Affiliation: Karolinska Institutet
- Structural basis for induced formation of the inflammatory mediator prostaglandin E2Caroline Jegerschöld
Department of Biosciences and Nutrition, Karolinska Institutet and School of Technology and Health, Royal Institute of Technology, Novum, S 141 57 Huddinge, Sweden
Proc Natl Acad Sci U S A 105:11110-5. 2008..Hence, insight into the dynamic behavior of MPGES1 and homologous membrane proteins in inflammation and detoxification is provided...
- Structural basis for detoxification and oxidative stress protection in membranesPeter J Holm
Department of Biosciences and Nutrition, Karolinska Institutet and School of Technology and Health, Royal Institute of Technology, SE 14157 Huddinge, Sweden
J Mol Biol 360:934-45. 2006..The architecture of the homotrimer supports a catalytic mechanism involving subunit interactions and reveals both cytosolic and membraneous substrate entry sites, providing a rationale for the membrane location of the enzyme...
- The structure of membrane associated proteins in eicosanoid and glutathione metabolism as determined by electron crystallographyHans Hebert
Karolinska Institutet, Department of Biosciences and Nutrition and Royal Institute of Technology, School of Technology and Health, Novum, S 141 57 Huddinge, Sweden
Curr Opin Struct Biol 17:396-404. 2007....
- Structural and Functional Analysis of Calcium Ion Mediated Binding of 5-Lipoxygenase to NanodiscsRamakrishnan B Kumar
Department of Biosciences and Nutrition, Karolinska Institutet, 14183 Huddinge, Sweden
PLoS ONE 11:e0152116. 2016..This study shows the advantages of nanodiscs to obtain basic structural information as well as functional information of a complex between a monotopic membrane protein and the membrane. ..