Ruxandra Covacu

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi request reprint TLR activation induces TNF-alpha production from adult neural stem/progenitor cells
    Ruxandra Covacu
    Department of Clinical Neurosciences, Division of Neuroimmunology, Division of Rheumatology, Karolinska Institutet, Stockholm, Sweden
    J Immunol 182:6889-95. 2009
  2. doi request reprint Endogenous spinal cord stem cells in multiple sclerosis and its animal model
    Ruxandra Covacu
    Department of Clinical Neuroscience, Division of Neurology R3 04, Center of Molecular Medicine, L8 04, Karolinska Institutet, Stockholm, Sweden Electronic address
    J Neuroimmunol . 2016
  3. doi request reprint Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis
    Asa Andersson
    Department of Clinical Neurosciences, Neuroimmunology Unit, Karolinska University Hospital at Solna, Karolinska Institutet, Stockholm, Sweden
    J Leukoc Biol 84:1248-55. 2008
  4. ncbi request reprint Nitric oxide exposure diverts neural stem cell fate from neurogenesis towards astrogliogenesis
    Ruxandra Covacu
    Department of Clinical Neuroscience, Division of Neurology, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden
    Stem Cells 24:2792-800. 2006
  5. doi request reprint Long-distance effects of inflammation on differentiation of adult spinal cord neural stem/progenitor cells
    Lisa Arvidsson
    Department of Clinical Neuroscience, Division of Neurosurgery, Karolinska Institutet, Stockholm, Sweden
    J Neuroimmunol 288:47-55. 2015
  6. doi request reprint Oxidative stress increases neurogenesis and oligodendrogenesis in adult neural progenitor cells
    Cynthia Pérez Estrada
    1 Neurology Unit, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Stem Cells Dev 23:2311-27. 2014
  7. ncbi request reprint Neurogenesis in the adult spinal cord in an experimental model of multiple sclerosis
    Alexandre I Danilov
    Department of Clinical Neuroscience, Karolinska Instiutet, Sweden
    Eur J Neurosci 23:394-400. 2006
  8. pmc Expression of Ccl11 associates with immune response modulation and protection against neuroinflammation in rats
    Milena Z Adzemovic
    Neuroimmunology Unit, Department of Clinical Neuroscience, Center of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e39794. 2012
  9. ncbi request reprint Effects of Neuroinflammation on Neural Stem Cells
    Ruxandra Covacu
    Depatment of Clinical Neuroscience, Neurology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
    Neuroscientist . 2015
  10. doi request reprint Nitric oxide-induced neuronal to glial lineage fate-change depends on NRSF/REST function in neural progenitor cells
    Maria Bergsland
    Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden Division of Neurosurgery, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Stem Cells 32:2539-49. 2014

Collaborators

Detail Information

Publications11

  1. doi request reprint TLR activation induces TNF-alpha production from adult neural stem/progenitor cells
    Ruxandra Covacu
    Department of Clinical Neurosciences, Division of Neuroimmunology, Division of Rheumatology, Karolinska Institutet, Stockholm, Sweden
    J Immunol 182:6889-95. 2009
    ..Additionally, activation of these receptors can induce production of proinflammatory cytokines. These findings suggest that NSCs may be primed to participate in cytokine production during neuroinflammatory or traumatic conditions...
  2. doi request reprint Endogenous spinal cord stem cells in multiple sclerosis and its animal model
    Ruxandra Covacu
    Department of Clinical Neuroscience, Division of Neurology R3 04, Center of Molecular Medicine, L8 04, Karolinska Institutet, Stockholm, Sweden Electronic address
    J Neuroimmunol . 2016
    ..In MS, cells with progenitor phenotypes accumulate in inflammatory lesions both in brain and SC, but the extent to which these cells contribute to repair remains to be revealed...
  3. doi request reprint Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis
    Asa Andersson
    Department of Clinical Neurosciences, Neuroimmunology Unit, Karolinska University Hospital at Solna, Karolinska Institutet, Stockholm, Sweden
    J Leukoc Biol 84:1248-55. 2008
    ..Significant expression of HMGB1 and its receptors on accumulating activated macrophages and resident microglia may thus provide a positive feedback loop that amplifies the inflammatory response during MS and EAE pathogenesis...
  4. ncbi request reprint Nitric oxide exposure diverts neural stem cell fate from neurogenesis towards astrogliogenesis
    Ruxandra Covacu
    Department of Clinical Neuroscience, Division of Neurology, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden
    Stem Cells 24:2792-800. 2006
    ..Our findings reveal a new role for NO during neuroinflammatory conditions, whereby its proastroglial fate-determining effect on neural stem cells might directly influence the neuroregenerative process...
  5. doi request reprint Long-distance effects of inflammation on differentiation of adult spinal cord neural stem/progenitor cells
    Lisa Arvidsson
    Department of Clinical Neuroscience, Division of Neurosurgery, Karolinska Institutet, Stockholm, Sweden
    J Neuroimmunol 288:47-55. 2015
    ..We conclude that inflammation has a long range effect on the NPCs in the diseased central nervous system, reaching NPC populations outside the lesion sites. ..
  6. doi request reprint Oxidative stress increases neurogenesis and oligodendrogenesis in adult neural progenitor cells
    Cynthia Pérez Estrada
    1 Neurology Unit, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Stem Cells Dev 23:2311-27. 2014
    ..Our findings indicate that H2O2 exposure has significant effects on NPC proliferation, differentiation, and vulnerability. These results have implications for regeneration after any neuroinflammatory event...
  7. ncbi request reprint Neurogenesis in the adult spinal cord in an experimental model of multiple sclerosis
    Alexandre I Danilov
    Department of Clinical Neuroscience, Karolinska Instiutet, Sweden
    Eur J Neurosci 23:394-400. 2006
    ..We thus provide the first evidence for the initiation of neurogenesis in neuroinflammatory lesions in the adult spinal cord...
  8. pmc Expression of Ccl11 associates with immune response modulation and protection against neuroinflammation in rats
    Milena Z Adzemovic
    Neuroimmunology Unit, Department of Clinical Neuroscience, Center of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e39794. 2012
    ..In addition, the congenic strain showed a reduced antigen specific response and a predominant anti-inflammatory Th2 phenotype. These results indicate novel mechanisms in the genetic regulation of neuroinflammation...
  9. ncbi request reprint Effects of Neuroinflammation on Neural Stem Cells
    Ruxandra Covacu
    Depatment of Clinical Neuroscience, Neurology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
    Neuroscientist . 2015
    ..In this review, we have summarized the effects of inflammation on NSCs in relation to their origin and briefly described the NSC activity during different neurological diseases or experimental models...
  10. doi request reprint Nitric oxide-induced neuronal to glial lineage fate-change depends on NRSF/REST function in neural progenitor cells
    Maria Bergsland
    Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden Division of Neurosurgery, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Stem Cells 32:2539-49. 2014
    ..This implicates NRSF/REST as a key factor in the NPC-specific response to innate immunity and suggests a novel mechanism by which signaling from inflamed tissue promotes the formation of glial cells...
  11. doi request reprint The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide
    Alexander Espinosa
    Rheumatology Unit, Department of Medicine, CMM L8 04, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Exp Cell Res 314:3605-13. 2008
    ..This suggests that Ro52 has both cytoplasmic and nuclear substrates, and that Ro52 mediates ubiquitination through UBE2D1 in the cytoplasm and through UBE2E1 in the nucleus...