- Enhanced synaptic connectivity and epilepsy in C1q knockout mice
Department of Neurology and Neurological Sciences and Neurobiology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 107:7975-80. 2010
..Results indicate that epileptogenesis in C1q KO mice is related to a genetically determined failure to prune excessive excitatory synapses during development...
- The classical complement cascade mediates CNS synapse elimination
Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 131:1164-78. 2007
..These findings support a model in which unwanted synapses are tagged by complement for elimination and suggest that complement-mediated synapse elimination may become aberrantly reactivated in neurodegenerative disease...
- The Down syndrome critical region regulates retinogeniculate refinement
Department of Psychiatry, Stanford University School of Medicine, Stanford, California, 94305, USA
J Neurosci 31:5764-76. 2011
..Thus, altered developmental refinement of visual circuits that occurs before sensory experience is likely to contribute to visual impairment in individuals with Down syndrome...
- The complement system: an unexpected role in synaptic pruning during development and disease
Alexander H Stephan
Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305 5125, USA
Annu Rev Neurosci 35:369-89. 2012
- Do glia drive synaptic and cognitive impairment in disease?
Won Suk Chung
Department of Neurobiology, Stanford University, School of Medicine, Palo Alto, California, USA
Nat Neurosci 18:1539-45. 2015
..Illuminating the mechanisms by which glia influence synapse function may lead to the development of new therapies and biomarkers for synaptic dysfunction. ..
- Neuron-astrocyte signaling in the development and plasticity of neural circuits
Department of Neurobiology, Stanford University School of Medicine, Stanford, CA, USA
Neurosignals 16:278-88. 2008
- NS21: re-defined and modified supplement B27 for neuronal cultures
Department of Pharmacology, University of Iowa, Iowa City, IA 52242 1109, United States
J Neurosci Methods 171:239-47. 2008
..Furthermore, we found that holo-transferrin used in NS21 is preferable over apo-transferrin used in B27 for the quality of neuronal cultures...
- Astrocytes promote myelination in response to electrical impulses
Nervous System Development and Plasticity Section, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
Neuron 49:823-32. 2006
..This activity-dependent mechanism promoting myelination could regulate myelination according to functional activity or environmental experience and may offer new approaches to treating demyelinating diseases...
- Glia: much more than the neuron's side-kick
Section on Nervous System Development and Plasticity, NICHD, National Institutes of Health, Bldg 49, Room 5A78, MSC 4495, 49 Convent Drive, Bethesda, Maryland 20892, USA
Curr Biol 13:R469-72. 2003
- Adenosine: a neuron-glial transmitter promoting myelination in the CNS in response to action potentials
Laboratory of Cellular and Synaptic Neurophysiology, National Institutes of Health, NICHD, Bethesda, MD 20892, USA
Neuron 36:855-68. 2002