Christer Betsholtz

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc A two-way communication between microglial cells and angiogenic sprouts regulates angiogenesis in aortic ring cultures
    Simin F Rymo
    Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 6:e15846. 2011
  2. pmc Correction: The importance of microglia in the development of the vasculature in the central nervous system
    Tom Arnold
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, Stockholm 17177, Sweden
    Vasc Cell 5:12. 2013
  3. pmc The importance of microglia in the development of the vasculature in the central nervous system
    Tom Arnold
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, 17177, Stockholm, Sweden
    Vasc Cell 5:4. 2013
  4. ncbi request reprint The glomerular transcriptome and proteome
    Christer Betsholtz
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Nephron Exp Nephrol 106:e32-6. 2007
  5. doi request reprint Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation
    Laleh Sistani
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Kidney Int 83:63-71. 2013
  6. pmc Podocin-green fluorescence protein allows visualization and functional analysis of podocytes
    Bing He
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden
    J Am Soc Nephrol 22:1019-23. 2011
  7. doi request reprint Glomerular transcriptome changes associated with lipopolysaccharide-induced proteinuria
    Ying Sun
    Department of Medical Biochemistry and Biophysics, Division of Matrix Biology, Karolinska Institutet, Stockholm, Sweden
    Am J Nephrol 29:558-70. 2009
  8. doi request reprint Pericytes regulate the blood-brain barrier
    Annika Armulik
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institute, Scheeles vag 2, SE 171 77 Stockholm, Sweden
    Nature 468:557-61. 2010
  9. doi request reprint Knockdown of Tmem234 in zebrafish results in proteinuria
    Patricia Q Rodriguez
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden KI AZ Integrated CardioMetabolic Center, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
    Am J Physiol Renal Physiol 309:F955-66. 2015
  10. doi request reprint Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics
    Ljubica Perisic
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Kidney Int 82:1071-83. 2012

Detail Information

Publications70

  1. pmc A two-way communication between microglial cells and angiogenic sprouts regulates angiogenesis in aortic ring cultures
    Simin F Rymo
    Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 6:e15846. 2011
    ..Recent studies correlate the presence of microglia in the developing CNS with vascular network formation, but it is not clear whether the effect is directly caused by microglia and their contact with the endothelium...
  2. pmc Correction: The importance of microglia in the development of the vasculature in the central nervous system
    Tom Arnold
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, Stockholm 17177, Sweden
    Vasc Cell 5:12. 2013
    ..To avoid confusion, the article is republished here in its entirety, with the citations referenced correctly.The Publisher and authors apologize to the readers for the inconvenience caused...
  3. pmc The importance of microglia in the development of the vasculature in the central nervous system
    Tom Arnold
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, 17177, Stockholm, Sweden
    Vasc Cell 5:4. 2013
    ....
  4. ncbi request reprint The glomerular transcriptome and proteome
    Christer Betsholtz
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Nephron Exp Nephrol 106:e32-6. 2007
    ....
  5. doi request reprint Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation
    Laleh Sistani
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Kidney Int 83:63-71. 2013
    ..Thus, three neuronal proteins are highly expressed in podocyte major process. Using these new markers we found that podocytes contribute to the formation of glomerular crescents...
  6. pmc Podocin-green fluorescence protein allows visualization and functional analysis of podocytes
    Bing He
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden
    J Am Soc Nephrol 22:1019-23. 2011
    ..This model should also be useful for high-throughput genetic or chemical analysis of glomerular development and function...
  7. doi request reprint Glomerular transcriptome changes associated with lipopolysaccharide-induced proteinuria
    Ying Sun
    Department of Medical Biochemistry and Biophysics, Division of Matrix Biology, Karolinska Institutet, Stockholm, Sweden
    Am J Nephrol 29:558-70. 2009
    ..Global gene expression patterns have recently been characterized in normal glomeruli, but gene expression changes that accompany glomerular disease remain poorly characterized...
  8. doi request reprint Pericytes regulate the blood-brain barrier
    Annika Armulik
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institute, Scheeles vag 2, SE 171 77 Stockholm, Sweden
    Nature 468:557-61. 2010
    ..Our results indicate a novel and critical role for pericytes in the integration of endothelial and astrocyte functions at the neurovascular unit, and in the regulation of the BBB...
  9. doi request reprint Knockdown of Tmem234 in zebrafish results in proteinuria
    Patricia Q Rodriguez
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden KI AZ Integrated CardioMetabolic Center, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
    Am J Physiol Renal Physiol 309:F955-66. 2015
    ..Identification of new molecular components of the kidney filtration barrier opens up possibilities to study their role in glomerulus biology and diseases. ..
  10. doi request reprint Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics
    Ljubica Perisic
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Kidney Int 82:1071-83. 2012
    ..In addition, Plekhh2 stabilizes the cortical actin cytoskeleton by attenuating actin depolymerization. Our findings suggest a structural and functional role for Plekhh2 in the podocyte foot processes...
  11. doi request reprint Identification of a core set of 58 gene transcripts with broad and specific expression in the microvasculature
    Elisabet Wallgard
    Department of Medical Biochemistry and Biophysics, KarolinskaInstitutet, Scheeles vag 2, A3, Floor 4, SE 171 77, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 28:1469-76. 2008
    ..Here we aimed at determining the endothelial cell-specific core transcriptome in vivo...
  12. doi request reprint Pdlim2 is a novel actin-regulating protein of podocyte foot processes
    Laleh Sistani
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Kidney Int 80:1045-54. 2011
    ..Hence, pdlim2 is a novel actin-regulating protein of podocyte foot processes that may have a role in the pathogenesis of glomerular diseases...
  13. pmc The glomerular transcriptome and a predicted protein-protein interaction network
    Liqun He
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77, Stockholm, Sweden
    J Am Soc Nephrol 19:260-8. 2008
    ....
  14. doi request reprint Zebrafish: a model system for the study of vertebrate renal development, function, and pathophysiology
    Lwaki Ebarasi
    Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Curr Opin Nephrol Hypertens 20:416-24. 2011
    ..This review summarizes recent advances in our current knowledge of the zebrafish pronephros as a valuable model system relevant to the study of human kidney biology and nephropathology...
  15. doi request reprint The absence of pericytes does not increase the sensitivity of tumor vasculature to vascular endothelial growth factor-A blockade
    Maya H Nisancioglu
    Laboratory of Vascular Biology, Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Cancer Res 70:5109-15. 2010
    ..Our observations suggest that additional targeting of pericytes does not increase the antitumor effect already generated by anti-VEGF drugs...
  16. pmc Glomerular podocytes express type 1 adenylate cyclase: inactivation results in susceptibility to proteinuria
    Zhijie Xiao
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Nephron Exp Nephrol 118:e39-48. 2011
    ..In this study, we characterized the expression and role of Adcy1 in the kidney...
  17. pmc Schip1 is a novel podocyte foot process protein that mediates actin cytoskeleton rearrangements and forms a complex with Nherf2 and ezrin
    Ljubica Perisic
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
    PLoS ONE 10:e0122067. 2015
    ..Podocyte foot process effacement accompanied by actin cytoskeleton rearrangements is a cardinal feature of many progressive human proteinuric diseases...
  18. pmc Glcci1 deficiency leads to proteinuria
    Yukino Nishibori
    Department of Medical Biochemistry and Biophysics, Division of Matrix Biology, Karolinska Institutet, 171 77 Stockholm, Sweden
    J Am Soc Nephrol 22:2037-46. 2011
    ..Taken together, these data suggest that Glcci1 promotes the normal development and maintenance of podocyte structure and function...
  19. doi request reprint Expression of novel podocyte-associated proteins sult1b1 and ankrd25
    Xiangjun Xu
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Nephron Exp Nephrol 117:e39-46. 2011
    ..Podocytes have a unique function in the renal ultrafiltration that is achieved by expressing proteins that are highly specific to podocytes. In this study, we identified two novel podocyte-associated proteins...
  20. doi request reprint The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2
    Konstantin Gaengel
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, 17177 Stockholm, Sweden
    Dev Cell 23:587-99. 2012
    ..Our data suggest that S1PR1 signaling acts as a vascular-intrinsic stabilization mechanism, protecting developing blood vessels against aberrant angiogenic responses...
  21. doi request reprint Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice
    Zhijie Xiao
    Department of Medical Biochemistry and Biophysics, Division of Matrix Biology, Karolinska Institutet, Stockholm, Sweden
    Dev Dyn 240:2646-56. 2011
    ..5. These findings therefore indicate a novel role for the Crumbs family of proteins...
  22. doi request reprint Endothelial-mural cell signaling in vascular development and angiogenesis
    Konstantin Gaengel
    Vascular Biology Laboratory, Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 29:630-8. 2009
    ..We further reflect recent data suggesting an important function for Notch3 signaling in mural cell maturation...
  23. pmc Large-scale identification of genes implicated in kidney glomerulus development and function
    Minoru Takemoto
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    EMBO J 25:1160-74. 2006
    ..We surmise that studies on the other novel glomerulus-enriched transcripts identified in this study will provide new insight into glomerular development and pathomechanisms of disease...
  24. doi request reprint A reverse genetic screen in the zebrafish identifies crb2b as a regulator of the glomerular filtration barrier
    Lwaki Ebarasi
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles vag 2, Plan 4 B1, SE 171 77 Stockholm, Sweden
    Dev Biol 334:1-9. 2009
    ..This report is the first to show a role for crb function in podocyte differentiation. Furthermore, these results suggest a novel link between epithelial polarization and the maintenance of a functional filtration barrier...
  25. ncbi request reprint Microarray analysis of blood microvessels from PDGF-B and PDGF-Rbeta mutant mice identifies novel markers for brain pericytes
    Cecilia Bondjers
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77, Stockholm, Sweden
    FASEB J 20:1703-5. 2006
    ..The three new brain pericyte markers are signaling molecules implicated in ion transport and intercellular signaling, potentially opening new windows on pericyte function in brain microvessels...
  26. pmc Lmx1b and FoxC combinatorially regulate podocin expression in podocytes
    Bing He
    Department of Medical Biochemistry and Biophysics, Division of Matrix Biology, and
    J Am Soc Nephrol 25:2764-77. 2014
    ..This finding provides insights into transcriptional mechanisms required for normal and pathologic podocyte functions...
  27. pmc Wtip- and gadd45a-interacting protein dendrin is not crucial for the development or maintenance of the glomerular filtration barrier
    Zhijie Xiao
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e83133. 2013
    ..Our results indicate that dendrin is dispensable for the function of the normal glomerular filtration barrier and that dendrin interacts with Wtip and Gadd45a. ..
  28. ncbi request reprint Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik
    Jaakko Patrakka
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden
    J Am Soc Nephrol 18:689-97. 2007
    ..This study provides fresh insights into glomerular biology and uncovers new possibilities to explore the role of these novel proteins in the glomerular physiology and pathology...
  29. doi request reprint PDGF-A and PDGF-B induces cardiac fibrosis in transgenic mice
    Radiosa Gallini
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Exp Cell Res 349:282-290. 2016
    ..e. the likely source of extracellular matrix depostion and fibrotic reaction. The apparent sensitivity of the heart to ectopic PDGFRα agonists supports a role for endogenous PDGFRα agonists in the pathogenesis of cardiac fibrosis...
  30. pmc Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain
    Thomas D Arnold
    Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 177 77 Stockholm, Sweden
    Development 141:4489-99. 2014
    ..Our data therefore suggest that abnormal vascular sprouting and patterning, not BBB dysfunction, underlie developmental cerebral hemorrhage...
  31. pmc Generation and characterization of rgs5 mutant mice
    Maya H Nisancioglu
    Karolinska Institutet, Laboratory of Vascular Biology, Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Scheelesväg 2, Plan4 A3, SE 171 77 Stockholm, Sweden
    Mol Cell Biol 28:2324-31. 2008
    ..The GFP expression in pericytes of rgs5(GFP) mice allows detection and sorting of these cells, thereby providing a valuable novel tool for pericyte research...
  32. doi request reprint Pericytes: developmental, physiological, and pathological perspectives, problems, and promises
    Annika Armulik
    Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Dev Cell 21:193-215. 2011
    ..Here, we review the history of these investigations, indicate emerging concepts, and point out problems and promise in the field of pericyte biology...
  33. pmc Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts
    Charlotte Anderberg
    Ludwig Institute for Cancer Research Ltd, Stockholm Branch, Nobels väg 3, Stockholm, Sweden
    Cancer Res 69:369-78. 2009
    ..In conclusion, we establish paracrine signaling by PDGF-CC as a potential drug target to reduce stromal support in malignant melanoma...
  34. ncbi request reprint Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
    Mats Hellstrom
    AngioGenetics Sweden AB, Scheeles vag 2, SE 171 77 Stockholm, Sweden
    Nature 445:776-80. 2007
    ....
  35. doi request reprint Notch3 is necessary for blood vessel integrity in the central nervous system
    Tanya L Henshall
    From the Department of Cell and Molecular Biology T H, S J, U L and Department of Medical Biochemistry and Biophysics, Division of Vascular Biology C B, E R, Karolinska Institute, Stockholm, Sweden Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden A K, L H, E R, M A M, C B EM Unit, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden B R J and Octapharma AB, Stockholm, Sweden E W
    Arterioscler Thromb Vasc Biol 35:409-20. 2015
    ..In this report, we explored the impact of the loss of VSMC in the Notch3(-/-) mouse on blood vessel integrity in the central nervous system...
  36. pmc Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development
    Alexandra Abramsson
    Department of Medical Biochemistry and Biophysics, Division of Matrix Biology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Genes Dev 21:316-31. 2007
    ....
  37. pmc Mice Lacking Platelet-Derived Growth Factor D Display a Mild Vascular Phenotype
    Hanna Gladh
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 11:e0152276. 2016
    ....
  38. doi request reprint An Endothelial Gene Signature Score Predicts Poor Outcome in Patients with Endocrine-Treated, Low Genomic Grade Breast Tumors
    Nicholas P Tobin
    Department of Oncology and Pathology, Karolinska Institutet and University Hospital, Stockholm, Sweden
    Clin Cancer Res 22:2417-26. 2016
    ..As such, we assessed the expression of genes representative of normal endothelial microvasculature (MV) in relation to treatment-specific patient subgroups...
  39. ncbi request reprint Getting to know the cast - cellular interactions and signaling at the neurovascular unit
    Maarja Mäe
    Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, SE 171 77, Stockholm, Sweden
    Curr Pharm Des 17:2750-4. 2011
    ..We also discuss the usefulness of various model organisms for studies of the brain vasculature...
  40. pmc Role of platelet-derived growth factors in physiology and medicine
    Johanna Andrae
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Genes Dev 22:1276-312. 2008
    ....
  41. ncbi request reprint Endothelial/pericyte interactions
    Annika Armulik
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Circ Res 97:512-23. 2005
    ..We finally highlight recent important data contributing to the understanding of the role of pericytes in tumor angiogenesis, diabetic retinopathy, and hereditary lymphedema...
  42. ncbi request reprint Mouse Notch 3 expression in the pre- and postnatal brain: relationship to the stroke and dementia syndrome CADASIL
    Nilima Prakash
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE 171 77, Stockholm, Sweden
    Exp Cell Res 278:31-44. 2002
    ..These data show that Notch 3 expression is conserved between mouse and human and suggest that the mouse is a valid system for analysis of CADASIL...
  43. ncbi request reprint Role of pericytes in vascular morphogenesis
    Christer Betsholtz
    Laboratory of Vascular Biology, Division of Matrix Biology, House A3, Plan 4, Department of Medical Biochemistry and Biophysics, Scheels vag 2, Karolinska Institutet, 17177 Stockholm, Sweden
    EXS . 2005
    ..The present review focuses on genetic data suggesting that pericytes take active part in developmental angiogenic processes...
  44. doi request reprint Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
    Amit Zeisel
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Science 347:1138-42. 2015
    ..Across the diversity of cortical cell types, transcription factors formed a complex, layered regulatory code, suggesting a mechanism for the maintenance of adult cell type identity. ..
  45. doi request reprint Lim domain binding 2: a key driver of transendothelial migration of leukocytes and atherosclerosis
    Ming Mei Shang
    From the Division of Cardiovascular Genomics M M S, H A T, H F A, A R, C C, J S, J L M B, Division of Vascular Biology, Department of Medical Biochemistry and Biophysics M M S, H A T, J J H, C N, H F A, A R, C C, C B, J S, J L M B, Computational Medicine Unit, Department of Medicine Solna, Center of Molecular Medicine M M S, and Department of Environmental Medicine B G, K L, U d F, Karolinska Institutet, Solna, Sweden Clinical Gene Networks AB, Karolinska Science Park, Solna, Sweden M M S, A R, J L M B Division of Cardiovascular Genomics, Department of Pathological Anatomy and Forensic Medicine
    Arterioscler Thromb Vasc Biol 34:2068-77. 2014
    ..Here, we used human genomics and atherosclerosis-prone mice to evaluate the possible role of LDB2 in TEML and atherosclerosis...
  46. doi request reprint Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment
    Sergey Rodin
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm SE 171 77, Sweden
    Nat Commun 5:3195. 2014
    ..This method can facilitate the generation of hES cell lines for development of different cell types for regenerative medicine purposes. ..
  47. ncbi request reprint Pericytes and vascular stability
    Desiree von Tell
    Vascular Biology Laboratory, Division of Matrix Biology, Department of Medical, Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Exp Cell Res 312:623-9. 2006
    ..Several ligand-receptor systems have been implicated in endothelial-pericyte interactions. Here, we discuss the role of some of these signaling systems in the regulation of vascular stability...
  48. pmc VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
    Holger Gerhardt
    Deparrment of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    J Cell Biol 161:1163-77. 2003
    ..Thus, vessel patterning during retinal angiogenesis depends on the balance between two different qualities of the extracellular VEGF-A distribution, which regulate distinct cellular responses in defined populations of endothelial cells...
  49. ncbi request reprint Endothelial-pericyte interactions in angiogenesis
    Holger Gerhardt
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, PO Box 440, SE 405 30, Goteborg, Sweden
    Cell Tissue Res 314:15-23. 2003
    ..Genetic data demonstrate the critical importance of pericytes for vascular morphogenesis and function, and imply specific roles for the cell type in various aspects of angiogenesis...
  50. pmc Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cells
    Cecilia Bondjers
    Department of Medical Biochemistry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Am J Pathol 162:721-9. 2003
    ..With RGS5 as a proof-of-principle, our data demonstrate the usefulness of microarray analysis of mouse models for abnormal pericyte development in the identification of new pericyte-specific markers...
  51. ncbi request reprint Analysis of mural cell recruitment to tumor vessels
    Alexandra Abramsson
    Department of Medical Biochemistry, Goteborg University, Goteborg, Sweden
    Circulation 105:112-7. 2002
    ..A limited support of mural cells may contribute to these abnormalities. Here, we characterized mural cell recruitment in 2 mouse tumor models and addressed the question of why tumor vessels fail to recruit a proper coat of mural cells...
  52. pmc Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
    Christiana Ruhrberg
    Endothelial Cell Biology Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
    Genes Dev 16:2684-98. 2002
    ..We conclude that differential VEGF-A isoform localization in the extracellular space provides a control point for regulating vascular branching pattern...
  53. pmc A new method for large scale isolation of kidney glomeruli from mice
    Minoru Takemoto
    Department of Medical Biochemistry, Goteborg University, Sweden
    Am J Pathol 161:799-805. 2002
    ..This method makes feasible transcript profiling and proteomic analysis of the developing, healthy and diseased mouse glomerulus...
  54. pmc Pericytes limit tumor cell metastasis
    Xiaojie Xian
    Stem Cell Center, Lund University, Lund, Sweden
    J Clin Invest 116:642-51. 2006
    ..These data support a new model for how tumor cells trigger metastasis by perturbing pericyte-endothelial cell-cell interactions...
  55. pmc Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy
    Maria Enge
    Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
    EMBO J 21:4307-16. 2002
    ..Our data suggest that a reduction of the pericyte density is sufficient to cause retinopathy in mice, implying that pericyte loss may also be a causal pathogenic event in human diabetic retinopathy...
  56. ncbi request reprint Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation
    Charlotte Rolny
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjoldsv 20, 751 85 Uppsala, Sweden
    Blood 108:1877-86. 2006
    ..Moreover, enhanced vascular remodeling was evident in the Rosa26-PDGF-BB yolk sacs. We conclude that PDGFR-beta is expressed on early hemangioprecursor cells, regulating vascular/hematopoietic development...
  57. ncbi request reprint Platelet-derived growth factor B retention is essential for development of normal structure and function of conduit vessels and capillaries
    Henrik C Nystrom
    Institute of Physiology and Pharmacology, Department of Physiology, Goteborg University, and RCEM and Wallenberg Laboratory, Sahlgrenska University Hospital, Sweden
    Cardiovasc Res 71:557-65. 2006
    ..We used the PDGF-B retention motif knockout mouse (RetKO) to study the effects of retention motif deletion on development of micro- and macrovascular structure and function...
  58. ncbi request reprint In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure
    Arianna Tocchetti
    Department of Medical Biochemistry, University of Goteborg, Sweden
    Genomics 81:234-44. 2003
    ..The data obtained will be instrumental in directing further experimental functional characterization of these genes...
  59. pmc Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall
    Per Lindblom
    Department of Medical Biochemistry, Goteborg University, Göteborg SE 405 30, Sweden
    Genes Dev 17:1835-40. 2003
    ..We conclude that retention of PDGF-B in microvessels is essential for proper recruitment and organization of pericytes and for renal and retinal function in adult mice...
  60. ncbi request reprint Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling
    Jody J Haigh
    Mount Sinai Hospital, Samuel Lunenfeld Research Institute, Toronto, Canada
    Dev Biol 262:225-41. 2003
    ..VEGF-A dosage is therefore a critical parameter regulating the density of the vascular plexus in the developing CNS that is in turn a key determinant in the development and architectural organization of the nervous system...
  61. pmc Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors
    Alexandra Abramsson
    Department of Medical Biochemistry, Sahlgrenska Academy at Göteberg University, Goteborg, Sweden
    J Clin Invest 112:1142-51. 2003
    ..Our data support the notion that pericytes serve an important function in tumor vessels and highlight PDGF-B and PDGF-Rbeta as promising molecular targets for therapeutic intervention...
  62. doi request reprint Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
    Tuomas Tammela
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 Haartmaninkatu 8, 00014 Helsinki, Finland
    Nature 454:656-60. 2008
    ..Our results implicate VEGFR-3 as a regulator of vascular network formation. Targeting VEGFR-3 may provide additional efficacy for anti-angiogenic therapies, especially towards vessels that are resistant to VEGF or VEGFR-2 inhibitors...
  63. ncbi request reprint Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities
    Mattias Bjarnegard
    Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
    Development 131:1847-57. 2004
    ..This spectrum of pathological changes is reminiscent of diabetic microangiopathy, suggesting that the endothelium-restricted Pdgfb knockouts may serve as models for some of the pathogenic events of vascular complications to diabetes...
  64. ncbi request reprint Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate
    Masao Furuhashi
    Ludwig Institute for Cancer Research, Uppsala Branch, Uppsala, Sweden
    Cancer Res 64:2725-33. 2004
    ..Our findings thus demonstrate that paracrine PDGF production stimulates pericyte recruitment to tumor vessels and suggest that pericyte abundance influences tumor cell apoptosis and tumor growth...
  65. ncbi request reprint Role of platelet-derived growth factor in mesangium development and vasculopathies: lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in mice
    Christer Betsholtz
    Department of Medical Biochemistry, University of Goteborg, Sweden
    Curr Opin Nephrol Hypertens 13:45-52. 2004
    ....
  66. ncbi request reprint Insight into the physiological functions of PDGF through genetic studies in mice
    Christer Betsholtz
    Department of Medical Biochemistry, University of Goteborg, P O Box 440, SE 405 30 Goteborg, Sweden
    Cytokine Growth Factor Rev 15:215-28. 2004
    ..The present review summarizes these findings and discusses their implications for mammalian development and disease...
  67. ncbi request reprint Under stress, the absence of intermediate filaments from Müller cells in the retina has structural and functional consequences
    Andrea Lundkvist
    Department of Medical Biochemistry, The Sahlgrenska Academy at Goteborg University, Medicinaregatan 9C, SE 41390 Göteborg, Sweden
    J Cell Sci 117:3481-8. 2004
    ..Furthermore, the absence of IFs in Müller cells leads to an abnormal response of the vascular system to ischemia, specifically decreased ability of newly formed blood vessels to traverse the ILM...
  68. ncbi request reprint Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system
    Holger Gerhardt
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    Dev Dyn 231:503-9. 2004
    ..These observations suggest that Nrp-1 plays an important role in allowing the endothelial tip cell filopodia to switch substrate and protrude in a new direction at a specific location in the developing brain...
  69. ncbi request reprint Identification of transcripts specific for physiological gene activation by platelet-derived growth factor (PDGF)-B in intact brain tissue
    Oliver Renner
    Experimental Therapeutics Programme, Spanish National Cancer Centre, E 28029 Madrid, Spain
    J Cell Biochem 95:859-67. 2005
    ....
  70. pmc The absence of platelet-derived growth factor-B in circulating cells promotes immune and inflammatory responses in atherosclerosis-prone ApoE-/- mice
    Jingjing Tang
    Department of Pathology, University of Washington, Seattle, WA 98104 2499, USA
    Am J Pathol 167:901-12. 2005
    ..Thus, our studies identify two independent negative immune regulatory pathways-PDGF-B and SOCS-that may help limit lesion expansion...