Saedis Saevarsdottir

Summary

Affiliation: Karolinska University Hospital
Country: Sweden

Publications

  1. doi request reprint Patients with early rheumatoid arthritis who smoke are less likely to respond to treatment with methotrexate and tumor necrosis factor inhibitors: observations from the Epidemiological Investigation of Rheumatoid Arthritis and the Swedish Rheumatology Reg
    Saedis Saevarsdottir
    Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Arthritis Rheum 63:26-36. 2011
  2. pmc Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers
    Saedis Saevarsdottir
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital Solna, D2 01, 17176 Stockholm, Sweden
    Arthritis Res Ther 13:R65. 2011
  3. ncbi request reprint Patients with rheumatoid arthritis have higher levels of mannan-binding lectin than their first-degree relatives and unrelated controls
    Saedis Saevarsdottir
    Department of Immunology and Center for Rheumatology Research, Landspitali University Hospital, Reykjavik, Iceland
    J Rheumatol 34:1692-5. 2007
  4. doi request reprint Predictors of response to methotrexate in early DMARD naive rheumatoid arthritis: results from the initial open-label phase of the SWEFOT trial
    Saedis Saevarsdottir
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden
    Ann Rheum Dis 70:469-75. 2011
  5. pmc Evaluation of hand bone loss by digital X-ray radiogrammetry as a complement to clinical and radiographic assessment in early rheumatoid arthritis: results from the SWEFOT trial
    Hamed Rezaei
    Unit of Clinical Therapy Research, Inflammatory Diseases ClinTRID, The Karolinska Institute, Stockholm, SE 171 76, Sweden
    BMC Musculoskelet Disord 14:79. 2013
  6. doi request reprint In early rheumatoid arthritis, patients with a good initial response to methotrexate have excellent 2-year clinical outcomes, but radiological progression is not fully prevented: data from the methotrexate responders population in the SWEFOT trial
    Hamed Rezaei
    Unit of Clinical Therapy Research, Inflammatory Diseases, The Karolinska Institute, Stockholm, Sweden
    Ann Rheum Dis 71:186-91. 2012
  7. pmc Association of a multibiomarker disease activity score at multiple time-points with radiographic progression in rheumatoid arthritis: results from the SWEFOT trial
    Karen Hambardzumyan
    Unit of Clinical Therapy Research, Inflammatory Diseases ClinTRID, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    RMD Open 2:e000197. 2016
  8. doi request reprint Association of three systemic lupus erythematosus susceptibility factors, PD-1.3A, C4AQ0, and low levels of mannan-binding lectin, with autoimmune manifestations in Icelandic multicase systemic lupus erythematosus families
    Helga Kristjansdottir
    Landspitali University Hospital, Reykjavik, Iceland
    Arthritis Rheum 58:3865-72. 2008
  9. pmc Brief report: enhancement of patient recruitment in rheumatoid arthritis clinical trials using a multi-biomarker disease activity score as an inclusion criterion
    Ronald F van Vollenhoven
    Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden
    Arthritis Rheumatol 67:2855-60. 2015
  10. pmc Changes in the anticitrullinated peptide antibody response in relation to therapeutic outcome in early rheumatoid arthritis: results from the SWEFOT trial
    Alf Kastbom
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden Department of Rheumatology and Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Ann Rheum Dis 75:356-61. 2016

Collaborators

Detail Information

Publications31

  1. doi request reprint Patients with early rheumatoid arthritis who smoke are less likely to respond to treatment with methotrexate and tumor necrosis factor inhibitors: observations from the Epidemiological Investigation of Rheumatoid Arthritis and the Swedish Rheumatology Reg
    Saedis Saevarsdottir
    Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Arthritis Rheum 63:26-36. 2011
    ..To determine whether cigarette smoking influences the response to treatment in patients with early rheumatoid arthritis (RA)...
  2. pmc Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers
    Saedis Saevarsdottir
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital Solna, D2 01, 17176 Stockholm, Sweden
    Arthritis Res Ther 13:R65. 2011
    ....
  3. ncbi request reprint Patients with rheumatoid arthritis have higher levels of mannan-binding lectin than their first-degree relatives and unrelated controls
    Saedis Saevarsdottir
    Department of Immunology and Center for Rheumatology Research, Landspitali University Hospital, Reykjavik, Iceland
    J Rheumatol 34:1692-5. 2007
    ..In the first family-based study, we compared MBL levels in patients with RA to population controls and also to their nonaffected first-degree relatives, who may be regarded as optimal controls because of less genetic variation...
  4. doi request reprint Predictors of response to methotrexate in early DMARD naive rheumatoid arthritis: results from the initial open-label phase of the SWEFOT trial
    Saedis Saevarsdottir
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden
    Ann Rheum Dis 70:469-75. 2011
    ..To identify predictors of response to methotrexate (MTX) in early rheumatoid arthritis (RA)...
  5. pmc Evaluation of hand bone loss by digital X-ray radiogrammetry as a complement to clinical and radiographic assessment in early rheumatoid arthritis: results from the SWEFOT trial
    Hamed Rezaei
    Unit of Clinical Therapy Research, Inflammatory Diseases ClinTRID, The Karolinska Institute, Stockholm, SE 171 76, Sweden
    BMC Musculoskelet Disord 14:79. 2013
    ....
  6. doi request reprint In early rheumatoid arthritis, patients with a good initial response to methotrexate have excellent 2-year clinical outcomes, but radiological progression is not fully prevented: data from the methotrexate responders population in the SWEFOT trial
    Hamed Rezaei
    Unit of Clinical Therapy Research, Inflammatory Diseases, The Karolinska Institute, Stockholm, Sweden
    Ann Rheum Dis 71:186-91. 2012
    ..To investigate the 2-year clinical and radiological outcomes of patients with early rheumatoid arthritis (RA; symptom duration <1 year) who had initially responded well to methotrexate monotherapy...
  7. pmc Association of a multibiomarker disease activity score at multiple time-points with radiographic progression in rheumatoid arthritis: results from the SWEFOT trial
    Karen Hambardzumyan
    Unit of Clinical Therapy Research, Inflammatory Diseases ClinTRID, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    RMD Open 2:e000197. 2016
    ..We evaluated the MBDA score at multiple time-points as a predictor of RP during 2 years of follow-up...
  8. doi request reprint Association of three systemic lupus erythematosus susceptibility factors, PD-1.3A, C4AQ0, and low levels of mannan-binding lectin, with autoimmune manifestations in Icelandic multicase systemic lupus erythematosus families
    Helga Kristjansdottir
    Landspitali University Hospital, Reykjavik, Iceland
    Arthritis Rheum 58:3865-72. 2008
    ..3A, C4AQ0, and low levels of mannan-binding lectin (MBL), with autoimmune disease in this population...
  9. pmc Brief report: enhancement of patient recruitment in rheumatoid arthritis clinical trials using a multi-biomarker disease activity score as an inclusion criterion
    Ronald F van Vollenhoven
    Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden
    Arthritis Rheumatol 67:2855-60. 2015
    ....
  10. pmc Changes in the anticitrullinated peptide antibody response in relation to therapeutic outcome in early rheumatoid arthritis: results from the SWEFOT trial
    Alf Kastbom
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden Department of Rheumatology and Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Ann Rheum Dis 75:356-61. 2016
    ..To determine the relationship between changes in antibody levels towards citrullinated peptides derived from different candidate autoantigens and therapeutic outcome in early rheumatoid arthritis (RA)...
  11. doi request reprint Thyroxin substitution and the risk of developing rheumatoid arthritis; results from the Swedish population-based EIRA study
    Camilla Bengtsson
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 73:1096-100. 2014
    ..We asked whether thyroxin substitution associated with risk of ACPA-positive or ACPA-negative RA, and whether interactions with established risk factors were present...
  12. doi request reprint Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritis
    Thierry Dervieux
    Exagen Diagnostics, Inc, Albuquerque, New Mexico, USA
    Pharmacogenet Genomics 22:1-9. 2012
    ..We sought to elucidate architecture of methotrexate response in three cohorts of patients with RA treated with methotrexate...
  13. pmc Current smoking status is a strong predictor of radiographic progression in early rheumatoid arthritis: results from the SWEFOT trial
    Saedis Saevarsdottir
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden Unit for Clinical Therapy Research, Karolinska Institute, Stockholm, Sweden
    Ann Rheum Dis 74:1509-14. 2015
    ..To study clinical predictors for radiographic progression after 1 year in an early rheumatoid arthritis (RA) trial...
  14. doi request reprint Overweight decreases the chance of achieving good response and low disease activity in early rheumatoid arthritis
    Maria E C Sandberg
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 73:2029-33. 2014
    ..To investigate whether overweight/obesity at diagnosis affects the chances of decrease in disease activity and pain in early rheumatoid arthritis (RA)...
  15. doi request reprint A multi-biomarker disease activity score and the choice of second-line therapy in early rheumatoid arthritis after methotrexate failure
    Karen Hambardzumyan
    Unit of Clinical Therapy Research, Inflammatory Diseases ClinTRID, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Arthritis Rheumatol . 2016
    ..We investigated whether the multi-biomarker disease activity (MBDA) score predicts optimal add-on treatment in methotrexate-inadequate-responders (MTX-IR) in early rheumatoid arthritis (RA)...
  16. pmc Parity influences the severity of ACPA-negative early rheumatoid arthritis: a cohort study based on the Swedish EIRA material
    Mitra Pikwer
    Rheumatology Unit, Mälarsjukhuset Hospital, Eskilstuna, Sweden
    Arthritis Res Ther 17:358. 2015
    ..Our aim was to explore the impact of parity, with stratification for anti-citrullinated protein antibody (ACPA) status as well as for onset during reproductive age or not...
  17. pmc A genetic risk score composed of rheumatoid arthritis risk alleles, HLA-DRB1 haplotypes, and response to TNFi therapy - results from a Swedish cohort study
    Xia Jiang
    Unit of Clinical Epidemiology KEP, Department of Medicine, Karolinska University Hospital, SE 171 76, Stockholm, Sweden
    Arthritis Res Ther 18:288. 2016
    ..Several previous studies have attempted to confirm this but results remain inconclusive. We expand on previous studies by including more RA risk alleles, and maximize power by combining them into a genetic risk score...
  18. pmc Higher education is associated with a better rheumatoid arthritis outcome concerning for pain and function but not disease activity: results from the EIRA cohort and Swedish rheumatology register
    Xia Jiang
    Unit of Cardiovascular disease, Institute of Environmental Medicine, Karolinska Institute, Box 210, Stockholm, 171 77, Sweden
    Arthritis Res Ther 17:317. 2015
    ....
  19. doi request reprint Recent infections are associated with decreased risk of rheumatoid arthritis: a population-based case-control study
    Maria E C Sandberg
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Epidemiology and Register Centre South, Skane University Hospital, Lund, Sweden
    Ann Rheum Dis 74:904-7. 2015
    ..Do recent infections affect the risk of rheumatoid arthritis (RA)?..
  20. pmc Pretreatment multi-biomarker disease activity score and radiographic progression in early RA: results from the SWEFOT trial
    Karen Hambardzumyan
    Unit of Clinical Therapy Research, Inflammatory Diseases ClinTRID, Karolinska Institute, Stockholm, Sweden
    Ann Rheum Dis 74:1102-9. 2015
    ..We evaluated a multi-biomarker disease activity (MBDA) score, based on 12 serum biomarkers as a baseline predictor for 1-year RP in eRA...
  21. pmc Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk
    Saedis Saevarsdottir
    Department of Immunology, Landspitali University Hospital, 101 Reykjavik, Iceland
    J Exp Med 201:117-25. 2005
    ..Our findings indicate that high MBL may predict decreased likelihood of MI, particularly in diabetics, and are consistent with the possibility that MBL may promote clearance of atherogenic agents...
  22. doi request reprint Very high levels of anti-citrullinated protein antibodies are associated with HLA-DRB1*15 non-shared epitope allele in patients with rheumatoid arthritis
    Judit Laki
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 64:2078-84. 2012
    ....
  23. pmc Remaining Pain in Early Rheumatoid Arthritis Patients Treated With Methotrexate
    Reem Altawil
    Karolinska Institute, Stockholm, Sweden
    Arthritis Care Res (Hoboken) 68:1061-8. 2016
    ....
  24. pmc Postmenopausal hormone therapy and the risk of rheumatoid arthritis: results from the Swedish EIRA population-based case-control study
    Cecilia Orellana
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Eur J Epidemiol 30:449-57. 2015
    ..PMH use might reduce the risk of ACPA-positive RA in post-menopausal women over 50 years of age, but not of ACPA-negative RA. The negative influence of this treatment on the risk of other chronic conditions cannot be overlooked...
  25. doi request reprint Patients with regular physical activity before onset of rheumatoid arthritis present with milder disease
    Maria E C Sandberg
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 73:1541-4. 2014
    ..Physical activity has been shown to decrease inflammatory markers; here we investigate the effect on the clinical presentation of rheumatoid arthritis (RA)...
  26. doi request reprint Does a family history of RA influence the clinical presentation and treatment response in RA?
    Thomas Frisell
    Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 75:1120-5. 2016
    ..To assess whether family history of rheumatoid arthritis (RA), among the strongest risk factors for developing RA, also carries information on the clinical presentation and treatment response...
  27. pmc Accelerating translational research by clinically driven development of an informatics platform--a case study
    Imad Abugessaisa
    Unit of Computational Medicine, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 9:e104382. 2014
    ..The maximum response time was found to be 0.12 seconds; no server or client errors of any kind were detected. In conclusion, the system can readily be used by clinicians and biomedical researchers in a translational medicine setting. ..
  28. ncbi request reprint Correlates of Leisure Time Physical Inactivity in a Scandinavian Population: A Basis for Interventions
    Stephanie E Bonn
    1 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Phys Act Health . 2016
    ..To target interventions we need knowledge of insufficiently active groups in society. This study aims to identify demographic and health-related correlates of leisure time physical inactivity in a general Scandinavian population...
  29. pmc Serum RANKL levels associate with anti- citrullinated protein antibodies in early untreated rheumatoid arthritis and are modulated following methotrexate
    Aase Haj Hensvold
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, L8 04 CMM, 171 76, Stockholm, Sweden
    Arthritis Res Ther 17:239. 2015
    ..Anti-citrullinated protein antibodies (ACPA) have been suggested to cause bone destruction by osteoclast activation. We investigated the relationship between RANKL and ACPA in patients with early untreated rheumatoid arthritis (RA)...
  30. ncbi request reprint [Postgraduate medical education in Iceland; medical students' and residents' attitude]
    Inga Sif Olafsdóttir
    Department of Medicine, Iceland University Hospital, Fossvogi, 108 Reykjavik, Iceland
    Laeknabladid 91:511-4. 2005
    ..Various parties have expressed interest in establishing formal postgraduate medical education programs. The interest of residents and medical students to such programs in Iceland has not been evaluated before...
  31. doi request reprint Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection
    Damon P Eisen
    Centre for Clinical Research Excellence in Infectious Diseases, Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Clin Infect Dis 47:510-6. 2008
    ..However, MBL deficiency has not been rigorously defined, and associations with sepsis outcomes have not been subjected to multivariable analysis...