Per Olof Berggren

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Glucose recruits K(ATP) channels via non-insulin-containing dense-core granules
    Shao Nian Yang
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Cell Metab 6:217-28. 2007
  2. pmc Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans
    Rayner Rodriguez-Diaz
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Nat Med 17:888-92. 2011
  3. ncbi request reprint Novel aspects on signal-transduction in the pancreatic beta-cell
    Per Olof Berggren
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska University Hospital Solna L3, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Nutr Metab Cardiovasc Dis 16:S7-10. 2006
  4. pmc Professor Rolf Luft, 1914--2007
    P O Berggren
    The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska Institutet L1 03, Karolinska University Hospital, SE 17176, Stockholm, Sweden
    Diabetologia 51:697-9. 2008
  5. ncbi request reprint Insulinotropic activity of the imidazoline derivative RX871024 in the diabetic GK rat
    Alexander M Efanov
    Endocrine and Diabetes Unit, Department of Molecular Medicine, Karolinska Institutet, S 171 76 Stockholm, Sweden
    Am J Physiol Endocrinol Metab 282:E117-24. 2002
  6. ncbi request reprint Tyrosine 537 within the Na+,K+-ATPase alpha-subunit is essential for AP-2 binding and clathrin-dependent endocytosis
    Stefania Cotta Doné
    Department of Molecular Medicine, Karolinska Institutet, The Rolf Luft Centrum for Diabetes Research, Karolinska Hospital, 171 76 Stockholm, Sweden
    J Biol Chem 277:17108-11. 2002
  7. ncbi request reprint Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis
    Lena Lilja
    Department of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    J Biol Chem 279:29534-41. 2004
  8. doi request reprint Insulin-feedback via PI3K-C2alpha activated PKBalpha/Akt1 is required for glucose-stimulated insulin secretion
    Barbara Leibiger
    Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden
    FASEB J 24:1824-37. 2010
  9. ncbi request reprint Rapid association of protein kinase C-epsilon with insulin granules is essential for insulin exocytosis
    Carlos F Mendez
    Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    J Biol Chem 278:44753-7. 2003
  10. pmc Automated, high-throughput assays for evaluation of human pancreatic islet function
    Over Cabrera
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Cell Transplant 16:1039-48. 2008

Collaborators

Detail Information

Publications108 found, 100 shown here

  1. ncbi request reprint Glucose recruits K(ATP) channels via non-insulin-containing dense-core granules
    Shao Nian Yang
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Cell Metab 6:217-28. 2007
    ..Our data suggest that glucose can recruit K(ATP) channels to the beta cell plasma membrane via non-insulin-containing dense-core granules in a Ca(2+)- and PKA-dependent manner...
  2. pmc Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans
    Rayner Rodriguez-Diaz
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Nat Med 17:888-92. 2011
    ..Cholinergic signaling within islets represents a potential therapeutic target in diabetes, highlighting the relevance of this advance to future drug development...
  3. ncbi request reprint Novel aspects on signal-transduction in the pancreatic beta-cell
    Per Olof Berggren
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska University Hospital Solna L3, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Nutr Metab Cardiovasc Dis 16:S7-10. 2006
    ..In the present mini-review we will discuss the role of signaling through some of these receptor-operated effector systems in the light of pancreatic beta-cell signal-transduction...
  4. pmc Professor Rolf Luft, 1914--2007
    P O Berggren
    The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska Institutet L1 03, Karolinska University Hospital, SE 17176, Stockholm, Sweden
    Diabetologia 51:697-9. 2008
  5. ncbi request reprint Insulinotropic activity of the imidazoline derivative RX871024 in the diabetic GK rat
    Alexander M Efanov
    Endocrine and Diabetes Unit, Department of Molecular Medicine, Karolinska Institutet, S 171 76 Stockholm, Sweden
    Am J Physiol Endocrinol Metab 282:E117-24. 2002
    ..These data support the idea that imidazoline compounds can form the basis for the development of novel drugs for treatment of type 2 diabetes, which can restore glucose sensitivity in diabetic beta-cells...
  6. ncbi request reprint Tyrosine 537 within the Na+,K+-ATPase alpha-subunit is essential for AP-2 binding and clathrin-dependent endocytosis
    Stefania Cotta Doné
    Department of Molecular Medicine, Karolinska Institutet, The Rolf Luft Centrum for Diabetes Research, Karolinska Hospital, 171 76 Stockholm, Sweden
    J Biol Chem 277:17108-11. 2002
    ....
  7. ncbi request reprint Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis
    Lena Lilja
    Department of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    J Biol Chem 279:29534-41. 2004
    ....
  8. doi request reprint Insulin-feedback via PI3K-C2alpha activated PKBalpha/Akt1 is required for glucose-stimulated insulin secretion
    Barbara Leibiger
    Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden
    FASEB J 24:1824-37. 2010
    ....
  9. ncbi request reprint Rapid association of protein kinase C-epsilon with insulin granules is essential for insulin exocytosis
    Carlos F Mendez
    Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    J Biol Chem 278:44753-7. 2003
    ..These results suggest that association of PKC-epsilon with insulin granule membranes represents an important component of the secretory network because it is essential for insulin exocytosis in response to glucose...
  10. pmc Automated, high-throughput assays for evaluation of human pancreatic islet function
    Over Cabrera
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Cell Transplant 16:1039-48. 2008
    ..These methodologies will enable functional characterization of human islet preparations before transplantation and thereby provide the basis for the establishment of predictive tests for beta-cell potency...
  11. pmc Nephrin is expressed on the surface of insulin vesicles and facilitates glucose-stimulated insulin release
    Alessia Fornoni
    Diabetes Research Institute, University of Miami L Miller School of Medicine, Miami, Florida, USA
    Diabetes 59:190-9. 2010
    ..The aim of this study was to investigate whether diabetes modulates nephrin expression in human pancreatic islets and to explore the role of nephrin in beta-cell function...
  12. ncbi request reprint Removal of Ca2+ channel beta3 subunit enhances Ca2+ oscillation frequency and insulin exocytosis
    Per Olof Berggren
    The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, S 17176 Stockholm, Sweden
    Cell 119:273-84. 2004
    ..Since the increase in insulin release was manifested only at high glucose concentrations, blocking the beta3 subunit in the beta cell may constitute the basis for a novel diabetes therapy...
  13. pmc Transthyretin constitutes a functional component in pancreatic beta-cell stimulus-secretion coupling
    Essam Refai
    Department of Medical Biochemistry and Biophysics, The Rolf Luft Center for Diabetes Research, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 102:17020-5. 2005
    ..Thus, TTR tetramer constitutes a component in normal beta-cell function. Conversion of TTR tetramer to monomer may be involved in the development of beta-cell failure/destruction in type 1 diabetes...
  14. ncbi request reprint Down-regulated expression of exocytotic proteins in pancreatic islets of diabetic GK rats
    Wei Zhang
    Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Biochem Biophys Res Commun 291:1038-44. 2002
    ..The data suggest that reduced expression of exocytotic proteins and decreased insulin content may contribute to the diabetic syndrome in the GK rat...
  15. pmc Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function
    Rayner Rodriguez-Diaz
    Diabetes Research Institute, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 109:21456-61. 2012
    ..This study directly demonstrates that autonomic axons innervating the islet modulate glucose homeostasis...
  16. ncbi request reprint Glucose metabolites inhibit protein phosphatases and directly promote insulin exocytosis in pancreatic beta-cells
    Ake Sjoholm
    Department of Internal Medicine, Karolinska Institutet, Stockholm South Hospital, SE 118 83 Stockholm, Sweden
    Endocrinology 143:4592-8. 2002
    ..Thus, an increase in phosphorylation state, through inhibition of protein dephosphorylation by metabolic intermediates, may be a novel regulatory mechanism linking glucose sensing to insulin exocytosis in the beta-cell...
  17. pmc Isoform-specific insulin receptor signaling involves different plasma membrane domains
    Sabine Uhles
    The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, S 171 76 Stockholm, Sweden
    J Cell Biol 163:1327-37. 2003
    ..Moreover, our data suggest that selective activation of the insulin and glucokinase promoters occurs by signaling from noncaveolae lipid rafts that are differently sensitive toward cholesterol depletion...
  18. ncbi request reprint Relevance of dopamine signals anchoring dynamin-2 to the plasma membrane during Na+,K+-ATPase endocytosis
    Riad Efendiev
    Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, Karolinska Institutet, Karolinska Hospital, S 171 76 Stockholm, Sweden
    J Biol Chem 277:44108-14. 2002
    ....
  19. pmc Apolipoprotein CIII hyperactivates β cell CaV1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src
    Yue Shi
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE 171 76, Stockholm, Sweden
    Cell Mol Life Sci 71:1289-303. 2014
    ..These data reveal that ApoCIII hyperactivates β cell CaV1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src. ..
  20. ncbi request reprint A novel method for the assessment of cellular composition and beta-cell viability in human islet preparations
    Hirohito Ichii
    Diabetes Research Institute, University of Miami, Leonard M Miller School of Medicine, Miami, FL, USA
    Am J Transplant 5:1635-45. 2005
    ....
  21. ncbi request reprint Pancreatic islet function in a transgenic mouse expressing fluorescent protein
    Daniel Nyqvist
    Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, Karolinska Institutet, Stockholm, Sweden
    J Endocrinol 186:333-41. 2005
    ..We conclude that isolated pancreatic islets from YC-3.0 animals implanted into recipients without any EYFP expression, constitute a novel and versatile model for studies of islet engraftment...
  22. ncbi request reprint RX871024 reduces NO production but does not protect against pancreatic beta-cell death induced by proinflammatory cytokines
    Irina I Zaitseva
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Biochem Biophys Res Commun 347:1121-8. 2006
    ....
  23. ncbi request reprint Growth hormone promotes Ca(2+)-induced Ca2+ release in insulin-secreting cells by ryanodine receptor tyrosine phosphorylation
    Qimin Zhang
    The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Mol Endocrinol 18:1658-69. 2004
    ..This process is mediated by tyrosine phosphorylation of ryanodine receptors and may play a crucial role in physiological Ca2+ handling in insulin-secreting cells...
  24. ncbi request reprint Phosphorylated inositol compounds in beta -cell stimulus-response coupling
    Christopher J Barker
    Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, Karolinska Institutet, S 171 76 Stockholm, Sweden
    Am J Physiol Endocrinol Metab 283:E1113-22. 2002
    ..More controversially, this insulin feedback has also been suggested to either terminate or enhance insulin secretion events...
  25. ncbi request reprint Glibenclamide inhibits islet carnitine palmitoyltransferase 1 activity, leading to PKC-dependent insulin exocytosis
    Mikael Lehtihet
    Dept of Internal Medicine, Karolinska Institutet, Stockholm South Hospital, SE 118 83 Stockholm, Sweden
    Am J Physiol Endocrinol Metab 285:E438-46. 2003
    ....
  26. pmc Munc18-1 and Munc18-2 proteins modulate beta-cell Ca2+ sensitivity and kinetics of insulin exocytosis differently
    Slavena A Mandic
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, 17176 Stockholm, Sweden
    J Biol Chem 286:28026-40. 2011
    ..Hence, Munc18-1 and Munc18-2 display distinct subcellular compartmentalization and can coordinate the insulin exocytotic process differently as a consequence of the actual [Ca(2+)](i)...
  27. ncbi request reprint Monomeric G-protein, Rhes, is not an imidazoline-regulated protein in pancreatic beta-cells
    Vladimir V Sharoyko
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital, Solna, SE 17176 Stockholm, Sweden
    Biochem Biophys Res Commun 338:1455-9. 2005
    ..Together, these data do not support the hypothesis that Rhes is an imidazoline-regulated protein...
  28. ncbi request reprint Dihydroxyacetone-induced oscillations in cytoplasmic free Ca2+ and the ATP/ADP ratio in pancreatic beta-cells at substimulatory glucose
    Lisa Juntti-Berggren
    Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, Karolinska Institutet, Karolinska Hospital, S 171 76 Stockholm, Sweden
    J Biol Chem 278:40710-6. 2003
    ....
  29. pmc Glucagon regulates its own synthesis by autocrine signaling
    Barbara Leibiger
    Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE 17176 Stockholm, Sweden
    Proc Natl Acad Sci U S A 109:20925-30. 2012
    ....
  30. pmc Dynamin-mediated Nephrin phosphorylation regulates glucose-stimulated insulin release in pancreatic beta cells
    Jongmin Jeon
    Diabetes Research Institute, University of Miami L Miller School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 287:28932-42. 2012
    ..Pharmacological modulation of Nephrin phosphorylation may thus facilitate pancreatic beta cell function...
  31. pmc ATP-gated P2X3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic beta cell
    M Caroline Jacques-Silva
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 107:6465-70. 2010
    ..This may explain how the human pancreatic beta cell can respond so effectively to relatively modest changes in glucose concentration under physiological conditions in vivo...
  32. pmc The unique cytoarchitecture of human pancreatic islets has implications for islet cell function
    Over Cabrera
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 103:2334-9. 2006
    ..We conclude that the unique cellular arrangement of human islets has functional implications for islet cell function...
  33. pmc Apolipoprotein CIII links islet insulin resistance to β-cell failure in diabetes
    Karin Åvall
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1, SE 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 112:E2611-9. 2015
    ....
  34. ncbi request reprint On-line monitoring of apoptosis in insulin-secreting cells
    Martin Kohler
    Department of Molecular Medicine, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
    Diabetes 52:2943-50. 2003
    ....
  35. doi request reprint Transthyretin binds to glucose-regulated proteins and is subjected to endocytosis by the pancreatic β-cell
    Nancy Dekki
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Cell Mol Life Sci 69:1733-43. 2012
    ..The conclusion is that TTR binds to Grp78 at the plasma membrane, is internalized into the β-cell via a clathrin-dependent pathway, and that this internalization is necessary for the effects of TTR on β-cell function...
  36. pmc Noninvasive high-resolution in vivo imaging of cell biology in the anterior chamber of the mouse eye
    Stephan Speier
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1, SE 17176 Stockholm, Sweden
    Nat Protoc 3:1278-86. 2008
    ..Transplantation to the anterior chamber of the eye takes 25 min, and in vivo imaging 1-5 h, depending on the features monitored...
  37. pmc Real-time detection of acetylcholine release from the human endocrine pancreas
    Rayner Rodriguez-Diaz
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Nat Protoc 7:1015-23. 2012
    ..The technique is versatile because biosensor cells expressing a variety of receptors can be used in many applications. The protocol takes ∼3 h...
  38. ncbi request reprint Mint1, a Munc-18-interacting protein, is expressed in insulin-secreting beta-cells
    Wei Zhang
    Department of Neuroscience, Karolinska Institutet, SE 171 77, Stockholm, Sweden
    Biochem Biophys Res Commun 320:717-21. 2004
    ..Expression of Mint proteins in pancreatic beta-cells suggests a functional role for these proteins in insulin granule exocytosis...
  39. ncbi request reprint Insulin feedback action on pancreatic beta-cell function
    Ingo B Leibiger
    The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Hospital L3, Karolinska Institutet, S 171 76 Stockholm, Sweden
    FEBS Lett 532:1-6. 2002
    ..While, historically, insulin was suggested to exert a negative effect on beta-cells, recent data provide evidence for a positive role of insulin in transcription, translation, ion flux, insulin secretion and beta-cell survival...
  40. ncbi request reprint Cytosolic multiple inositol polyphosphate phosphatase in the regulation of cytoplasmic free Ca2+ concentration
    Jia Yu
    Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, L3, Karolinska Institutet, Karolinska Hospital, Stockholm SE 171 76, Sweden
    J Biol Chem 278:46210-8. 2003
    ....
  41. pmc CaV2.3 channel and PKClambda: new players in insulin secretion
    Shao Nian Yang
    The Rolf Luft Center for Diabetes Research, Karolinska Diabetes Center, Department of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Clin Invest 115:16-20. 2005
    ....
  42. doi request reprint One-step purification of functional human and rat pancreatic alpha cells
    Martin Kohler
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1 03, SE 17176, Stockholm, Sweden
    Integr Biol (Camb) 4:209-19. 2012
    ....
  43. pmc Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron
    Shao Nian Yang
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden
    Proc Natl Acad Sci U S A 109:12183-8. 2012
    ..Therefore, elevated InsP(6) in activated neurons serves as a unique negative feedback signal to control hippocampal excitatory neurotransmission...
  44. pmc Reporter islets in the eye reveal the plasticity of the endocrine pancreas
    Erwin Ilegems
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1, Stockholm SE 171 76, Sweden
    Proc Natl Acad Sci U S A 110:20581-6. 2013
    ..Hence, reporter islets serve as optically accessible indicators of islet function in the pancreas, and also reflect the efficacy of specific treatment regimens aimed at regulating islet plasticity in vivo. ..
  45. doi request reprint The pancreatic islet as a signaling hub
    Christopher J Barker
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, 171 76 Stockholm, Sweden
    Adv Biol Regul 53:156-63. 2013
    ..e. when being innervated and connected to the blood supply...
  46. ncbi request reprint Donor islet endothelial cells participate in formation of functional vessels within pancreatic islet grafts
    Daniel Nyqvist
    The Rolf Luft Center for Diabetes Research L3, Department of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, S 17176 Stockholm, Sweden
    Diabetes 54:2287-93. 2005
    ..Therefore, preservation of intraislet endothelial cell mass may improve long-term graft function...
  47. pmc aP2-Cre-mediated inactivation of estrogen receptor alpha causes hydrometra
    Per Antonson
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Huddinge, Sweden
    PLoS ONE 9:e85581. 2014
    ..We propose that in aP2-Cre/ERα(flox/flox) mice, increased serum estrogen levels cause over-stimulation in the uterus and genital tracts resulting in hydrometra and vaginal obstruction. ..
  48. pmc Donor islet endothelial cells in pancreatic islet revascularization
    Daniel Nyqvist
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden
    Diabetes 60:2571-7. 2011
    ..We have characterized how donor islet endothelial cells (DIECs) may contribute to the revascularization rate, vascular density, and endocrine graft function after transplantation of freshly isolated and cultured islets...
  49. pmc Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance
    Jason Miska
    Department of Microbiology and Immunology and 2 Department of Surgery, 3 Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL 33136 4 Department of Biomedical Engineering, University of Miami, Coral Gables, FL 33124
    J Exp Med 211:441-56. 2014
    ..This study illustrates tolerance induction by contact-based immune cell interaction in target tissues and highlights potentials of tissue regeneration under antigenic incognito in inflammatory settings...
  50. pmc High-resolution, noninvasive longitudinal live imaging of immune responses
    Midhat H Abdulreda
    Diabetes Research Institute, Department of Biomedical Engineering, University of Miami, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 108:12863-8. 2011
    ....
  51. pmc Evidence for Ca(2+)-regulated ATP release in gastrointestinal stromal tumors
    Erik Berglund
    Section for Endocrine and Sarcoma Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Exp Cell Res 319:1229-38. 2013
    ..Additionally, release of ATP from GISTs may have importance for tumor tissue homeostasis and immune surveillance escape...
  52. ncbi request reprint DARPP-32 and inhibitor-1 are expressed in pancreatic beta-cells
    Lena Lilja
    The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Biochem Biophys Res Commun 329:673-7. 2005
    ..These data indicate a potential role for DARPP-32 and inhibitor-1 in the regulation of PP1 activity in pancreatic beta-cell stimulus-secretion coupling...
  53. doi request reprint New horizons in cellular regulation by inositol polyphosphates: insights from the pancreatic β-cell
    Christopher J Barker
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, 171 76 Stockholm, Sweden
    Pharmacol Rev 65:641-69. 2013
    ..We conclude with some of the new perspectives that are likely to become apparent in the next few years...
  54. pmc Lowering apolipoprotein CIII delays onset of type 1 diabetes
    Rebecka Holmberg
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 108:10685-9. 2011
    ..ApoCIII thus serves as a diabetogenic factor, and intervention with this apolipoprotein in the prediabetic state can arrest disease progression. These findings suggest apoCIII as a target for the treatment of type 1 diabetes...
  55. pmc Noninvasive in vivo imaging of pancreatic islet cell biology
    Stephan Speier
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1, SE 17176 Stockholm, Sweden
    Nat Med 14:574-8. 2008
    ....
  56. doi request reprint CaV1.2 and CaV1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serum
    Guang Yang
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, 171 76, Stockholm, Sweden
    Cell Mol Life Sci 72:1197-207. 2015
    ..These data demonstrate that T1D serum hyperactivates both CaV1.2 and CaV1.3 channels by increasing their conductivity and number. These findings suggest CaV1.2 and CaV1.3 channels as potential targets for anti-diabetes therapy. ..
  57. pmc Lipotoxicity and decreased islet graft survival
    Cristiane B Leitao
    Diabetes Research Institute, Miami, Florida, USA
    Diabetes Care 33:658-60. 2010
    ..Prospective clinical trials should address whether it is directly caused by lipotoxicity and if strategies focusing on lowering serum lipids may prolong islet graft survival...
  58. ncbi request reprint Tomosyn is expressed in beta-cells and negatively regulates insulin exocytosis
    Wei Zhang
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Diabetes 55:574-81. 2006
    ..Hence, in the pancreatic beta-cell, tomosyn negatively regulates insulin exocytosis...
  59. ncbi request reprint Selective gene activation by spatial segregation of insulin receptor B signaling
    Sabine Uhles
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, S 171 76 Stockholm, Sweden
    FASEB J 21:1609-21. 2007
    ..By using IR-B as an example it is thus possible to demonstrate how spatial segregation allows simultaneous and selective signaling via the same receptor isoform in the same cell...
  60. ncbi request reprint Cyclin-dependent kinase 5 activators p35 and p39 facilitate formation of functional synapses
    Jenny U Johansson
    Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, Karolinska Institutet, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Brain Res Mol Brain Res 138:215-27. 2005
    ..These findings demonstrate that Cdk5, p35, and p39 are endogenously expressed in NG108-15 cells, exhibit distinct subcellular localizations, and that both Cdk5/p35 and Cdk5/p39 are central in formation of functional synapses...
  61. doi request reprint Suppressor of cytokine signaling-1 inhibits caspase activation and protects from cytokine-induced beta cell death
    Irina I Zaitseva
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital, L1, 171 76 Stockholm, Sweden
    Cell Mol Life Sci 66:3787-95. 2009
    ..In summary, we show that interference with IFNgamma signal transduction pathways by SOCS-1 inhibits cytokine-stimulated pancreatic beta cell death...
  62. pmc Non-invasive cell type selective in vivo monitoring of insulin resistance dynamics
    Meike Paschen
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Sci Rep 6:21448. 2016
    ..This technique allows monitoring of cell type specific insulin sensitivity/resistance in real-time in the context of whole body insulin resistance during progression and intervention of disease. ..
  63. doi request reprint Secretome protein signature of human gastrointestinal stromal tumor cells
    Erik Berglund
    Endocrine and Sarcoma Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden Department of Breast and Endocrine Surgery, Karolinska University Hospital, Stockholm, Sweden Electronic address
    Exp Cell Res 336:158-70. 2015
    ..In the search for suitable biomarkers in the more complex GIST patient samples, this study aids in the understanding of basic GIST secretome characteristics. ..
  64. doi request reprint Differential regulation of mouse pancreatic islet insulin secretion and Smad proteins by activin ligands
    Haiya Wu
    Department of Neuroscience, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Berzelius vag 35, B3 Box 285, SE 171 77, Stockholm, Sweden
    Diabetologia 57:148-56. 2014
    ..Activins A and B signal through a common set of intracellular components, but it is unclear whether they display similar or distinct functions in glucose homeostasis...
  65. doi request reprint Ionic mechanisms in pancreatic β cell signaling
    Shao Nian Yang
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE 171 76, Stockholm, Sweden
    Cell Mol Life Sci 71:4149-77. 2014
    ..This review concisely discusses various ionic mechanisms in β cell signaling and highlights KATP channel-, CaV1 channel- and KV2.1 channel-mediated ion fluxes. ..
  66. ncbi request reprint Two generations of insulinotropic imidazoline compounds
    Suad Efendic
    Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Diabetes 51:S448-54. 2002
    ..We conclude that BL11282 belongs to a new class of insulinotropic compounds that demonstrate a strong glucose-dependent effect on insulin exocytosis...
  67. ncbi request reprint Interference with tissue factor prolongs intrahepatic islet allograft survival in a nonhuman primate marginal mass model
    Dora M Berman
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Transplantation 84:308-15. 2007
    ..We tested whether peritransplant protection of islets from IBMIR with a monoclonal anti-TF antibody (CNTO859) would enhance engraftment in our nonhuman primate marginal mass model...
  68. ncbi request reprint Beta-cell CaV channel regulation in physiology and pathophysiology
    Shao Nian Yang
    The Rolf Luft Center for Diabetes Research, Karolinska Diabetes Center, Department of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Am J Physiol Endocrinol Metab 288:E16-28. 2005
    ..This minireview highlights characteristic features of customary mechanisms of CaV channel regulation in beta-cells and also reviews our studies on newly identified mechanisms of beta-cell CaV channel regulation...
  69. ncbi request reprint An autocrine insulin feedback loop maintains pancreatic beta-cell 3-phosphorylated inositol lipids
    Jia Yu
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institute, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    Mol Endocrinol 21:2775-84. 2007
    ..Therefore, autocrine insulin signaling, a feature compromised in diabetes, is essential to up-regulate both basal and glucose-stimulated levels of a vital family of second messengers that preserve and drive pancreatic beta-cell function...
  70. doi request reprint The pancreatic beta cell as a paradigm for advances in inositide research
    Christopher J Barker
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, 171 76 Stockholm, Sweden
    Adv Biol Regul 52:361-8. 2012
    ..We examine each of these in turn and close with an assessment of the likely future directions the research will take...
  71. doi request reprint PI3K-C2α Knockdown Results in Rerouting of Insulin Signaling and Pancreatic Beta Cell Proliferation
    Barbara Leibiger
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, 171 76 Stockholm, Sweden
    Cell Rep 13:15-22. 2015
    ..Hence, factors involved in the rerouting of the insulin signal represent tentative therapeutic targets in the treatment of insulin resistance. ..
  72. ncbi request reprint Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells
    Christopher Illies
    Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE 171 76, Stockholm, Sweden
    Science 318:1299-302. 2007
    ..Maintenance of high concentrations of IP7 in the pancreatic beta cell may enhance the immediate exocytotic capacity and consequently allow rapid adjustment of insulin secretion in response to increased demand...
  73. pmc Apolipoprotein CIII promotes Ca2+-dependent beta cell death in type 1 diabetes
    Lisa Juntti-Berggren
    Department of Molecular Medicine, Rolf Luft Center for Diabetes Research, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 101:10090-4. 2004
    ..Increased serum levels of apoCIII can thus account for the increase in beta cell [Ca(2+)](i) and thereby beta cell apoptosis associated with T1D...
  74. doi request reprint Novel aspects on pancreatic beta-cell signal-transduction
    Ingo B Leibiger
    The Rolf Luft Research Center for Diabetes and Endocrinology L1 03, Karolinska Institutet, SE 17176 Stockholm, Sweden
    Biochem Biophys Res Commun 396:111-5. 2010
    ..Finally we present a newly developed experimental platform that allows non-invasive and longitudinal in vivo imaging of pancreatic islet/beta-cell biology at single-cell resolution...
  75. doi request reprint HPLC separation of inositol polyphosphates
    Christopher J Barker
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden
    Methods Mol Biol 645:21-46. 2010
    ..We describe important elements of sample preparation for effective separations and give examples of how changing factors, such as pH, can considerably improve the resolving ability of the HPLC chromatogram...
  76. doi request reprint β-Cell Ca(2+) dynamics and function are compromised in aging
    Christopher J Barker
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1, SE 171 76 Stockholm, Sweden
    Adv Biol Regul 57:112-9. 2015
    ..Our findings underscore an important concept, namely that even relatively small, time-dependent changes in β-cell signal-transduction result in compromised insulin release and in a diabetic phenotype. ..
  77. doi request reprint Defects in β-cell Ca2+ dynamics in age-induced diabetes
    Luosheng Li
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Diabetes 63:4100-14. 2014
    ..This is conceptually important since it emphasizes that even relatively modest changes in β-cell signal transduction over time lead to compromised insulin release and a diabetic phenotype...
  78. pmc Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function
    Philippe Bertolino
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:7246-51. 2008
    ..We propose that ALK7 plays an important role in regulating the functional plasticity of pancreatic islets, negatively affecting beta-cell function by mediating the effects of activin B on Ca(2+) signaling...
  79. doi request reprint Diphosphosinositol polyphosphates and energy metabolism: assay for ATP/ADP ratio
    Andreas Nagel
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden
    Methods Mol Biol 645:123-31. 2010
    ..This method gives a better signal-to-noise ratio than other methods that do not degrade the sample ATP, but convert ADP directly to ATP and then measure the sum of ATP plus ADP...
  80. doi request reprint The role of inositol and the principles of labelling, extraction, and analysis of inositides in mammalian cells
    Christopher J Barker
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden
    Methods Mol Biol 645:1-19. 2010
    ....
  81. doi request reprint Antiviral treatments reduce severity of diabetes in Ljungan virus-infected CD-1 mice and delay onset in diabetes-prone BB rats
    Rebecka Holmberg
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE 171 76, Uppsala, Sweden
    Microbiol Immunol 53:567-72. 2009
    ..In the group treated with antiviral drugs, the onset was significantly delayed. These results indicate that the presence of LV can be involved in the pathogenesis of diabetes in these animal models...
  82. pmc Estrogen signalling and the metabolic syndrome: targeting the hepatic estrogen receptor alpha action
    Marko Matic
    Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    PLoS ONE 8:e57458. 2013
    ..Collectively, our findings indicate that hepatic ERα action may not be the responsible factor for the previously identified hepatic insulin resistance in ERαKO mice...
  83. ncbi request reprint 3H-serotonin as a marker of oscillatory insulin secretion in clonal beta-cells (INS-1)
    Jude T Deeney
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, S 171 76, Stockholm, Sweden
    FEBS Lett 581:4080-4. 2007
    ..The use of 3H-serotonin provides a real-time indicator of exocytosis from populations of clonal insulin-secreting cells...
  84. ncbi request reprint The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology
    Shao Nian Yang
    The Rolf Luft Research Center for Diabetes and Endocrinology L1 03, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    Endocr Rev 27:621-76. 2006
    ..This review summarizes current knowledge of CaV channels in beta-cell physiology and pathophysiology...
  85. pmc Electrical short-circuit in β-cells from a patient with non-insulinoma pancreatogenous hypoglycemic syndrome (NIPHS): a case report
    Robert Bränström
    The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    J Med Case Rep 4:315. 2010
    ..Non-insulinoma pancreatogenous hypoglycemic syndrome is a rare disorder among adults, and, to our knowledge, only about 40 cases have been reported in the literature...
  86. doi request reprint Inositol pyrophosphates: structure, enzymology and function
    Christopher John Barker
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, 171 76 Stockholm, Sweden
    Cell Mol Life Sci 66:3851-71. 2009
    ....
  87. doi request reprint Insulin signaling in the pancreatic beta-cell
    Ingo B Leibiger
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden
    Annu Rev Nutr 28:233-51. 2008
    ..Current insights on the role of insulin on pancreatic beta-cell function are discussed...
  88. doi request reprint Proteins in the insulin-secreting cell line MIN6 bind the imidazoline compound BL11282
    Jawed Shafqat
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    FEBS Lett 582:1613-7. 2008
    ..Masspectrometric analysis revealed the approximately 50 kDa band to be EF1A and the approximately 100 kDa band to be glucose regulated P94, both of interest in insulin synthesis and secretion...
  89. pmc An ancient duplication of exon 5 in the Snap25 gene is required for complex neuronal development/function
    Jenny U Johansson
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden
    PLoS Genet 4:e1000278. 2008
    ..We conclude that the ancient exon duplication in the Snap25 gene provides additional SNAP-25-function required for complex neuronal processes in higher eukaryotes...
  90. ncbi request reprint Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors
    Xiaosong Ma
    Department of Molecular and Cellular Physiology, Diabetes Research Unit, Institute of Physiological Sciences, Biomedical Center B11 SE 221 84 Lund, Sweden
    Mol Endocrinol 19:198-212. 2005
    ..We conclude that glucagon released from the alpha-cells, in addition to its well-documented systemic effects and paracrine actions within the islet, also represents an autocrine regulator of alpha-cell function...
  91. ncbi request reprint Implantation site-dependent dysfunction of transplanted pancreatic islets
    Joey Lau
    Department of Medical Cell Biology, Biomedical Center, Uppsala University, Uppsala, Sweden
    Diabetes 56:1544-50. 2007
    ..Clinical islet transplantations are performed through infusion of islets via the portal vein into the liver. This study aimed at characterizing the influence of the implantation microenvironment on islet graft metabolism and function...
  92. ncbi request reprint Modulation of L-type Ca(2+) channels by distinct domains within SNAP-25
    Junzhi Ji
    Department of Medicine, University of Toronto, Toronto, Canada
    Diabetes 51:1425-36. 2002
    ..The present study suggests that distinct domains within SNAP-25 modulate L(C) subtype Ca(2+) channel activity in both primary beta-cells and insulinoma HIT-T15 cells...
  93. ncbi request reprint R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion
    Quan Zhang
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK
    Nat Cell Biol 9:453-60. 2007
    ..Glucose-induced somatostatin secretion is instead primarily dependent on Ca(2+)-induced Ca(2+)-release (CICR). This constitutes a novel mechanism for K(ATP)-channel-independent metabolic control of pancreatic hormone secretion...
  94. pmc Inositol hexakisphosphate promotes dynamin I- mediated endocytosis
    Marianne Høy
    Laboratory of Islet Cell Physiology, Novo Nordisk A S, Novo Alle, DK 2880 Bagsvaerd, Denmark
    Proc Natl Acad Sci U S A 99:6773-7. 2002
    ..In regulating both exocytosis and endocytosis, InsP(6) thus may have an essential integral role in membrane trafficking...
  95. ncbi request reprint Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose
    Chiyo Shiota
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 277:37176-83. 2002
    ....
  96. pmc SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells
    Lena Eliasson
    Department of Molecular and Cellular Physiology, Institute of Physiological Sciences, SE 221 84 Lund, Sweden
    J Gen Physiol 121:181-97. 2003
    ..We conclude that the role of SUR1 in the B cell extends beyond being a subunit of the plasma membrane K(ATP)-channel and that it also plays an unexpected but important role in the cAMP-dependent regulation of Ca(2+)-induced exocytosis...
  97. ncbi request reprint A SIRTain role in pancreatic beta cell function
    Ingo B Leibiger
    The Rolf Luft Center for Diabetes Research Department of Molecular Medicine and Surgery Karolinska Institutet SE 171 76 Stockholm Sweden
    Cell Metab 2:80-2. 2005
    ..Moynihan et al.(2005[this issue of Cell Metabolism]) now demonstrate that increasing levels of Sirt1 in the pancreatic beta cells of mice result in a more efficient glucose handling due to enhanced glucose-stimulated insulin secretion...
  98. pmc Neuronal calcium sensor-1 potentiates glucose-dependent exocytosis in pancreatic beta cells through activation of phosphatidylinositol 4-kinase beta
    Jesper Gromada
    Lilly Research Laboratories, Essener Bogen 7, D 22419 Hamburg, Germany
    Proc Natl Acad Sci U S A 102:10303-8. 2005
    ..We also demonstrate that NCS-1 and its downstream target, PI 4-kinase beta, are critical players in this process by virtue of their capacity to regulate the release competence of the secretory granules...
  99. ncbi request reprint Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells
    Joachim Størling
    Laboratory for Beta Cell Biology, Steno Diabetes Center, Niels Steensensvej 8, NSPP, DK 2820 Gentofte, Denmark
    Endocrinology 146:3026-36. 2005
    ..Our data suggest that Ca(2+) plays a permissive role in IL-1beta activation of the JNK signaling pathway in insulin-secreting cells...
  100. pmc Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells
    Hervør L Olsen
    Islet Cell Physiology, Novo Nordisk AS, Novo Alle, DK 2880 Bagsvaerd, Denmark
    Proc Natl Acad Sci U S A 100:5187-92. 2003
    ..We conclude that ADP-induced changes in PI 4-kinase activity, via generation of PI(4,5)P(2), represents a metabolic sensor in the beta cell by virtue of its capacity to regulate the release competence of the secretory granules...
  101. pmc Glutamate is a positive autocrine signal for glucagon release
    Over Cabrera
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Cell Metab 7:545-54. 2008
    ..This is a prerequisite to guarantee adequate glucagon release despite relatively modest changes in blood glucose concentration under physiological conditions...