Paul W Ackermann

Summary

Affiliation: Karolinska University Hospital
Country: Sweden

Publications

  1. doi General Overview and Summary of Concepts Regarding Tendon Disease Topics Addressed Related to Metabolic Disorders
    Paul W Ackermann
    Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 17176, Stockholm, Sweden
    Adv Exp Med Biol 920:293-8. 2016
  2. doi Tendon Innervation
    Paul W Ackermann
    Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 17176, Stockholm, Sweden
    Adv Exp Med Biol 920:35-51. 2016
  3. pmc Neuronal regulation of tendon homoeostasis
    Paul W Ackermann
    Karolinska Institutet, Department of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, Sweden
    Int J Exp Pathol 94:271-86. 2013
  4. doi Anti-inflammatory cytokine profile in early human tendon repair
    P W Ackermann
    Integrative Orthopedic Laboratory, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Knee Surg Sports Traumatol Arthrosc 21:1801-6. 2013
  5. ncbi Neuronal pathways in tendon healing
    Paul W Ackermann
    Orthopedic Laboratory, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Front Biosci (Landmark Ed) 14:5165-87. 2009
  6. doi Type 2 diabetes impairs tendon repair after injury in a rat model
    Aisha S Ahmed
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Appl Physiol (1985) 113:1784-91. 2012
  7. doi Joint immobilization reduces the expression of sensory neuropeptide receptors and impairs healing after tendon rupture in a rat model
    Daniel K I Bring
    Section of Orthopaedics and Sports Medicine, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    J Orthop Res 27:274-80. 2009
  8. ncbi Intermittent pneumatic compression enhances neurovascular ingrowth and tissue proliferation during connective tissue healing: a study in the rat
    Johan Dahl
    Karolinska Institutet, Department of Molecular Medicine and Surgery, Section of Orthopaedics and Sports Medicine, Orthopedic Laboratory, M3 02 Karolinska University Hospital, S 171 76 Stockholm, Sweden
    J Orthop Res 25:1185-92. 2007
  9. ncbi Physical activity modulates nerve plasticity and stimulates repair after Achilles tendon rupture
    Daniel K I Bring
    Section of Orthopaedics and Sports Medicine, Department of Molecular Medicine and Surgery, Karolinska Institutet, Research Center M3 00, Karolinska Hospital, S 171 76 Stockholm, Sweden
    J Orthop Res 25:164-72. 2007
  10. pmc Compromised Neurotrophic and Angiogenic Regenerative Capability during Tendon Healing in a Rat Model of Type-II Diabetes
    Aisha S Ahmed
    Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden
    PLoS ONE 12:e0170748. 2017

Collaborators

Detail Information

Publications19

  1. doi General Overview and Summary of Concepts Regarding Tendon Disease Topics Addressed Related to Metabolic Disorders
    Paul W Ackermann
    Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 17176, Stockholm, Sweden
    Adv Exp Med Biol 920:293-8. 2016
    ..Necessary interactions between researchers and clinicians with different subspecialties have to be initiated in order to optimize tissue metabolism for improved healing potentials. ..
  2. doi Tendon Innervation
    Paul W Ackermann
    Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 17176, Stockholm, Sweden
    Adv Exp Med Biol 920:35-51. 2016
    ..Targeted approaches to the peripheral nervous system including neuronal mediators and their receptors may prove to be effective therapies for painful, degenerative and traumatic tendon disorders. ..
  3. pmc Neuronal regulation of tendon homoeostasis
    Paul W Ackermann
    Karolinska Institutet, Department of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, Sweden
    Int J Exp Pathol 94:271-86. 2013
    ..Thus there is a prospect that in the future pharmacotherapy and tissue engineering approaches targeting neuronal mediators and their receptors may prove to be effective therapies for painful, degenerative and traumatic tendon disorders. ..
  4. doi Anti-inflammatory cytokine profile in early human tendon repair
    P W Ackermann
    Integrative Orthopedic Laboratory, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Knee Surg Sports Traumatol Arthrosc 21:1801-6. 2013
    ..The aim of this study was to assess inflammation and the presence and relative levels of cytokines, which may be involved in regulating early human Achilles tendon healing...
  5. ncbi Neuronal pathways in tendon healing
    Paul W Ackermann
    Orthopedic Laboratory, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Front Biosci (Landmark Ed) 14:5165-87. 2009
    ..In a future perspective, neuronal mediators may prove to be useful in targeted pharmacotherapy and tissue engineering in painful, degenerative and traumatic tendon disorders...
  6. doi Type 2 diabetes impairs tendon repair after injury in a rat model
    Aisha S Ahmed
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Appl Physiol (1985) 113:1784-91. 2012
    ..Further our data suggest that therapeutic modulation of collagens or MMPs might be targets for new regenerative approaches in operated, injured, or maybe also degenerative tendon diseases in diabetes...
  7. doi Joint immobilization reduces the expression of sensory neuropeptide receptors and impairs healing after tendon rupture in a rat model
    Daniel K I Bring
    Section of Orthopaedics and Sports Medicine, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    J Orthop Res 27:274-80. 2009
    ..Therefore, immobilization postrupture appears to hamper tendon healing, a process which may prove to be directly linked to a downregulated peripheral sensitivity to sensory neuropeptide stimulation...
  8. ncbi Intermittent pneumatic compression enhances neurovascular ingrowth and tissue proliferation during connective tissue healing: a study in the rat
    Johan Dahl
    Karolinska Institutet, Department of Molecular Medicine and Surgery, Section of Orthopaedics and Sports Medicine, Orthopedic Laboratory, M3 02 Karolinska University Hospital, S 171 76 Stockholm, Sweden
    J Orthop Res 25:1185-92. 2007
    ..Daily IPC treatment improves neurovascular ingrowth and fibroblast proliferation in the healing tendon and may accelerate the repair process...
  9. ncbi Physical activity modulates nerve plasticity and stimulates repair after Achilles tendon rupture
    Daniel K I Bring
    Section of Orthopaedics and Sports Medicine, Department of Molecular Medicine and Surgery, Karolinska Institutet, Research Center M3 00, Karolinska Hospital, S 171 76 Stockholm, Sweden
    J Orthop Res 25:164-72. 2007
    ..02) lower than that in the controls, suggesting an earlier neuronal in-growth and disappearance in the more active group. Physical activity speeds up tendon healing, which may prove to be linked to accelerated neuronal plasticity...
  10. pmc Compromised Neurotrophic and Angiogenic Regenerative Capability during Tendon Healing in a Rat Model of Type-II Diabetes
    Aisha S Ahmed
    Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden
    PLoS ONE 12:e0170748. 2017
    ..Thus, novel approaches for regeneration of injured, including tendinopathic, and surgically repaired diabetic tendons may include therapeutic molecular modulation of neurotrophic pathways such as NGF and its receptors...
  11. doi Compression therapy promotes proliferative repair during rat Achilles tendon immobilization
    Nikos Schizas
    Orthopaedic Laboratory, Department of Molecular Medicine and Surgery, M1 02, The King Gustav V Research Building, Karolinska University Hospital 171 76 Stockholm, Sweden
    J Orthop Res 28:852-8. 2010
    ....
  12. doi Residual substance P levels after capsaicin treatment correlate with tendon repair
    Daniel K I Bring
    Section of Orthopaedics and Sports Medicine, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Wound Repair Regen 20:50-60. 2012
    ..89, p = 0.006 and r = 0.78, p = 0.015) at week 4. In conclusion, rats with higher residual SP levels after capsaicin-induced neuropathy develop improved tensile strength and stress at failure in the healing of Achilles tendon...
  13. doi Expressional changes in growth and inflammatory mediators during Achilles tendon repair in diabetic rats: new insights into a possible basis for compromised healing
    Aisha S Ahmed
    Department of Clinical Neuroscience, Karolinska Institutet, 17177, Stockholm, Sweden
    Cell Tissue Res 357:109-17. 2014
    ..Our data suggest that therapeutic modulation of Tβ-4 and VEGF represent a new regenerative approach in operated, injured, or degenerative tendon diseases in diabetes. ..
  14. ncbi Neuronal plasticity in relation to nociception and healing of rat achilles tendon
    Paul W Ackermann
    Department of Surgical Sciences, Orthopedic Laboratory, Research Center M3 02, Karolinska Hospital, S 171 76 Stockholm, Sweden
    J Orthop Res 21:432-41. 2003
    ..It may prove that the observed temporal occurrence of different neuropeptides reflects a role of the peripheral nervous system in regulating synchronously nociception and healing...
  15. ncbi Increase in sensory neuropeptides surrounding the Achilles tendon in rats with adjuvant arthritis
    Daniel K I Bring
    Orthopedic Laboratory, Department of Surgical Sciences, Research Center M3 02, Karolinska Hospital, S 171 76 Stockholm, Sweden
    J Orthop Res 23:294-301. 2005
    ..Whether a neuronal pathogenic mechanism underlies tendon overuse disorders in non-arthritic tendinopathies and the development of degeneration, i.e. tendinosis, remains to be studied...
  16. ncbi Neuronal pathways in tendon healing and tendinopathy--update
    Paul W Ackermann
    Integrative Orthopaedic Laboratory, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Front Biosci (Landmark Ed) 19:1251-78. 2014
    ..As our understanding of these processes improves, neuronal mediators may prove to be useful in the development of targeted pharmacotherapy and tissue engineering approaches to painful, degenerative and traumatic tendon disorders. ..
  17. ncbi Early nerve regeneration after achilles tendon rupture--a prerequisite for healing? A study in the rat
    Paul W Ackermann
    Department of Orthopedics, Research Center, Karolinska Hospital, Stockholm, Sweden
    J Orthop Res 20:849-56. 2002
    ..The observed pattern of neuronal regeneration and neuropeptide expression may prove to be important for normal connective tissue healing...
  18. doi Glutamate receptors in tendinopathic patients
    Nikos Schizas
    Orthopedic Laboratory, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    J Orthop Res 30:1447-52. 2012
    ..Increased NMDAR1 excitability may be related to increased SP and mGluR5. The unique co-existence of SP and phospho-NMDAR1 in tendinopathy presumably reflects a tissue proliferative and nociceptive role...
  19. pmc Tendinopathy in sport
    Paul W Ackermann
    Section of Orthopedics and Sports Medicine, Department of Molecular Medicine and Surgery, Stockholm Sports Trauma Research Center, Karolinska Institutet, Stockholm, Sweden
    Sports Health 4:193-201. 2012
    ..Despite the magnitude of the disorder, high-quality scientific data on etiology and available treatments have been limited...