Helene Alexanderson

Summary

Affiliation: Karolinska University Hospital
Country: Sweden

Publications

  1. doi request reprint Resistive home exercise in patients with recent-onset polymyositis and dermatomyositis -- a randomized controlled single-blinded study with a 2-year followup
    Helene Alexanderson
    From the Department of NVS, Division of Physical Therapy, Karolinska Institutet, Huddinge Rheumatology Unit, Department of Medicine, and Department of Physical Therapy, Orthopedic Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet Rheumatology Clinic, Karolinska University Hospital, Huddinge, Stockholm, Sweden H Alexanderson, PhD, RPT, Department of NVS, Division of Physical Therapy, Karolinska Institutet, Huddinge, and Department of Physical Therapy, Orthopedic Rheumatology Unit, Karolinska University Hospital, Solna L Alemo Munters, PhD, RPT, Rheumatology Unit, Department of Medicine, and Department of Physical Therapy, Orthopedic Rheumatology Unit, Karolinska University Hospital, Solna M Dastmalchi, MD, PhD I Loell, PhD, Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm M Heimbürger, PhD, MD
    J Rheumatol 41:1124-32. 2014
  2. pmc Intensive aerobic and muscle endurance exercise in patients with systemic sclerosis: a pilot study
    Helene Alexanderson
    Department of Neurobiology, Care Science and Society, Division of Physical Therapy, Karolinska Institutet, Stockholm, Sweden
    BMC Res Notes 7:86. 2014
  3. doi request reprint The Myositis Activities Profile -- initial validation for assessment of polymyositis/dermatomyositis in the USA
    Helene Alexanderson
    Department of Medicine, Rheumatology Unit, Karolinska Institutet, Solna, Stockholm, Sweden
    J Rheumatol 39:2134-41. 2012
  4. doi request reprint Exercise effects in patients with adult idiopathic inflammatory myopathies
    Helene Alexanderson
    Department of Physical Therapy, Karolinska University Hospital, Stockholm, Sweden
    Curr Opin Rheumatol 21:158-63. 2009
  5. ncbi request reprint Benefits of intensive resistance training in patients with chronic polymyositis or dermatomyositis
    Helene Alexanderson
    Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Arthritis Rheum 57:768-77. 2007
  6. ncbi request reprint Functional index-2: Validity and reliability of a disease-specific measure of impairment in patients with polymyositis and dermatomyositis
    Helene Alexanderson
    Physical Therapy Department, Rheumatology Unit D2 07, Karolinska Institutet and Karolinska University Hospital, Solna, SE 171 76 Stockholm, Sweden
    Arthritis Rheum 55:114-22. 2006
  7. ncbi request reprint Effect of physical training on the proportion of slow-twitch type I muscle fibers, a novel nonimmune-mediated mechanism for muscle impairment in polymyositis or dermatomyositis
    Maryam Dastmalchi
    Karolinska University Hospital, Solna, Karolinska Instituet, Stockholm, Sweden
    Arthritis Rheum 57:1303-10. 2007
  8. doi request reprint Endurance Exercise Improves Molecular Pathways of Aerobic Metabolism in Patients With Myositis
    Li Alemo Munters
    Vanderbilt University, Nashville, Tennessee, and Karolinska Institutet and Karolinska University Hospital, Solna, Stockholm, Sweden
    Arthritis Rheumatol 68:1738-50. 2016
  9. doi request reprint TLR4 as receptor for HMGB1 induced muscle dysfunction in myositis
    Mei Zong
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 72:1390-9. 2013
  10. doi request reprint Effects of immunosuppressive treatment on interleukin-15 and interleukin-15 receptor α expression in muscle tissue of patients with polymyositis or dermatomyositis
    Mei Zong
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 71:1055-63. 2012

Collaborators

Detail Information

Publications35

  1. doi request reprint Resistive home exercise in patients with recent-onset polymyositis and dermatomyositis -- a randomized controlled single-blinded study with a 2-year followup
    Helene Alexanderson
    From the Department of NVS, Division of Physical Therapy, Karolinska Institutet, Huddinge Rheumatology Unit, Department of Medicine, and Department of Physical Therapy, Orthopedic Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet Rheumatology Clinic, Karolinska University Hospital, Huddinge, Stockholm, Sweden H Alexanderson, PhD, RPT, Department of NVS, Division of Physical Therapy, Karolinska Institutet, Huddinge, and Department of Physical Therapy, Orthopedic Rheumatology Unit, Karolinska University Hospital, Solna L Alemo Munters, PhD, RPT, Rheumatology Unit, Department of Medicine, and Department of Physical Therapy, Orthopedic Rheumatology Unit, Karolinska University Hospital, Solna M Dastmalchi, MD, PhD I Loell, PhD, Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm M Heimbürger, PhD, MD
    J Rheumatol 41:1124-32. 2014
    ..To evaluate the outcome of resistive home exercise and its possible longterm influence on health, disability, and disease activity in patients with active polymyositis (PM) or dermatomyositis (DM)...
  2. pmc Intensive aerobic and muscle endurance exercise in patients with systemic sclerosis: a pilot study
    Helene Alexanderson
    Department of Neurobiology, Care Science and Society, Division of Physical Therapy, Karolinska Institutet, Stockholm, Sweden
    BMC Res Notes 7:86. 2014
    ..The objective of this study was to examine the effect of an eight-week intensive aerobic exercise and muscle endurance training program for patients with systemic sclerosis with 50-100% of forced vital capacity...
  3. doi request reprint The Myositis Activities Profile -- initial validation for assessment of polymyositis/dermatomyositis in the USA
    Helene Alexanderson
    Department of Medicine, Rheumatology Unit, Karolinska Institutet, Solna, Stockholm, Sweden
    J Rheumatol 39:2134-41. 2012
    ..To evaluate some measurement properties of the Myositis Activities Profile (MAP) in adult patients with polymyositis (PM) and dermatomyositis (DM) in the United States...
  4. doi request reprint Exercise effects in patients with adult idiopathic inflammatory myopathies
    Helene Alexanderson
    Department of Physical Therapy, Karolinska University Hospital, Stockholm, Sweden
    Curr Opin Rheumatol 21:158-63. 2009
    ..To give an update on recent findings on effects of exercise in patients with adult inflammatory myopathies...
  5. ncbi request reprint Benefits of intensive resistance training in patients with chronic polymyositis or dermatomyositis
    Helene Alexanderson
    Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Arthritis Rheum 57:768-77. 2007
    ..To investigate the benefits and safety of an intensive muscular training program in patients with chronic polymyositis (PM) and dermatomyositis (DM)...
  6. ncbi request reprint Functional index-2: Validity and reliability of a disease-specific measure of impairment in patients with polymyositis and dermatomyositis
    Helene Alexanderson
    Physical Therapy Department, Rheumatology Unit D2 07, Karolinska Institutet and Karolinska University Hospital, Solna, SE 171 76 Stockholm, Sweden
    Arthritis Rheum 55:114-22. 2006
    ..To revise the content of the Functional Index in myositis (FI) and to evaluate measurement properties of a revised FI...
  7. ncbi request reprint Effect of physical training on the proportion of slow-twitch type I muscle fibers, a novel nonimmune-mediated mechanism for muscle impairment in polymyositis or dermatomyositis
    Maryam Dastmalchi
    Karolinska University Hospital, Solna, Karolinska Instituet, Stockholm, Sweden
    Arthritis Rheum 57:1303-10. 2007
    ..To compare muscle fiber type composition and muscle fiber area in patients with chronic polymyositis or dermatomyositis and healthy controls, and to determine whether physical training for 12 weeks could alter these muscle characteristics...
  8. doi request reprint Endurance Exercise Improves Molecular Pathways of Aerobic Metabolism in Patients With Myositis
    Li Alemo Munters
    Vanderbilt University, Nashville, Tennessee, and Karolinska Institutet and Karolinska University Hospital, Solna, Stockholm, Sweden
    Arthritis Rheumatol 68:1738-50. 2016
    ....
  9. doi request reprint TLR4 as receptor for HMGB1 induced muscle dysfunction in myositis
    Mei Zong
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 72:1390-9. 2013
    ..In this study, we investigated the mechanisms by which high mobility group box protein 1 (HMGB1) acts to accelerate muscle fatigue development...
  10. doi request reprint Effects of immunosuppressive treatment on interleukin-15 and interleukin-15 receptor α expression in muscle tissue of patients with polymyositis or dermatomyositis
    Mei Zong
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 71:1055-63. 2012
    ..To investigate the expression of interleukin (IL)-15 and IL-15 receptor α (IL-15Rα) in muscle tissue from patients with polymyositis or dermatomyositis before and after conventional immunosuppressive (IS) treatment...
  11. pmc Effects of conventional immunosuppressive treatment on CD244+ (CD28null) and FOXP3+ T cells in the inflamed muscle of patients with polymyositis and dermatomyositis
    Jayesh M Pandya
    Rheumatology Unit, Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
    Arthritis Res Ther 18:80. 2016
    ..The sensitivity of CD28null T cells towards glucocorticoid and Treg-mediated immunosuppression was also investigated...
  12. doi request reprint Anakinra treatment in patients with refractory inflammatory myopathies and possible predictive response biomarkers: a mechanistic study with 12 months follow-up
    Mei Zong
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Solna, Stockholm, Sweden
    Ann Rheum Dis 73:913-20. 2014
    ..To perform a mechanistic study on the effect of interleukin (IL)-1 blockade by anakinra in patients with refractory myositis and to explore possible predictive biomarkers...
  13. doi request reprint Improvement in health and possible reduction in disease activity using endurance exercise in patients with established polymyositis and dermatomyositis: a multicenter randomized controlled trial with a 1-year open extension followup
    Li Alemo Munters
    Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Arthritis Care Res (Hoboken) 65:1959-68. 2013
    ....
  14. pmc Limited effects of high-dose intravenous immunoglobulin (IVIG) treatment on molecular expression in muscle tissue of patients with inflammatory myopathies
    Sevim Barbasso Helmers
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 66:1276-83. 2007
    ....
  15. doi request reprint Patients' Experience of Myositis and Further Validation of a Myositis-specific Patient Reported Outcome Measure - Establishing Core Domains and Expanding Patient Input on Clinical Assessment in Myositis. Report from OMERACT 12
    Malin Regardt
    From the Department of Occupational Therapy, Karolinska University Hospital Department of Learning, Informatics and Medical Education, Karolinska Institutet, Stockholm, Sweden Division of Rheumatology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA Division of Rheumatology, Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Stockholm, Sweden Division of Rheumatology, Department of Internal Medicine, Medical Research Center, College of Medicine, Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Korea Department of Care Science and Society, Division of Physiotherapy, Karolinska Institutet and Department of Physical Therapy, Karolinska University Hospital, Stockholm, Sweden M Regardt, PhD, Occupational Therapist, Department of Occupational Therapy, Karolinska University Hospital, and Department of Learning, Informatics and Medical Education, Karolinska Institutet P Basharat, MD L Christopher Stine, MD, Division of Rheumatology, Department of Medicine, Johns Hopkins University C Sarver, Patient Research Partner, Baltimore, Maryland, USA A Björn, Department of Medical and Surgical Sciences
    J Rheumatol 42:2492-5. 2015
    ..The Outcome Measures in Rheumatology (OMERACT) myositis working group was established to examine patient-reported outcomes (PRO) as well as to validate patient-reported outcome measures (PROM) in myositis...
  16. ncbi request reprint Development of the myositis activities profile--validity and reliability of a self-administered questionnaire to assess activity limitations in patients with polymyositis/dermatomyositis
    Helene Alexanderson
    Physical Therapy Unit and Department of Rheumatology, Karolinska Hospital, Stockholm, Sweden
    J Rheumatol 29:2386-92. 2002
    ..To develop a disease-specific questionnaire for assessing limitations in activities of daily life, the Myositis Activities Profile (MAP), and to investigate its validity and reliability...
  17. ncbi request reprint The role of exercise in the rehabilitation of idiopathic inflammatory myopathies
    Helene Alexanderson
    Department of Physical Therapy, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm, Sweden
    Curr Opin Rheumatol 17:164-71. 2005
    ..The objective of this review is to provide an update on exercise and clinical assessment in the idiopathic inflammatory myopathies...
  18. ncbi request reprint Technology insight: tools for research, diagnosis and clinical assessment of treatment in idiopathic inflammatory myopathies
    Ingrid E Lundberg
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Nat Clin Pract Rheumatol 3:282-90. 2007
    ..This Review focuses on advances in diagnostic and outcome tools and their roles in clinical practice and clinical research in patients with polymyositis and dermatomyositis...
  19. pmc Effects on muscle tissue remodeling and lipid metabolism in muscle tissue from adult patients with polymyositis or dermatomyositis treated with immunosuppressive agents
    Ingela Loell
    Karolinska Institutet, Department of Medicine, Rheumatology Unit, Karolinska University Hospital Solna, Stockholm, Sweden
    Arthritis Res Ther 18:136. 2016
    ..We aimed to investigate molecular mechanisms that might contribute to the persisting muscle impairment despite immunosuppressive treatment in adult patients with PM or DM using gene expression profiling of repeated muscle biopsies...
  20. ncbi request reprint Down-regulation of the aberrant expression of the inflammation mediator high mobility group box chromosomal protein 1 in muscle tissue of patients with polymyositis and dermatomyositis treated with corticosteroids
    Ann Kristin Ulfgren
    Rheumatology Research Unit, CMM L8 04, Karolinska Hospital, Karolinska Institutet, 171 76 Stockholm, Sweden
    Arthritis Rheum 50:1586-94. 2004
    ..The present study was therefore undertaken to investigate how HMGB-1 is expressed in muscle tissue of patients with myositis and, if so, whether such expression is modulated by prednisolone therapy...
  21. doi request reprint Activated LTB4 pathway in muscle tissue of patients with polymyositis or dermatomyositis
    Ingela Loell
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm SE 171 76, Sweden
    Ann Rheum Dis 72:293-9. 2013
    ..To investigate the involvement of the leukotriene B4 (LTB4) pathway in polymyositis (PM) and dermatomyositis (DM) and the effect of immunosuppressive treatment on the LTB4 pathway...
  22. doi request reprint Exercise in inflammatory myopathies, including inclusion body myositis
    Helene Alexanderson
    Department of Medicine, Rheumatology Unit, Karolinska Institutet, Solna, Stockholm, Sweden
    Curr Rheumatol Rep 14:244-51. 2012
    ....
  23. doi request reprint Patients with polymyositis or dermatomyositis have reduced grip force and health-related quality of life in comparison with reference values: an observational study
    Malin Regardt
    Department of Neurobiology, Karolinska Institutet, Care Sciences and Society, Huddinge, Sweden
    Rheumatology (Oxford) 50:578-85. 2011
    ....
  24. doi request reprint Exercise as a therapeutic modality in patients with idiopathic inflammatory myopathies
    Helene Alexanderson
    Department of Medicine, Rheumatology Unit, Karolinska Institutet, Solna, Stockholm, Sweden
    Curr Opin Rheumatol 24:201-7. 2012
    ..To present scientific evidence on clinical and molecular effects of exercise in adult and juvenile idiopathic inflammatory myopathies focusing on recent studies...
  25. ncbi request reprint Sporadic inclusion body myositis: pilot study on the effects of a home exercise program on muscle function, histopathology and inflammatory reaction
    Snjolaug Arnardottir
    Department of Clinical Neuroscience Division of Neurology, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    J Rehabil Med 35:31-5. 2003
    ..To evaluate the safety and effect of a home training program on muscle function in 7 patients with sporadic inclusion body myositis...
  26. ncbi request reprint Inflammatory muscle disease: clinical presentation and assessment of patients
    Helene Alexanderson
    Department of Physical Therapy, Rheumatology Unit D2 07, Karolinska University Hospital, Solna SE 171 76, Stockholm, Sweden
    Curr Rheumatol Rep 9:273-9. 2007
    ....
  27. ncbi request reprint Exercise: an important component of treatment in the idiopathic inflammatory myopathies
    Helene Alexanderson
    Department of Physical Therapy, Rheumatology Unit D2 07, Karolinska University Hospital, Solna SE 171 76, Stockholm, Sweden
    Curr Rheumatol Rep 7:115-24. 2005
    ..An increasing number of valid and reliable outcome measures are available for patients with polymyositis and dermatomyositis, but for patients with inclusion body myositis reliable and sensitive outcome measures are still needed...
  28. doi request reprint Hand exercise intervention in patients with polymyositis and dermatomyositis: a pilot study
    Malin Regardt
    Department of Occupational Therapy, Karolinska University Hospital, Solna, Sweden Department of neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden
    Musculoskeletal Care 12:160-72. 2014
    ....
  29. pmc New insights into the benefits of exercise for muscle health in patients with idiopathic inflammatory myositis
    Li Alemo Munters
    Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, D2 01, 171 76, Stockholm, Sweden
    Curr Rheumatol Rep 16:429. 2014
    ..There is a need for RCTs to study effects of exercise in active disease and IBM. ..
  30. doi request reprint The host defense peptide LL-37 a possible inducer of the type I interferon system in patients with polymyositis and dermatomyositis
    Xin Lu
    Department of Rheumatology, China Japan Friendship Hospital, Beijing, China Department of Medicine, Unit of Rheumatology, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    J Autoimmun . 2016
    ..The prolonged exposure of the immune system to type I IFNs may eventually break tolerance and lead to autoimmune myositis...
  31. doi request reprint Disabilities of importance for patients to improve--using a patient preference tool in rheumatoid arthritis
    Li Alemo Munters
    Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
    Disabil Rehabil 36:1762-7. 2014
    ..Also to categorize patient preference selected disabilities using the ICF, to correlate the MACTAR score to RA core set measures and to evaluate the MACTAR's test-retest reliability...
  32. doi request reprint Therapy of myositis: biological and physical
    Ingrid E Lundberg
    aRheumatology Unit, Department of Medicine, Karolinska Institutet, Solna, Stockholm, Sweden bInstitute of Rheumatology, Prague, Czech Republic cDivision of Physiotherapy, Department of Neurobiology, Care Science and Society, Karolinska Institutet and Physical Therapy Clinic, Karolinska University Hospital, Solna, Stockholm, Sweden
    Curr Opin Rheumatol 26:704-11. 2014
    ..To give an update on reported use and effects of biological and physical therapies in patients with myositis...
  33. doi request reprint Patient-reported outcomes and adult patients' disease experience in the idiopathic inflammatory myopathies. report from the OMERACT 11 Myositis Special Interest Group
    Helene Alexanderson
    From the Department of Neuroscience, Care Science and Society, Division of Physical Therapy, Karolinska Institutet, Stockholm, Sweden Department of Rheumatology, Klinik St Katharinental, Diessenhofen, Switzerland Division of Rheumatology, Johns Hopkins University, Baltimore Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA Division of Rheumatology, Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    J Rheumatol 41:581-92. 2014
    ....
  34. ncbi request reprint Creatine supplements in patients with idiopathic inflammatory myopathies who are clinically weak after conventional pharmacologic treatment: Six-month, double-blind, randomized, placebo-controlled trial
    Yuen Li Chung
    King s College London School of Medicine, and the MRC Clinical Science Centre, Hammersmith Hospital, Imperial College School of Medicine, London, UK
    Arthritis Rheum 57:694-702. 2007
    ....
  35. ncbi request reprint [Exercise is beneficial for patients with myositis. Both pharmaceuticals and physical activity should be included in the therapy of chronic rheumatic muscle inflammation]
    Ingrid E Lundberg
    Neurologkliniken, Karolinska sjukhuset, Stockholm
    Lakartidningen 100:2754-9. 2003