Kamila Czene

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Incidence and prognosis of synchronous and metachronous bilateral breast cancer
    Mikael Hartman
    Department of Medical Epidemiology and Biostatistics, Stockholm Söder Hospital and Oncologic Center, CLINTEC, Stockholm, Sweden
    J Clin Oncol 25:4210-6. 2007
  2. pmc Genetic variation of ESR1 and its co-activator PPARGC1B is synergistic in augmenting the risk of estrogen receptor-positive breast cancer
    Yuqing Li
    Human Genetics, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore
    Breast Cancer Res 13:R10. 2011
  3. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
  4. pmc ESR1 and EGF genetic variation in relation to breast cancer risk and survival
    Kristjana Einarsdóttir
    Centre for Health Services Research, School of Population Health, University of Western Australia, 6009 Crawley, Perth, Western Australia
    Breast Cancer Res 10:R15. 2008
  5. pmc Do Asian breast cancer patients have poorer survival than their western counterparts? A comparison between Singapore and Stockholm
    Benita Kiat Tee Tan
    Department of General Surgery, Singapore General Hospital, Outram Road, Singapore, Singapore
    Breast Cancer Res 11:R4. 2009
  6. pmc A constant risk for familial breast cancer? A population-based family study
    Kamila Czene
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    Breast Cancer Res 11:R30. 2009
  7. ncbi request reprint Sex- and kindred-specific familial risk of non-Hodgkin's lymphoma
    Kamila Czene
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE 171 77, Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 16:2496-9. 2007
  8. doi request reprint Breast cancer onset in twins and women with bilateral disease
    Mikael Hartman
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Clin Oncol 26:4086-91. 2008
  9. doi request reprint Influence of radiotherapy for the first tumor on aggressiveness of contralateral breast cancer
    Maria E C Sandberg
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 132:2388-94. 2013
  10. ncbi request reprint Etiology of familial aggregation in melanoma and squamous cell carcinoma of the skin
    Linda S Lindström
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, P O Box 281, Stockholm 17177, Sweden
    Cancer Epidemiol Biomarkers Prev 16:1639-43. 2007

Collaborators

Detail Information

Publications87

  1. ncbi request reprint Incidence and prognosis of synchronous and metachronous bilateral breast cancer
    Mikael Hartman
    Department of Medical Epidemiology and Biostatistics, Stockholm Söder Hospital and Oncologic Center, CLINTEC, Stockholm, Sweden
    J Clin Oncol 25:4210-6. 2007
    ..Little is known, however, about incidence trends and prognostic features of bilateral breast cancer...
  2. pmc Genetic variation of ESR1 and its co-activator PPARGC1B is synergistic in augmenting the risk of estrogen receptor-positive breast cancer
    Yuqing Li
    Human Genetics, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore
    Breast Cancer Res 13:R10. 2011
    ....
  3. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
    ....
  4. pmc ESR1 and EGF genetic variation in relation to breast cancer risk and survival
    Kristjana Einarsdóttir
    Centre for Health Services Research, School of Population Health, University of Western Australia, 6009 Crawley, Perth, Western Australia
    Breast Cancer Res 10:R15. 2008
    ..We sought to determine if common genetic variation in the ESR1 and EGF genes affects breast cancer risk, tumour characteristics or breast cancer survival...
  5. pmc Do Asian breast cancer patients have poorer survival than their western counterparts? A comparison between Singapore and Stockholm
    Benita Kiat Tee Tan
    Department of General Surgery, Singapore General Hospital, Outram Road, Singapore, Singapore
    Breast Cancer Res 11:R4. 2009
    ..We have recently shown that Swedish women are two to three times more likely to be diagnosed with breast cancer compared with Singaporean women. In the present paper, we compare breast cancer survival in the two countries...
  6. pmc A constant risk for familial breast cancer? A population-based family study
    Kamila Czene
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    Breast Cancer Res 11:R30. 2009
    ..We investigated whether there is a similar pattern in the breast cancer incidence in first-degree relatives of breast cancer patients. We studied the risk for breast cancer in mothers at ages older than their daughter's age at diagnosis...
  7. ncbi request reprint Sex- and kindred-specific familial risk of non-Hodgkin's lymphoma
    Kamila Czene
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE 171 77, Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 16:2496-9. 2007
    ..5 (95% CI, 1.2-1.9). Our results suggest that part of the familial risk of NHL may be attributable to shared environmental exposures, particularly between same-sex siblings...
  8. doi request reprint Breast cancer onset in twins and women with bilateral disease
    Mikael Hartman
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Clin Oncol 26:4086-91. 2008
    ..Little is known of the onset of breast cancer in high-risk populations. We investigated the risk of breast cancer in twin sisters and in the contralateral breast taking family history into consideration...
  9. doi request reprint Influence of radiotherapy for the first tumor on aggressiveness of contralateral breast cancer
    Maria E C Sandberg
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 132:2388-94. 2013
    ..In conclusion, patients diagnosed with CBC within 5 years had worse prognosis and more aggressive tumor characteristics of the second cancer, if they had received radiotherapy for their first cancer, compared to no radiotherapy...
  10. ncbi request reprint Etiology of familial aggregation in melanoma and squamous cell carcinoma of the skin
    Linda S Lindström
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, P O Box 281, Stockholm 17177, Sweden
    Cancer Epidemiol Biomarkers Prev 16:1639-43. 2007
    ..Because the malignancies are dependent on UV radiation, we did separate analyses for sun-covered and sun-exposed sites...
  11. doi request reprint Evaluation of bias in familial risk estimates: a study of common cancers using Swedish population-based registers
    Monica Leu
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Natl Cancer Inst 100:1318-25. 2008
    ..Bias in estimates of familial cancer may result if population-based registers fail to identify relatives as affected when disease occurs before the start-up of registration (ie, "left-truncation" of family history)...
  12. ncbi request reprint Genetic implications of bilateral breast cancer: a population based cohort study
    Mikael Hartman
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    Lancet Oncol 6:377-82. 2005
    ..Women with breast cancer are at high risk of bilateral breast cancer. We aimed to assess the incidence of bilateral breast cancer in relation to age and time since diagnosis of first cancer...
  13. doi request reprint Prognostic implications of estrogen receptor pattern of both tumors in contralateral breast cancer
    Maria E C Sandberg
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Breast Cancer Res Treat 134:793-800. 2012
    ..Our results indicate that this might be due to endocrine therapy resistance...
  14. pmc The influence of menopausal hormone therapy on tumour characteristics and survival in endometrial cancer patients
    Chantal C Orgéas
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE 17177 Stockholm, Sweden
    Eur J Cancer 45:3064-73. 2009
    ..We investigated the effects of ever use of MHT on tumour grade and depth of myometrial invasion and 5-year relative survival in postmenopausal endometrial cancer patients...
  15. ncbi request reprint The impact of truncation and missing family links in population-based registers on familial risk estimates
    Monica Leu
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Am J Epidemiol 166:1461-7. 2007
    ..In summary, truncation, and to a lesser extent missing family links, induces bias in familial risk estimates from population-based registers...
  16. pmc Is genetic background important in lung cancer survival?
    Linda S Lindström
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    PLoS ONE 4:e5588. 2009
    ..The aim of this study was to investigate the familial concordance in lung cancer survival by means of analyses of pairs with different degrees of familial relationships...
  17. ncbi request reprint Environmental and heritable causes of cancer among 9.6 million individuals in the Swedish Family-Cancer Database
    Kamila Czene
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 99:260-6. 2002
    ....
  18. ncbi request reprint Incidence trends and familial risks in invasive and in situ cutaneous melanoma by sun-exposed body sites
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 104:764-71. 2003
    ..90 at covered and 2.53 at exposed sites. The data suggest that the higher melanoma density at exposed sites masks familial effects. Furthermore, sun exposure does not appear to reinforce the familial effect...
  19. doi request reprint The influence of mammographic density on breast tumor characteristics
    Louise Eriksson
    Institution of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels Väg 12 A, 171 77 Stockholm, Sweden
    Breast Cancer Res Treat 134:859-66. 2012
    ..In conclusion, PD does not seem to be differentially associated with tumor phenotype, except for tumor size, after taking mode of detection into consideration...
  20. pmc Effects of childhood body size on breast cancer tumour characteristics
    Jingmei Li
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Breast Cancer Res 12:R23. 2010
    ..Although a role of childhood body size in postmenopausal breast cancer risk has been established, less is known about its influence on tumour characteristics...
  21. doi request reprint Timing of familial breast cancer in sisters
    Paola Rebora
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Box 281, 17177 Stockholm, Sweden
    J Natl Cancer Inst 100:721-7. 2008
    ....
  22. doi request reprint Longitudinal fluctuation in mammographic percent density differentiates between interval and screen-detected breast cancer
    Fredrik Strand
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 140:34-40. 2017
    ..Whether this is entirely related to a reduced mammographic detectability or to a biological phenotype promoting faster tumor growth remains to be elucidated...
  23. doi request reprint A unified model for estimating and testing familial aggregation
    Myeongjee Lee
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177, Stockholm, Sweden
    Stat Med 32:5353-65. 2013
    ..The recognition of such kindred-specific disease risk could be a first step in the design of more informative genetic biomarker studies...
  24. pmc Is breast cancer prognosis inherited?
    Mikael Hartman
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Breast Cancer Res 9:R39. 2007
    ..A genetic component is well established in the etiology of breast cancer. It is not well known, however, whether genetic traits also influence prognostic features of the malignant phenotype...
  25. pmc Estrogen receptor status in relation to risk of contralateral breast cancer-a population-based cohort study
    Maria E C Sandberg
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e46535. 2012
    ..It is unclear whether estrogen receptor (ER)-status of first primary breast cancer is associated with risk of metachronous (non-simultaneous) contralateral breast cancer (CBC), and to what extent endocrine therapy affects this association...
  26. pmc Partitioning of excess mortality in population-based cancer patient survival studies using flexible parametric survival models
    Sandra Eloranta
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, Stockholm, Sweden
    BMC Med Res Methodol 12:86. 2012
    ..For this purpose we extend flexible parametric survival models for relative survival, which use restricted cubic splines for the baseline cumulative excess hazard and for any time-dependent effects...
  27. pmc The influence of menstrual risk factors on tumor characteristics and survival in postmenopausal breast cancer
    Chantal C Orgéas
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels vag 12a, Stockholm, SE 17177, Sweden
    Breast Cancer Res 10:R107. 2008
    ..Our study investigated the effects of menstrual risk factors on tumor characteristics and survival in postmenopausal breast cancer...
  28. doi request reprint A combined analysis of genome-wide association studies in breast cancer
    Jingmei Li
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 17177 Stockholm, Sweden
    Breast Cancer Res Treat 126:717-27. 2011
    ..More effort focused in these aspects of oncology can potentially open up promising avenues for the understanding of breast cancer and its prevention...
  29. ncbi request reprint Familial concordance in cancer survival: a Swedish population-based study
    Linda S Lindström
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Lancet Oncol 8:1001-6. 2007
    ..Nowadays, the fact that cancers can aggregate in families is generally accepted. The aim of this study was to complete a comprehensive analysis of cancer-survival concordance in parents and their children diagnosed with the same cancer...
  30. ncbi request reprint Familial papillary renal cell tumors and subsequent cancers: a nationwide epidemiological study from Sweden
    Kamila Czene
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    J Urol 169:1271-5. 2003
    ..Familial risks in papillary renal cell carcinoma and association with second primary malignancies were studied using the nationwide Swedish Family Cancer Data Base...
  31. pmc Breast cancer risk prediction and individualised screening based on common genetic variation and breast density measurement
    Hatef Darabi
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, P, O, Box 281, Stockholm 177 71, Sweden
    Breast Cancer Res 14:R25. 2012
    ..Over the last decade several breast cancer risk alleles have been identified which has led to an increased interest in individualised risk prediction for clinical purposes...
  32. pmc Coffee consumption modifies risk of estrogen-receptor negative breast cancer
    Jingmei Li
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Breast Cancer Res 13:R49. 2011
    ..We assessed the association between coffee consumption and postmenopausal breast cancer risk in a large population-based study (2,818 cases and 3,111 controls), overall, and stratified by ER tumour subtypes...
  33. doi request reprint Genetic variation in the androgen estrogen conversion pathway in relation to breast cancer prognosticators
    Hatef Darabi
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Breast Cancer Res Treat 127:503-9. 2011
    ..008 and 0.011; 1-sided, respectively). Our results provide new evidence that CYP19A1 is involved in both breast cancer risk and prognosis...
  34. ncbi request reprint Chemotherapy, Genetic Susceptibility, and Risk of Venous Thromboembolism in Breast Cancer Patients
    Judith S Brand
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Clin Cancer Res 22:5249-5255. 2016
    ..Venous thromboembolism (VTE) is highly heritable and a serious complication of cancer and its treatment. We examined the individual and joint effects of chemotherapy and genetic susceptibility on VTE risk in patients with breast cancer...
  35. pmc Evaluation of exome sequencing to estimate tumor burden in plasma
    Daniel Klevebring
    Department of Medical Epidemiology and Biostatistics, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 9:e104417. 2014
    ..To enable a broad implementation in the diagnostic settings, the efficiency limitations of sequence capture and the inherent noise levels of the Illumina sequencing technology must be further improved...
  36. ncbi request reprint Parental age and risk of childhood cancers: a population-based cohort study from Sweden
    Benjamin H Yip
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, 171 77 Stockholm, Sweden
    Int J Epidemiol 35:1495-503. 2006
    ..A population-based cohort study of parental ages and other prenatal risk factors for five main childhood cancers was performed with the use of a linkage between several national-based registries...
  37. ncbi request reprint Time trends and familial risks in squamous cell carcinoma of the skin
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Arch Dermatol 139:885-9. 2003
    ..To study time trends and familial clustering of invasive and in situ squamous cell skin cancers (SCC), with particular reference to sun-exposed and covered sites of the body...
  38. doi request reprint Bias correction of estimates of familial risk from population-based cohort studies
    Monica Leu
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Int J Epidemiol 39:80-8. 2010
    ..These estimates may be biased due to failure to identify relatives as affected if they are diagnosed before the start-up date of disease registration...
  39. ncbi request reprint Socioeconomic factors in cancer in Sweden
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Int J Cancer 105:692-700. 2003
    ..The overall population-attributable fraction for selected sites was 16.7% for men and 10.9% for women and it was highest, over 50%, for lung cancer in both genders...
  40. doi request reprint Validation of smoking history in cancer patients
    Michaela Prochazka
    The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Acta Oncol 47:1004-8. 2008
    ..The aim of the study was to investigate the agreement between patient records and the information reported from relatives, and how the relationship and time since patient's death affected the response rate and the quality of the data...
  41. pmc Risk of hospitalisation and death due to bone fractures after breast cancer: a registry-based cohort study
    Edoardo Colzani
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobelsväg 12A, Stockholm SE 171 77, Sweden
    Br J Cancer 115:1400-1407. 2016
    ..Bone fractures may have an impact on prognosis of breast cancer. The long-term risks of bone fracture in breast cancer patients have not been thoroughly studied...
  42. doi request reprint Infection-related hospitalizations in breast cancer patients: Risk and impact on prognosis
    Judith S Brand
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden Electronic address
    J Infect 72:650-8. 2016
    ..Infections are a common cause of hospitalization in breast cancer patients. We studied the risk, clinical characteristics and outcomes of infection-related hospitalizations in this patient population...
  43. doi request reprint Associations of Breast Cancer Risk Prediction Tools With Tumor Characteristics and Metastasis
    Johanna Holm
    All authors Karolinska Institutet, Stockholm, Sweden
    J Clin Oncol 34:251-8. 2016
    ....
  44. doi request reprint Prognosis of patients with breast cancer: causes of death and effects of time since diagnosis, age, and tumor characteristics
    Edoardo Colzani
    Department of Medical Epidemiology and Biostatistics MEB, Karolinska Institutet, Stockholm, Sweden
    J Clin Oncol 29:4014-21. 2011
    ..Because breast cancer-specific deaths decrease with time since diagnosis, it is important to assess the burden of other causes of death in women diagnosed with breast cancer...
  45. ncbi request reprint Cancer risks in hairdressers: assessment of carcinogenicity of hair dyes and gels
    Kamila Czene
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 105:108-12. 2003
    ..Bladder cancer was not increased among hairdressers in the recent decades and is therefore not likely to be associated with modern hair dyes...
  46. ncbi request reprint Familial and attributable risks in cutaneous melanoma: effects of proband and age
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    J Invest Dermatol 120:217-23. 2003
    ..Melanoma associated with breast, nervous system, and skin cancers, and in situ melanoma possibly also with connective tissue and thyroid tumors and multiple myeloma...
  47. ncbi request reprint Attributable risks of familial cancer from the Family-Cancer Database
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Cancer Epidemiol Biomarkers Prev 11:1638-44. 2002
    ..The data show that the familial PAF of prostate cancer was 20.55%, and breast cancer 10.61%, but for most other sites, it was between 1 and 3%...
  48. ncbi request reprint Attributable risks for familial breast cancer by proband status and morphology: a nationwide epidemiologic study from Sweden
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 100:214-9. 2002
    ..The data show that the familial PAF of breast cancer among a 0-66-year-old population of daughters was 7% and independent of the morphologic type. If contribution from the paternal side was allowed for, the PAF would be 11%...
  49. doi request reprint Volumetric mammographic density: heritability and association with breast cancer susceptibility loci
    Judith S Brand
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden JSB, KH, ME, PH, KC Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, Cambridge, UK DJT Human Genetics, Genome Institute of Singapore, Singapore, Singapore JL
    J Natl Cancer Inst 106:. 2014
    ..We studied the heritability of volumetric mammographic density ascertained by a fully-automated method and the association with breast cancer susceptibility loci...
  50. pmc Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)
    Hatef Darabi
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Sci Rep 6:32512. 2016
    ..Expression studies in breast tumor tissues found SNP rs2787486 to be associated with increased STXBP4 expression, suggesting this may be a target gene of this locus. ..
  51. ncbi request reprint Molecular differences between screen-detected and interval breast cancers are largely explained by PAM50 subtypes
    Jingmei Li
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
    Clin Cancer Res . 2016
    ..A comprehensive picture of somatic changes that drive tumors to become symptomatic in the screening interval can improve understanding of the biology underlying these aggressive tumors...
  52. doi request reprint Breaking the matching in nested case-control data offered several advantages for risk estimation
    Bénédicte Delcoigne
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, P O Box 281, SE 17177 Stockholm, Sweden Electronic address
    J Clin Epidemiol . 2016
    ..To demonstrate the advantage of using weighted Cox regression to analyse nested case-control data in overcoming limitations encountered with traditional conditional logistic regression...
  53. doi request reprint Worse quality of life in young and recently diagnosed breast cancer survivors compared with female survivors of other cancers: A cross-sectional study
    Jingmei Li
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 171 77, Sweden
    Int J Cancer 139:2415-25. 2016
    ..BC survivors perform poorly in HRQoL in comparison with female survivors of other cancers. Our results emphasize the importance of age- and gender-appropriate comparison groups. ..
  54. doi request reprint Time-dependent risk and predictors of venous thromboembolism in breast cancer patients: A population-based cohort study
    Judith S Brand
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Cancer . 2016
    ..Venous thromboembolism (VTE) is a serious complication of cancer and its treatment. The current study assessed the risk and clinical predictors of VTE in breast cancer patients by time since diagnosis...
  55. pmc Sequencing-based breast cancer diagnostics as an alternative to routine biomarkers
    Mattias Rantalainen
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Sci Rep 6:38037. 2016
    ..Our results suggest that sequencing-based breast cancer diagnostics in a near future can replace routine biomarkers...
  56. pmc Background risk of breast cancer and the association between physical activity and mammographic density
    Thang Trinh
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, Stockholm, 17177, Sweden
    Breast Cancer Res 17:50. 2015
    ..We tested the hypothesis that the risk of developing breast cancer in the next 10 years according to the Tyrer-Cuzick prediction model influences the association between physical activity and mammographic density...
  57. pmc Identification of two novel mammographic density loci at 6Q25.1
    Judith S Brand
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels vag 12a, 171 77, Stockholm, Sweden
    Breast Cancer Res 17:75. 2015
    ..We performed a large-scale genetic association study including 8,419 women of European ancestry to identify MD loci...
  58. pmc Area and volumetric density estimation in processed full-field digital mammograms for risk assessment of breast cancer
    Abbas Cheddad
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 9:e110690. 2014
    ..We describe fully automated methods for measuring both area and volumetric mammographic density from processed images...
  59. doi request reprint Automated measurement of volumetric mammographic density: a tool for widespread breast cancer risk assessment
    Judith S Brand
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 23:1764-72. 2014
    ..We evaluated the performance of a fully automated volumetric method (Volpara)...
  60. doi request reprint The role of mammography screening attendance and detection mode in predicting breast cancer survival-is there added prognostic value?
    Cornelis Biesheuvel
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    Cancer Epidemiol 35:545-50. 2011
    ..We also assessed the effect of hormone replacement therapy (HRT) on the association of detection mode with breast cancer survival...
  61. ncbi request reprint Age specific and attributable risks of familial prostate carcinoma from the family-cancer database
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Cancer 95:1346-53. 2002
    ....
  62. doi request reprint Breast cancer incidence after hormonal infertility treatment in Sweden: a cohort study
    Chantal C Orgéas
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    Am J Obstet Gynecol 200:72.e1-7. 2009
    ..To assess the impact of infertility treatment with causes of infertility on incidence of breast cancer...
  63. doi request reprint Diagnostic work-up of contralateral breast cancers has not improved over calendar period
    Maria E C Sandberg
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Box 281, 171 77 Stockholm, Sweden
    Breast Cancer Res Treat 122:889-95. 2010
    ..This study gives no indications that any improvement in diagnostic work-up of CBC have occurred over the last 25 years...
  64. ncbi request reprint Familial risk of cancer: data for clinical counseling and cancer genetics
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 108:109-14. 2004
    ..If, for example, a familial SIR of 2.2 would be use as an action level, counseling would be needed for most cancers at some diagnostic age groups. The present data provide the basis for clinical counseling...
  65. ncbi request reprint Ionizing radiation and tobacco use increases the risk of a subsequent lung carcinoma in women with breast cancer: case-only design
    Michaela Prochazka
    Department of Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE 171 77, Stockholm, Sweden
    J Clin Oncol 23:7467-74. 2005
    ..We accessed the lung dose in relation to different radiotherapy techniques, provided the excess relative risk (ERR) estimate for radiation-associated lung cancer, and evaluated the influence of tobacco use...
  66. ncbi request reprint How to treat male breast cancer
    Kamila Czene
    Department of Medical Epidemiology and Biostatistics MEB, Karolinska Institutet, Stockholm, Sweden
    Breast 16:S147-54. 2007
    ..Different chemotherapy regimens have been used in the adjuvant and metastatic setting. The use of adjuvant therapy has in institutional and review comparisons been demonstrated to result in an improved outcome...
  67. pmc Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer
    Jingmei Li
    Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden
    Breast Cancer Res 12:R19. 2010
    ..In this study, we evaluate the association between mammographic density and genetic variants of the estrogen metabolic pathway...
  68. ncbi request reprint "Population lab": the creation of virtual populations for genetic epidemiology research
    Monica Leu
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Epidemiology 18:433-40. 2007
    ..Furthermore, there are no standard tools for testing the validity of estimates from standard epidemiologic designs and from new analytic strategies using register data...
  69. ncbi request reprint Cancer risks in first-generation immigrants to Sweden
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 99:218-28. 2002
    ..Women from Yugoslavia and Turkey had an excess of thyroid tumours. All immigrant groups showed breast, endometrial and ovarian cancers at or below the Swedish level but the differences were no more than 2-fold...
  70. doi request reprint Exome sequencing of contralateral breast cancer identifies metastatic disease
    Daniel Klevebring
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Breast Cancer Res Treat 151:319-24. 2015
    ..Genomic profiling of both tumors help the clinicians distinguish between true CBCs and subsequent metastases...
  71. doi request reprint Pectoral muscle attenuation as a marker for breast cancer risk in full-field digital mammography
    Abbas Cheddad
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 24:985-91. 2015
    ..We now investigate whether our novel feature is associated with risk in a study based on full-field digital mammography (FFDM)...
  72. doi request reprint Public interest in and acceptability of the prospect of risk-stratified screening for breast and prostate cancer
    Marie Koitsalu
    a Karolinska Institutet, Department of Oncology Pathology, Karolinska University Hospital, Stockholm, Sweden
    Acta Oncol 55:45-51. 2016
    ..Investigating public interest in stratified screening and its acceptability to the public is therefore essential since as yet little is known...
  73. doi request reprint Patterns of changing cancer risks with time since diagnosis of a sibling
    Myeongjee Lee
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 136:1948-56. 2015
    ..Our findings can help inform the screening and counseling of family members of cancer patients...
  74. pmc Enhancement of mammographic density measures in breast cancer risk prediction
    Abbas Cheddad
    Authors Affiliations Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 23:1314-23. 2014
    ..Mammographic density is a strong risk factor for breast cancer...
  75. pmc Library preparation and multiplex capture for massive parallel sequencing applications made efficient and easy
    Marten Neiman
    Department of Medical Epidemiology and Biostatistics, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e48616. 2012
    ..In all samples we see a high concordance (>99.4%) of SNP calls when comparing to commercially available SNP-chip platforms...
  76. pmc Breast cancer tumour growth modelling for studying the association of body size with tumour growth rate and symptomatic detection using case-control data
    Linda Abrahamsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, Stockholm, SE 171 77, Sweden
    Breast Cancer Res 17:116. 2015
    ..A large body size is associated with larger breast cancer tumours at diagnosis. Standard regression models for tumour size at diagnosis are not sufficient for unravelling the mechanisms behind the association...
  77. doi request reprint Predictors of Discontinuation of Adjuvant Hormone Therapy in Patients With Breast Cancer
    Wei He
    Wei He, Fang Fang, Mikael Eriksson, Per Hall, Kamila Czene, Karolinska Institutet, Stockholm, Sweden and Catherine Varnum, School of Medicine, University of Maryland, Baltimore, MD
    J Clin Oncol 33:2262-9. 2015
    ..To identify predictors of discontinuation of adjuvant hormone therapy in patients with breast cancer...
  78. pmc Influence of lifestyle factors on mammographic density in postmenopausal women
    Judith S Brand
    Institution of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels vag 12a, Stockholm, Sweden
    PLoS ONE 8:e81876. 2013
    ..Mammographic density is a strong risk factor for breast cancer. Apart from hormone replacement therapy (HRT), little is known about lifestyle factors that influence breast density...
  79. pmc A genome-wide association scan on estrogen receptor-negative breast cancer
    Jingmei Li
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden
    Breast Cancer Res 12:R93. 2010
    ..ER status of breast cancer is important clinically, and is used both as a prognostic indicator and treatment predictor. In this study, we focused on identifying genetic markers associated with ER-negative breast cancer risk...
  80. ncbi request reprint BRAF mutations in metastatic melanoma: a possible association with clinical outcome
    Rajiv Kumar
    Department of Biosciences, Karolinska Institute, Novum, 141 57 Huddinge, Sweden
    Clin Cancer Res 9:3362-8. 2003
    ..Recently, activating mutations in the BRAF gene, were reported in a large proportion of melanomas. We have studied mutations in the BRAF gene and their association with clinical parameters...
  81. pmc Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression
    Hatef Darabi
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden
    Am J Hum Genet 97:22-34. 2015
    ..Luciferase assays did not identify SNPs that affect transactivation of ZNF365, but identified a protective haplotype in iCHAV2, associated with silencing of the NRBF2 promoter, implicating this gene in the etiology of breast cancer. ..
  82. doi request reprint The impact of co-morbidity on health-related quality of life in breast cancer survivors and controls
    Dounya Schoormans
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Acta Oncol 54:727-34. 2015
    ....
  83. doi request reprint Distinct effects of anti-inflammatory and anti-thrombotic drugs on cancer characteristics at diagnosis
    Yudi Pawitan
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden Electronic address
    Eur J Cancer 51:751-7. 2015
    ..We aim to explain these distinct effects in terms of the anti-inflammatory and anti-thrombotic properties of aspirin...
  84. ncbi request reprint Kidney cancer in the Swedish Family Cancer Database: familial risks and second primary malignancies
    Kamila Czene
    Department of Biosciences, Novum, Karolinska Institute, Huddinge, Sweden
    Kidney Int 61:1806-13. 2002
    ..Familial risks in kidney cancer and association with second primary malignancies were studied using the nationwide Swedish Family Cancer Database...
  85. pmc Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America
    PLoS Genet 4:e1000054. 2008
    ..Understanding the etiologic heterogeneity of breast cancer may ultimately result in improvements in prevention, early detection, and treatment...
  86. ncbi request reprint Familial risk of urological cancers: data for clinical counseling
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    World J Urol 21:377-81. 2004
    ..Urological cancers also offer a challenge to molecular geneticists attempting to identify the susceptibility genes underlying the familial clustering...
  87. ncbi request reprint Association of first ocular melanoma with subsequent cutaneous melanoma: results from the Swedish Family-Cancer Database
    Kari Hemminki
    Int J Cancer 104:257-8. 2003