Karin Wirdefeldt

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi request reprint Epidemiology and etiology of Parkinson's disease: a review of the evidence
    Karin Wirdefeldt
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Eur J Epidemiol 26:S1-58. 2011
  2. pmc Complete ascertainment of Parkinson disease in the Swedish Twin Registry
    Karin Wirdefeldt
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Neurobiol Aging 29:1765-73. 2008
  3. pmc Heritability of Parkinson disease in Swedish twins: a longitudinal study
    Karin Wirdefeldt
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Neurobiol Aging 32:1923.e1-8. 2011
  4. pmc Accuracy and sensitivity of Parkinsonian disorder diagnoses in two Swedish national health registers
    Adina L Feldman
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Neuroepidemiology 38:186-93. 2012
  5. doi request reprint Evidence for modest familial co-aggregation between dementia and parkinsonism
    Adina L Feldman
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 17177, Stockholm, Sweden
    Eur J Epidemiol 29:49-56. 2014
  6. ncbi request reprint Risk and protective factors for Parkinson's disease: a study in Swedish twins
    Karin Wirdefeldt
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 181 77 Stockholm, Sweden
    Ann Neurol 57:27-33. 2005
  7. pmc Personality traits and the risk for Parkinson disease: a prospective study
    Johanna Sieurin
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, 171 77, Stockholm, Sweden
    Eur J Epidemiol 31:169-75. 2016
  8. ncbi request reprint No evidence for heritability of Parkinson disease in Swedish twins
    Karin Wirdefeldt
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Neurology 63:305-11. 2004
  9. doi request reprint Amyotrophic lateral sclerosis and cancer: a register-based study in Sweden
    Fang Fang
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    Amyotroph Lateral Scler Frontotemporal Degener 14:362-8. 2013
  10. doi request reprint Head injury and Parkinson's disease: a population-based study
    Fang Fang
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Mov Disord 27:1632-5. 2012

Detail Information

Publications20

  1. doi request reprint Epidemiology and etiology of Parkinson's disease: a review of the evidence
    Karin Wirdefeldt
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Eur J Epidemiol 26:S1-58. 2011
    ..Future epidemiologic studies of PD should be large, include detailed quantifications of exposure, and collect information on environmental exposures as well as genetic polymorphisms...
  2. pmc Complete ascertainment of Parkinson disease in the Swedish Twin Registry
    Karin Wirdefeldt
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Neurobiol Aging 29:1765-73. 2008
    ..Overall prevalence rate for PD was 496 per 100,000 individuals. Among the 132 PD cases identified, there were only three concordant twin pairs. In total 7.2% of PD cases reported a first degree relative with PD...
  3. pmc Heritability of Parkinson disease in Swedish twins: a longitudinal study
    Karin Wirdefeldt
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Neurobiol Aging 32:1923.e1-8. 2011
    ..Concordance rates for PD or parkinsonism were somewhat higher but the heritability estimate was nonsignificant. Our longitudinal analyses demonstrate that PD and parkinsonism are modestly heritable...
  4. pmc Accuracy and sensitivity of Parkinsonian disorder diagnoses in two Swedish national health registers
    Adina L Feldman
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Neuroepidemiology 38:186-93. 2012
    ..Swedish population-based national health registers are widely used data sources in epidemiological research. Register-based diagnoses of Parkinson's disease have not been validated against clinical information...
  5. doi request reprint Evidence for modest familial co-aggregation between dementia and parkinsonism
    Adina L Feldman
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 17177, Stockholm, Sweden
    Eur J Epidemiol 29:49-56. 2014
    ..Thus, co-occurrence of dementia and parkinsonism is not primarily caused by shared familial risk between AD and PD...
  6. ncbi request reprint Risk and protective factors for Parkinson's disease: a study in Swedish twins
    Karin Wirdefeldt
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 181 77 Stockholm, Sweden
    Ann Neurol 57:27-33. 2005
    ..We confirm the protective effect of smoking on Parkinson's disease and establish that the association is only partially explained by genetic and familial environmental factors...
  7. pmc Personality traits and the risk for Parkinson disease: a prospective study
    Johanna Sieurin
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, 171 77, Stockholm, Sweden
    Eur J Epidemiol 31:169-75. 2016
    ..There was a weak association between introversion and PD and this effect was at least partly mediated through smoking. The observed effects may partly be explained by familial factors shared by twins...
  8. ncbi request reprint No evidence for heritability of Parkinson disease in Swedish twins
    Karin Wirdefeldt
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Neurology 63:305-11. 2004
    ..Although several genes are implicated in Parkinson disease (PD), they explain only a small fraction of cases. The etiology of most cases is yet unknown...
  9. doi request reprint Amyotrophic lateral sclerosis and cancer: a register-based study in Sweden
    Fang Fang
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    Amyotroph Lateral Scler Frontotemporal Degener 14:362-8. 2013
    ..64; 95% CI 0.45-0.88). Our results provide no evidence for comorbidity of cancer and ALS overall. Surveillance biases seem the most likely explanation for the limited associations detected...
  10. doi request reprint Head injury and Parkinson's disease: a population-based study
    Fang Fang
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Mov Disord 27:1632-5. 2012
    ..The epidemiological evidence on head injury and the risk of Parkinson's disease (PD) has been inconsistent...
  11. pmc Socioeconomic status in relation to Parkinson's disease risk and mortality: A population-based prospective study
    Fei Yang
    aDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden bDepartment of Psychology, University of Southern California, Los Angeles, CA, USA cDepartment of Clinical Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    Medicine (Baltimore) 95:e4337. 2016
    ..Lower socioeconomic status was associated with higher all-cause mortality among individuals with and without PD, but such impact was weaker among PD patients. ..
  12. pmc Occupational exposure in parkinsonian disorders: a 43-year prospective cohort study in men
    Adina L Feldman
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Parkinsonism Relat Disord 17:677-82. 2011
    ..Common findings are increased risk associated with pesticide exposure and no association between Parkinson's disease and welding...
  13. ncbi request reprint Moist smokeless tobacco (Snus) use and risk of Parkinson's disease
    Fei Yang
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Int J Epidemiol . 2016
    ..The aim of this study was to determine whether snus use was associated with a lower risk of Parkinson's disease...
  14. doi request reprint Physical activity and risk of Parkinson's disease in the Swedish National March Cohort
    Fei Yang
    1 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden
    Brain 138:269-75. 2015
    ..66 (95% confidence interval 0.57-0.78) for highest versus lowest physical activity level. Our results indicate that a medium level of physical activity lowers Parkinson's disease risk. ..
  15. doi request reprint Familial coaggregation of Alzheimer's disease and Parkinson's disease: systematic review and meta-analysis
    Adina L Feldman
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Neuroepidemiology 42:69-80. 2014
    ..Familial aggregation has been shown for Alzheimer's disease (AD) and Parkinson's disease (PD) separately, and it has been hypothesized that these diseases also coaggregate in families...
  16. pmc CNS infections, sepsis and risk of Parkinson's disease
    Fang Fang
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Int J Epidemiol 41:1042-9. 2012
    ..Neuroinflammation may play an important role in the aetiology of Parkinson's disease (PD); however, little is known about infections in relation to future PD risk...
  17. pmc Early-Life Factors and Risk of Parkinson's Disease: A Register-Based Cohort Study
    Bojing Liu
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 11:e0152841. 2016
    ..The finding of a lower PD risk among individuals with older siblings will need confirmation and further investigation. ..
  18. pmc Depression in amyotrophic lateral sclerosis
    Elin Roos
    From the Departments of Medical Epidemiology and Biostatistics E R, D M, C L, K W, F F and Clinical Neuroscience C I, K W, and Institute of Environmental Medicine P M R, Karolinska Institutet, Stockholm, Sweden and Department of Neurology P M R, Division of Clinical Neurophysiology, Oslo University Hospital, Oslo, Norway
    Neurology 86:2271-7. 2016
    ..To examine the relative risk of depression among patients with amyotrophic lateral sclerosis (ALS), both in terms of depression diagnosis and use of antidepressant drugs, before and after diagnosis...
  19. pmc Is a cancer diagnosis associated with subsequent risk of transient global amnesia?
    Jianwei Zhu
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China
    PLoS ONE 10:e0122960. 2015
    ..Psychological stress has been associated with transient global amnesia (TGA). Whether a cancer diagnosis, a severely stressful life event, is associated with subsequent risk of TGA has not been studied...
  20. pmc A linkage study of candidate loci in familial Parkinson's Disease
    Karin Wirdefeldt
    Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    BMC Neurol 3:6. 2003
    ..These loci have been implicated in familial Parkinson's disease or in syndromes with a clinical presentation that overlaps with parkinsonism, as well as potentially in the pathogenesis of the disease...