E Arenas

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi Engineering a dopaminergic phenotype in stem/precursor cells: role of Nurr1, glia-derived signals, and Wnts
    Ernest Arenas
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles vägen 1, 17 177, Stockholm, Sweden
    Ann N Y Acad Sci 1049:51-66. 2005
  2. ncbi Stem cells in the treatment of Parkinson's disease
    E Arenas
    Laboratory of Molecular Neurobiology, Karolinska Institute, Stockholm, Sweden
    Brain Res Bull 57:795-808. 2002
  3. ncbi Distinct roles of the Y1 and Y2 receptors on neuropeptide Y-induced sensitization to sedation
    P Naveilhan
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    J Neurochem 78:1201-7. 2001
  4. ncbi Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease
    P Akerud
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S 17177 Stockholm, Sweden
    J Neurosci 21:8108-18. 2001
  5. ncbi Persephin-overexpressing neural stem cells regulate the function of nigral dopaminergic neurons and prevent their degeneration in a model of Parkinson's disease
    P Akerud
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles vag 1, 17177 Stockholm, Sweden
    Mol Cell Neurosci 21:205-22. 2002
  6. ncbi Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes
    J Wagner
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Nat Biotechnol 17:653-9. 1999
  7. ncbi Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor
    P Naveilhan
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry, Karolinska Institute, S17177 Stockholm, Sweden
    Nat Med 5:1188-93. 1999
  8. ncbi BDNF regulates reelin expression and Cajal-Retzius cell development in the cerebral cortex
    T Ringstedt
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Neuron 21:305-15. 1998
  9. ncbi Neuropeptide Y alters sedation through a hypothalamic Y1-mediated mechanism
    P Naveilhan
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheelesvag 1, S17177 Stockholm, Sweden
    Eur J Neurosci 13:2241-6. 2001
  10. ncbi Differential effects of glial cell line-derived neurotrophic factor and neurturin on developing and adult substantia nigra dopaminergic neurons
    P Akerud
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    J Neurochem 73:70-8. 1999

Collaborators

Detail Information

Publications43

  1. ncbi Engineering a dopaminergic phenotype in stem/precursor cells: role of Nurr1, glia-derived signals, and Wnts
    Ernest Arenas
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles vägen 1, 17 177, Stockholm, Sweden
    Ann N Y Acad Sci 1049:51-66. 2005
    ....
  2. ncbi Stem cells in the treatment of Parkinson's disease
    E Arenas
    Laboratory of Molecular Neurobiology, Karolinska Institute, Stockholm, Sweden
    Brain Res Bull 57:795-808. 2002
    ....
  3. ncbi Distinct roles of the Y1 and Y2 receptors on neuropeptide Y-induced sensitization to sedation
    P Naveilhan
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    J Neurochem 78:1201-7. 2001
    ..These data demonstrate the physiological and pharmacological impact of the Y1 and Y2 receptors on sedation...
  4. ncbi Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease
    P Akerud
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S 17177 Stockholm, Sweden
    J Neurosci 21:8108-18. 2001
    ....
  5. ncbi Persephin-overexpressing neural stem cells regulate the function of nigral dopaminergic neurons and prevent their degeneration in a model of Parkinson's disease
    P Akerud
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles vag 1, 17177 Stockholm, Sweden
    Mol Cell Neurosci 21:205-22. 2002
    ..Thus, our findings are consistent with a direct action of PSP on developing and adult midbrain dopamine neurons and suggest that the delivery of PSP by NSCs may constitute a very useful strategy in the treatment of Parkinson's disease...
  6. ncbi Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes
    J Wagner
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Nat Biotechnol 17:653-9. 1999
    ..Moreover, this procedure yields an unlimited number of cells that can engraft in vivo and that may constitute a useful source material for neuronal replacement in Parkinson's disease...
  7. ncbi Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor
    P Naveilhan
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry, Karolinska Institute, S17177 Stockholm, Sweden
    Nat Med 5:1188-93. 1999
    ..These findings indicate an inhibitory role for the Y2 receptor subtype in the central regulation of body weight and control of food intake...
  8. ncbi BDNF regulates reelin expression and Cajal-Retzius cell development in the cerebral cortex
    T Ringstedt
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Neuron 21:305-15. 1998
    ..These results demonstrate a role for BDNF on cortical CR cells and identify Reelin as a direct effector of this neurotrophin during brain development...
  9. ncbi Neuropeptide Y alters sedation through a hypothalamic Y1-mediated mechanism
    P Naveilhan
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheelesvag 1, S17177 Stockholm, Sweden
    Eur J Neurosci 13:2241-6. 2001
    ..These results show that Y1 is essential for NPY-induced enhancement of sedation and place this activity of NPY in the posterior hypothalamic area, a region of the brain previously implicated in the regulation of the wake-sleep cycle...
  10. ncbi Differential effects of glial cell line-derived neurotrophic factor and neurturin on developing and adult substantia nigra dopaminergic neurons
    P Akerud
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    J Neurochem 73:70-8. 1999
    ..Such differences are likely to underlie unique roles for each factor in postnatal development and may ultimately be exploited in the treatment of Parkinson's disease...
  11. ncbi Increased cell death and delayed development in the cerebellum of mice lacking the rev-erbA(alpha) orphan receptor
    P Chomez
    Department of Cell and Molecular Biology and Department of Medical Biochemistry and Biophysics, Karolinska Institute, S 171 77 Stockholm, Sweden
    Development 127:1489-98. 2000
    ..Taken together, our data underline the importance of rev-erbA(alpha)expression for the appropriate balance of transcriptional activators and repressors during postnatal cerebellar development...
  12. ncbi Complementary and overlapping expression of Y1, Y2 and Y5 receptors in the developing and adult mouse nervous system
    P Naveilhan
    Department of Medical Biophysics and Biochemistry, Karolinska Institute, Stockholm, Sweden
    Neuroscience 87:289-302. 1998
    ....
  13. doi The beta-chemokines CCL2 and CCL7 are two novel differentiation factors for midbrain dopaminergic precursors and neurons
    Linda C Edman
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles vag 1, 17177 Stockholm, Sweden
    Exp Cell Res 314:2123-30. 2008
    ..These data also suggest that beta-chemokines may become useful tools to enhance the differentiation of DA cell preparations for cell replacement therapy and drug discovery in Parkinson's disease (PD)...
  14. ncbi Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion
    Goncalo Castelo-Branco
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles vag 1, A1, plan 2, 17177 Stockholm, Sweden
    Mol Cell Neurosci 31:251-62. 2006
    ..Thus, our results identify Wnt-5a as an important component of the dopaminergic inductive activity of the ventral midbrain glia...
  15. ncbi A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo
    Nilima Prakash
    GSF National Research Center for Environment and Health, Technical University Munich, Institute of Developmental Genetics, Ingolstaedter Landstrasse 1, 85764 Munich Neuherberg, Germany
    Development 133:89-98. 2006
    ..They also suggest the Wnt1-controlled signaling pathway as a promising target for new therapeutic strategies in the treatment of Parkinson's disease...
  16. ncbi Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons
    Julianna Kele
    Laboratory of Molecular Neurobiology, MBB, Karolinska Institutet, Retzius building A1, Stockholm, Sweden
    Development 133:495-505. 2006
    ..These results demonstrate that Ngn2 is uniquely required for the development of midbrain dopaminergic neurons...
  17. ncbi Neural progenitor cells engineered to secrete GDNF show enhanced survival, neuronal differentiation and improve cognitive function following traumatic brain injury
    Asha Bakshi
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA
    Eur J Neurosci 23:2119-34. 2006
    ..2 cells. Our results suggest that transplantation of GDNF-expressing NPCs in the acute post-traumatic period promotes graft survival, migration, neuronal differentiation and improves cognitive outcome following traumatic brain injury...
  18. ncbi Function of Wnts in dopaminergic neuron development
    Goncalo Castelo-Branco
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Stockholm, Sweden
    Neurodegener Dis 3:5-11. 2006
    ..We hereby propose that Wnts are likely to contribute in the future to improve stem/precursor cell replacement therapy approaches to PD...
  19. ncbi BMPs, FGF8 and Wnts regulate the differentiation of locus coeruleus noradrenergic neuronal precursors
    Pontus C Holm
    Laboratory of Molecular Neurobiology, MBB, Karolinska Institutet, Stockholm, Sweden
    J Neurochem 99:343-52. 2006
    ..Instead, our results suggest that these patterning signals of rhombomere 1 may work to promote the differentiation of noradrenergic progenitors at later stages of development...
  20. ncbi Microarray analyses support a role for Nurr1 in resistance to oxidative stress and neuronal differentiation in neural stem cells
    Kyle M Sousa
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Stem Cells 25:511-9. 2007
    ..Thus, our results confirm the presence of both secreted and cell-intrinsic survival signals modulated by Nurr1 and suggest that Nurr1 is a key regulator of both survival and dopaminergic differentiation...
  21. ncbi Midbrain dopaminergic neurogenesis and behavioural recovery in a salamander lesion-induced regeneration model
    Clare L Parish
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, Center of Excellence in Developmental Biology, Stockholm, Sweden
    Development 134:2881-7. 2007
    ..The salamander model provides insights into the mechanisms of DA regeneration/neurogenesis and may contribute to the development of novel regenerative strategies for the mammalian brain...
  22. ncbi Stem-cell-based strategies for the treatment of Parkinson's disease
    Clare L Parish
    Laboratory of Molecular Neurobiology, Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Neurodegener Dis 4:339-47. 2007
    ..However, limited tissue availability has haltered the widespread use of this therapy and begs the demand for alternative tissue sources. In this regard, stem cells may constitute one such source...
  23. doi Alpha-chemokines regulate proliferation, neurogenesis, and dopaminergic differentiation of ventral midbrain precursors and neurospheres
    Linda C Edman
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles vag 1, 17177 Stockholm, Sweden
    Stem Cells 26:1891-900. 2008
    ..Thus, alpha-chemokines may find an application in the preparation of cells for drug development or Parkinson's disease cell replacement therapy...
  24. pmc Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice
    Clare L Parish
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    J Clin Invest 118:149-60. 2008
    ....
  25. ncbi Increased Wnt levels in the neural tube impair the function of adherens junctions during neurulation
    Maria Shariatmadari
    Neonatal Unit, Department of Woman and Child Health, Astrid Lindgren Children s Hospital, Q2 09, Karolinska Institutet, S 171 76 Stockholm, Sweden
    Mol Cell Neurosci 30:437-51. 2005
    ..Thus, our findings suggest that Wnt7a overexpression disrupts normal Wnt signaling in the neural tube, resulting in defective adherens junctions and neurulation...
  26. ncbi Cripto as a target for improving embryonic stem cell-based therapy in Parkinson's disease
    Clare L Parish
    Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Naples, Italy
    Stem Cells 23:471-6. 2005
    ..The use of knockout ES cells that can generate dopamine cells while eliminating tumor risk holds enormous potential for cell replacement therapy in Parkinson's disease...
  27. ncbi Region-specific effects of glia on neuronal induction and differentiation with a focus on dopaminergic neurons
    Anita C Hall
    Laboratory of Molecular Neurobiology, MBB, Retzius Laboratory, Karolinska Institute, Stockholm, Sweden
    Glia 43:47-51. 2003
    ..Mol Cell Neurosci 17:811-820, 2001). We propose that RG not only generate and guide newborn neurons, but could also instruct their own neuronal progeny to adopt appropriate region-specific phenotypes...
  28. ncbi BMP-2 and cAMP elevation confer locus coeruleus neurons responsiveness to multiple neurotrophic factors
    Julia Reiriz
    Department of Medical Biochemistry and Biophysics, Laboratory of Molecular Neurobiology, Karolinska Institute, Stockholm, Sweden
    J Neurobiol 50:291-304. 2002
    ....
  29. ncbi NTera2: a model system to study dopaminergic differentiation of human embryonic stem cells
    Catherine M Schwartz
    Gerontology Research Center, Stem Cell Biology Unit, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Stem Cells Dev 14:517-34. 2005
    ..Therefore, NTera2 cell dopaminergic neuronal differentiation and PSA-NCAM enrichment provides a useful system for the future study of hESCs...
  30. pmc Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells
    Asa Wallen-Mackenzie
    The Ludwig Institute for Cancer Research, Stockholm Branch, S 171 77 Stockholm, Sweden
    Genes Dev 17:3036-47. 2003
    ..Finally, our findings identify RXR-Nurr1 heterodimers as a potential target in the treatment of neurodegenerative disease...
  31. ncbi GSK-3beta inhibition/beta-catenin stabilization in ventral midbrain precursors increases differentiation into dopamine neurons
    Goncalo Castelo-Branco
    Laboratory of Molecular Neurobiology, Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles vag 1, A1, plan 2, 17177 Stockholm, Sweden
    J Cell Sci 117:5731-7. 2004
    ..The three- to fivefold increase in DA differentiation of precursor cells by GSK-3beta inhibitors suggests that such compounds could be used to improve stem/precursor cell therapy approaches in Parkinson's disease...
  32. ncbi Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation
    Gunnar Schulte
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Neurochem 92:1550-3. 2005
    ..Furthermore, we identify dishevelled as a key player in transducing both Wnt canonical and non-canonical signals in dopaminergic cells...
  33. ncbi Disruption of EphA/ephrin-a signaling in the nigrostriatal system reduces dopaminergic innervation and dissociates behavioral responses to amphetamine and cocaine
    Beth Anne Sieber
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Mol Cell Neurosci 26:418-28. 2004
    ..Together, these results reveal an unexpected role for EphA/ephrin-A signaling in the normal connectivity and function of midbrain dopaminergic neurons...
  34. ncbi Striatopallidal neurons are selectively protected by neurturin in an excitotoxic model of Huntington's disease
    Sonia Marco
    Departament de Biologia Celcenter dotlular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, IDIBAPS, Casanova 143, E 08036 Barcelona, Spain
    J Neurobiol 50:323-32. 2002
    ..Thus, our findings show that NRTN is a selective neuroprotective factor for striatopallidal neurons, suggesting that it might be a candidate for the treatment of movement disorders in which this neuronal population is affected...
  35. doi Foxa2: the rise and fall of dopamine neurons
    Ernest Arenas
    Laboratory of Molecular Neurobiology, MBB, Center of Excellence in Developmental Biology, Karolinska Institute, Scheeles vägen 1, plan 2, Retzius building A1, 17 177 Stockholm, Sweden
    Cell Stem Cell 2:110-2. 2008
    ..A recent PLoS Biology report (Kittappa et al., 2007) reveals that Foxa2 regulates dopamine neuron generation and differentiation, and that aging foxa2(+/-) mice spontaneously develop Parkinsonism...
  36. doi Identification of midbrain floor plate radial glia-like cells as dopaminergic progenitors
    Sonia Bonilla
    Laboratory of Molecular Neurobiology, MBB, Karolinska Institutet, Scheeles vag 1, A1 2, 171 77 Stockholm, Sweden
    Glia 56:809-20. 2008
    ..Combined, our experiments support the concept that the midbrain FP differs from other FP regions and demonstrate that FP radial glia-like cells in the midbrain are neurogenic and give rise to midbrain DA neurons...
  37. doi Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation
    Michael Andäng
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden
    Nature 451:460-4. 2008
    ..These results indicate the presence of a fundamentally different mechanism of proliferation control in these stem cells, in comparison with most somatic cells, involving proteins in the DNA damage checkpoint pathway...
  38. ncbi Neurturin is a neuritogenic but not a survival factor for developing and adult central noradrenergic neurons
    Pontus C Holm
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    J Neurochem 81:1318-27. 2002
    ..These data, combined with data in the literature, suggest that GDNF family ligands are able to independently regulate neuronal survival and/or neuritogenesis...
  39. pmc Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a
    Goncalo Castelo-Branco
    Laboratory of Molecular Neurobiology, Medical Biochemistry, and Biophysics, Karolinska Institute, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 100:12747-52. 2003
    ..These findings indicate that Wnts are key regulators of proliferation and differentiation of DA precursors during VM neurogenesis and that different Wnts have specific and unique activity profiles...
  40. ncbi Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons
    Pontus C Holm
    Department of Medical Biochemistry and Biophysics, Laboratory of Molecular Neurobiology, Karolinska Institutet, Stockholm S 171 77, Sweden
    Development 130:3535-45. 2003
    ..In summary, our findings suggest that, unlike NT3 and GDNF, TrkB ligands are required and sufficient to promote the development of central noradrenergic neurons...
  41. ncbi An efficient method for the derivation of mouse embryonic stem cells
    Vítezlav Bryja
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet S 171 77, Stockholm, Sweden
    Stem Cells 24:844-9. 2006
    ..In summary, we provide a simplified and improved protocol to derive mESCs that can be useful for laboratories aiming to isolate transgenic mESCs for the first time...
  42. ncbi Novel isoforms of the TFIID subunit TAF4 modulate nuclear receptor-mediated transcriptional activity
    Adrian Brunkhorst
    Group of Transcriptional Networks, Unit of Functional Genomics, Center for Genomics and Bioinformatics CGB, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Biochem Biophys Res Commun 325:574-9. 2004
    ..Our results indicate an additional level of complexity in TAF4-mediated regulation of transcription and suggest context-specific roles for these new TAF4 isoforms in transcriptional regulation in vivo...
  43. ncbi Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism
    Vitezslav Bryja
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Cell Sci 120:586-95. 2007
    ....