Shao Nian Yang

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Removal of Ca2+ channel beta3 subunit enhances Ca2+ oscillation frequency and insulin exocytosis
    Per Olof Berggren
    The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, S 17176 Stockholm, Sweden
    Cell 119:273-84. 2004
  2. ncbi request reprint Glucose recruits K(ATP) channels via non-insulin-containing dense-core granules
    Shao Nian Yang
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Cell Metab 6:217-28. 2007
  3. doi request reprint Ionic mechanisms in pancreatic β cell signaling
    Shao Nian Yang
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE 171 76, Stockholm, Sweden
    Cell Mol Life Sci 71:4149-77. 2014
  4. pmc Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron
    Shao Nian Yang
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden
    Proc Natl Acad Sci U S A 109:12183-8. 2012
  5. ncbi request reprint The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology
    Shao Nian Yang
    The Rolf Luft Research Center for Diabetes and Endocrinology L1 03, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    Endocr Rev 27:621-76. 2006
  6. pmc Apolipoprotein CIII hyperactivates β cell CaV1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src
    Yue Shi
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE 171 76, Stockholm, Sweden
    Cell Mol Life Sci 71:1289-303. 2014
  7. pmc Transthyretin constitutes a functional component in pancreatic beta-cell stimulus-secretion coupling
    Essam Refai
    Department of Medical Biochemistry and Biophysics, The Rolf Luft Center for Diabetes Research, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 102:17020-5. 2005
  8. ncbi request reprint Growth hormone promotes Ca(2+)-induced Ca2+ release in insulin-secreting cells by ryanodine receptor tyrosine phosphorylation
    Qimin Zhang
    The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Mol Endocrinol 18:1658-69. 2004
  9. doi request reprint CaV1.2 and CaV1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serum
    Guang Yang
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, 171 76, Stockholm, Sweden
    Cell Mol Life Sci 72:1197-207. 2015
  10. ncbi request reprint Cytosolic multiple inositol polyphosphate phosphatase in the regulation of cytoplasmic free Ca2+ concentration
    Jia Yu
    Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, L3, Karolinska Institutet, Karolinska Hospital, Stockholm SE 171 76, Sweden
    J Biol Chem 278:46210-8. 2003

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Removal of Ca2+ channel beta3 subunit enhances Ca2+ oscillation frequency and insulin exocytosis
    Per Olof Berggren
    The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, S 17176 Stockholm, Sweden
    Cell 119:273-84. 2004
    ..Since the increase in insulin release was manifested only at high glucose concentrations, blocking the beta3 subunit in the beta cell may constitute the basis for a novel diabetes therapy...
  2. ncbi request reprint Glucose recruits K(ATP) channels via non-insulin-containing dense-core granules
    Shao Nian Yang
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Cell Metab 6:217-28. 2007
    ..Our data suggest that glucose can recruit K(ATP) channels to the beta cell plasma membrane via non-insulin-containing dense-core granules in a Ca(2+)- and PKA-dependent manner...
  3. doi request reprint Ionic mechanisms in pancreatic β cell signaling
    Shao Nian Yang
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE 171 76, Stockholm, Sweden
    Cell Mol Life Sci 71:4149-77. 2014
    ..This review concisely discusses various ionic mechanisms in β cell signaling and highlights KATP channel-, CaV1 channel- and KV2.1 channel-mediated ion fluxes. ..
  4. pmc Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron
    Shao Nian Yang
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden
    Proc Natl Acad Sci U S A 109:12183-8. 2012
    ..Therefore, elevated InsP(6) in activated neurons serves as a unique negative feedback signal to control hippocampal excitatory neurotransmission...
  5. ncbi request reprint The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology
    Shao Nian Yang
    The Rolf Luft Research Center for Diabetes and Endocrinology L1 03, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    Endocr Rev 27:621-76. 2006
    ..This review summarizes current knowledge of CaV channels in beta-cell physiology and pathophysiology...
  6. pmc Apolipoprotein CIII hyperactivates β cell CaV1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src
    Yue Shi
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE 171 76, Stockholm, Sweden
    Cell Mol Life Sci 71:1289-303. 2014
    ..These data reveal that ApoCIII hyperactivates β cell CaV1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src. ..
  7. pmc Transthyretin constitutes a functional component in pancreatic beta-cell stimulus-secretion coupling
    Essam Refai
    Department of Medical Biochemistry and Biophysics, The Rolf Luft Center for Diabetes Research, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 102:17020-5. 2005
    ..Thus, TTR tetramer constitutes a component in normal beta-cell function. Conversion of TTR tetramer to monomer may be involved in the development of beta-cell failure/destruction in type 1 diabetes...
  8. ncbi request reprint Growth hormone promotes Ca(2+)-induced Ca2+ release in insulin-secreting cells by ryanodine receptor tyrosine phosphorylation
    Qimin Zhang
    The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Mol Endocrinol 18:1658-69. 2004
    ..This process is mediated by tyrosine phosphorylation of ryanodine receptors and may play a crucial role in physiological Ca2+ handling in insulin-secreting cells...
  9. doi request reprint CaV1.2 and CaV1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serum
    Guang Yang
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, 171 76, Stockholm, Sweden
    Cell Mol Life Sci 72:1197-207. 2015
    ..These data demonstrate that T1D serum hyperactivates both CaV1.2 and CaV1.3 channels by increasing their conductivity and number. These findings suggest CaV1.2 and CaV1.3 channels as potential targets for anti-diabetes therapy. ..
  10. ncbi request reprint Cytosolic multiple inositol polyphosphate phosphatase in the regulation of cytoplasmic free Ca2+ concentration
    Jia Yu
    Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, L3, Karolinska Institutet, Karolinska Hospital, Stockholm SE 171 76, Sweden
    J Biol Chem 278:46210-8. 2003
    ....
  11. pmc CaV2.3 channel and PKClambda: new players in insulin secretion
    Shao Nian Yang
    The Rolf Luft Center for Diabetes Research, Karolinska Diabetes Center, Department of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Clin Invest 115:16-20. 2005
    ....
  12. ncbi request reprint Beta-cell CaV channel regulation in physiology and pathophysiology
    Shao Nian Yang
    The Rolf Luft Center for Diabetes Research, Karolinska Diabetes Center, Department of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Am J Physiol Endocrinol Metab 288:E16-28. 2005
    ..This minireview highlights characteristic features of customary mechanisms of CaV channel regulation in beta-cells and also reviews our studies on newly identified mechanisms of beta-cell CaV channel regulation...
  13. pmc Apolipoprotein CIII promotes Ca2+-dependent beta cell death in type 1 diabetes
    Lisa Juntti-Berggren
    Department of Molecular Medicine, Rolf Luft Center for Diabetes Research, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 101:10090-4. 2004
    ..Increased serum levels of apoCIII can thus account for the increase in beta cell [Ca(2+)](i) and thereby beta cell apoptosis associated with T1D...
  14. ncbi request reprint Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells
    Christopher Illies
    Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE 171 76, Stockholm, Sweden
    Science 318:1299-302. 2007
    ..Maintenance of high concentrations of IP7 in the pancreatic beta cell may enhance the immediate exocytotic capacity and consequently allow rapid adjustment of insulin secretion in response to increased demand...
  15. doi request reprint Differential regulation of mouse pancreatic islet insulin secretion and Smad proteins by activin ligands
    Haiya Wu
    Department of Neuroscience, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Berzelius vag 35, B3 Box 285, SE 171 77, Stockholm, Sweden
    Diabetologia 57:148-56. 2014
    ..Activins A and B signal through a common set of intracellular components, but it is unclear whether they display similar or distinct functions in glucose homeostasis...
  16. doi request reprint Akt signals upstream of L-type calcium channels to optimize insulin secretion
    Xiuli Cui
    Endocrinology and Metabolic Diseases Laboratory, Tianjin Medical University, Tianjin, China
    Pancreas 41:15-21. 2012
    ..Akt recruits the L-type calcium channel to and maintains them in the plasma membrane. This study aimed to characterize the role of L-type calcium channels in mediation of Akt signaling in glucose-stimulated insulin secretion...
  17. ncbi request reprint Modulation of L-type Ca(2+) channels by distinct domains within SNAP-25
    Junzhi Ji
    Department of Medicine, University of Toronto, Toronto, Canada
    Diabetes 51:1425-36. 2002
    ..The present study suggests that distinct domains within SNAP-25 modulate L(C) subtype Ca(2+) channel activity in both primary beta-cells and insulinoma HIT-T15 cells...
  18. ncbi request reprint Suppression of beta cell energy metabolism and insulin release by PGC-1alpha
    J Cliff Yoon
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA
    Dev Cell 5:73-83. 2003
    ..These results strongly suggest that PGC-1alpha plays a key functional role in the beta cell and is involved in the pathogenesis of the diabetic phenotype...
  19. pmc Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells
    Hervør L Olsen
    Islet Cell Physiology, Novo Nordisk AS, Novo Alle, DK 2880 Bagsvaerd, Denmark
    Proc Natl Acad Sci U S A 100:5187-92. 2003
    ..We conclude that ADP-induced changes in PI 4-kinase activity, via generation of PI(4,5)P(2), represents a metabolic sensor in the beta cell by virtue of its capacity to regulate the release competence of the secretory granules...