Affiliation: Karolinska Institutet
- Characterization by phenotype of families with atopic dermatitisM Bradley
Department of Dermatology and Venereology, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
Acta Derm Venereol 80:106-10. 2000..Although the families were selected for genetic sib-pair linkage analysis, we believe that this material is representative of atopic dermatitis families managed at hospitals in Stockholm...
- The Wiskott-Aldrich syndrome gene as a candidate gene for atopic dermatitisM Bradley
Department of Dermatology and Venereology, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
Acta Derm Venereol 81:340-2. 2001..Our results indicate that either the WAS gene or another gene in the area contributes to the severity of atopic dermatitis...
- Linkage and association to candidate regions in Swedish atopic dermatitis familiesC Söderhäll
Department of Molecular Medicine, CMM 02, Karolinska Institutet, SE 171 76 Stockholm, Sweden
Hum Genet 109:129-35. 2001..009). When a quantitative variable for the severity of atopic dermatitis was studied, evidence was found in favour of linkage to the 5q31-33 region, with the highest Z-score (2.06) close to the marker D5S458 (P<0.005)...
- Susceptibility loci for atopic dermatitis on chromosome 21 in a Swedish populationL M Bu
Department of Molecular Medicine, Karolinska Institutet at Karolinska Hospital, Stockholm, Sweden
Allergy 61:617-21. 2006..We have previously found several loci showing suggestive linkage on chromosomes 3q14, 13q14, 15q14-15 and 17q21, and weaker linkage to chromosomes 1p32, 4q24-26 and 21q21 in 109 Swedish families...
- Lack of association between filaggrin gene mutations and onset of psoriasis in childhoodM C G Winge
Dermatology Unit, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
J Eur Acad Dermatol Venereol 27:e124-7. 2013..Psoriasis is a highly heterogeneous disease and so far genetic studies have not taken the distinct sub-phenotype childhood onset into account...
- Cornulin, a marker of late epidermal differentiation, is down-regulated in eczemaA Lieden
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Allergy 64:304-11. 2009..We then investigated CRNN as an eczema candidate gene and studied its polymorphism and the expression in the skin of eczema patients...
- Genome-wide linkage analysis of allergic rhinoconjunctivitis in a Swedish populationL M Bu
Department of Molecular Medicine and Surgery, Stockholm Karolinska Institutet, Stockholm, Sweden
Clin Exp Allergy 36:204-10. 2006..Like other atopic disorders such as allergic asthma and atopic dermatitis, the development involves complex interactions of genes and environmental factors...
- Analysis of association and linkage for the interleukin-4 and interleukin-4 receptor b;alpha; regions in Swedish atopic dermatitis familiesC Söderhäll
Departments of Molecular Medicine, Karolinska Institute at Karolinska Hospital, Stockholm, Sweden
Clin Exp Allergy 32:1199-202. 2002..Several lines of evidence suggest that the IL-4 gene and the IL-4-receptor alpha (IL-4Ralpha) gene are involved in the development of atopic diseases...
- Novel filaggrin mutation but no other loss-of-function variants found in Ethiopian patients with atopic dermatitisM C G Winge
Dermatology Unit, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
Br J Dermatol 165:1074-80. 2011..However, it is unknown whether FLG mutations in the African population are a causative genetic factor for IV and predispose to AD, or whether other mechanisms are more prominent...
- The tight junction gene Claudin-1 is associated with atopic dermatitis among EthiopiansS Asad
Department of Molecular Medicine and Surgery and the Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
J Eur Acad Dermatol Venereol 30:1939-1941. 2016..Although the filaggrin (FLG) gene is the major AD risk gene in European and Asian populations, disease-associated variants remain elusive in African populations...
- Elevated expression and genetic association links the SOCS3 gene to atopic dermatitisE Ekelund
Department of Molecular Medicine and Surgery, Department of Medicine, Karolinska University Hospital, Stockholm, SE 171 76, Sweden
Am J Hum Genet 78:1060-5. 2006..02 and P<.03). These results strongly suggest that SOCS3, located in a chromosomal region previously linked to the disease (17q25), is a susceptibility gene for atopic dermatitis...