Affiliation: Karolinska Institutet
- Placebo and opioid analgesia-- imaging a shared neuronal networkPredrag Petrovic
Cognitive Neurophysiology Research Group, Department of Clinical Neuroscience, Karolinska Institute, Stockholm 171 76, Sweden, Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Finland
Science 295:1737-40. 2002..These findings indicate a related neural mechanism in placebo and opioid analgesia...
- Oxytocin attenuates affective evaluations of conditioned faces and amygdala activityPredrag Petrovic
Wellcome Trust Functional Imaging Laboratory, University College London, London WC1N 3BG, United Kingdom
J Neurosci 28:6607-15. 2008..The data suggest that oxytocin modulates the expression of evaluative conditioning for socially relevant faces via influences on amygdala and fusiform gyrus, an effect that may explain its prosocial effects...
- Brainstem involvement in the initial response to painPredrag Petrovic
PET Cognitive Neurophysiology, Department of Clinical Neuroscience, Karolinska Insitute, 171 76 Stockholm, Sweden
Neuroimage 22:995-1005. 2004..The findings indicate that areas in the brainstem are involved in the initial response to noxious stimulation, which is also characterized by an increased sympathetic response...
- Placebo in emotional processing--induced expectations of anxiety relief activate a generalized modulatory networkPredrag Petrovic
Cognitive Neurophysiology Research Group R2 01, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
Neuron 46:957-69. 2005..Thus, the placebo effect may be considered to be a general process of modulation induced by the subjects' expectations...
- Emotional perception modulated by an opioid and a cholecystokinin agonistKatarina Gospic
MR Centre, Department of Clinical Neuroscience, Karolinska Institutet, N 8, Karolinska University Hospital, 17176 Stockholm, Sweden
Psychopharmacology (Berl) 197:295-307. 2008..In this behavioral study, we generalize this idea and suggest that CCK and opioids can modulate the processing of other external signals, e.g., visual stimuli rather than only noxious input...
- Significant grey matter changes in a region of the orbitofrontal cortex in healthy participants predicts emotional dysregulationPredrag Petrovic
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Soc Cogn Affect Neurosci 11:1041-9. 2016..Our findings support the concept of continuous properties in psychiatric symptomatology. ..
- Learning affective values for faces is expressed in amygdala and fusiform gyrusPredrag Petrovic
Wellcome Trust Centre for Neuroimaging, University College of London, 12 Queen Square, London, WC1N 3BG, UK
Soc Cogn Affect Neurosci 3:109-18. 2008..We conclude that amygdala and fusiform encode affective value in a manner that closely approximates a standard computational solution to learning...
- Blocking central opiate function modulates hedonic impact and anterior cingulate response to rewards and lossesPredrag Petrovic
Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, United Kingdom
J Neurosci 28:10509-16. 2008..Our data indicate that a central opioid system contributes to both reward and loss processing in humans and directly modulates the hedonic experience of outcomes...
- A prefrontal non-opioid mechanism in placebo analgesiaPredrag Petrovic
Cognitive Neurophysiology Research Group, Stockholm Brain Institute, Osher Center for Integrative Medicine, Karolinska Institutet, Stockholm, Sweden
Pain 150:59-65. 2010..Our results thus support that placebo is different from specific treatment with a prefrontal top-down influence on rACC...
- Predictability modulates the affective and sensory-discriminative neural processing of painKatrina Carlsson
Department of Clinical Neuroscience, MRC N8, Karolinska Institute and Hospital, SE 171 76 Stockholm, Sweden, and F C Donders Center, Radboud University Nijmegen, The Netherlands
Neuroimage 32:1804-14. 2006..This context also prompted increased activity in the posterior parietal cortex and lateral prefrontal cortex that we attribute to enhanced alertness and sustained attention during unpredictability...
- From threat to fear: the neural organization of defensive fear systems in humansDean Mobbs
Wellcome Trust Centre for Neuroimaging, University College London, London WC1 3BG, United Kingdom
J Neurosci 29:12236-43. 2009....
- Context-dependent deactivation of the amygdala during painPredrag Petrovic
Karolinska Institute Karolinska Hospital, Stockholm, Sweden
J Cogn Neurosci 16:1289-301. 2004....
- When fear is near: threat imminence elicits prefrontal-periaqueductal gray shifts in humansDean Mobbs
Wellcome Trust Centre for Neuroimaging, Functional Imaging Laboratory, University College London, London WC1N 3BG, UK
Science 317:1079-83. 2007..Our findings cast light on the neural dynamics of threat anticipation and have implications for the neurobiology of human anxiety-related disorders...
- Subliminal instrumental conditioning demonstrated in the human brainMathias Pessiglione
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N3BG, UK
Neuron 59:561-7. 2008..We conclude that, even without conscious processing of contextual cues, our brain can learn their reward value and use them to provide a bias on decision making...
- A regression analysis study of the primary somatosensory cortex during painPredrag Petrovic
PET, Cognitive Neurophysiology, Department of Clinical Neuroscience, Multidisciplinary Pain Center, Department of Rehabilitation Medicine, Karolinska Institute, Karolinska Hospital, Sweden
Neuroimage 16:1142-50. 2002..The results indicate that the S1-cortex may be engaged in or affected by the processing of pain although no differential activity is observed when pain is compared with the reference condition...
- Limbic justice--amygdala involvement in immediate rejection in the Ultimatum GameKatarina Gospic
MR Research Center and Osher Center for Integrative Medicine, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
PLoS Biol 9:e1001054. 2011..Our results also prompt an ethical discussion as we demonstrated that a commonly used drug influences core functions in the human brain that underlie individual autonomy and economic decision making...
- Cortical thickness, volume and surface area in patients with bipolar disorder types I and IIChristoph Abé
From the Departments of Clinical Neuroscience Abé, Ekman, Petrovic, Ingvar, Landén, Physiology and Pharmacology Sellgren, and Medical Epidemiology and Biostatistics Landén, Karolinska Institutet, Stockholm, Sweden and the Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden Landén
J Psychiatry Neurosci 41:240-50. 2016..The aim of our study was to investigate abnormalities in patients with BDI and BDII by simultaneously analyzing cortical volume, thickness and surface area, which yields more information about disease- and symptom-related neurobiology...
- A History of Psychosis in Bipolar Disorder is Associated With Gray Matter Volume ReductionCarl Johan Ekman
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Schizophr Bull . 2016..These areas have previously been structurally and functionally coupled to delusions and hallucinations. Our finding adds further evidence to the probability of these regions as key areas in the development of psychotic symptoms...
- Effects of L-dopa and oxazepam on resting-state functional magnetic resonance imaging connectivity: a randomized, cross-sectional placebo studyPär Flodin
Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
Brain Connect 2:246-53. 2012....
- The NMDA agonist D-cycloserine facilitates fear memory consolidation in humansRaffael Kalisch
Functional Imaging Laboratory, Wellcome Department of Imaging Neuroscience, University College London, London, UK
Cereb Cortex 19:187-96. 2009..DCS also enhanced CS-evoked neural responses in a posterior hippocampus/collateral sulcus region and in the medial prefrontal cortex at test. Our data suggest a role for NMDA receptors in regulating fear memory consolidation in humans...
- Altruism costs-the cheap signal from amygdalaKatarina Gospic
MR Research Center and Osher Center for Integrative Medicine, Department of Clinical Neuroscience, Karolinska Institute, Retzius vag 8, 17177 Stockholm, KTH Royal Institute of Technology, Department of Transport Science, Teknikringen 10, 100 44 Stockholm and VTI, Transport Economics Unit, PO Box 920, 781 29 Borlänge, Sweden
Soc Cogn Affect Neurosci 9:1325-32. 2014..Our findings imply that the emotional system has an important role in real decision making as it signals what kind of immediate cost and reward an outcome is associated with. ..
- Manic episodes are related to changes in frontal cortex: a longitudinal neuroimaging study of bipolar disorder 1Christoph Abé
1 Department of Clinical Neuroscience, Osher Center, Karolinska Institutet, Stockholm, Sweden
Brain 138:3440-8. 2015..Our results indicate that volume decrease in frontal brain regions can be attributed to the incidence of manic episodes. ..
- Executive functions predict the success of top-soccer playersTorbjörn Vestberg
Department of Clinical Neuroscience, Karolinska Institutet Stockholm, Stockholm, Sweden
PLoS ONE 7:e34731. 2012..The results from this study strongly suggest that results in cognitive function tests predict the success of ball sport players...
- Imaging cognitive modulation of pain processingPredrag Petrovic
Cognitive Neurophysiology Research Group R2 01, Department of Clinical Neuroscience, Karolinska Institute, 171 76 Stockholm, Sweden
Pain 95:1-5. 2002
- Intrinsic functional connectivity of insular cortex and symptoms of sickness during acute experimental inflammationMats Lekander
Stress Research Institute, Stockholm University, Stockholm, Sweden Osher Center for Integrative Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden Division of Psychology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden Electronic address
Brain Behav Immun 56:34-41. 2016....
- The Effects of Positive or Neutral Communication during Acupuncture for Relaxing Effects: A Sham-Controlled Randomized TrialAnnelie Rosén
Department of Clinical Neuroscience, Osher Centre for Integrative Medicine, Karolinska Institute, 171 77 Stockholm, Sweden
Evid Based Complement Alternat Med 2016:3925878. 2016..Our data highlights the importance of expectations for treatment outcome and demonstrates that expectations can be effectively manipulated using a standardized protocol that in future research may be implemented in clinical trials. ..
- Testosterone Administration Related Differences in Brain Activation during the Ultimatum GameEleni Kopsida
Department of Clinical Neuroscience, MR Research Center and Osher Center for Integrative Medicine, Karolinska Institutet Stockholm, Sweden
Front Neurosci 10:66. 2016..Increased testosterone levels were related to greater caudate activity. Our findings suggest a complex role of testosterone in social behavior and decision-making. ..