Tommy Cederholm

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Effects of docosahexaenoic acid-rich n-3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study
    Inger Vedin
    Department of Medicine and the Division of Clinical Nutrition and Metabolism Research, Uppsala University Hospital, Uppsala, Sweden
    Am J Clin Nutr 87:1616-22. 2008
  2. ncbi request reprint Nutrition and acute leukemia in adults: relation to remission rate and survival
    Tommy Cederholm
    Department of Geriatric Medicine, B56, Karolinska Institutet at Huddinge University Hospital, S 141 86 Stockholm, Sweden
    Haematologia (Budap) 32:405-17. 2002
  3. ncbi request reprint Nutritional treatment of bone fracture
    Tommy Cederholm
    Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Curr Opin Clin Nutr Metab Care 8:377-81. 2005
  4. doi request reprint Renal function associates with energy intake in elderly community-dwelling men
    Desiree Luis
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, K56, Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
    Br J Nutr 111:2184-9. 2014
  5. pmc Reduced prostaglandin F2 alpha release from blood mononuclear leukocytes after oral supplementation of omega3 fatty acids: the OmegAD study
    Inger Vedin
    Department of Medicine, Caring Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Lipid Res 51:1179-85. 2010
  6. doi request reprint Effects on transthyretin in plasma and cerebrospinal fluid by DHA-rich n - 3 fatty acid supplementation in patients with Alzheimer's disease: the OmegAD study
    Gerd Faxén-Irving
    Department of NVS, Section of Clinical Nutrition, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Alzheimers Dis 36:1-6. 2013
  7. doi request reprint Effects of omega-3 fatty acids on inflammatory markers in cerebrospinal fluid and plasma in Alzheimer's disease: the OmegAD study
    Yvonne Freund-Levi
    Department NVS, Division of Clinical Geriatrics, Karolinska University Hospital, Stockholm, Sweden
    Dement Geriatr Cogn Disord 27:481-90. 2009
  8. doi request reprint Omega-3 fatty acids enhance phagocytosis of Alzheimer's disease-related amyloid-β42 by human microglia and decrease inflammatory markers
    Erik Hjorth
    Division of Neurodegeneration, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    J Alzheimers Dis 35:697-713. 2013
  9. doi request reprint Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: the omega-3 Alzheimer's disease study
    Gerd Faxén Irving
    Department of Neurobiology, Karolinska Institutet, Karolinska University, Hospital Huddinge, Stockholm, Sweden
    J Am Geriatr Soc 57:11-7. 2009
  10. pmc Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study
    Inger Vedin
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    PLoS ONE 7:e35425. 2012

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Effects of docosahexaenoic acid-rich n-3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study
    Inger Vedin
    Department of Medicine and the Division of Clinical Nutrition and Metabolism Research, Uppsala University Hospital, Uppsala, Sweden
    Am J Clin Nutr 87:1616-22. 2008
    ..Whereas most studies have explored the effects of predominantly EPA-based n-3 FAs preparations, few have addressed the effects of n-3 FAs preparations with DHA as the main FA...
  2. ncbi request reprint Nutrition and acute leukemia in adults: relation to remission rate and survival
    Tommy Cederholm
    Department of Geriatric Medicine, B56, Karolinska Institutet at Huddinge University Hospital, S 141 86 Stockholm, Sweden
    Haematologia (Budap) 32:405-17. 2002
    ..We may conclude that in adult acute leukemia patients a moderate weight loss (together with intermediate duration of neutropenia and fever) was associated with the highest remission rates...
  3. ncbi request reprint Nutritional treatment of bone fracture
    Tommy Cederholm
    Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Curr Opin Clin Nutr Metab Care 8:377-81. 2005
    ..The purpose of this review was to summarize recent studies that evaluated the effect of the nutritional or anabolic treatment of patients with osteoeporotic, e.g. hip, fractures...
  4. doi request reprint Renal function associates with energy intake in elderly community-dwelling men
    Desiree Luis
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, K56, Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
    Br J Nutr 111:2184-9. 2014
    ..We speculate on a possible link between renal dysfunction and malnutrition in the elderly...
  5. pmc Reduced prostaglandin F2 alpha release from blood mononuclear leukocytes after oral supplementation of omega3 fatty acids: the OmegAD study
    Inger Vedin
    Department of Medicine, Caring Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Lipid Res 51:1179-85. 2010
    ..The stimulus-specific PGF(2alpha) release from PBMC after 6 months of oral supplementation with the DHA-rich fish oil might be one event related to reduced inflammatory reactions associated with omega-3 fatty acid intake...
  6. doi request reprint Effects on transthyretin in plasma and cerebrospinal fluid by DHA-rich n - 3 fatty acid supplementation in patients with Alzheimer's disease: the OmegAD study
    Gerd Faxén-Irving
    Department of NVS, Section of Clinical Nutrition, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Alzheimers Dis 36:1-6. 2013
    ..172, p = 0.028). Thus, n - 3 FA treatment appeared to increase plasma-TTR in patients with AD. Since TTR may influence Aβ deposition in the brain, the results warrant further exploration...
  7. doi request reprint Effects of omega-3 fatty acids on inflammatory markers in cerebrospinal fluid and plasma in Alzheimer's disease: the OmegAD study
    Yvonne Freund-Levi
    Department NVS, Division of Clinical Geriatrics, Karolinska University Hospital, Stockholm, Sweden
    Dement Geriatr Cogn Disord 27:481-90. 2009
    ..omega-3 fatty acids (omega-3 FAs) found in dietary fish or fish oils are anti-inflammatory agents that may influence Alzheimer's disease (AD)...
  8. doi request reprint Omega-3 fatty acids enhance phagocytosis of Alzheimer's disease-related amyloid-β42 by human microglia and decrease inflammatory markers
    Erik Hjorth
    Division of Neurodegeneration, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    J Alzheimers Dis 35:697-713. 2013
    ..DHA and EPA can be beneficial in AD by enhancing removal of Aβ42, increasing neurotrophin production, decreasing pro-inflammatory cytokine production, and by inducing a shift in phenotype away from pro-inflammatory M1 activation...
  9. doi request reprint Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: the omega-3 Alzheimer's disease study
    Gerd Faxén Irving
    Department of Neurobiology, Karolinska Institutet, Karolinska University, Hospital Huddinge, Stockholm, Sweden
    J Am Geriatr Soc 57:11-7. 2009
    ..To study the effects of omega (Omega)-3 fatty acid (FA) supplements on weight and appetite in patients with mild to moderate Alzheimer's disease (AD) in relation to inflammatory biomarkers and apolipoprotein E epsilon4 (APOEepsilon4)...
  10. pmc Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study
    Inger Vedin
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    PLoS ONE 7:e35425. 2012
    ..Hence, our aim was to determine the effects of 6 mo of dietary supplementation with an n-3 FA preparation rich in DHA on global gene expression in peripheral blood mononuclear cells...
  11. doi request reprint Rheumatoid cachexia, central obesity and malnutrition in patients with low-active rheumatoid arthritis: feasibility of anthropometry, Mini Nutritional Assessment and body composition techniques
    Ann Charlotte Elkan
    Department of Rheumatology, R92, Karolinska Institute, Karolinska University Hospital Huddinge, 141 86, Stockholm, Sweden
    Eur J Nutr 48:315-22. 2009
    ..The objectives of this study were to evaluate body composition and nutritional status in patients with RA and the feasibility of bioelectrical impedance (BIA) to detect rheumatoid cachexia...
  12. doi request reprint Circulating Alpha-Tocopherol and Insulin Sensitivity Among Older Men With Chronic Kidney Disease
    Hong Xu
    Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    J Ren Nutr 26:177-82. 2016
    ..We here explore the potential role of vitamin E as a modifiable risk factor for insulin resistance among individuals with CKD...
  13. doi request reprint Validation of insulin sensitivity surrogate indices and prediction of clinical outcomes in individuals with and without impaired renal function
    Ting Jia
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden
    Kidney Int 86:383-91. 2014
    ..For research matters, OGTT-derived ISIs may be preferred. Our data do not support the hypothesis of kidney function mediating insulin sensitivity (IS)-associated outcomes nor a role for IS as a predictor of mortality. ..
  14. doi request reprint Dietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men
    Hong Xu
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital K56, Karolinska Institutet, 14186, Stockholm, Sweden
    Diabetologia 57:1561-8. 2014
    ..We tested the hypothesis that dietary acid load may increase the risk of type 2 diabetes, and studied the association between acid load and insulin sensitivity as a possible mechanism involved...
  15. pmc Mediterranean diet, kidney function, and mortality in men with CKD
    Xiaoyan Huang
    Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention, and Technology, Stockholm, Sweden
    Clin J Am Soc Nephrol 8:1548-55. 2013
    ..Adherence to a Mediterranean diet may link to a better preserved kidney function in the community as well as a favorable cardiometabolic profile and reduced mortality risk in individuals with manifest CKD...
  16. pmc Effects of protein-rich nutritional supplementation and bisphosphonates on body composition, handgrip strength and health-related quality of life after hip fracture: a 12-month randomized controlled study
    Lena Flodin
    Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden
    BMC Geriatr 15:149. 2015
    ..The aim of this study was to evaluate the combined effects of protein-rich nutritional supplementation and bisphosphonate on body composition, handgrip strength and health-related quality of life following hip fracture...
  17. pmc Clinical correlates of insulin sensitivity and its association with mortality among men with CKD stages 3 and 4
    Hong Xu
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden, Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China, Division of Nephrology, Peking University Shenzhen Hospital, Peking University, Shenzhen, China, Department of Public Health and Caring Sciences, Section of Geriatrics, and, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden, School of Health and Social Studies, Dalarna University, Falun, Sweden, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Clin J Am Soc Nephrol 9:690-7. 2014
    ..CKD patients have impaired insulin sensitivity, but the clinical correlates and outcome associations of impaired insulin sensitivity in this vulnerable population are not well defined...
  18. doi request reprint Serum and adipose tissue fatty acid composition as biomarkers of habitual dietary fat intake in elderly men with chronic kidney disease
    Xiaoyan Huang
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden
    Nephrol Dial Transplant 29:128-36. 2014
    ..Because both dietary intake and FA biomarkers associate with renal function, our aim was to identify which CE and AT FAs are useful biomarkers of habitual FA intake in individuals with chronic kidney disease (CKD)...
  19. doi request reprint Low bone mineral density and fat-free mass in younger patients with a femoral neck fracture
    Amer N Al-Ani
    Division of Orthopaedics, Department of Clinical Science Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Eur J Clin Invest 45:800-6. 2015
    ..The aim of this study was to examine body composition and BMD and their relationship with trauma mechanisms in young and middle-aged patients with femoral neck fracture...
  20. doi request reprint Polyunsaturated Fat Intake Estimated by Circulating Biomarkers and Risk of Cardiovascular Disease and All-Cause Mortality in a Population-Based Cohort of 60-Year-Old Men and Women
    Matti Marklund
    From Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden M M, P S, T C, U R Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine K L, M V, F L, B G, U d F and Division of Cardiovascular Medicine, Department of Clinical Sciences, Danderyds Hospital B G, Karolinska Institutet, Stockholm, Sweden and Department of Medicine, Cardiology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden M L H
    Circulation 132:586-94. 2015
    ..We investigated sex-specific associations of the major dietary PUFAs, eicosapentaenoic acid, docohexaenoic acid, linoleic acid, and α-linolenic acid, with incident CVD and all-cause mortality in a population-based cohort...
  21. ncbi request reprint Omega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptoms
    Yvonne Freund-Levi
    Department of NVS, Section of Clinical Geriatrics, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
    Int J Geriatr Psychiatry 23:161-9. 2008
    ..An association with APOEomega4 carriers and neuropsychiatric symptoms in AD has also been suggested...
  22. doi request reprint Early operation on patients with a hip fracture improved the ability to return to independent living. A prospective study of 850 patients
    Amer N Al-Ani
    Karolinska Institutet, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    J Bone Joint Surg Am 90:1436-42. 2008
    ..The outcome for many patients with a hip fracture remains poor. The aim of the present study was to investigate whether the timing of surgery in such patients could influence the short-term clinical outcome...
  23. pmc Additive effects of nutritional supplementation, together with bisphosphonates, on bone mineral density after hip fracture: a 12-month randomized controlled study
    Lena Flodin
    Department of Geriatric Medicine, Karolinska University Hospital Stockholm, Sweden Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden
    Clin Interv Aging 9:1043-50. 2014
    ..The aim of this study was to evaluate the effects of postoperative treatment with calcium, vitamin D, and bisphosphonates (alone or together) with nutritional supplementation on total hip and total body bone mineral density (BMD)...
  24. doi request reprint Essential polyunsaturated fatty acids, inflammation and mortality in dialysis patients
    Xiaoyan Huang
    Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden
    Nephrol Dial Transplant 27:3615-20. 2012
    ..We investigated the association of essential dietary PUFA intake, reflected by plasma fatty acid composition, with inflammation and mortality in dialysis patients...
  25. pmc Functional changes in adipose tissue in a randomised controlled trial of physical activity
    Per Sjogren
    Atherosclerosis Research Unit, Department of Medicine, Solna Karolinska Institutet, Stockholm, Sweden
    Lipids Health Dis 11:80. 2012
    ..Lifestyle changes such as increased physical activity improve a range of cardiometabolic risk factors. The objective of this study was to examine whether functional changes in adipose tissue were related to these improvements...
  26. doi request reprint Validity of food frequency questionnaire-based estimates of long-term long-chain n-3 polyunsaturated fatty acid intake
    Alice Wallin
    Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, 171 77, Stockholm, Sweden
    Eur J Nutr 53:549-55. 2014
    ..To evaluate how long-term dietary intake of long-chain n-3 polyunsaturated fatty acids (LCn-3 PUFAs), estimated by repeated food frequency questionnaires (FFQs) over 15 years, is correlated with LCn-3 PUFAs in adipose tissue (AT)...
  27. doi request reprint A comparative study of tissue ω-6 and ω-3 polyunsaturated fatty acids (PUFA) in benign and malignant pathologic stage pT2a radical prostatectomy specimens
    Martin C Schumacher
    Department of Molecular Medicine and Surgery, Karolinska Institutet Department of Urology, Stockholm, Sweden
    Urol Oncol 31:318-24. 2013
    ..To analyze different polyunsaturated fatty acid (PUFA) tissue levels in malignant compared with benign prostatic tissue from the same prostate specimens...
  28. ncbi request reprint Nutritional supplementation and dietary advice in geriatric patients at risk of malnutrition
    Margareta Persson
    Department of Geriatric Medicine, Dalens Hospital and Karolinska Institutet, Stockholm, Sweden
    Clin Nutr 26:216-24. 2007
    ..Effects of combined nutritional treatment of patients at risk of protein-energy malnutrition (PEM) discharged from a geriatric service were evaluated...
  29. pmc Rheumatoid cachexia is associated with dyslipidemia and low levels of atheroprotective natural antibodies against phosphorylcholine but not with dietary fat in patients with rheumatoid arthritis: a cross-sectional study
    Ann Charlotte Elkan
    Department of Rheumatology, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Arthritis Res Ther 11:R37. 2009
    ..The aim of this study was to analyze the associations between diet, body composition, lipids and atheroprotective natural antibodies against phosphorylcholine (anti-PC) in patients with RA...
  30. ncbi request reprint Nutritional and cognitive relationships and long-term mortality in patients with various dementia disorders
    Gerd Faxén-Irving
    Karolinska Institutet, Department of Geriatric Medicine, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Age Ageing 34:136-41. 2005
    ..Subjects with dementia are at risk for protein-energy malnutrition...
  31. ncbi request reprint Nutritional status and a 3-year follow-up in elderly receiving support at home
    Anja Saletti
    Neurotec Department, Karolinska Institutet, Stockholm, Sweden
    Gerontology 51:192-8. 2005
    ..Elderly receiving public services and care are often frail, suffer from chronic diseases, and sustain a high risk for malnutrition...
  32. ncbi request reprint Effects of protein-rich supplementation and nandrolone in lean elderly women with femoral neck fractures
    Jan Tidermark
    Karolinska Institutet, Sweden
    Clin Nutr 23:587-96. 2004
    ....
  33. ncbi request reprint Metabolism and catabolism in hip fracture patients: nutritional and anabolic intervention--a review
    Margareta Hedstrom
    Division of Orthopedics, Karolinska University Hospital, Huddinge, Sweden
    Acta Orthop 77:741-7. 2006
    ..Studies of higher scientific quality are needed, and enteral feeding, anabolic treatment and multimodal approaches need to be evaluated in greater depth...
  34. ncbi request reprint Effects of protein-rich supplementation and nandrolone on bone tissue after a hip fracture
    Birgitta Tengstrand
    Karolinska Institutet, Rheumatology Unit at Karolinska University Hospital Huddinge, Sweden
    Clin Nutr 26:460-5. 2007
    ..The aim of this study was to investigate the effects on bone tissue of protein-rich supplementation alone or in combination with nandrolone decanoate in lean elderly women after a hip fracture...
  35. ncbi request reprint Truncal fat mass as a contributor to inflammation in end-stage renal disease
    Jonas Axelsson
    Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital, Stockholm
    Am J Clin Nutr 80:1222-9. 2004
    ..Adipose tissue is an endocrine organ that may contribute to an inflammatory burden by secreting adipocytokines such as interleukin 6 (IL-6)...
  36. ncbi request reprint Mini Nutritional Assessment of rural elderly people in Bangladesh: the impact of demographic, socio-economic and health factors
    Zarina Nahar Kabir
    Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Box 6401, SE 113 82 Stockholm, Sweden
    Public Health Nutr 9:968-74. 2006
    ..Nutritional status of the elderly population in low-income countries is seldom focused upon. The present study aimed to evaluate the magnitude of malnutrition among an elderly population in rural Bangladesh...
  37. ncbi request reprint [Malnutrition common within Swedish health care. Assessment of the evidence status gives clear results: time to concentrate on clinical nutrition!]
    Tommy Cederholm
    Institutionen för folkhälso och värdvetenskap, klinisk nutrition och metabolism, Uppsala universitet, Akademiska sjukhuset, Uppsala
    Lakartidningen 103:1713, 1715-7. 2006