Niaz Ahmed

Summary

Affiliation: Karolinska University Hospital
Country: Sweden

Publications

  1. doi request reprint Results of intravenous thrombolysis within 4.5 to 6 hours and updated results within 3 to 4.5 hours of onset of acute ischemic stroke recorded in the Safe Implementation of Treatment in Stroke International Stroke Thrombolysis Register (SITS-ISTR): an obs
    Niaz Ahmed
    Department of Clinical Neurosciences, Karolinska Institutet
    JAMA Neurol 70:837-44. 2013
  2. doi request reprint Relationship of blood pressure, antihypertensive therapy, and outcome in ischemic stroke treated with intravenous thrombolysis: retrospective analysis from Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SITS-ISTR
    Niaz Ahmed
    SITS International Coordination Office, Karolinska Stroke Research, Department of Neurology, Karolinska University Hospital Solna, Stockholm, Sweden
    Stroke 40:2442-9. 2009
  3. doi request reprint Association of admission blood glucose and outcome in patients treated with intravenous thrombolysis: results from the Safe Implementation of Treatments in Stroke International Stroke Thrombolysis Register (SITS-ISTR)
    Niaz Ahmed
    Karolinska Stroke Research Unit, Department of Neurology, Karolinska University Hospital Solna, Stockholm, Sweden
    Arch Neurol 67:1123-30. 2010
  4. doi request reprint Predicting the risk of symptomatic intracerebral hemorrhage in ischemic stroke treated with intravenous alteplase: safe Implementation of Treatments in Stroke (SITS) symptomatic intracerebral hemorrhage risk score
    Michael Mazya
    Department of Neurology, Karolinska University Hospital Solna, Karolinska Stroke Research, Stockholm, Sweden
    Stroke 43:1524-31. 2012
  5. doi request reprint Multivariable analysis of outcome predictors and adjustment of main outcome results to baseline data profile in randomized controlled trials: Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy (SITS-MOST)
    Nils Wahlgren
    Department of Neurology, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Stroke 39:3316-22. 2008
  6. doi request reprint Within-day and weekly variations of thrombolysis in acute ischemic stroke: results from safe implementation of treatments in stroke-international stroke thrombolysis register
    Svetlana Lorenzano
    From the Emergency Department Stroke Unit, Department of Neurology and Psychiatry, Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy S L, D T Karolinska Stroke Research Unit, Department of Neurology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden N A, N W Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland T T Acute Stroke Unit, Department of Neuroscience, Hospital Universitari Germas Trias i Pujol, Universidad Autonoma de Barcelona, Barcelona, Spain M G, A D International Clinical Research Center, Neurology Department, St Anne s Hospital, Brno, Czech Republic R M Department of Neurology, University Hospital, Plzen, Czech Republic P S and Department of Neurology and Rehabilitation, Tampere University Hospital, Tampere, Finland J O
    Stroke 45:176-84. 2014
  7. doi request reprint Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: an updated analysis from SITS-ISTR
    Niaz Ahmed
    Department of Neurology, Karolinska University Hospital, and Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden
    Lancet Neurol 9:866-74. 2010
  8. doi request reprint Thrombolysis with alteplase 3-4.5 h after acute ischaemic stroke (SITS-ISTR): an observational study
    Nils Wahlgren
    Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden
    Lancet 372:1303-9. 2008
  9. doi request reprint Remote or extraischemic intracerebral hemorrhage--an uncommon complication of stroke thrombolysis: results from the safe implementation of treatments in stroke-international stroke thrombolysis register
    Michael V Mazya
    From the Department of Neurology, Karolinska University Hospital M V M, N A, N W and Department of Clinical Neuroscience M V M, N A, N W, Karolinska Institutet, Stockholm, Sweden Stroke Research Group, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom G A F Department of Neurology, University of Leipzig, Leipzig, Germany C H International Clinical Research Center, Neurology Department, St Anne s Hospital, Brno, Czech Republic R M and Stroke Unit, Centro Hospitalar Lisboa Central, Lisbon, Portugal A P N
    Stroke 45:1657-63. 2014
  10. doi request reprint Safety of intravenous thrombolysis for ischemic stroke in patients treated with warfarin
    Michael V Mazya
    Department of Neurology, Karolinska University Hospital and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Ann Neurol 74:266-74. 2013

Collaborators

Detail Information

Publications25

  1. doi request reprint Results of intravenous thrombolysis within 4.5 to 6 hours and updated results within 3 to 4.5 hours of onset of acute ischemic stroke recorded in the Safe Implementation of Treatment in Stroke International Stroke Thrombolysis Register (SITS-ISTR): an obs
    Niaz Ahmed
    Department of Clinical Neurosciences, Karolinska Institutet
    JAMA Neurol 70:837-44. 2013
    ..Pooled analysis of randomized controlled trials of intravenous thrombolysis shows no statistically significant benefit beyond 4.5 hours, with the possible advantage perhaps offset by risk...
  2. doi request reprint Relationship of blood pressure, antihypertensive therapy, and outcome in ischemic stroke treated with intravenous thrombolysis: retrospective analysis from Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SITS-ISTR
    Niaz Ahmed
    SITS International Coordination Office, Karolinska Stroke Research, Department of Neurology, Karolinska University Hospital Solna, Stockholm, Sweden
    Stroke 40:2442-9. 2009
    ..We determined retrospectively the association of BP and antihypertensive therapy with clinical outcomes after stroke thrombolysis...
  3. doi request reprint Association of admission blood glucose and outcome in patients treated with intravenous thrombolysis: results from the Safe Implementation of Treatments in Stroke International Stroke Thrombolysis Register (SITS-ISTR)
    Niaz Ahmed
    Karolinska Stroke Research Unit, Department of Neurology, Karolinska University Hospital Solna, Stockholm, Sweden
    Arch Neurol 67:1123-30. 2010
    ..To determine the association between admission blood glucose and outcome in ischemic stroke patients treated with thrombolysis...
  4. doi request reprint Predicting the risk of symptomatic intracerebral hemorrhage in ischemic stroke treated with intravenous alteplase: safe Implementation of Treatments in Stroke (SITS) symptomatic intracerebral hemorrhage risk score
    Michael Mazya
    Department of Neurology, Karolinska University Hospital Solna, Karolinska Stroke Research, Stockholm, Sweden
    Stroke 43:1524-31. 2012
    ..Symptomatic intracerebral hemorrhage (SICH) is a serious complication in patients with acute ischemic stroke treated with intravenous thrombolysis. We aimed to develop a clinical score that can easily be applied to predict the risk of SICH...
  5. doi request reprint Multivariable analysis of outcome predictors and adjustment of main outcome results to baseline data profile in randomized controlled trials: Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy (SITS-MOST)
    Nils Wahlgren
    Department of Neurology, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Stroke 39:3316-22. 2008
    ..We aimed to identify outcome predictors and adjust the outcomes of the SITS-MOST to the baseline characteristics of RCTs...
  6. doi request reprint Within-day and weekly variations of thrombolysis in acute ischemic stroke: results from safe implementation of treatments in stroke-international stroke thrombolysis register
    Svetlana Lorenzano
    From the Emergency Department Stroke Unit, Department of Neurology and Psychiatry, Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy S L, D T Karolinska Stroke Research Unit, Department of Neurology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden N A, N W Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland T T Acute Stroke Unit, Department of Neuroscience, Hospital Universitari Germas Trias i Pujol, Universidad Autonoma de Barcelona, Barcelona, Spain M G, A D International Clinical Research Center, Neurology Department, St Anne s Hospital, Brno, Czech Republic R M Department of Neurology, University Hospital, Plzen, Czech Republic P S and Department of Neurology and Rehabilitation, Tampere University Hospital, Tampere, Finland J O
    Stroke 45:176-84. 2014
    ..In this large cohort study, we evaluated whether thrombolytic treatment has a within-day and weekly variability corresponding to circadian and weekly patterns of ischemic stroke onset, and whether these have impact on clinical outcome...
  7. doi request reprint Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: an updated analysis from SITS-ISTR
    Niaz Ahmed
    Department of Neurology, Karolinska University Hospital, and Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden
    Lancet Neurol 9:866-74. 2010
    ..5 h after stroke onset. We aimed to assess the implementation of the wider time window, its effect on the admission-to-treatment time, and safety and functional outcome in patients recorded in SITS-ISTR...
  8. doi request reprint Thrombolysis with alteplase 3-4.5 h after acute ischaemic stroke (SITS-ISTR): an observational study
    Nils Wahlgren
    Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden
    Lancet 372:1303-9. 2008
    ..5 h versus those treated within 3 h, who were recorded in the in the Safe Implementation of Treatments in Stroke (SITS), a prospective internet-based audit of the International Stroke Thrombolysis Registry (ISTR)...
  9. doi request reprint Remote or extraischemic intracerebral hemorrhage--an uncommon complication of stroke thrombolysis: results from the safe implementation of treatments in stroke-international stroke thrombolysis register
    Michael V Mazya
    From the Department of Neurology, Karolinska University Hospital M V M, N A, N W and Department of Clinical Neuroscience M V M, N A, N W, Karolinska Institutet, Stockholm, Sweden Stroke Research Group, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom G A F Department of Neurology, University of Leipzig, Leipzig, Germany C H International Clinical Research Center, Neurology Department, St Anne s Hospital, Brno, Czech Republic R M and Stroke Unit, Centro Hospitalar Lisboa Central, Lisbon, Portugal A P N
    Stroke 45:1657-63. 2014
    ..We aimed to describe risk factors, 3-month mortality, and functional outcome in patients with the poorly understood complication of remote intracerebral hemorrhage, as well as local intracerebral hemorrhage...
  10. doi request reprint Safety of intravenous thrombolysis for ischemic stroke in patients treated with warfarin
    Michael V Mazya
    Department of Neurology, Karolinska University Hospital and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Ann Neurol 74:266-74. 2013
    ..7. The influence of warfarin on symptomatic intracerebral hemorrhage (SICH), arterial recanalization, and long-term functional outcome in stroke thrombolysis remains unclear...
  11. doi request reprint Does sex influence the response to intravenous thrombolysis in ischemic stroke?: answers from safe implementation of treatments in Stroke-International Stroke Thrombolysis Register
    Svetlana Lorenzano
    From the Emergency Department Stroke Unit, Department of Neurology and Psychiatry, Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy S L, A F, D T Karolinska Stroke Research Unit, Department of Neurology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden N A, N W International Clinical Research Center, Neurology Department, St Anne s Hospital, Brno, Czech Republic R M Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland T T and Stroke Research Offices, Royal Infirmary, Keele University, North Staffordshire, United Kingdom C R
    Stroke 44:3401-6. 2013
    ..We aimed to evaluate differences in 3-month outcome between sexes in intravenous tissue-type plasminogen activator-treated patients registered in the Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register...
  12. ncbi request reprint Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study
    Nils Wahlgren
    Department of Neurology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Lancet 369:275-82. 2007
    ..Under European Union regulations, SITS-MOST was required to assess the safety profile of alteplase in clinical practice by comparison with results in randomised controlled trials...
  13. doi request reprint External validation of the SEDAN score for prediction of intracerebral hemorrhage in stroke thrombolysis
    Michael V Mazya
    Department of Neurology, SITS International Coordination Office, Karolinska Stroke Research, Karolinska University Hospital, Solna, Stockholm 17176, Sweden
    Stroke 44:1595-600. 2013
    ..We assessed the performance of the score in predicting SICH per the ECASS II and Safe Implementation of Treatments in Stroke Monitoring Study (SITS-MOST) definitions in the SITS-International Stroke Thrombolysis Register (SITS-ISTR)...
  14. doi request reprint Association of early National Institutes of Health Stroke Scale improvement with vessel recanalization and functional outcome after intravenous thrombolysis in ischemic stroke
    Tatiana Kharitonova
    Karolinska Stroke Research Unit, Department of Neurology, Karolinska University Hospital, Sweden
    Stroke 42:1638-43. 2011
    ....
  15. doi request reprint Hyperdense middle cerebral artery sign on admission CT scan--prognostic significance for ischaemic stroke patients treated with intravenous thrombolysis in the safe implementation of thrombolysis in Stroke International Stroke Thrombolysis Register
    Tatiana Kharitonova
    Department of Neurology, Karolinska Stroke Research Unit, SITS International Coordination Office, Karolinska University Hospital Solna, Stockholm, Sweden
    Cerebrovasc Dis 27:51-9. 2009
    ..Hyperdense middle cerebral artery sign (HMCAS) on CT scan before stroke thrombolysis is associated with increased risk for haemorrhage and unfavourable outcome in several small studies...
  16. ncbi request reprint Salivary cortisol, a biological marker of stress, is positively associated with 24-hour systolic blood pressure in patients with acute ischaemic stroke
    Niaz Ahmed
    Stroke Research Unit, Department of Neurology, Karolinska University Hospital, Stockholm, Sweden
    Cerebrovasc Dis 18:206-13. 2004
    ..The cause of elevated blood pressure (BP) in acute stroke is unknown. Stress is often suggested as a main contributing factor. We aimed to investigate the relationship between BP and stress in patients with acute stroke...
  17. pmc IV thrombolysis in very severe and severe ischemic stroke: Results from the SITS-ISTR Registry
    Michael V Mazya
    From the Department of Neurology M V M, N W, N A, Karolinska University Hospital, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden Acute Stroke Unit and Cerebrovascular Clinic K R L, Institute of Cardiovascular and Medical Sciences, University of Glasgow Stroke Unit D C, Watford General Hospital, UK Department of Neurology V M R, North Estonia Medical Centre, Tallinn, Estonia International Clinical Research Center and Department of Neurology R M, St Anne s University Hospital, Brno, Czech Republic and Department of Neurology and Psychiatry D T, Sapienza University of Rome, Italy
    Neurology 85:2098-106. 2015
    ..To study the safety of off-label IV thrombolysis in patients with very severe stroke (NIH Stroke Scale [NIHSS] scores >25) compared with severe stroke (NIHSS scores 15-25), where treatment is within European regulations...
  18. doi request reprint Is the maximum dose of 90 mg alteplase sufficient for patients with ischemic stroke weighing >100 kg?
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 42:1615-20. 2011
    ..We investigated if the lower per-kilogram dose is associated with poor early neurological improvement and worse outcome after thrombolysis...
  19. doi request reprint Threshold for NIH stroke scale in predicting vessel occlusion and functional outcome after stroke thrombolysis
    Charith Cooray
    Department of Clinical Neurosciences, Karolinska Institutet, Solna, Sweden
    Int J Stroke 10:822-9. 2015
    ..Data are limited on optimal threshold for baseline National Institutes of Health Stroke Scale in predicting outcome after stroke thrombolysis (intravenous thrombolysis)...
  20. ncbi request reprint Neuroprotection in cerebral ischaemia: facts and fancies--the need for new approaches
    Nils Gunnar Wahlgren
    Stroke Research Unit, Department of Neurology, Karolinska Hospital, Stockholm, Sweden
    Cerebrovasc Dis 17:153-66. 2004
    ..This article will summarize neuroprotection trials to date, some facts and fancies about neuroprotection, ischaemic pathophysiology and possible reasons for the apparent failure of human neuroprotective stroke trials...
  21. doi request reprint Changes in European Label and Guideline Adherence After Updated Recommendations for Stroke Thrombolysis: Results From the Safe Implementation of Treatments in Stroke Registry
    Nadim Anani
    From the Health Informatics Centre, Department of Learning, Informatics, Management and Ethics N Anani, R C, S K and Stroke Research Unit, Department of Clinical Neuroscience M V M, O B, N Ahmed, N W, T P M, Karolinska Institutet, Stockholm, Sweden Karolinska Stroke Research Unit, Department of Neurology, Karolinska University Hospital Solna, Stockholm, Sweden M V M, N Ahmed, N W, T P M Department of Neurology, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland O B and Cambio Healthcare Systems, Stockholm, Sweden R C
    Circ Cardiovasc Qual Outcomes 8:S155-62. 2015
    ..5 hours, which the label still prohibited. Our aim was to compare contraindication nonadherence before and after the guideline update...
  22. doi request reprint Mobile Phone-Based Questionnaire for Assessing 3 Months Modified Rankin Score After Acute Stroke: A Pilot Study
    Charith Cooray
    From the Department of Clinical Neurosciences, Karolinska Institutet and Department of Neurology, Karolinska University Hospital, Stockholm, Sweden
    Circ Cardiovasc Qual Outcomes 8:S125-30. 2015
    ..We investigated whether automatic assessment of the modified Rankin Scale (mRS) based on a mobile phone questionnaire may serve as an alternative to mRS assessments at clinical visits after stroke...
  23. pmc How common is isolated dysphasia among patients with stroke treated with intravenous thrombolysis, and what is their outcome? Results from the SITS-ISTR
    Erik Lundström
    Department of Neurology, Karolinska University Hospital and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    BMJ Open 5:e009109. 2015
    ..To describe the frequency and outcome of isolated dysphasia among patients treated with intravenous thrombolysis (IVT)...
  24. ncbi request reprint Effects of blood pressure lowering in the acute phase of total anterior circulation infarcts and other stroke subtypes
    Niaz Ahmed
    Stroke Research Unit, Department of Neurology, Karolinska Hospital, Stockholm, Sweden
    Cerebrovasc Dis 15:235-43. 2003
    ..To investigate whether heterogeneity exists between stroke subtypes in the response to BP lowering, we analysed data from the Intravenous Nimodipine West European Stroke Trial (INWEST)...
  25. doi request reprint Safety of intravenous thrombolysis for acute ischemic stroke in patients receiving antiplatelet therapy at stroke onset
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 41:288-94. 2010
    ..Antiplatelets (APs) may increase the risk of symptomatic intracerebral hemorrhage (ICH) following intravenous thrombolysis after ischemic stroke...