Genomes and Genes
Affiliation: Karolinska Institutet
- TLR activation induces TNF-alpha production from adult neural stem/progenitor cellsRuxandra Covacu
Department of Clinical Neurosciences, Division of Neuroimmunology, Division of Rheumatology, Karolinska Institutet, Stockholm, Sweden
J Immunol 182:6889-95. 2009..Additionally, activation of these receptors can induce production of proinflammatory cytokines. These findings suggest that NSCs may be primed to participate in cytokine production during neuroinflammatory or traumatic conditions...
- Endogenous spinal cord stem cells in multiple sclerosis and its animal modelRuxandra Covacu
Department of Clinical Neuroscience, Division of Neurology R3 04, Center of Molecular Medicine, L8 04, Karolinska Institutet, Stockholm, Sweden Electronic address
J Neuroimmunol . 2016..In MS, cells with progenitor phenotypes accumulate in inflammatory lesions both in brain and SC, but the extent to which these cells contribute to repair remains to be revealed...
- Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosisAsa Andersson
Department of Clinical Neurosciences, Neuroimmunology Unit, Karolinska University Hospital at Solna, Karolinska Institutet, Stockholm, Sweden
J Leukoc Biol 84:1248-55. 2008..Significant expression of HMGB1 and its receptors on accumulating activated macrophages and resident microglia may thus provide a positive feedback loop that amplifies the inflammatory response during MS and EAE pathogenesis...
- Nitric oxide exposure diverts neural stem cell fate from neurogenesis towards astrogliogenesisRuxandra Covacu
Department of Clinical Neuroscience, Division of Neurology, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden
Stem Cells 24:2792-800. 2006..Our findings reveal a new role for NO during neuroinflammatory conditions, whereby its proastroglial fate-determining effect on neural stem cells might directly influence the neuroregenerative process...
- Long-distance effects of inflammation on differentiation of adult spinal cord neural stem/progenitor cellsLisa Arvidsson
Department of Clinical Neuroscience, Division of Neurosurgery, Karolinska Institutet, Stockholm, Sweden
J Neuroimmunol 288:47-55. 2015..We conclude that inflammation has a long range effect on the NPCs in the diseased central nervous system, reaching NPC populations outside the lesion sites. ..
- Oxidative stress increases neurogenesis and oligodendrogenesis in adult neural progenitor cellsCynthia Pérez Estrada
1 Neurology Unit, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Stem Cells Dev 23:2311-27. 2014..Our findings indicate that H2O2 exposure has significant effects on NPC proliferation, differentiation, and vulnerability. These results have implications for regeneration after any neuroinflammatory event...
- Neurogenesis in the adult spinal cord in an experimental model of multiple sclerosisAlexandre I Danilov
Department of Clinical Neuroscience, Karolinska Instiutet, Sweden
Eur J Neurosci 23:394-400. 2006..We thus provide the first evidence for the initiation of neurogenesis in neuroinflammatory lesions in the adult spinal cord...
- Expression of Ccl11 associates with immune response modulation and protection against neuroinflammation in ratsMilena Z Adzemovic
Neuroimmunology Unit, Department of Clinical Neuroscience, Center of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 7:e39794. 2012..In addition, the congenic strain showed a reduced antigen specific response and a predominant anti-inflammatory Th2 phenotype. These results indicate novel mechanisms in the genetic regulation of neuroinflammation...
- Effects of Neuroinflammation on Neural Stem CellsRuxandra Covacu
Depatment of Clinical Neuroscience, Neurology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
Neuroscientist . 2015..In this review, we have summarized the effects of inflammation on NSCs in relation to their origin and briefly described the NSC activity during different neurological diseases or experimental models...
- Nitric oxide-induced neuronal to glial lineage fate-change depends on NRSF/REST function in neural progenitor cellsMaria Bergsland
Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden Division of Neurosurgery, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Stem Cells 32:2539-49. 2014..This implicates NRSF/REST as a key factor in the NPC-specific response to innate immunity and suggests a novel mechanism by which signaling from inflamed tissue promotes the formation of glial cells...
- The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxideAlexander Espinosa
Rheumatology Unit, Department of Medicine, CMM L8 04, Karolinska Institutet, SE 171 76 Stockholm, Sweden
Exp Cell Res 314:3605-13. 2008..This suggests that Ro52 has both cytoplasmic and nuclear substrates, and that Ro52 mediates ubiquitination through UBE2D1 in the cytoplasm and through UBE2E1 in the nucleus...