M Svoboda

Summary

Publications

  1. doi request reprint HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients
    Miroslav Svoboda
    Institute of Experimental Medicine, ASCR, Prague 14220, Czech Republic, Institute of Biology and Medical Genetics, First Medical Faculty, Charles University, Prague 12000, Czech Republic
    Carcinogenesis 35:1510-5. 2014
  2. ncbi request reprint Micro-RNAs miR125b and miR137 are frequently upregulated in response to capecitabine chemoradiotherapy of rectal cancer
    M Svoboda
    Oncobios Research Group, CZ 612 00 Brno, Czech Republic
    Int J Oncol 33:541-7. 2008
  3. ncbi request reprint Preoperative radiotherapy and concomitant capecitabine treatment induce thymidylate synthase and thymidine phosphorylase mRNAs in rectal carcinoma
    I Kocakova
    Clinic of Comprehensive Cancer Care, Laboratory of Predictive Oncology, Dept of Clin and Exp Pathology, Masaryk Memorial Cancer Institute, Brno, Czech Republic
    Neoplasma 54:447-53. 2007
  4. doi request reprint Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer
    O Slaby
    Departments of Clinical and Experimental Pathology, Masaryk Memorial Cancer Institute, Masaryk University, Brno, Czech Republic
    Oncology 72:397-402. 2007
  5. ncbi request reprint [Involvement of microRNAs in cancer biology and possibilities of their application to diagnostic and predictive oncology]
    O Slaby
    Oddelení klinické a experimentální patologie, Masarykův Onkologický ústav, Brno
    Cas Lek Cesk 147:25-31. 2008
  6. ncbi request reprint [Gene expression profiling in prediction of tumor response to neoadjuvant concomitant chemoradiotherapy in patients with locally advanced rectal carcinoma: pilot study]
    I Garajova
    klinika komplexní onkologické péce, Masarykův Onkologický ústav, Brno
    Cas Lek Cesk 147:381-6. 2008

Collaborators

Detail Information

Publications6

  1. doi request reprint HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients
    Miroslav Svoboda
    Institute of Experimental Medicine, ASCR, Prague 14220, Czech Republic, Institute of Biology and Medical Genetics, First Medical Faculty, Charles University, Prague 12000, Czech Republic
    Carcinogenesis 35:1510-5. 2014
    ..Upregulated HOTAIR relative expression in primary tumors and in blood of CRC patients is associated with unfavorable prognosis. Our data suggest that HOTAIR blood levels may serve as potential surrogate prognostic marker in sporadic CRC...
  2. ncbi request reprint Micro-RNAs miR125b and miR137 are frequently upregulated in response to capecitabine chemoradiotherapy of rectal cancer
    M Svoboda
    Oncobios Research Group, CZ 612 00 Brno, Czech Republic
    Int J Oncol 33:541-7. 2008
    ..Moreover, our results for the first time show that higher induced levels of miR125b and miR137 are associated with worse response to the therapy...
  3. ncbi request reprint Preoperative radiotherapy and concomitant capecitabine treatment induce thymidylate synthase and thymidine phosphorylase mRNAs in rectal carcinoma
    I Kocakova
    Clinic of Comprehensive Cancer Care, Laboratory of Predictive Oncology, Dept of Clin and Exp Pathology, Masaryk Memorial Cancer Institute, Brno, Czech Republic
    Neoplasma 54:447-53. 2007
    ..TP induction is in accordance with the expected role of TP in the activation of capecitabine and the known promoting role of TP in tissue fibrosis frequently associated with tumor regression...
  4. doi request reprint Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer
    O Slaby
    Departments of Clinical and Experimental Pathology, Masaryk Memorial Cancer Institute, Masaryk University, Brno, Czech Republic
    Oncology 72:397-402. 2007
    ..MicroRNAs (miRNAs) are endogenously expressed regulatory noncoding RNAs. Previous, mainly preclinical studies showed altered expression levels of several miRNAs in CRC...
  5. ncbi request reprint [Involvement of microRNAs in cancer biology and possibilities of their application to diagnostic and predictive oncology]
    O Slaby
    Oddelení klinické a experimentální patologie, Masarykův Onkologický ústav, Brno
    Cas Lek Cesk 147:25-31. 2008
    ..In this review we attempt to introduce basic knowledge of miRNAs biogenesis and biological functions and in particular summarise reports focused on miRNAs in oncology research area...
  6. ncbi request reprint [Gene expression profiling in prediction of tumor response to neoadjuvant concomitant chemoradiotherapy in patients with locally advanced rectal carcinoma: pilot study]
    I Garajova
    klinika komplexní onkologické péce, Masarykův Onkologický ústav, Brno
    Cas Lek Cesk 147:381-6. 2008
    ..It is based on fluoropyrimidines (5-fluorouracil, capecitabine) with concurrent radiotherapy. The aim of the study was to evaluate the capability of gene expression method to identify nonresponders (NR) pretherapeutically...