Affiliation: Karolinska Institutet
- Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD studyInger Vedin
Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
PLoS ONE 7:e35425. 2012..Hence, our aim was to determine the effects of 6 mo of dietary supplementation with an n-3 FA preparation rich in DHA on global gene expression in peripheral blood mononuclear cells...
- Reduced prostaglandin F2 alpha release from blood mononuclear leukocytes after oral supplementation of omega3 fatty acids: the OmegAD studyInger Vedin
Department of Medicine, Caring Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
J Lipid Res 51:1179-85. 2010..The stimulus-specific PGF(2alpha) release from PBMC after 6 months of oral supplementation with the DHA-rich fish oil might be one event related to reduced inflammatory reactions associated with omega-3 fatty acid intake...
- Effects of omega-3 fatty acids on inflammatory markers in cerebrospinal fluid and plasma in Alzheimer's disease: the OmegAD studyYvonne Freund-Levi
Department NVS, Division of Clinical Geriatrics, Karolinska University Hospital, Stockholm, Sweden
Dement Geriatr Cogn Disord 27:481-90. 2009..omega-3 fatty acids (omega-3 FAs) found in dietary fish or fish oils are anti-inflammatory agents that may influence Alzheimer's disease (AD)...
- Effects on transthyretin in plasma and cerebrospinal fluid by DHA-rich n - 3 fatty acid supplementation in patients with Alzheimer's disease: the OmegAD studyGerd Faxén-Irving
Department of NVS, Section of Clinical Nutrition, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
J Alzheimers Dis 36:1-6. 2013..172, p = 0.028). Thus, n - 3 FA treatment appeared to increase plasma-TTR in patients with AD. Since TTR may influence Aβ deposition in the brain, the results warrant further exploration...
- Omega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptomsYvonne Freund-Levi
Department of NVS, Section of Clinical Geriatrics, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
Int J Geriatr Psychiatry 23:161-9. 2008..An association with APOEomega4 carriers and neuropsychiatric symptoms in AD has also been suggested...
- Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: the omega-3 Alzheimer's disease studyGerd Faxén Irving
Department of Neurobiology, Karolinska Institutet, Karolinska University, Hospital Huddinge, Stockholm, Sweden
J Am Geriatr Soc 57:11-7. 2009..To study the effects of omega (Omega)-3 fatty acid (FA) supplements on weight and appetite in patients with mild to moderate Alzheimer's disease (AD) in relation to inflammatory biomarkers and apolipoprotein E epsilon4 (APOEepsilon4)...
- Omega-3 fatty acids enhance phagocytosis of Alzheimer's disease-related amyloid-β42 by human microglia and decrease inflammatory markersErik Hjorth
Division of Neurodegeneration, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
J Alzheimers Dis 35:697-713. 2013..DHA and EPA can be beneficial in AD by enhancing removal of Aβ42, increasing neurotrophin production, decreasing pro-inflammatory cytokine production, and by inducing a shift in phenotype away from pro-inflammatory M1 activation...
- Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trialYvonne Freund-Levi
Department of Neurobiology, Caring Sciences and Society, Section of Clinical Geriatrics, Karolinska University Hospital Huddinge, Stockholm
Arch Neurol 63:1402-8. 2006..Epidemiologic and animal studies have suggested that dietary fish or fish oil rich in omega-3 fatty acids, for example, docosahexaenoic acid and eicosapentaenoic acid, may prevent Alzheimer disease (AD)...
- Effects of n-3 FA supplementation on the release of proresolving lipid mediators by blood mononuclear cells: the OmegAD studyXiuzhe Wang
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, SE 141 57, Huddinge, Stockholm, Sweden Department of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025, Shanghai, China
J Lipid Res 56:674-81. 2015..We conclude that supplementation with n-3 PUFAs for 6 months prevented a reduction in SPMs released from PBMCs of AD patients, which was associated with changes in cognitive function. ..
- X-linked thrombocytopenia with thalassemia displays bone marrow reticulin fibrosis and enhanced angiogenesis: comparisons with primary myelofibrosisMaria Aström
Department of Medicine, Faculty of Medicine and Health, Orebro University, Orebro, Sweden Department of Laboratory Medicine, Faculty of Medicine and Health, Orebro University, Orebro, Sweden
Am J Hematol 90:E44-8. 2015..Additional comparisons between these disorders may increase the understanding of mechanisms behind BM fibrosis in relation to pathological megakaryopoiesis...