Jan Ake Gustafsson

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Discovery of estrogen receptor alpha target genes and response elements in breast tumor cells
    Chin Yo Lin
    Genome Institute of Singapore, Singapore 117528
    Genome Biol 5:R66. 2004
  2. pmc Inhibitory effects of estrogen receptor beta on specific hormone-responsive gene expression and association with disease outcome in primary breast cancer
    Chin Yo Lin
    Genome Institute of Singapore, Singapore 138672, Republic of Singapore
    Breast Cancer Res 9:R25. 2007
  3. pmc Impact of estrogen receptor gene polymorphisms and mRNA levels on obesity and lipolysis--a cohort study
    Maria Nilsson
    Departments of Biosciences and Nutrition, Karolinska Institutet, S 141 57 Huddinge, Sweden
    BMC Med Genet 8:73. 2007
  4. pmc Functional and genetic analysis in type 2 diabetes of liver X receptor alleles--a cohort study
    Ingrid Dahlman
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    BMC Med Genet 10:27. 2009
  5. pmc Estren promotes androgen phenotypes in primary lymphoid organs and submandibular glands
    Ulrika Islander
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, Goteborg University, Sweden
    BMC Immunol 6:16. 2005
  6. ncbi What pharmacologists can learn from recent advances in estrogen signalling
    Jan Ake Gustafsson
    Department of Medical Nutrition, Karolinska Institute, Huddinge University Hospital, S 141 86 Huddinge, Sweden
    Trends Pharmacol Sci 24:479-85. 2003
  7. ncbi An update on estrogen receptors
    J A Gustafsson
    Department of Medical Nutrition, Karolinska Institute, Huddinge University Hospital, Sweden
    Semin Perinatol 24:66-9. 2000
  8. ncbi Estrogen receptor beta in the breast: role in estrogen responsiveness and development of breast cancer
    J A Gustafsson
    Department of Medical Nutrition, Novum, Karolinska Institute, Huddinge University Hospital, S 141 86, Huddinge, Sweden
    J Steroid Biochem Mol Biol 74:245-8. 2000
  9. ncbi Different regulation of the LXRalpha promoter activity by isoforms of CCAAT/enhancer-binding proteins
    Knut R Steffensen
    Department of Biosciences, Novum Research Park, Karolinska Institute, Huddinge S 14157, Sweden
    Biochem Biophys Res Commun 293:1333-40. 2002
  10. ncbi An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling
    Anastasios E Damdimopoulos
    Department of Biosciences, Novum, Karolinska Institute, S 141 57 Huddinge, Sweden
    J Biol Chem 279:38721-9. 2004

Detail Information

Publications150 found, 100 shown here

  1. pmc Discovery of estrogen receptor alpha target genes and response elements in breast tumor cells
    Chin Yo Lin
    Genome Institute of Singapore, Singapore 117528
    Genome Biol 5:R66. 2004
    ..In this study, we utilized an integrated genome-wide molecular and computational approach to characterize the interaction between the activated estrogen receptor (ER) and the regulatory elements of candidate target genes...
  2. pmc Inhibitory effects of estrogen receptor beta on specific hormone-responsive gene expression and association with disease outcome in primary breast cancer
    Chin Yo Lin
    Genome Institute of Singapore, Singapore 138672, Republic of Singapore
    Breast Cancer Res 9:R25. 2007
    ..The goal of this study was to examine transcriptomic alterations in cancer cells co-expressing both receptors and the association of gene expression signatures with disease outcome...
  3. pmc Impact of estrogen receptor gene polymorphisms and mRNA levels on obesity and lipolysis--a cohort study
    Maria Nilsson
    Departments of Biosciences and Nutrition, Karolinska Institutet, S 141 57 Huddinge, Sweden
    BMC Med Genet 8:73. 2007
    ..In this report we analyse ESR1 and ESR2 gene single nucleotide polymorphisms (SNPs) for association with obesity. We also relate adipose tissue ESR1 mRNA levels and ESR1 SNPs to adipocyte lipolysis and lipogenesis phenotypes...
  4. pmc Functional and genetic analysis in type 2 diabetes of liver X receptor alleles--a cohort study
    Ingrid Dahlman
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    BMC Med Genet 10:27. 2009
    ..This project aimed to determine whether common genetic variations in LXRA and LXRB associate with type 2 diabetes (T2D) and quantitative measures of glucose homeostasis, and, if so, reveal the underlying mechanisms...
  5. pmc Estren promotes androgen phenotypes in primary lymphoid organs and submandibular glands
    Ulrika Islander
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, Goteborg University, Sweden
    BMC Immunol 6:16. 2005
    ..Estrogen receptors (ERs) were blocked by treatment of mice with the ER-antagonist ICI 182,780; also, knock-out mice lacking one or both ERs were used...
  6. ncbi What pharmacologists can learn from recent advances in estrogen signalling
    Jan Ake Gustafsson
    Department of Medical Nutrition, Karolinska Institute, Huddinge University Hospital, S 141 86 Huddinge, Sweden
    Trends Pharmacol Sci 24:479-85. 2003
    ....
  7. ncbi An update on estrogen receptors
    J A Gustafsson
    Department of Medical Nutrition, Karolinska Institute, Huddinge University Hospital, Sweden
    Semin Perinatol 24:66-9. 2000
    ..Attempts are ongoing in several labs to develop specific ligands to the two receptors. Such ligands may well turn out to be extremely important in treating the mentioned diseases and symptoms as well as possibly others...
  8. ncbi Estrogen receptor beta in the breast: role in estrogen responsiveness and development of breast cancer
    J A Gustafsson
    Department of Medical Nutrition, Novum, Karolinska Institute, Huddinge University Hospital, S 141 86, Huddinge, Sweden
    J Steroid Biochem Mol Biol 74:245-8. 2000
    ..Studies of the breasts of ERbeta knock out mice (BERKO) revealed abnormal epithelial growth, overexpression of Ki67 and severe cystic breast disease as mice age...
  9. ncbi Different regulation of the LXRalpha promoter activity by isoforms of CCAAT/enhancer-binding proteins
    Knut R Steffensen
    Department of Biosciences, Novum Research Park, Karolinska Institute, Huddinge S 14157, Sweden
    Biochem Biophys Res Commun 293:1333-40. 2002
    ..Monitoring of the LXR mRNA levels during adipose tissue differentiation showed that LXRbeta is constitutively expressed during the entire differentiation process while LXRalpha is induced upon addition of differentiation mix...
  10. ncbi An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling
    Anastasios E Damdimopoulos
    Department of Biosciences, Novum, Karolinska Institute, S 141 57 Huddinge, Sweden
    J Biol Chem 279:38721-9. 2004
    ..In summary, our results suggest that TrxR1b is an important modulator of estrogen signaling...
  11. pmc Regulation of subnuclear localization is associated with a mechanism for nuclear receptor corepression by RIP140
    Hiroshi Tazawa
    Departments of Medical Nutrition Biosciences, Karolinska Institutet, Novum, S 141 86 Huddinge, Sweden
    Mol Cell Biol 23:4187-98. 2003
    ....
  12. ncbi Accumulation of foam cells in liver X receptor-deficient mice
    Gertrud U Schuster
    Department of Biosciences at Novum, Karolinska Institutet, Huddinge, Sweden
    Circulation 106:1147-53. 2002
    ..The present study aimed to elucidate the physiological relevance of both LXRs with regard to lipid metabolism and macrophage cholesterol efflux...
  13. pmc Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration
    Ling Wang
    Department of Medical Nutrition, Novum, Karolinska Institute, Huddinge University Hospital, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 99:13878-83. 2002
    ..Further characterization of the role of LXRs in the brain could lead to new insights into the etiology and treatment of some neurodegenerative disorders...
  14. doi Fasting-induced FGF21 is repressed by LXR activation via recruitment of an HDAC3 corepressor complex in mice
    Amena Archer
    Department of Biosciences and Nutrition and Center for Biosciences at NOVUM, Karolinska Institute, S 141 83 Huddinge, Sweden
    Mol Endocrinol 26:1980-90. 2012
    ..Our data clearly demonstrate that there is a cross talk between the LXR and FGF21 signaling pathways in the adaptive response to fasting...
  15. ncbi A role for the androgen receptor in follicular atresia of estrogen receptor beta knockout mouse ovary
    Guojun Cheng
    Department of Medical Nutrition, Karolinska Institute, Novum, S 14186 Huddinge, Sweden
    Biol Reprod 66:77-84. 2002
    ....
  16. pmc An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth
    Zhang Weihua
    Department of Medical Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 99:13589-94. 2002
    ..In this pathway, ERbeta is an antiproliferative receptor, 3betaAdiol is an ERbeta ligand, and CYP7B1 is the enzyme that regulates ERbeta function by regulating the level of 3betaAdiol...
  17. doi Genome-wide mapping of estrogen receptor-beta-binding regions reveals extensive cross-talk with transcription factor activator protein-1
    Chunyan Zhao
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden
    Cancer Res 70:5174-83. 2010
    ..Together, our results broaden insights into ERbeta DNA-binding at the genomic level by revealing crosstalk with the AP-1 transcription factor...
  18. ncbi The anti-estrogenic effect of all-trans-retinoic acid on the breast cancer cell line MCF-7 is dependent on HES-1 expression
    Patrick Muller
    Center for Biotechnology, Karolinska Institute, Novum, S 141 57 Huddinge, Sweden
    J Biol Chem 277:28376-9. 2002
    ..This finding indicates that Hairy and Enhancer of Split homologue-1 is a mediator of the antiproliferative effect of all-trans-retinoic acid in estrogen receptor alpha-positive breast cancer cell lines...
  19. ncbi Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver
    Hui Gao
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, S 14157 Huddinge, Sweden
    Mol Endocrinol 22:10-22. 2008
    ..These results extend our previous studies using gene expression profiling to characterize estrogen signaling in mouse liver, by characterizing the first step in this signaling cascade, the binding of ERalpha to DNA in intact chromatin...
  20. ncbi Estrogen receptor beta inhibits angiogenesis and growth of T47D breast cancer xenografts
    Johan Hartman
    Center for Biotechnology, Karolinska Institutet, Huddinge, Sweden
    Cancer Res 66:11207-13. 2006
    ..Taken together, these data show that introduction of ERbeta into malignant cells inhibits their growth and prevents tumor expansion by inhibiting angiogenesis...
  21. pmc Muscle GLUT4 regulation by estrogen receptors ERbeta and ERalpha
    Rodrigo P A Barros
    Department of Biosciences and Nutrition, Karolinska Institute, S 141 86 Novum, Sweden
    Proc Natl Acad Sci U S A 103:1605-8. 2006
    ....
  22. ncbi Human estrogen receptor beta 548 is not a common variant in three distinct populations
    Li Xu
    Karolinska Institute, Department of Biosciences at Novum, SE 14157 Huddinge, Sweden
    Endocrinology 144:3541-6. 2003
    ..We did not detect any alleles that correspond to hERbeta548 in these samples or in additional samples of heterogeneous origin. It is concluded that hERbeta548 is not a common variant in Africans, Caucasians, or Asians...
  23. pmc Estrogen receptor alpha and imprinting of the neonatal mouse ventral prostate by estrogen
    Yoko Omoto
    Department of Medical Nutrition, Karolinska Institute, 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 102:1484-9. 2005
    ..We conclude that imprinting and branching morphogenesis of the ventral prostate are mediated by estrogen acting directly on epithelial and stromal ERalpha during the first 2 weeks of life...
  24. ncbi Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity
    Thomas M Stulnig
    Department of Medical Nutrition and Biosciences, Karolinska Institutet, Huddinge, Sweden
    Diabetes 51:2426-33. 2002
    ..In conclusion, LXR ligands could mediate beneficial metabolic effects in insulin resistance syndromes including type 2 diabetes by interfering with peripheral glucocorticoid activation...
  25. ncbi The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands
    Mathias Farnegardh
    Karo Bio AB, Novum, Karolinska Institute, Huddinge University Hosptial, Sweden
    J Biol Chem 278:38821-8. 2003
    ..Both ligands induce a fixed "agonist conformation" of helix H12 (also called the AF-2 domain), resulting in a transcriptionally active receptor...
  26. ncbi Transcriptional synergism on the pS2 gene promoter between a p160 coactivator and estrogen receptor-alpha depends on the coactivator subtype, the type of estrogen response element, and the promoter context
    Tomas Barkhem
    Karo Bio AB, Novum, S 141 57 Huddinge, Sweden
    Mol Endocrinol 16:2571-81. 2002
    ..These results highlight several mechanisms whereby fine-tuning of estrogen responsiveness of an individual gene may be achieved...
  27. pmc Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction
    Per Antonson
    Department of Biosciences at Novum, Karolinska Institutet, Novum, S 14157 Huddinge, Sweden
    Mol Cell Biol 23:1260-8. 2003
    ..Our results demonstrate that RAP250 is necessary for placental development and thus essential for embryonic development...
  28. doi RBCK1 drives breast cancer cell proliferation by promoting transcription of estrogen receptor alpha and cyclin B1
    Nina Gustafsson
    Department of Biosciences and Nutrition, Karolinska Institute, Novum, S 141 57 Huddinge, Sweden
    Cancer Res 70:1265-74. 2010
    ..Our findings suggest that RBCK1 regulates cell cycle progression and proliferation of ERalpha-positive breast cancer cells by supporting transcription of ERalpha and cyclin B1...
  29. doi Skeletal muscle as a target of LXR agonist after long-term treatment: focus on lipid homeostasis
    Amena Archer
    Department of Biosciences and Nutrition and Center for Biosciences at NOVUM, Karolinska Institute, Huddinge, Sweden
    Am J Physiol Endocrinol Metab 306:E494-502. 2014
    ..Importantly, we show that, after chronic treatment with GW3965, SM becomes the target tissue for LXR activation, as opposed to liver, in acute treatment. ..
  30. ncbi Gene expression profiling in adipose tissue indicates different transcriptional mechanisms of liver X receptors alpha and beta, respectively
    Knut R Steffensen
    Department of Biosciences, Karolinska Institutet at NOVUM, Huddinge, Sweden
    Biochem Biophys Res Commun 310:589-93. 2003
    ..These results indicate a role of LXR in early developmental stages of adipose tissue...
  31. ncbi Estrogen receptor beta2 negatively regulates the transactivation of estrogen receptor alpha in human breast cancer cells
    Chunyan Zhao
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden
    Cancer Res 67:3955-62. 2007
    ..Our data suggest that ERbeta2 could influence ERalpha-mediated effects relevant for breast cancer development, including hormone responsiveness...
  32. ncbi Dilatory responses to estrogenic compounds in small femoral arteries of male and female estrogen receptor-beta knockout mice
    Maria Natalia Cruz
    Institution for Clinical Science, Intervention, and Technology, Division of Obstetrics and Gynecology, Karolinska Institutet, Huddinge, 14186 Stockholm, Sweden
    Am J Physiol Heart Circ Physiol 290:H823-9. 2006
    ..Because NO appeared to contribute to responses to 17beta-E2 in arteries from beta-ERKO but not WT mice, the presence of ER- apparently inhibits ER--mediated NO relaxation...
  33. ncbi pS2 Gene expression in HepG2 cells: complex regulation through crosstalk between the estrogen receptor alpha, an estrogen-responsive element, and the activator protein 1 response element
    Tomas Barkhem
    Karo Bio AB, Huddinge, Sweden
    Mol Pharmacol 61:1273-83. 2002
    ....
  34. pmc Involvement of estrogen receptor beta in terminal differentiation of mammary gland epithelium
    Carola Förster
    Department of Medical Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 99:15578-83. 2002
    ..We speculate that, because a reduced risk for breast cancer is conferred on women who breast-feed at an early age, ERbeta could contribute to this risk reduction by facilitating terminal differentiation of the mammary gland...
  35. pmc Gonadotropin-positive pituitary tumors accompanied by ovarian tumors in aging female ERbeta-/- mice
    Xiaotang Fan
    Division of Medical Nutrition, Department of Biosciences and Nutrition, Karolinska Institute, Novum 141 86, Sweden
    Proc Natl Acad Sci U S A 107:6453-8. 2010
    ..The absence of tumors in the ERalphabeta(-/-) mice suggests that tumor development requires the presence of ERalpha...
  36. pmc Regulation of postnatal lung development and homeostasis by estrogen receptor beta
    Cesare Patrone
    Department of Medical Nutrition, Karolinska Institute, Novum, Huddinge University Hospital, SE14186 Huddinge, Sweden
    Mol Cell Biol 23:8542-52. 2003
    ..These results provide a potential molecular mechanism for the gender differences in alveolar structure observed in the adult lung and establish ERbeta as a previously unknown regulator of postnatal lung development and homeostasis...
  37. pmc Estrogen signalling and the metabolic syndrome: targeting the hepatic estrogen receptor alpha action
    Marko Matic
    Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    PLoS ONE 8:e57458. 2013
    ..Collectively, our findings indicate that hepatic ERα action may not be the responsible factor for the previously identified hepatic insulin resistance in ERαKO mice...
  38. ncbi Analysis of estrogen receptor expression in tissues
    Margaret Warner
    Karolinska Institute, Huddinge University Hospital, Novum, Huddinge, S 14186, Sweden
    Methods Enzymol 364:448-63. 2003
  39. ncbi Involvement of androgen receptor in 17beta-estradiol-induced cell proliferation in rat uterus
    Zhang Weihua
    Departments of Medical Nutrition and Bioscience, Karolinska Institute, Novum, Huddinge, Stockholm S 141 86, Sweden
    Biol Reprod 67:616-23. 2002
    ..These results indicate an important role for AR in proliferation of the uterus, where estrogen and androgen do not represent separate pathways but are sequential steps in one pathway...
  40. ncbi Update on estrogen signaling
    Zhang Weihua
    Department of Medical Nutrition, Department of Biosciences, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    FEBS Lett 546:17-24. 2003
    ..The use of ERbeta-specific ligands against certain forms of cancer represents one of the many pharmaceutical possibilities that have been created thanks to the discovery of ERbeta...
  41. ncbi Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue
    Thomas M Stulnig
    Department of Medical Nutrition and Biosciences, Karolinska Institutet, Huddinge, Sweden
    Mol Pharmacol 62:1299-305. 2002
    ....
  42. pmc Estrogen receptor beta regulates epithelial cellular differentiation in the mouse ventral prostate
    Otabek Imamov
    Department of Medical Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 101:9375-80. 2004
    ..The continued proliferation of intermediate cells leads to the prostatic epithelial hyperplasia observed in the absence of ER beta signaling...
  43. ncbi Differential regulation of estrogen receptor (ER)alpha and ERbeta in primate mammary gland
    Guojun Cheng
    Department of Medical Nutrition, Karolinska Institute, Novum, S14186, Huddinge, Sweden
    J Clin Endocrinol Metab 90:435-44. 2005
    ..As selective receptor ligands become available, they will be helpful in delineation of the functions of these receptors...
  44. doi Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis
    Spyridon Theofilopoulos
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Nat Chem Biol 9:126-33. 2013
    ..Moreover, 24,25-EC promoted dopaminergic differentiation of embryonic stem cells, suggesting that Lxr ligands may thus contribute to the development of cell replacement and regenerative therapies for Parkinson's disease...
  45. doi SOX9 mediates the retinoic acid-induced HES-1 gene expression in human breast cancer cells
    Patrick Muller
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, 141 57, Huddinge, Sweden
    Breast Cancer Res Treat 120:317-26. 2010
    ..Taken together, we present here a novel transcriptional mechanism in regulating hormone-dependent cancer cell proliferation...
  46. ncbi Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal transducer and activator of transcription 3
    Hui Gao
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, S 14157 Huddinge, Sweden
    Mol Endocrinol 20:1287-99. 2006
    ..We propose that this may be mediated, at least partially, via estrogen stimulation of the hepatic expression of Stat3, leading to decreased expression of hepatic lipogenic genes, and thereby to antidiabetic effects...
  47. pmc Role of estrogen receptor beta in colonic epithelium
    Osamu Wada-Hiraike
    Department of Biosciences and Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 103:2959-64. 2006
    ..In this way, hyperproliferative cells that lack ERbeta do not form hyperplastic lesions and do not accumulate in the superficial epithelium...
  48. ncbi Genome-wide expression profiling; a panel of mouse tissues discloses novel biological functions of liver X receptors in adrenals
    Knut R Steffensen
    Department of Biosciences, Karolinska Institutet at NOVUM, Huddinge, Sweden
    J Mol Endocrinol 33:609-22. 2004
    ..These results indicate novel biological roles of the LXR including regulation of energy metabolism, glycolysis and steroidogenesis in the adrenals via alteration of expression profiles of putative target genes...
  49. ncbi Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death
    Anastasios E Damdimopoulos
    Department of Biosciences at Novum, Karolinska Institute, S 141 57 Huddinge, Sweden
    J Biol Chem 277:33249-57. 2002
    ..Taken together, these results suggest that Trx2 interacts with specific components of the mitochondrial respiratory chain and plays an important role in the regulation of the mitochondrial membrane potential...
  50. pmc Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D
    Anders Strom
    Department of Biosciences, Karolinska Institutet, Novum, S 14157 Huddinge, Sweden
    Proc Natl Acad Sci U S A 101:1566-71. 2004
    ..These findings suggest a possible role for ERbeta in breast cancer and imply that ERbeta-specific ligands may reduce proliferation of ER-positive breast cancer cells through actions on the G(1) phase cell-cycle machinery...
  51. doi Expression of estrogen receptor beta increases integrin alpha1 and integrin beta1 levels and enhances adhesion of breast cancer cells
    Karolina Lindberg
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Stockholm, Sweden
    J Cell Physiol 222:156-67. 2010
    ..In addition, ERbeta expression was associated to less cell migration. These results indicate that ERbeta affects integrin expression and clustering and consequently modulates adhesion and migration of breast cancer cells...
  52. ncbi Reflections on the discovery and significance of estrogen receptor beta
    Konrad F Koehler
    Department of Biosciences and Medical Nutrition, Karolinska Institutet, Novum, SE 141 57 Huddinge, Sweden
    Endocr Rev 26:465-78. 2005
    ..Some of the diseases in which there is hope that ERbeta agonists will be of benefit are prostate cancer, autoimmune diseases, colon cancer, malignancies of the immune system, and neurodegeneration...
  53. pmc Disruption of the estrogen receptor beta gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisis
    Gil Jin Shim
    Department of Medical Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 100:6694-9. 2003
    ..Furthermore, we suggest that ERbeta agonists might have clinical value in the treatment of leukemia...
  54. pmc Estrogen receptor (ER)beta knockout mice reveal a role for ERbeta in migration of cortical neurons in the developing brain
    Ling Wang
    Departments of Medical Nutrition and Biosciences, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 100:703-8. 2003
    ..These findings suggest that by influencing migration and neuronal survival, ERbeta has an important role in brain development...
  55. ncbi Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11
    Luisa A Helguero
    Department of Medical Nutrition, Karolinska Institutet, Novum, Huddinge, Sweden
    Oncogene 24:6605-16. 2005
    ..We suggest that use of ERbeta agonists will be a useful addition in treatment of breast cancer, which, at present, is only aimed at inhibition of ERalpha...
  56. ncbi What is the value of measuring MTA-1s in breast cancer?
    Guojun Cheng
    Department of Medical Nutrition, Karolinska Institute, Sweden
    Mol Interv 2:360-2, 338. 2002
    ..caution that these results must be interpreted carefully with regard to what is known about estrogen-dependent and -independent tumor growth and chemotherapeutic strategies to destroy them...
  57. ncbi The human RAP250 gene: genomic structure and promoter analysis
    Per Antonson
    Department of Biosciences at Novum, Karolinska Institutet, Novum, S 14157 Huddinge, Sweden
    Gene 327:233-8. 2004
    ..Our data show that the RAP250 has a complex genomic structure with a promoter that is regulated by multiple transcription factors for its basal expression...
  58. pmc Lung dysfunction causes systemic hypoxia in estrogen receptor beta knockout (ERbeta-/-) mice
    Andrea Morani
    Department of Biosciences and Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 103:7165-9. 2006
    ..Systemic hypoxia may be responsible for the reported left and right heart ventricular hypertrophy and systemic hypertension in ERbeta-/- mice...
  59. pmc Estrogen receptor beta is essential for sprouting of nociceptive primary afferents and for morphogenesis and maintenance of the dorsal horn interneurons
    Xiaotang Fan
    Division of Medical Nutrition, Department of Biosciences and Nutrition, Karolinska Institute, Novum, SE 141 86 Stockholm, Sweden
    Proc Natl Acad Sci U S A 104:13696-701. 2007
    ....
  60. doi Activation of the liver X receptor-β potently inhibits osteoclastogenesis from lipopolysaccharide-exposed bone marrow-derived macrophages
    Kirsten M Robertson Remen
    Dept of Biosciences and Nutrition at NOVUM, Huddinge, Sweden
    J Leukoc Biol 93:71-82. 2013
    ..In this respect, activation of the LXR could have a beneficial, therapeutic effect in the prevention of bacterial-induced bone erosion...
  61. pmc Cytosolic glucocorticoid receptor interaction with nuclear factor-kappa B proteins in rat liver cells
    Christina Widén
    Department of Medical Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Biochem J 373:211-20. 2003
    ....
  62. doi Microarray analysis of altered gene expression in ERbeta-overexpressing HEK293 cells
    Chunyan Zhao
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, 141 57, Huddinge, Sweden
    Endocrine 36:224-32. 2009
    ..The results of Gene Ontology analysis and proliferation assays are consistent with an antiproliferative role of ERbeta independent of ERalpha...
  63. ncbi Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride (GW3965)
    Pia Kotokorpi
    Dept of Biosciences and Nutrition, Karolinska Institutet, Novum, S 141 57 Huddinge, Sweden
    Mol Pharmacol 72:947-55. 2007
    ..In summary, the risk of hepatic steatosis upon pharmaceutical targeting of LXR may be a particularly serious consequence in humans...
  64. pmc aP2-Cre-mediated inactivation of estrogen receptor alpha causes hydrometra
    Per Antonson
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Huddinge, Sweden
    PLoS ONE 9:e85581. 2014
    ..We propose that in aP2-Cre/ERα(flox/flox) mice, increased serum estrogen levels cause over-stimulation in the uterus and genital tracts resulting in hydrometra and vaginal obstruction. ..
  65. ncbi Anti-inflammatory nuclear receptor superfamily in multiple sclerosis patients from Sardinia and Sweden
    Xuan Liu
    Neurotec Department, Division of Neuroimmunology, Karolinska Institute, 141 86 Stockholm, Sweden
    Neurobiol Dis 20:961-8. 2005
    ..Higher levels of AR mRNA are present in HC from Sassari. The findings indicate that the expression levels of anti-inflammatory nuclear receptor superfamily genes in MS appear to reflect both ethnic and environmental influences...
  66. pmc Aromatase-deficient mice spontaneously develop a lymphoproliferative autoimmune disease resembling Sjogren's syndrome
    Gil Jin Shim
    Department of Biosciences, Karolinska Institute, Novum Research Park, S 141 57 Huddinge, Sweden
    Proc Natl Acad Sci U S A 101:12628-33. 2004
    ..These results reveal that estrogen deficiency results in a lymphoproliferative autoimmune disease resembling SS and suggest that estrogen might have clinical value in the prevention or treatment of this disease...
  67. ncbi Glucocorticoid response and promoter occupancy of the mouse LXRalpha gene
    Knut R Steffensen
    Department of Biosciences, Karolinska Institutet at NOVUM, Huddinge, Sweden
    Biochem Biophys Res Commun 312:716-24. 2003
    ..Addition of dexamethasone, a GR agonist, abolished this effect suggesting cross talk between GR and LXR signalling...
  68. doi Effects of short-term estradiol and norethindrone acetate treatment on the breasts of normal postmenopausal women
    Guojun Cheng
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Sweden
    Menopause 20:496-503. 2013
    ....
  69. pmc LXR activation by GW3965 alters fat tissue distribution and adipose tissue inflammation in ob/ob female mice
    Amena Archer
    Department of Biosciences and Nutrition, Karolinska Insitutet, Huddinge, Sweden, TX, USA
    J Lipid Res 54:1300-11. 2013
    ..In line with this, the expression and secretion of proinflammatory markers was decreased in both fat deposits with GW3965 treatment...
  70. pmc Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia
    Hyun Jin Kim
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, SE 14186 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:2094-9. 2008
    ..These include activation of microglia, accumulation of protein aggregates in the cytoplasm of large motor neurons, and depletion of brain cholesterol...
  71. ncbi Improved metabolic control by depletion of Liver X Receptors in mice
    Gertrud U Schuster
    Department of Biosciences and Nutrition, Karolinska University Hospital, Novum, Karolinska Institutet, S 141 57 Huddinge, Sweden
    Biochem Biophys Res Commun 348:176-82. 2006
    ..LXRalpha(-/-)beta(-/-) mice responded to this diet by induction of SREBP-1c. Our study suggests that in LXRalpha(-/-)beta(-/-) mice, glucose utilization seems to be privileged possibly due to reduced circulating free fatty acid levels...
  72. ncbi Identification of a functional variant of estrogen receptor beta in an African population
    Chunyan Zhao
    Karolinska Institute, Department of Biosciences at Novum, S 141 57 Huddinge, Sweden
    Carcinogenesis 25:2067-73. 2004
    ..To our knowledge, this represents the first identification of a functional polymorphism in the ERbeta gene. This novel polymorphism provides a tool for human genetic studies of diseases in the African population...
  73. ncbi Estrogen receptor functional activity changes during differentiation of mammary epithelial cells
    Malin Hedengran Faulds
    Department of Medical Nutrition, Karolinska Institutet, Novum, S 141 86 Huddinge, Sweden
    Mol Endocrinol 18:412-21. 2004
    ..In summary, our results show that ER functional activity changes during differentiation of HC11 cells...
  74. pmc Characterization of the ERbeta-/-mouse heart
    Carola Förster
    Department of Medical Nutrition, Karolinska Institutet, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 101:14234-9. 2004
    ..Because neither ERalpha nor ERbeta could be detected in heart muscle, the effects of estrogen on the myocardium seem to be indirect...
  75. ncbi Possible involvement of truncated signal transducer and activator of transcription-5 in the GH pattern-dependent regulation of CYP2C12 gene expression in rat liver
    Hanna Helander
    Department of Medical Nutrition, Karolinska Institutet, Novum, S 141 86 Huddinge, Sweden
    Mol Endocrinol 16:1598-611. 2002
    ..We speculate that binding of Stat5beta to the 3'-UTR element could be of relevance for the GH-dependent and sex-specific expression of CYP2C12...
  76. pmc Early onset of puberty and early ovarian failure in CYP7B1 knockout mice
    Yoko Omoto
    Department of Medical Nutrition, Karolinska Institute, 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 102:2814-9. 2005
    ..When CYP7B1 is inactivated, 3betaAdiol activates estrogen receptors indiscriminately, and the overall effect is prolonged and inappropriate exposure to estrogen...
  77. ncbi Polymorphisms in the estrogen receptor beta gene and risk of breast cancer: no association
    Asta Forsti
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Breast Cancer Res Treat 79:409-13. 2003
    ..No difference in the allele distribution of the six studied polymorphisms was found between the breast cancer and control groups...
  78. doi Liver X receptors regulate de novo lipogenesis in a tissue-specific manner in C57BL/6 female mice
    Marion Korach-Andre
    Department of Biosciences and Nutrition and Center for Biosciences at NOVUM, Karolinska Institutet, Lipid Laboratory, Huddinge, Sweden
    Am J Physiol Endocrinol Metab 301:E210-22. 2011
    ..These results show tissue-specific regulation of LXR activity, a crucial finding for drug development...
  79. ncbi Nuclear immobilization of DsRed1 tagged proteins: a novel tool for studying DNA-protein interactions?
    Anastasios E Damdimopoulos
    Department of Biosciences at Novum, Karolinska Institute, S 141 57 Huddinge, Sweden
    Biochim Biophys Acta 1773:687-90. 2007
    ..In addition, it could be employed for studies on protein-DNA interactions as well as protein-protein interactions during protein complex formation on chromatin in the event of transcription initiation and regulation...
  80. ncbi Estrogen receptor-alpha regulates SOCS-3 expression in human breast cancer cells
    Jason Matthews
    Department of Biosciences at Novum, Karolinska Institutet, Novum, S 14157 Huddinge, Sweden
    Biochem Biophys Res Commun 335:168-74. 2005
    ..In summary, this study shows that ERalpha directly regulates human SOCS-3 promoter activity in human breast cancer cells, thus modulating cytokine activity...
  81. ncbi Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity
    Ingrid Dahlman
    Department of Medicine, Karolinska Institute, Huddinge, Stockholm, Sweden
    Pharmacogenet Genomics 16:881-9. 2006
    ..LXRA and LXRB genes regulate adiposity, energy dissipation, as well as glucose and lipid homeostasis in mice. We investigated the LXR genes in human obesity...
  82. ncbi Proteomic identification of glucocorticoid receptor interacting proteins
    Erik Hedman
    Department of Biosciences and Nutrition, Division of Medical Nutrition, Karolinska Institutet, Novum, S 141 86 Stockholm, Sweden
    Proteomics 6:3114-26. 2006
    ..Our findings suggest the existence of several new mechanisms for GR signaling and regulation...
  83. ncbi HES-1, a novel target gene for the aryl hydrocarbon receptor
    Jane Sohn Thomsen
    Department of Biosciences at Novum, Karolinska Institutet, Huddinge, Sweden
    Mol Pharmacol 65:165-71. 2004
    ..Our observation that both the estrogen receptor and AhR signaling pathways regulate HES-1, but with opposing effects, suggests the existence of a new pathway by which AhR represses E2-signaling...
  84. doi Binding of estrogen receptor alpha/beta heterodimers to chromatin in MCF-7 cells
    Zoi Papoutsi
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Huddinge, Sweden
    J Mol Endocrinol 43:65-72. 2009
    ..Our results confirmed the recruitment of ERalpha/beta heterodimers to all these regions. This study represents the first demonstration of binding of ERalpha/beta heterodimers to various DNA-binding regions in intact chromatin...
  85. pmc Estrogen receptors ER alpha and ER beta in proliferation in the rodent mammary gland
    Guojun Cheng
    Department of Medical Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 101:3739-46. 2004
    ..ER beta facilitates the return of ER alpha to the nucleus and restores responsiveness to E(2). By down-regulating ER beta, tamoxifen may prolong refractoriness to E(2) in mammary epithelium...
  86. ncbi Isoflavone treatment for acute menopausal symptoms
    Guojun Cheng
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Huddinge, Sweden
    Menopause 14:468-73. 2007
    ..The aim of present study was to evaluate the effects of isoflavone treatment in postmenopausal women...
  87. ncbi Sex and the liver - a journey through five decades
    Agneta Mode
    Department of Medical Nutrition, Karolinska Institute, Novum, Huddinge, Sweden
    Drug Metab Rev 38:197-207. 2006
    ....
  88. ncbi Estrogen receptor beta in the prostate
    Zhang Weihua
    Department of Medical Nutrition, Huddinge Hospital, Karolinska Institute at NOVUM, Huddinge, Stockholm S 141 86, Sweden
    Mol Cell Endocrinol 193:1-5. 2002
  89. ncbi The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism
    Björn Kauppi
    Structure Biology, Karo Bio AB, Novum, SE 141 57 Huddinge, Sweden
    J Biol Chem 278:22748-54. 2003
    ..All three RU-486 GR-LBD structures show that GR has a very flexible region between the end of helix 11 and the end of helix 12...
  90. pmc Proteomics analysis of the estrogen receptor alpha receptosome
    Ivan Nalvarte
    Department of Biosciences and Nutrition, Karolinska Institute, SE 14183 Huddinge, Sweden
    Mol Cell Proteomics 9:1411-22. 2010
    ..Thus, this approach provides an easy and relevant way of identifying ERalpha cofactor and transcription factor recruitment under different conditions...
  91. ncbi Purification of functional full-length liver X receptor beta produced in Escherichia coli
    Gudrun Toresson
    Department of Biosciences, Novum, Karolinska Institute, Huddinge SE 14157, Sweden
    Protein Expr Purif 35:190-8. 2004
    ..The purified LXRbeta constitutes an important tool for further functional and structural studies...
  92. pmc Estrogen receptor beta: an overview and update
    Chunyan Zhao
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden
    Nucl Recept Signal 6:e003. 2008
    ..ERbeta agonists are being explored and validated as drugs for a growing number of indications. Hopefully, some ERbeta targeted drugs will prove to be efficient in enhancing human health...
  93. pmc The genome landscape of ERalpha- and ERbeta-binding DNA regions
    Yawen Liu
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, SE 14157 Huddinge, Sweden
    Proc Natl Acad Sci U S A 105:2604-9. 2008
    ..Differences in the properties of ER bound regions might explain some of the differences in gene expression programs and physiological effects shown by the respective estrogen receptors...
  94. pmc A role for epithelial-mesenchymal transition in the etiology of benign prostatic hyperplasia
    Paloma Alonso-Magdalena
    Department of Biosciences and Nutrition, Karolinska Institute, Novum, SE 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 106:2859-63. 2009
    ..TGF-beta is thought to play a key role in EMT. Our data suggests that TGF-beta/Smad should be considered as targets for treatment of BPH...
  95. doi Estrogen-dependent downregulation of hairy and enhancer of split homolog-1 gene expression in breast cancer cells is mediated via a 3' distal element
    Patrick Muller
    Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    J Endocrinol 200:311-9. 2009
    ..Our findings are consistent with a novel type of repressive estrogen response element in the distal 3' region of the HES-1 gene...
  96. pmc Effects of two common polymorphisms in the 3' untranslated regions of estrogen receptor beta on mRNA stability and translatability
    Milica Putnik
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, S 141 57 Huddinge, Sweden
    BMC Genet 10:55. 2009
    ..These two ERbeta SNPs have been investigated for association with disease in a large number of reports...
  97. pmc Expression levels of estrogen receptor beta are modulated by components of the molecular clock
    Wen Cai
    Department of Biosciences and Nutrition, Karolinska Institute, S 141 57 Huddinge, Sweden
    Mol Cell Biol 28:784-93. 2008
    ..Furthermore, using small interfering RNA-mediated knockdown assays, we show that the expression levels of the circadian regulatory factors directly influence estrogen signaling by regulating the intracellular levels of endogenous ERbeta...
  98. pmc Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice
    Galyna Bryzgalova
    Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
    Am J Physiol Endocrinol Metab 295:E904-12. 2008
    ..Decreased plasma levels of resistin probably also play an important role in this context...
  99. ncbi Functional characterization of a novel variant of estrogen receptor beta identified in screening of DNA derived from African Americans
    Chunyan Zhao
    Department of Biosciences and Nutrition, Novum, Karolinska Institute, S 141 57 Huddinge, Sweden
    Pharmacogenet Genomics 16:379-83. 2006
    ..Information on single nucleotide polymorphisms in the estrogen receptor beta (ERbeta) gene is lacking for the African American population...