Genomes and Genes
Affiliation: Karolinska Institutet
- The zebrafish transcriptome during early developmentLiselotte Vesterlund
Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
BMC Dev Biol 11:30. 2011..In this study RNA-Seq is used to compare the transcription profiles of four early developmental stages in zebrafish (Danio rerio) on a global scale...
- Co-localization of neural cell adhesion molecule and fibroblast growth factor receptor 2 in early embryo developmentLiselotte Vesterlund
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
Int J Dev Biol 55:313-9. 2011..In summary these findings show a co-localization of NCAM and FGFR2 in early vertebrate development with intracellular signaling pathways present to enable a cellular response...
- Differences in gene expression between mouse and human for dynamically regulated genes in early embryoElo Madissoon
Department of Biosciences and Nutrition Center for Biosciences, Karolinska Institutet, Huddinge, Sweden
PLoS ONE 9:e102949. 2014..We also describe four cancer-testis antigen families that are also highly expressed in human embryos: PRAME, SSX, GAGE and MAGEA. ..
- Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human developmentVirpi Tohonen
Department of Biosciences and Nutrition, Karolinska Institutet, Novum, 141 83 Huddinge, Sweden
Nat Commun 6:8207. 2015..Our high-resolution analysis of the human transcriptome during preimplantation development may have important implications on future studies of human pluripotent stem cells and cell reprograming. ..
- The zebrafish orthologue of the dyslexia candidate gene DYX1C1 is essential for cilia growth and functionGayathri Chandrasekar
Center for Biosciences, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
PLoS ONE 8:e63123. 2013..Considering all these results, we propose an essential role for dyx1c1 in cilia growth and function...
- Aberrant splicing of genes involved in haemoglobin synthesis and impaired terminal erythroid maturation in SF3B1 mutated refractory anaemia with ring sideroblastsSimona Conte
Karolinska Institutet, Department of Medicine Huddinge, Centre for Hematology and Regenerative Medicine, Stockholm, Sweden
Br J Haematol 171:478-90. 2015..In conclusion, SF3B1 mutated RARS progenitors display impaired splicing with potential downstream consequences for genes of key importance for haemoglobin synthesis and terminal erythroid differentiation. ..