Pharmacology, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, MD 20892, USA
    Exp Brain Res 130:401-9. 2000
    ....
  62. ncbi The mouse genes for the EP1 prostanoid receptor and the PKN protein kinase overlap
    B Båtshake
    Division of Molecular Neurobiology, Wallenberg Neurocentre, Lund University, Sweden
    Biochem Biophys Res Commun 227:70-6. 1996
    ..The 3' part of the PKN gene is highly fragmented and its intron/exon organisation is reminiscent of that of the Drosophila protein kinase C gene. The possibility of a natural antisense regulation of these genes is discussed...