Akihiro Takano

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S,S)-[18F]FMeNER-D2: a human whole-body PET study
    Akihiro Takano
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 35:630-6. 2008
  2. doi request reprint A human [(11)C]T-773 PET study of PDE10A binding after oral administration of TAK-063, a PDE10A inhibitor
    Akihiro Takano
    Karolinska Institutet, Department of Clinical Neuroscience, Center for Psychiatric Research, Stockholm, Sweden Electronic address
    Neuroimage 141:10-7. 2016
  3. pmc Guidelines to PET measurements of the target occupancy in the brain for drug development
    Akihiro Takano
    Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 43:2255-2262. 2016
  4. pmc In vivo TSPO imaging in patients with multiple sclerosis: a brain PET study with [18F]FEDAA1106
    Akihiro Takano
    Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm SE 171 77, Sweden
    EJNMMI Res 3:30. 2013
  5. doi request reprint SERT and NET occupancy by venlafaxine and milnacipran in nonhuman primates: a PET study
    Akihiro Takano
    Karolinska Institutet, Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska University Hospital Solna R5 02, SE 171 76 Stockholm, Sweden
    Psychopharmacology (Berl) 226:147-53. 2013
  6. pmc Synthesis and evaluation of 2-chloro N-[(S)-{(S)-1-[11 C]methylpiperidin-2-yl} (phenyl)methyl]3-trifluoromethyl-benzamide ([11 C]N-methyl-SSR504734) as a PET radioligand for glycine transporter 1
    Takeshi Fuchigami
    Karolinska Institutet, Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska University Hospital, R5 02, Stockholm 171 76, Sweden
    EJNMMI Res 2:37. 2012
  7. doi request reprint Saturated norepinephrine transporter occupancy by atomoxetine relevant to clinical doses: a rhesus monkey study with (S,S)-[(18)F]FMeNER-D (2)
    Akihiro Takano
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, S 171 76, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 36:1308-14. 2009
  8. ncbi request reprint [Clinical evaluation of CNS drugs with PET]
    Akihiro Takano
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, S 171 76 Stockholm, Sweden
    Nihon Shinkei Seishin Yakurigaku Zasshi 29:61-5. 2009
  9. doi request reprint Comparative evaluations of norepinephrine transporter radioligands with reference tissue models in rhesus monkeys: (S,S)-[18F]FMeNER-D2 and (S,S)-[11C]MeNER
    Akihiro Takano
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, 171 76 Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 36:1885-91. 2009
  10. ncbi request reprint The application of PET technique for the development and evaluation of novel antipsychotics
    Akihiro Takano
    Karolinska Insitutet, Department of Clinical Neuroscience, Stockholm, Sweden
    Curr Pharm Des 16:371-7. 2010

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S,S)-[18F]FMeNER-D2: a human whole-body PET study
    Akihiro Takano
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 35:630-6. 2008
    ..The aim of this study was to provide dosimetry estimates for (S,S)-[(18)F]FMeNER-D(2) based on human whole-body PET measurements...
  2. doi request reprint A human [(11)C]T-773 PET study of PDE10A binding after oral administration of TAK-063, a PDE10A inhibitor
    Akihiro Takano
    Karolinska Institutet, Department of Clinical Neuroscience, Center for Psychiatric Research, Stockholm, Sweden Electronic address
    Neuroimage 141:10-7. 2016
    ..At 23hours postdose, PDE10A occupancy in the putamen was 0 to 42.8% following administration of 3 to 100mg of TAK-063. In conclusion, [(11)C]T-773 showed good characteristics as a PET radioligand for PDE10A in the human brain. ..
  3. pmc Guidelines to PET measurements of the target occupancy in the brain for drug development
    Akihiro Takano
    Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 43:2255-2262. 2016
    ..This guideline is intended to present information specifically adapted to European practice. The information provided should be applied within the context of local conditions and regulations...
  4. pmc In vivo TSPO imaging in patients with multiple sclerosis: a brain PET study with [18F]FEDAA1106
    Akihiro Takano
    Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm SE 171 77, Sweden
    EJNMMI Res 3:30. 2013
    ..18F]FEDAA1106 is a recently developed PET radioligand for the in vivo quantification of TSPO. In the present study, we aimed at investigating the diagnostic usefulness of [18F]FEDAA1106 in patients with MS...
  5. doi request reprint SERT and NET occupancy by venlafaxine and milnacipran in nonhuman primates: a PET study
    Akihiro Takano
    Karolinska Institutet, Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska University Hospital Solna R5 02, SE 171 76 Stockholm, Sweden
    Psychopharmacology (Berl) 226:147-53. 2013
    ..6 for milnacipran. In this study in nonhuman primates, we aimed to investigate the relationship between SERT and NET affinity by measuring the in vivo occupancy at both transporters of venlafaxine and milnacipran...
  6. pmc Synthesis and evaluation of 2-chloro N-[(S)-{(S)-1-[11 C]methylpiperidin-2-yl} (phenyl)methyl]3-trifluoromethyl-benzamide ([11 C]N-methyl-SSR504734) as a PET radioligand for glycine transporter 1
    Takeshi Fuchigami
    Karolinska Institutet, Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska University Hospital, R5 02, Stockholm 171 76, Sweden
    EJNMMI Res 2:37. 2012
    ..The aim of this study was to assess the potential of 2-chloro N-[(S)-{(S)-1-[11 C]methylpiperidin-2-yl} (phenyl)methyl] 3-trifluoromethyl-benzamide ([11 C]N-methyl-SSR504734) as a PET imaging agent for GlyT1...
  7. doi request reprint Saturated norepinephrine transporter occupancy by atomoxetine relevant to clinical doses: a rhesus monkey study with (S,S)-[(18)F]FMeNER-D (2)
    Akihiro Takano
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, S 171 76, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 36:1308-14. 2009
    ..It may therefore be difficult to translate the results to the clinical situations. In the present study, the detailed change of NET occupancy was investigated among a wider range of doses in a more advanced manner...
  8. ncbi request reprint [Clinical evaluation of CNS drugs with PET]
    Akihiro Takano
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, S 171 76 Stockholm, Sweden
    Nihon Shinkei Seishin Yakurigaku Zasshi 29:61-5. 2009
    ..As biomarkers, the change in the distribution in beta amyloid and microglia after the drug treatment could be detected...
  9. doi request reprint Comparative evaluations of norepinephrine transporter radioligands with reference tissue models in rhesus monkeys: (S,S)-[18F]FMeNER-D2 and (S,S)-[11C]MeNER
    Akihiro Takano
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, 171 76 Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 36:1885-91. 2009
    ..Although two norepinephrine transporter (NET) radioligands, (S,S)-[(18)F]FMeNER-D(2) and (S,S)-[(11)C]MeNER, have been reported to have different characteristics, there has not been a direct comparative study in vivo...
  10. ncbi request reprint The application of PET technique for the development and evaluation of novel antipsychotics
    Akihiro Takano
    Karolinska Insitutet, Department of Clinical Neuroscience, Stockholm, Sweden
    Curr Pharm Des 16:371-7. 2010
    ..PET technique with the radioligands developed for these targets has potentials to rationalize and speed up the process of the drug development for the treatment of schizophrenia...
  11. doi request reprint NET occupancy by clomipramine and its active metabolite, desmethylclomipramine, in non-human primates in vivo
    Akihiro Takano
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, 171 76, Stockholm, Sweden
    Psychopharmacology (Berl) 216:279-86. 2011
    ..However, the NET occupancy of clomipramine and desmethylclomipramine has not fully been evaluated in vivo...
  12. doi request reprint Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [18F]FEDAA1106: a human whole-body PET study
    Akihiro Takano
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, 171 76, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 38:2058-65. 2011
    ..TSPO imaging is expected to be useful for the clinical evaluation of neuroinflammatory diseases. The aim of this study was to provide dosimetry estimates for [(18)F]FEDAA1106 based on human whole-body PET measurements...
  13. doi request reprint In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Synapse 63:871-80. 2009
    ..The potential influence of the two radiometabolites on PET quantification requires further evaluation...
  14. doi request reprint Brain PET measurement of PDE10A occupancy by TAK-063, a new PDE10A inhibitor, using [11 C]T-773 in nonhuman primates
    Akihiro Takano
    Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden
    Synapse 70:253-63. 2016
    ..These results warrant further clinical occupancy study for TAK-063...
  15. doi request reprint Simplified quantification and whole-body distribution of [18F]FE-PE2I in nonhuman primates: prediction for human studies
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, SE 17176 Stockholm, Sweden
    Nucl Med Biol 39:295-303. 2012
    ..18)F]FE-PE2I is a promising dopamine transporter (DAT) radioligand. In nonhuman primates, we examined the accuracy of simplified quantification methods and the estimates of radiation dose of [(18)F]FE-PE2I...
  16. ncbi request reprint Imaging the norepinephrine transporter with positron emission tomography: initial human studies with (S,S)-[18F]FMeNER-D2
    Akihiro Takano
    Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, 171 76, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 35:153-7. 2008
    ..A monkey occupancy study with the radioligand indicated that (S,S)-[(18)F]FMeNER-D(2) can be useful for quantitative PET analysis. In this preliminary study, regional distributions in the living human brain were evaluated...
  17. doi request reprint Mapping of the norepinephrine transporter in the human brain using PET with (S,S)-[18F]FMeNER-D2
    Akihiro Takano
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Neuroimage 42:474-82. 2008
    ..This study indicated that (S,S)-[(18)F]FMeNER-D(2) combined with a template method provides detailed information on the distribution of NET in vivo and that functional ROIs on the template would be useful in further clinical studies...
  18. doi request reprint Discovery and Preclinical Validation of [(11)C]AZ13153556, a Novel Probe for the Histamine Type 3 Receptor
    Magnus Schou
    AstraZeneca Translational Science Centre at Karolinska Institutet, PET Centre of Excellence, Department of Clinical Neuroscience, S 17176 Stockholm, Sweden
    ACS Chem Neurosci 7:177-84. 2016
    ..Whereas [(11)C]1 showed similar binding characteristics in vivo, the binding kinetics appeared faster for [(11)C]5 than for [(11)C]1...
  19. doi request reprint Molecular Imaging of PDE10A Knockout Mice with a Novel PET Radiotracer: [(11)C]T-773
    Miklos Toth
    Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, SE 171 76, Stockholm, Sweden
    Mol Imaging Biol 17:445-9. 2015
    ..An appropriate PET radioligand for PDE10A would help to facilitate drug development and drug evaluation...
  20. doi request reprint Evaluation of a novel PDE10A PET radioligand, [(11) C]T-773, in nonhuman primates: brain and whole body PET and brain autoradiography
    Akihiro Takano
    Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden
    Synapse 69:345-55. 2015
    ..Dosimetry results support multiple PET measurements per person in human studies. Further research is required with [(11) C]T-773 in order to test the radioligand's potential clinical applications...
  21. doi request reprint Kinetic analysis and quantification of the dopamine transporter in the nonhuman primate brain with 11C-PE2I and 18F-FE-PE2I
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Hospital, Stockholm, Sweden
    J Nucl Med 52:132-9. 2011
    ....
  22. pmc Large Variation in Brain Exposure of Reference CNS Drugs: a PET Study in Nonhuman Primates
    Magnus Schou
    AstraZeneca Translational Science Centre at Karolinska Institutet, Stockholm, Sweden Drs Schou and Farde Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden Drs Varnäs, Lundquist, Nakao, Amini, Takano, Finnema, and Halldin AstraZeneca, Innovative Medicines, CNS and Pain, Sodertalje, Sweden Dr Lundquist
    Int J Neuropsychopharmacol 18:pyv036. 2015
    ..The aim of the present study was to examine and compare the brain exposure of 12 commercially available CNS drugs and one non-CNS drug...
  23. doi request reprint In vivo imaging of the 18-kDa translocator protein (TSPO) with [18F]FEDAA1106 and PET does not show increased binding in Alzheimer's disease patients
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Hospital, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 40:921-31. 2013
    ..The aim of this study was to quantify in vivo binding of [(18)F]FEDAA1106 to TSPO in control subjects and AD patients...
  24. pmc Quantitative analysis of [11C]AZ10419369 binding to 5-HT1B receptors in human brain
    Katarina Varnas
    Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Cereb Blood Flow Metab 31:113-23. 2011
    ..The findings support the use of reference tissue models in applied clinical studies with [(11)C]AZ10419369...
  25. pmc Neurokinin-3 Receptor Binding in Guinea Pig, Monkey, and Human Brain: In Vitro and in Vivo Imaging Using the Novel Radioligand, [18F]Lu AF10628
    Katarina Varnas
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden Drs Varnäs, Finnema, Stepanov, Takano, Toth, Svedberg, Halldin, and Farde Lundbeck Research, H Lundbeck A S, 9 Ottiliavej, DK 2500 Copenhagen Valby, Denmark Drs Møller Nielsen, Khanzhin, Juhl, and Bang Andersen AstraZeneca Translational Science Centre at Karolinska Institutet, PET CoE, Stockholm, Sweden Dr Farde Present address Glycom A S, Diplomvej 373, 1, DK 2800 Kgs Lyngby, Denmark N A K
    Int J Neuropsychopharmacol 19:. 2016
    ..Hitherto available radioligands have displayed low affinity for the human neurokinin 3 receptor relative to the rodent homologue and may thus not be optimal for cross-species analyses of the expression of this protein...
  26. doi request reprint Positron emission tomography imaging of the 18-kDa translocator protein (TSPO) with [18F]FEMPA in Alzheimer's disease patients and control subjects
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 42:438-46. 2015
    ..The aims of this study were to quantify the binding of [(18)F]FEMPA to TSPO in AD patients and controls and to investigate whether higher [(18)F]FEMPA binding in AD patients than in controls could be detected in vivo...
  27. doi request reprint Age and disease related changes in the translocator protein (TSPO) system in the human brain: positron emission tomography measurements with [11C]vinpocetine
    Balazs Gulyas
    Karolinska Institutet, Department of Clinical Neuroscience, Centrum for Psychiatry Research, Stockholm, Sweden
    Neuroimage 56:1111-21. 2011
    ....
  28. pmc Characterization of [11C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain
    Kai Chun Yang
    Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 44:308-320. 2017
    ..39 nM) and may also be suitable for examination of the substantia nigra, a region with low density of PDE10A. Here, we report characterization of regional [11C]Lu AE92686 binding to PDE10A in the nonhuman primate (NHP) brain...
  29. doi request reprint Graphic plot analysis for estimating binding potential of translocator protein (TSPO) in positron emission tomography studies with [¹⁸F]FEDAA1106
    Yoko Ikoma
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, SE 171 76, Stockholm, Sweden
    Neuroimage 69:78-86. 2013
    ..In this paper, we evaluated two types of GA for reliable quantification of BP(ND) in PET study with [(18)F]FEDAA1106 using computer simulations and human data...
  30. doi request reprint Development of a series of novel carbon-11 labeled PDE10A inhibitors
    Vladimir Stepanov
    Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden
    J Labelled Comp Radiopharm 58:202-8. 2015
    ..In particular [(11)C]KIT-6, named [(11)C]T-773, is a promising PET tool for further examination of PDE10A in human brain...
  31. doi request reprint Synthesis of ([(11)C]carbonyl)raclopride and a comparison with ([(11)C]methyl)raclopride in a monkey PET study
    Obaidur Rahman
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska University Hospital, R5 U1, 17176 Stockholm, Sweden Bencar AB, Dag Hammarskjöldsväg 34B, 75183 Uppsala, Sweden Department of Chemistry BMC, Uppsala University, Husargatan 3, 75237 Uppsala, Sweden
    Nucl Med Biol 42:893-8. 2015
    ....
  32. doi request reprint Low brain CB1 receptor occupancy by a second generation CB1 receptor antagonist TM38837 in comparison with rimonabant in nonhuman primates: a PET study
    Akihiro Takano
    Department of Clinical Neuroscience, Karolinska Institutet, Center for Psychiatric Research and Education, Stockholm, Sweden
    Synapse 68:89-97. 2014
    ..TM38837 showed rather lower CB1R occupancy than rimonabant at the expected therapeutic plasma level, which is expected to reduce CNS side effects in clinical situations. Further clinical development of TM38837 is warranted...