Genomes and Genes
Affiliation: Huddinge University Hospital
- APOE polymorphism and clinical duration determine regional neuropathology in Swedish APP(670, 671) mutation carriers: implications for late-onset Alzheimer's diseaseN Bogdanovic
Neurotec, Geriatric Section, KI, Novum, KFC, Level 4, S 14186, Stockholm, Sweden
J Cell Mol Med 6:199-214. 2002..This raises the possibility that early Braak Stage I-II lesions might also follow this pattern of promotion...
- Growth-associated protein GAP-43 in the frontal cortex and in the hippocampus in Alzheimer's disease: an immunohistochemical and quantitative studyN Bogdanovic
Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Huddinge Hospital, Sweden
J Neural Transm (Vienna) 107:463-78. 2000..Our findings may suggest that in the frontal cortex, GAP-43 levels decline as a consequence of the synaptic degeneration, while in the hippocampus, sprouting processes, involving GAP-43, are active...
- Quantitative autoradiography of [3H]forskolin binding sites in post-mortem brain staged for Alzheimer's disease neurofibrillary changes and amyloid depositsA Garcia-Jimenez
Karolinska Institutet, Neurotec, Huddinge, Sweden
Brain Res 850:104-17. 1999..The specific change in the effect of a low concentration of Gpp[NH]p on the binding could indicate the loss of Ca2+/calmodulin-sensitive AC isoforms in AD...
- The Swedish APP670/671 Alzheimer's disease mutation: the first evidence for strikingly increased oxidative injury in the temporal inferior cortexN Bogdanovic
Geriatric Department, Neurotec, Karolinska Institute, Stockholm, Sweden
Dement Geriatr Cogn Disord 12:364-70. 2001..Increased OS might play a crucial role in the rapid progression of Swedish FAD from the associative temporal cortex to the primary cerebrocortical areas...
- Neuroglia in the inferior olivary nucleus during normal aging and Alzheimer's diseaseH Lasn
Section for Clinical Geriatric, NEUROTEC Institutionen, Karolinska Institutet, Stockholm, Sweden
J Cell Mol Med 10:145-56. 2006..Using a novel unbiased quantitative method, we were able to describe significant oligodendroglial loss in the PO but the pathogenic mechanism behind remains unknown...
- Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's diseaseJ A Prince
Center for Genomics Research, Karolinska Institute, Stockholm, Sweden
Eur J Hum Genet 9:437-44. 2001....
- Sound stimulation increases calcium-binding protein immunoreactivity in the inferior colliculus in miceE Idrizbegovic
Karolinska Institutet, Department of Audiology, Huddinge University Hospital, Sweden
Neurosci Lett 259:49-52. 1999....
- Regional distribution of subtypes of nicotinic receptors in human brain and effect of aging studied by (+/-)-[3H]epibatidineA Marutle
Department of Neuroscience and Family Medicine, Division of Molecular Neuropharmacology, Karolinska Institutet, Huddinge University Hospital, B 84 Huddinge S 141 86, Sweden
Brain Res 801:143-9. 1998..The findings indicate that a specifically modulate regional nicotinic receptors in human brain...
- Peripheral cell loss related to calcium binding protein immunocytochemistry in the dorsal cochlear nucleus in CBA/CaJ mice during agingE Idrizbegovic
Department of Audiology, Huddinge University Hospital, Karolinska Institutet, Huddinge, Sweden
Audiol Neurootol 6:132-9. 2001..These findings imply that the pathophysiological state of the auditory periphery may influence the neuronal homeostasis in the dorsal cochlear nucleus...
- The total number of neurons and calcium binding protein positive neurons during aging in the cochlear nucleus of CBA/CaJ mice: a quantitative studyE Idrizbegovic
Deparment of Audiology, Huddinge University Hospital, Karolinska Institutet, Sweden
Hear Res 158:102-15. 2001..While the neuronal number in the DCN and PVCN was decreased or unchanged, respectively, the calcium binding protein positive neuronal number showed a graded increase during aging in a region-specific and protein-specific manner...
- Modulating calbindin and parvalbumin immunoreactivity in the cochlear nucleus by moderate noise exposure in mice. . A quantitative study on the dorsal and posteroventral cochlear nucleusE Idrizbegovic
Dept of Audiology, Huddinge University Hospital, Huddinge, Sweden
Brain Res 800:86-96. 1998..The ability to map sound-induced calcium-binding protein changes in auditory neurons may be useful in future studies designed for detecting early patterns of neurodegeneration and neuroprotection in the central auditory pathway...
- Involvement of glutaredoxin-1 and thioredoxin-1 in beta-amyloid toxicity and Alzheimer's diseaseS Akterin
Section of Experimental Geriatrics, Neurotec Department, Karolinska Institutet, Kliniskt Forskningscentrum KFC, Novum, Huddinge, Sweden
Cell Death Differ 13:1454-65. 2006..Thus, Abeta neurotoxicity might be mediated by oxidation of GRX1 or TRX1 and subsequent activation of the ASK1 cascade. Deregulation of GRX1 and TRX1 antioxidant systems could be important events in AD pathogenesis...
- Loss of stimulatory effect of guanosine triphosphate on [(35)S]GTPgammaS binding correlates with Alzheimer's disease neurofibrillary pathology in entorhinal cortex and CA1 hippocampal subfieldA Garcia-Jimenez
Karolinska Institutet, Neurotec, Division of Experimental Geriatrics, Novum, KFC, Huddinge, Sweden
J Neurosci Res 67:388-98. 2002..These alterations appear to occur prior to stages corresponding to clinical disease and could lead to an impaired regulation of several signaling systems in AD brain...
- Beta-secretase-cleaved amyloid precursor protein in Alzheimer brain: a morphologic studyKristina Sennvik
Karolinska Institutet, Neurotec, Section of Experimental Geriatrics, KFC Novum, Huddinge, S 141 86, Sweden
J Cell Mol Med 8:127-34. 2004..beta-sAPP was also found surrounding senile plaques and cerebral blood vessels. The results presented here show altered beta-sAPP staining in the AD brain, suggestive of abnormal processing and transport of APP...
- Multiple sclerosis and amyloid deposits in the white matter of the brainI Nennesmo
Division of Pathology, Karolinska Institute, Huddinge Hospital, Sweden
Acta Neuropathol 93:205-9. 1997..Previous reports of amyloid deposits in MS are reviewed and the possible relationship between amyloid deposits and the increased production of immunoglobulin free light chains in MS is discussed...
- Jargonagraphia in a case of frontotemporal dementiaP Ostberg
Division of Geriatric Medicine, Huddinge University Hospital, Neurotec, Karolinska Institutet, Stockholm, Sweden
Brain Lang 79:333-9. 2001..The agraphia in this case is discussed with reference to both specific macroscopic and microscopic pathoanatomical lesions. We suggest that jargonagraphia can appear in frontotemporal dementia depending on the localization of lesions...
- Environmental enrichment and the brainA H Mohammed
Division of Geriatric Medicine, Neurotec, Karolinska Institutet, S 141 86 Huddinge, Stockholm, Sweden
Prog Brain Res 138:109-33. 2002
- The distribution and the modulation of tyrosine hydroxylase immunoreactivity in the lateral olivocochlear system of the guinea-pigX Niu
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Neuroscience 125:725-33. 2004..It is now demonstrated that protection against acoustic trauma by sound conditioning has a central component that is governed by TH in the LSO and the surrounding periolivary DLPO region...
- Cortical morphometric subclassification of frontotemporal lobar degenerationO Lindberg
Department of Neurobiology, Care Science and Society, Section of Clinical Geriatrics, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden
AJNR Am J Neuroradiol 30:1233-9. 2009..We hypothesized that these symptoms would be correlated to characteristic patterns of brain atrophy, which could be indentified and used for subclassification of subjects with FTLD...
- Increased frequency of a new polymorphism in the cell division cycle 2 (cdc2) gene in patients with Alzheimer's disease and frontotemporal dementiaA Johansson
Department of Clinical Neuroscience, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Neurosci Lett 340:69-73. 2003..In the combined tauopathy (AD and FTD) group the odds ratio (OR) was 1.77 (95% CI 1.19-2.63) for the Ex6+7II genotype. Our findings suggest that the Ex6+7I allele is associated with tauopathies, both AD and FTD...
- A quantitative and immunohistochemical study on apolipoprotein E in brain tissue in Alzheimer's diseaseC Hesse
Department of Clinical Neuroscience, Unit of Neurochemistry, University of Goteborg, Sahlgren s University Hospital, Molndal, Sweden
Dement Geriatr Cogn Disord 10:452-9. 1999..One may speculate whether the decrease in ApoE may suggest a disturbance in the ApoE system in AD that is unrelated to ApoE isoforms, beta-amyloid deposition and NFT formation. Copyrightz1999S.KargerAG,Basel..
- Possible signaling by glutathione and its novel analogue through potent stimulation of fontocortical G proteins in normal aging and in Alzheimer's diseaseE Karelson
Department of Biochemistry, Tartu University, 50411 Tartu, Estonia
Ann N Y Acad Sci 973:537-40. 2002..Stimulation of G proteins and coupled signaling by GSH antioxidant analogues, as potential signaling molecules, may ameliorate the oxidative impairments of neuronal signaling in AD...
- Critical role of methionine-722 in the stimulation of human brain G-proteins and neurotoxicity induced by London familial Alzheimer's disease (FAD) mutated V717G-APP(714-723)K Reis
Department of Neurochemistry, Stockholm University, S 106 91 Stockholm, Sweden
Neuroscience 144:571-8. 2007....
- 17beta-Oestradiol stimulation of G-proteins in aged and Alzheimer's human brain: comparison with phytoestrogensV Jefremov
Department of Biochemistry, Tartu University, Tartu, Estonia
J Neuroendocrinol 20:587-96. 2008..Both of these mechanisms could be involved in the neuroprotective signalling of oestrogens that contributes to their preventive/therapeutic action against postmenopausal neurological disorders...
- On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cellsN Bogdanovic
Division of Geriatric Medicine, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden
Neurosci Lett 314:45-8. 2001..The dynamic changes in the mechanisms for cholesterol efflux from the brain are of interest in relation to the link between brain cholesterol and amyloid beta-protein in AD...