Katarina Varnas

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi request reprint Integrated Strategy for Use of Positron Emission Tomography in Nonhuman Primates to Confirm Multitarget Occupancy of Novel Psychotropic Drugs: An Example with AZD3676
    Katarina Varnas
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm K V, P J, M S, C H, L F AstraZeneca Translational Science Centre at Karolinska Institutet, PET CoE, Stockholm P J, M S, L F AstraZeneca R and D, Södertälje A J, C A, P S, S G, E J, J M, L A, Sweden
    J Pharmacol Exp Ther 358:464-71. 2016
  2. pmc Neurokinin-3 Receptor Binding in Guinea Pig, Monkey, and Human Brain: In Vitro and in Vivo Imaging Using the Novel Radioligand, [18F]Lu AF10628
    Katarina Varnas
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden Drs Varnäs, Finnema, Stepanov, Takano, Toth, Svedberg, Halldin, and Farde Lundbeck Research, H Lundbeck A S, 9 Ottiliavej, DK 2500 Copenhagen Valby, Denmark Drs Møller Nielsen, Khanzhin, Juhl, and Bang Andersen AstraZeneca Translational Science Centre at Karolinska Institutet, PET CoE, Stockholm, Sweden Dr Farde Present address Glycom A S, Diplomvej 373, 1, DK 2800 Kgs Lyngby, Denmark N A K
    Int J Neuropsychopharmacol 19:. 2016
  3. pmc Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects
    Aurelija Jucaite
    AstraZeneca Global Clinical Development, Södertälje 151 85, Sweden
    EJNMMI Res 2:15. 2012
  4. doi request reprint A PET study with [11C]AZ10419369 to determine brain 5-HT1B receptor occupancy of zolmitriptan in healthy male volunteers
    Katarina Varnas
    Karolinska Institutet, Department of Clinical Neuroscience, SE 17176 Stockholm, Sweden
    Cephalalgia 33:853-60. 2013
  5. doi request reprint Modeling of PET data in CNS drug discovery and development
    Katarina Varnas
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Pharmacokinet Pharmacodyn 40:267-79. 2013
  6. doi request reprint Dose-dependent binding of AZD3783 to brain 5-HT1B receptors in non-human primates and human subjects: a positron emission tomography study with [11C]AZ10419369
    Katarina Varnas
    Karolinska Institutet, Department of Clinical Neuroscience, Karolinska University Hospital, Stockholm, Sweden
    Psychopharmacology (Berl) 213:533-45. 2011
  7. pmc Quantitative analysis of [11C]AZ10419369 binding to 5-HT1B receptors in human brain
    Katarina Varnas
    Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Cereb Blood Flow Metab 31:113-23. 2011
  8. ncbi request reprint Cerebellar volumes in men with schizophrenia and alcohol dependence
    Katarina Varnas
    Institute of Psychiatry, University of Oslo, Oslo, Norway
    Psychiatry Clin Neurosci 61:326-9. 2007
  9. doi request reprint Brain-derived neurotrophic factor polymorphisms and frontal cortex morphology in schizophrenia
    Katarina Varnas
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Psychiatr Genet 18:177-83. 2008
  10. pmc Low background and high contrast PET imaging of amyloid-β with [11C]AZD2995 and [11C]AZD2184 in Alzheimer's disease patients
    Anton Forsberg
    Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 40:580-93. 2013

Detail Information

Publications34

  1. doi request reprint Integrated Strategy for Use of Positron Emission Tomography in Nonhuman Primates to Confirm Multitarget Occupancy of Novel Psychotropic Drugs: An Example with AZD3676
    Katarina Varnas
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm K V, P J, M S, C H, L F AstraZeneca Translational Science Centre at Karolinska Institutet, PET CoE, Stockholm P J, M S, L F AstraZeneca R and D, Södertälje A J, C A, P S, S G, E J, J M, L A, Sweden
    J Pharmacol Exp Ther 358:464-71. 2016
    ..Importantly, earlier introduction of PET studies in nonhuman primates may reduce future development costs and the requirement for animal experiments in preclinical CNS drug development programs. ..
  2. pmc Neurokinin-3 Receptor Binding in Guinea Pig, Monkey, and Human Brain: In Vitro and in Vivo Imaging Using the Novel Radioligand, [18F]Lu AF10628
    Katarina Varnas
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden Drs Varnäs, Finnema, Stepanov, Takano, Toth, Svedberg, Halldin, and Farde Lundbeck Research, H Lundbeck A S, 9 Ottiliavej, DK 2500 Copenhagen Valby, Denmark Drs Møller Nielsen, Khanzhin, Juhl, and Bang Andersen AstraZeneca Translational Science Centre at Karolinska Institutet, PET CoE, Stockholm, Sweden Dr Farde Present address Glycom A S, Diplomvej 373, 1, DK 2800 Kgs Lyngby, Denmark N A K
    Int J Neuropsychopharmacol 19:. 2016
    ..Hitherto available radioligands have displayed low affinity for the human neurokinin 3 receptor relative to the rodent homologue and may thus not be optimal for cross-species analyses of the expression of this protein...
  3. pmc Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects
    Aurelija Jucaite
    AstraZeneca Global Clinical Development, Södertälje 151 85, Sweden
    EJNMMI Res 2:15. 2012
    ..In the present test-retest study, we examine the characteristics of [11C](R)-PK11195 binding in detail, using the classical compartment analysis with a metabolite-corrected arterial input function...
  4. doi request reprint A PET study with [11C]AZ10419369 to determine brain 5-HT1B receptor occupancy of zolmitriptan in healthy male volunteers
    Katarina Varnas
    Karolinska Institutet, Department of Clinical Neuroscience, SE 17176 Stockholm, Sweden
    Cephalalgia 33:853-60. 2013
    ..To investigate the occupancy at brain 5-hydroxytryptamine (5-HT) 1B receptors in human subjects after administration of the antimigraine drug zolmitriptan...
  5. doi request reprint Modeling of PET data in CNS drug discovery and development
    Katarina Varnas
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Pharmacokinet Pharmacodyn 40:267-79. 2013
    ..The utility of PET kinetic modeling in the development of novel CNS drugs is illustrated by examples from studies of the brain kinetic properties of radiolabeled drug molecules...
  6. doi request reprint Dose-dependent binding of AZD3783 to brain 5-HT1B receptors in non-human primates and human subjects: a positron emission tomography study with [11C]AZ10419369
    Katarina Varnas
    Karolinska Institutet, Department of Clinical Neuroscience, Karolinska University Hospital, Stockholm, Sweden
    Psychopharmacology (Berl) 213:533-45. 2011
    ..AZD3783 is a recently developed, orally bioavailable 5-HT(1B) receptor antagonist with potential antidepressant properties...
  7. pmc Quantitative analysis of [11C]AZ10419369 binding to 5-HT1B receptors in human brain
    Katarina Varnas
    Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Cereb Blood Flow Metab 31:113-23. 2011
    ..The findings support the use of reference tissue models in applied clinical studies with [(11)C]AZ10419369...
  8. ncbi request reprint Cerebellar volumes in men with schizophrenia and alcohol dependence
    Katarina Varnas
    Institute of Psychiatry, University of Oslo, Oslo, Norway
    Psychiatry Clin Neurosci 61:326-9. 2007
    ..The results provide indications for differential morphological abnormalities of the cerebellar vermis in patients with schizophrenia and alcohol dependence...
  9. doi request reprint Brain-derived neurotrophic factor polymorphisms and frontal cortex morphology in schizophrenia
    Katarina Varnas
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Psychiatr Genet 18:177-83. 2008
    ..To investigate associations between brain-derived neurotrophic factor (BDNF) gene polymorphisms and regional frontal cortical thickness and volume in patients with schizophrenia and healthy control participants...
  10. pmc Low background and high contrast PET imaging of amyloid-β with [11C]AZD2995 and [11C]AZD2184 in Alzheimer's disease patients
    Anton Forsberg
    Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 40:580-93. 2013
    ..The aim of this study was to evaluate AZD2995 side by side with AZD2184 as novel PET radioligands for imaging of amyloid-β in Alzheimer's disease (AD)...
  11. doi request reprint Radiolabeling of the cannabinoid receptor agonist AZD1940 with carbon-11 and PET microdosing in non-human primate
    Magnus Schou
    AstraZeneca Translational Sciences Centre, PET CoE, Dept of Clinical Neuroscience, Karolinska Institutet, Karolinska Hospital, SE 17176 Stockholm, Sweden
    Nucl Med Biol 40:410-4. 2013
    ..As part of the preclinical evaluation of AZD1940, a microdosing study with positron emission tomography (PET) was conducted to assess brain exposure...
  12. doi request reprint Radiosynthesis and evaluation of new α1-adrenoceptor antagonists as PET radioligands for brain imaging
    Anu J Airaksinen
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska Hospital, S 17176 Stockholm, Sweden
    Nucl Med Biol 40:747-54. 2013
    ..Our aim was to develop an α1-adrenoceptor specific PET radioligand for brain imaging...
  13. pmc Large Variation in Brain Exposure of Reference CNS Drugs: a PET Study in Nonhuman Primates
    Magnus Schou
    AstraZeneca Translational Science Centre at Karolinska Institutet, Stockholm, Sweden Drs Schou and Farde Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden Drs Varnäs, Lundquist, Nakao, Amini, Takano, Finnema, and Halldin AstraZeneca, Innovative Medicines, CNS and Pain, Sodertalje, Sweden Dr Lundquist
    Int J Neuropsychopharmacol 18:pyv036. 2015
    ..The aim of the present study was to examine and compare the brain exposure of 12 commercially available CNS drugs and one non-CNS drug...
  14. ncbi request reprint Regional thinning of the cerebral cortex in schizophrenia: effects of diagnosis, age and antipsychotic medication
    Ragnar Nesvåg
    Department of Psychiatric Research, Diakonhjemmet Hospital, and Institute of Psychiatry, University of Oslo, Norway
    Schizophr Res 98:16-28. 2008
    ..The lack of significant influence from antipsychotic medication supports that regional cortical thinning is an inherent feature of the neurobiological disease process in schizophrenia...
  15. pmc Arterial input function derived from pairwise correlations between PET-image voxels
    Martin Schain
    Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden
    J Cereb Blood Flow Metab 33:1058-65. 2013
    ..This approach performed similarly or even better than the other methods, and could be considered in applied clinical studies. Applications to other radioligands are needed for further verification. ..
  16. doi request reprint Investigating possible subtypes of schizophrenia patients and controls based on brain cortical thickness
    Glenn Lawyer
    Institute of Psychiatry, University of Oslo, Oslo, Norway
    Psychiatry Res 164:254-64. 2008
    ..The study found no subtypes specific to patients. It suggested, however, that associations between abnormally thin cortex and schizophrenia are more widespread than shown by previously published results based on significance testing...
  17. doi request reprint Grey and white matter proportional relationships in the cerebellar vermis altered in schizophrenia
    Glenn Lawyer
    Institute of Psychiatry, University of Oslo, Oslo, Norway
    Cerebellum 8:52-60. 2009
    ..Tissue class volumes in the cerebellar vermis were strongly interrelated in controls. These relationships were disturbed in patients with schizophrenia...
  18. doi request reprint Synthesis, radiolabeling, and in vivo pharmacokinetic evaluation of the amyloid beta radioligand [11C]AZD4694 in nonhuman primates
    Magnus Schou
    AstraZeneca Translational Science Centre, PET Centre of Excellence, Department of Clinical Neuroscience, Karolinska University Hospital, Karolinska Institutet, 171 76, Stockholm, Sweden
    Mol Imaging Biol 16:173-9. 2014
    ..4 min) labeled isotopolog [(11)C]AZD4694 and compare [(11)C]AZD4694 with the hitherto most widely applied amyloid PET radioligand [(11)C]Pittsburgh Compound B (PiB)...
  19. pmc GABAA receptor occupancy by subtype selective GABAAα2,3 modulators: PET studies in humans
    Aurelija Jucaite
    Department of Clinical Neuroscience, AstraZeneca PET Center, Karolinska Institutet, R5 02, SE 17176, Stockholm, Sweden
    Psychopharmacology (Berl) . 2016
    ..AZD7325 and AZD6280 are novel, subtype-selective GABAAα2,3 receptor positive modulators with limited sedative effects...
  20. doi request reprint Radiosynthesis of the candidate beta-amyloid radioligand [(11)C]AZD2184: Positron emission tomography examination and metabolite analysis in cynomolgus monkeys
    Jan D Andersson
    Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden
    Synapse 64:733-41. 2010
    ..On the basis of the labeling chemistry and the results of the biological evaluation, we conclude that [(11)C]5 should be useful for routine clinical studies...
  21. ncbi request reprint Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain
    Katarina Varnas
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, Stockholm, Sweden
    Hum Brain Mapp 22:246-60. 2004
    ..The qualitative and quantitative information reported in this study might provide important complements to in vivo neuroimaging studies of the 5-HT system...
  22. doi request reprint Local and covariate-modulated false discovery rates applied in neuroimaging
    Glenn Lawyer
    Department of Psychiatry, University of Oslo, Oslo, Norway
    Neuroimage 47:213-9. 2009
    ..The increased statistical precision from more accurate models of the distribution of the test statistic demonstrates the potential of these methods for neuroimaging and suggests the possibility to test novel hypothesis...
  23. ncbi request reprint Longitudinal microPET imaging of the zQ175 mouse model of Huntington's disease shows in vivo changes of molecular targets in the striatum and the cerebral cortex
    Jenny Häggkvist
    Karolinska Institutet, Sweden
    J Nucl Med . 2016
    ..In the present study we used small animal positron emission tomography (PET) to characterize the expression of molecular targets in the recently reported HD animal model, the zQ175 mouse model...
  24. doi request reprint Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease
    Aurelija Jucaite
    1 AstraZeneca Translational Science Centre at Karolinska Institutet, PET CoE, Stockholm, Sweden 2 Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden
    Brain 138:2687-700. 2015
    ..The results of the present study provide support for proof of mechanism of AZD3241 and warrant extended studies on the efficacy of AZD3241 in neurodegenerative disorders. ..
  25. doi request reprint Positron emission tomography imaging of 5-hydroxytryptamine1B receptors in Parkinson's disease
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden Stockholm Brain Institute, Stockholm, Sweden Electronic address
    Neurobiol Aging 35:867-75. 2014
    ..The demonstrated age effect on 5-HT(1B) receptors suggest a physiologic and PD-related decline of serotonin function, indicating the importance of controlling for age in clinical studies...
  26. doi request reprint Evaluation of two automated methods for PET region of interest analysis
    Martin Schain
    Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden
    Neuroinformatics 12:551-62. 2014
    ..Thus, the choice of method could be based upon necessity of fast analysis as provided by AAL, or more detailed ROIs and measures of cortical thickness as provided by FreeSurfer...
  27. ncbi request reprint Distribution of 5-HT7 receptors in the human brain: a preliminary autoradiographic study using [3H]SB-269970
    Katarina Varnas
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska Hospital, S 17176 Stockholm, Sweden
    Neurosci Lett 367:313-6. 2004
    ..The distribution pattern obtained in this study supports the involvement of this receptor subtype in affective behavior and cognition...
  28. pmc Amphetamine decreases α2C-adrenoceptor binding of [11C]ORM-13070: a PET study in the primate brain
    Sjoerd J Finnema
    Karolinska Institutet, Department of Clinical Neuroscience, Center for Psychiatric Research, Stockholm, Sweden Drs Finnema, Stepanov, Nakao, Varnäs, Varrone, Farde, and Halldin Pfizer, Neuroscience Research Unit, Cambridge, MA Drs Hughes, Babalola, and Grimwood University of Turku, Turku PET Centre, Turku, Finland Drs Haaparanta Solin, Arponen, Marjamäki, and Solin University of Turku, Department of Pharmacology, Drug Development and Therapeutics, and Turku University Hospital, Unit of Clinical Pharmacology, Turku, Finland Drs Pohjanoksa, Vuorilehto, and Scheinin Orion Corporation, Orion Pharma, Research and Development, Turku, Finland Dr Sallinen AstraZeneca, Translational Science Center at Karolinska Institutet, Stockholm, Sweden Dr Farde
    Int J Neuropsychopharmacol 18:. 2014
    ..Examination of synaptic norepinephrine concentrations in the living brain may be possible with positron emission tomography (PET), but has been hampered by the lack of suitable radioligands...
  29. doi request reprint Discovery and Preclinical Validation of [(11)C]AZ13153556, a Novel Probe for the Histamine Type 3 Receptor
    Magnus Schou
    AstraZeneca Translational Science Centre at Karolinska Institutet, PET Centre of Excellence, Department of Clinical Neuroscience, S 17176 Stockholm, Sweden
    ACS Chem Neurosci 7:177-84. 2016
    ..Whereas [(11)C]1 showed similar binding characteristics in vivo, the binding kinetics appeared faster for [(11)C]5 than for [(11)C]1...
  30. doi request reprint Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing
    Peter Johnström
    AstraZeneca Translational Science Centre at Karolinska Institutet, Stockholm, Sweden Karolinska Institutet, Department of Clinical Neuroscience, Center for Psychiatric Research and Education, Stockholm, Sweden Electronic address
    Nucl Med Biol 42:555-60. 2015
    ..For that purpose a rapid multistep method for (11)C-labeling of AZD3241 was developed...
  31. doi request reprint Low brain CB1 receptor occupancy by a second generation CB1 receptor antagonist TM38837 in comparison with rimonabant in nonhuman primates: a PET study
    Akihiro Takano
    Department of Clinical Neuroscience, Karolinska Institutet, Center for Psychiatric Research and Education, Stockholm, Sweden
    Synapse 68:89-97. 2014
    ..TM38837 showed rather lower CB1R occupancy than rimonabant at the expected therapeutic plasma level, which is expected to reduce CNS side effects in clinical situations. Further clinical development of TM38837 is warranted...
  32. ncbi request reprint Distribution of 5-HT4 receptors in the postmortem human brain--an autoradiographic study using [125I]SB 207710
    Katarina Varnas
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, S 17176 Stockholm, Sweden
    Eur Neuropsychopharmacol 13:228-34. 2003
    ....
  33. ncbi request reprint Regional expression of 5-HT1B receptor mRNA in the human brain
    Katarina Varnas
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, S 17176 Stockholm, Sweden
    Synapse 56:21-8. 2005
    ..This is in line with the localization of this receptor subtype in nerve terminals. The results give support to species differences in the cortical mRNA expression pattern of this receptor subtype...
  34. pmc Antidepressant effects on serotonin 1A/1B receptors in the rat brain using a gene x environment model
    Stal Saurav Shrestha
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA Electronic address
    Neurosci Lett 559:163-8. 2014
    ..Taken together, our findings demonstrate that antidepressant effects on the serotonergic system are shaped by a GxE interaction that depends on antidepressant class and brain region. ..