Tibor Harkany

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor
    Paul Berghuis
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institutet, S 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 102:19115-20. 2005
  2. pmc Wiring and firing neuronal networks: endocannabinoids take center stage
    Tibor Harkany
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institute, SE 17177 Stockholm, Sweden
    Curr Opin Neurobiol 18:338-45. 2008
  3. ncbi request reprint The emerging functions of endocannabinoid signaling during CNS development
    Tibor Harkany
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE 17177, Sweden
    Trends Pharmacol Sci 28:83-92. 2007
  4. ncbi request reprint Brain-derived neurotrophic factor selectively regulates dendritogenesis of parvalbumin-containing interneurons in the main olfactory bulb through the PLCgamma pathway
    Paul Berghuis
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Neurobiol 66:1437-51. 2006
  5. pmc Miswiring the brain: Δ9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway
    Giuseppe Tortoriello
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    EMBO J 33:668-85. 2014
  6. ncbi request reprint Hardwiring the brain: endocannabinoids shape neuronal connectivity
    Paul Berghuis
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 17177 Stockholm, Sweden
    Science 316:1212-6. 2007
  7. pmc Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning
    Jan Mulder
    Department of Neuroscience, Retzius vag 8, and Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles vag 1, Karolinska Institutet, 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:8760-5. 2008
  8. pmc Input specificity and dependence of spike timing-dependent plasticity on preceding postsynaptic activity at unitary connections between neocortical layer 2/3 pyramidal cells
    Misha Zilberter
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Cereb Cortex 19:2308-20. 2009
  9. ncbi request reprint Brain-derived neurotrophic factor controls functional differentiation and microcircuit formation of selectively isolated fast-spiking GABAergic interneurons
    Paul Berghuis
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institutet, S 17177 Stockholm, Sweden
    Eur J Neurosci 20:1290-306. 2004
  10. ncbi request reprint Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors
    Isaac Shemer
    Department of Neuroscience, Retzius väg 8 A3 417, Karolinska Institutet, S 17177 Stockholm, Sweden
    Eur J Neurosci 23:2035-47. 2006

Detail Information

Publications46

  1. pmc Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor
    Paul Berghuis
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institutet, S 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 102:19115-20. 2005
    ..Moreover, eCBs use TrkB receptor-dependent signaling pathways to regulate subtype-selective interneuron migration and specification...
  2. pmc Wiring and firing neuronal networks: endocannabinoids take center stage
    Tibor Harkany
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institute, SE 17177 Stockholm, Sweden
    Curr Opin Neurobiol 18:338-45. 2008
    ..Current challenges include fitting novel molecular candidates into regulatory eCB signaling pathways, and defining the temporal dynamics of context-dependent signaling mechanisms underpinning particular neuronal specification events...
  3. ncbi request reprint The emerging functions of endocannabinoid signaling during CNS development
    Tibor Harkany
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE 17177, Sweden
    Trends Pharmacol Sci 28:83-92. 2007
    ..Here, we summarize recent findings regarding the ontogeny of the endocannabinoid system in neurons that sculpt the temporal and spatial diversity of cellular functions during CNS development...
  4. ncbi request reprint Brain-derived neurotrophic factor selectively regulates dendritogenesis of parvalbumin-containing interneurons in the main olfactory bulb through the PLCgamma pathway
    Paul Berghuis
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Neurobiol 66:1437-51. 2006
    ..Collectively, our results provide genetic evidence that BDNF and TrkB signaling selectively regulate PV expression and dendrite growth in a subset of neurochemically-defined GABAergic interneurons via activation of the PLCgamma pathway...
  5. pmc Miswiring the brain: Δ9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway
    Giuseppe Tortoriello
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    EMBO J 33:668-85. 2014
    ..These data highlight the maintenance of cytoskeletal dynamics as a molecular target for cannabis, whose imbalance can limit the computational power of neuronal circuitries in affected offspring. ..
  6. ncbi request reprint Hardwiring the brain: endocannabinoids shape neuronal connectivity
    Paul Berghuis
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 17177 Stockholm, Sweden
    Science 316:1212-6. 2007
    ....
  7. pmc Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning
    Jan Mulder
    Department of Neuroscience, Retzius vag 8, and Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles vag 1, Karolinska Institutet, 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:8760-5. 2008
    ..Likewise, axonal pathfinding becomes impaired after in utero pharmacological blockade of CB(1)Rs. Overall, eCBs are fundamental developmental cues controlling pyramidal cell development during corticogenesis...
  8. pmc Input specificity and dependence of spike timing-dependent plasticity on preceding postsynaptic activity at unitary connections between neocortical layer 2/3 pyramidal cells
    Misha Zilberter
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Cereb Cortex 19:2308-20. 2009
    ..We also highlight differences in STDP at excitatory synapses onto L2/3 pyramidal cells which allow for input specific modulation of synaptic gain...
  9. ncbi request reprint Brain-derived neurotrophic factor controls functional differentiation and microcircuit formation of selectively isolated fast-spiking GABAergic interneurons
    Paul Berghuis
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institutet, S 17177 Stockholm, Sweden
    Eur J Neurosci 20:1290-306. 2004
    ..Our results show that BDNF, along with membrane depolarization, is critical for FS cells to establish inhibitory circuitries during corticogenesis...
  10. ncbi request reprint Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors
    Isaac Shemer
    Department of Neuroscience, Retzius väg 8 A3 417, Karolinska Institutet, S 17177 Stockholm, Sweden
    Eur J Neurosci 23:2035-47. 2006
    ..We propose that soluble Abeta(ol)s trigger the diminution of synaptic plasticity in neocortical pyramidal cell networks during early stages of AD pathogenesis by preferentially targeting postsynaptic AMPA receptors...
  11. ncbi request reprint Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra
    Raquel Martín-Ibáñez
    Laboratory for Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1
    Eur J Neurosci 23:1063-70. 2006
    ..Collectively, our data indicate that VGLUT3 identifies a novel excitatory terminal subset that contributes to the tuning of DA cell excitability in the substantia nigra...
  12. ncbi request reprint Dendritic release of retrograde messengers controls synaptic transmission in local neocortical networks
    Yuri Zilberter
    Karolinska Institute, Stockholm, Sweden
    Neuroscientist 11:334-44. 2005
    ..The present review discusses these findings and the mechanisms underlying synaptic retrograde signaling...
  13. ncbi request reprint Turning the heterogeneous into homogeneous: studies on selectively isolated GABAergic interneuron subsets
    Paul Berghuis
    Department of Medical Biochemistry and Biophysics, Laboratory for Molecular Neurobiology, Scheeles väg 1 A1, Karolinska Institutet, S 17177 Stockholm, Sweden
    Int J Dev Neurosci 22:533-43. 2004
    ..In addition, we discuss therapeutic prospects of modulating increased excitatory output in the hippocampus and subthalamic nucleus by re-adjusting the inhibitory control of principal cells...
  14. pmc Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture
    Katarzyna Maleńczyk
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 17177 Stockholm, Sweden Nencki Institute of Experimental Biology, 02 093 Warsaw, Poland Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, A 1090 Vienna, Austria
    Proc Natl Acad Sci U S A 112:E6185-94. 2015
    ..Overall, our data mechanistically link endocannabinoids to cell proliferation and sorting during pancreatic islet formation, as well as to life-long programming of hormonal determinants of glucose homeostasis. ..
  15. pmc Sticking out of the crowd: the molecular identity and development of cholecystokinin-containing basket cells
    Erik Keimpema
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institutet, S 17177 Stockholm, Sweden
    J Physiol 590:703-14. 2012
    ....
  16. ncbi request reprint Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3
    Tibor Harkany
    Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 17177 Stockholm, Sweden
    J Neurosci 24:4978-88. 2004
    ....
  17. pmc Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling
    Alan Alpar
    1 Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles väg 1 A1, SE 17177 Stockholm, Sweden 2
    Nat Commun 5:4421. 2014
    ....
  18. doi request reprint Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease
    Misha Zilberter
    Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    J Neurochem 125:157-71. 2013
    ..Altogether, our results suggest that early AD-related neuronal malfunctions underlying hyperexcitability and energy metabolism deficiency can be prevented by dietary supplementation with native energy substrates...
  19. pmc WNT signaling in activated microglia is proinflammatory
    Carina Halleskog
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Glia 59:119-31. 2011
    ..In summary, our data suggest that the WNT family of lipoglycoproteins can instruct proinflammatory microglia transformation and emphasize the pathogenic significance of β-catenin-signaling networks in this cell type...
  20. ncbi request reprint Region-specific generation of functional neurons from naive embryonic stem cells in adult brain
    Tibor Harkany
    Department of Medical Biochemistry and Biophysics Center of Excellence in Developmental Biology, Karolinska Institutet, Stockholm, Sweden
    J Neurochem 88:1229-39. 2004
    ....
  21. pmc Molecular reorganization of endocannabinoid signalling in Alzheimer's disease
    Jan Mulder
    European Neuroscience Institute at Aberdeen, School of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Brain 134:1041-60. 2011
    ..Thus, enhanced endocannabinoid signalling, particularly around senile plaques, can exacerbate synaptic failure in Alzheimer's disease...
  22. pmc GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain
    Erik Keimpema
    Department of Neuroscience, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE 17177, Sweden
    Cereb Cortex 24:3277-88. 2014
    ..Overall, our data define the cellular specificity and molecular complexity of galanin action in the developing basal forebrain. ..
  23. doi request reprint Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord
    Ming Dong Zhang
    Department of Neuroscience, Karolinska Institutet, 17177, Stockholm, Sweden
    Brain Struct Funct 221:3803-23. 2016
    ....
  24. ncbi request reprint Functional Differentiation of Cholecystokinin-Containing Interneurons Destined for the Cerebral Cortex
    Daniela Calvigioni
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A 1090 Vienna, Austria
    Cereb Cortex . 2016
    ..5 and reliable adult-like excitability by embryonic day 18.5. Cumulatively, this study defines key positional, molecular, and biophysical properties of CCK+interneurons in the prenatal brain...
  25. pmc Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes
    János Fuzik
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Nat Biotechnol 34:175-83. 2016
    ..Our findings demonstrate the ability of Patch-seq to precisely map neuronal subtypes and predict their network contributions in the brain...
  26. pmc Diacylglycerol lipase α manipulation reveals developmental roles for intercellular endocannabinoid signaling
    Erik Keimpema
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Sci Rep 3:2093. 2013
    ..Overall, these data suggest that extracellular 2-AG concentrations can be sufficient to activate CB₁Rs along discrete spherical boundaries to modulate neuronal responsiveness...
  27. pmc En masse in vitro functional profiling of the axonal mechanosensitivity of sensory neurons
    Dmitry Usoskin
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 107:16336-41. 2010
    ..This result allows for the characterization of two critical steps of mechanosensation in vivo: primary signal detection and signal conversion into specific action potential firing patterns in axons...
  28. doi request reprint Autoantibodies in autoimmune polyglandular syndrome type I patients react with major brain neurotransmitter systems
    Serguei O Fetissov
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Comp Neurol 513:1-20. 2009
    ..Only in a few cases, however, there was evidence that these autoAbs can be associated with neurological manifestations in APS1 patients, as, e.g., shown in previous studies in stiff-man syndrome...
  29. pmc Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels
    Ming Dong Zhang
    Department of Neuroscience, Karolinska Institutet, Stockholm 171 77, Sweden
    Proc Natl Acad Sci U S A 113:E6686-E6695. 2016
    ..Taken together, our results suggest that attenuated BDNF release and signaling in the dentate gyrus may account for cognitive and mental deficits sometimes observed after surgery...
  30. pmc Neuronal calcium-binding proteins 1/2 localize to dorsal root ganglia and excitatory spinal neurons and are regulated by nerve injury
    Ming Dong Zhang
    Department of Neuroscience, Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, and Science for Life Laboratory, Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 111:E1149-58. 2014
    ....
  31. pmc Neuronal substrates and functional consequences of prenatal cannabis exposure
    Daniela Calvigioni
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177, Stockholm, Sweden
    Eur Child Adolesc Psychiatry 23:931-41. 2014
    ....
  32. pmc A secretagogin locus of the mammalian hypothalamus controls stress hormone release
    Roman A Romanov
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    EMBO J 34:36-54. 2015
    ..Cumulatively, these data define a novel secretagogin neuronal locus and molecular axis underpinning stress responsiveness. ..
  33. pmc Targeted lipidomics in Drosophila melanogaster identifies novel 2-monoacylglycerols and N-acyl amides
    Giuseppe Tortoriello
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e67865. 2013
    ..Data here suggest that Drosophila represent another model system to use for the study of 2-acyl glycerol and N-acyl amide signaling. ..
  34. pmc Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
    Sueli Marques
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Science 352:1326-9. 2016
    ..Our study reveals the dynamics of oligodendrocyte differentiation and maturation, uncoupling them at a transcriptional level and highlighting oligodendrocyte heterogeneity in the CNS. ..
  35. pmc Protracted brain development in a rodent model of extreme longevity
    Orsolya K Penz
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Sci Rep 5:11592. 2015
    ....
  36. doi request reprint The molecular interplay between endocannabinoid and neurotrophin signals in the nervous system and beyond
    Erik Keimpema
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles väg 1 A1, SE 17177, Stockholm, Sweden Department of Molecular Neuroscience, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A 1090, Vienna, Austria
    Eur J Neurosci 39:334-43. 2014
    ....
  37. ncbi request reprint Complementary distribution of type 1 cannabinoid receptors and vesicular glutamate transporter 3 in basal forebrain suggests input-specific retrograde signalling by cholinergic neurons
    Tibor Harkany
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institutet, S 17177 Stockholm, Sweden
    Eur J Neurosci 18:1979-92. 2003
    ....
  38. pmc Pyramidal cell communication within local networks in layer 2/3 of rat neocortex
    Carl Holmgren
    Karolinska Institute, Department of Neuroscience, Retzius vag 8, B2 2, S 17177 Stockholm, Sweden
    J Physiol 551:139-53. 2003
    ..With such a high degree of connectivity with surrounding pyramidal cells, local interneurons are ideally poised to both coordinate and expand the local pyramidal cell network via pyramidal-interneuron-pyramidal communication...
  39. pmc H1N1 influenza virus induces narcolepsy-like sleep disruption and targets sleep-wake regulatory neurons in mice
    Chiara Tesoriero
    Department of Neuroscience, Karolinska Institutet, Stockholm SE 17177, Sweden Department of Neurological and Movement Sciences, University of Verona, Verona 37134, Italy
    Proc Natl Acad Sci U S A 113:E368-77. 2016
    ..Because changes occurred in the absence of adaptive autoimmune responses, the findings show that brain infections with H1N1 virus have the potential to cause per se narcoleptic-like sleep disruption. ..
  40. doi request reprint Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer's disease
    Csaba Adori
    Department of Neuroscience, Retzius Laboratory, Karolinska Institutet, Retzius vag 8, 17177, Stockholm, Sweden
    Acta Neuropathol 129:541-63. 2015
    ....
  41. doi request reprint Endocannabinoid signals in the developmental programming of delayed-onset neuropsychiatric and metabolic illnesses
    Erik Keimpema
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Biochem Soc Trans 41:1569-76. 2013
    ..Moreover, we propose that the placenta, fetal adipose and nervous tissues interact via endocannabinoid signals. Thus endocannabinoids are hypothesized to act as a molecular substrate of maternal programming. ..
  42. ncbi request reprint Neurotrophin-4 mediated TrkB activation reinforces morphine-induced analgesia
    Guilherme Lucas
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 17177 Stockholm, Sweden
    Nat Neurosci 6:221-2. 2003
  43. ncbi request reprint Neonatal handling increases sensitivity to acute neurodegeneration in adult rats
    Katalin M Horvath
    Department of Molecular Neurobiology, Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, 9750 AA Haren, The Netherlands
    J Neurobiol 60:463-72. 2004
    ..The present results provide evidence for an enhanced vulnerability of postnatally handled rats to acute neurodegeneration in contrast to the previously reported attenuation of spontaneous aging-related neurodegenerative processes...
  44. pmc Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro
    Mauricio G Martin
    VIB and Department of Human Genetics, Catholic University of Leuven, B 3000 Leuven, Belgium
    Mol Biol Cell 19:2101-12. 2008
    ....
  45. doi request reprint Endocannabinoid functions controlling neuronal specification during brain development
    Tibor Harkany
    Institute of Medical Sciences, School of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, United Kingdom
    Mol Cell Endocrinol 286:S84-90. 2008
    ..Finally, we discuss how these novel principles affect the formation of complex neuronal networks...
  46. ncbi request reprint Post-lesion administration of 5-HT1A receptor agonist 8-OH-DPAT protects cholinergic nucleus basalis neurons against NMDA excitotoxicity
    Bart J Oosterink
    Department of Molecular Neurobiology, Graduate School of Behavioural and Cognitive Neurosciences, University of Groningen, Kerklaan 30, NL 9750 AA Haren, The Netherlands
    Neuroreport 14:57-60. 2003
    ....