John Stambas

Summary

Publications

  1. ncbi request reprint Oxidised mannan as a novel adjuvant inducing mucosal IgA production
    John Stambas
    Department of Microbiology and Immunology, University of Melbourne, 3052, Vic, Parkville, Australia
    Vaccine 20:1068-78. 2002
  2. ncbi request reprint Oxidised mannan-listeriolysin O conjugates induce Th1/Th2 cytokine responses after intranasal immunisation
    John Stambas
    Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3052, Australia
    Vaccine 20:1877-86. 2002
  3. doi request reprint Narrowed TCR diversity for immunised mice challenged with recombinant influenza A-HIV Env(311-320) virus
    Tania Cukalac
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne, VIC 3010, Australia
    Vaccine 27:6755-61. 2009
  4. doi request reprint Diversity and clonotypic composition of influenza-specific CD8+ TCR repertoires remain unaltered in the absence of Aire
    Katherine Kedzierska
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne, Vic, Australia
    Eur J Immunol 40:849-58. 2010
  5. pmc Trivalent live attenuated influenza-simian immunodeficiency virus vaccines: efficacy and evolution of cytotoxic T lymphocyte escape in macaques
    Jeanette C Reece
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Virol 87:4146-60. 2013
  6. doi request reprint Recombinant influenza virus expressing HIV-1 p24 capsid protein induces mucosal HIV-specific CD8 T-cell responses
    Hyon Xhi Tan
    Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria 3010, Australia
    Vaccine 34:1172-9. 2016
  7. doi request reprint Glutathione peroxidase-1 reduces influenza A virus-induced lung inflammation
    Selcuk Yatmaz
    Department of Pharmacology, The University of Melbourne, Parkville, Vic, Australia
    Am J Respir Cell Mol Biol 48:17-26. 2013
  8. pmc Comparison of influenza and SIV specific CD8 T cell responses in macaques
    Sinthujan Jegaskanda
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    PLoS ONE 7:e32431. 2012
  9. doi request reprint Sindbis virus vectors elicit hemagglutinin-specific humoral and cellular immune responses and offer a dose-sparing strategy for vaccination
    Annett Miller
    Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Australia
    Vaccine 26:5641-8. 2008
  10. doi request reprint Killer T cells in influenza
    John Stambas
    Department of Microbiology and Immunology, University of Melbourne, Royal Parade, Parkville, Victoria 3010, Australia
    Pharmacol Ther 120:186-96. 2008

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Oxidised mannan as a novel adjuvant inducing mucosal IgA production
    John Stambas
    Department of Microbiology and Immunology, University of Melbourne, 3052, Vic, Parkville, Australia
    Vaccine 20:1068-78. 2002
    ..Thus, oxidised mannan, which is non-toxic and can be administered without injection, is a suitable adjuvant coupled with protective antigens for vaccinating against a number of infections that occur via the mucous membranes...
  2. ncbi request reprint Oxidised mannan-listeriolysin O conjugates induce Th1/Th2 cytokine responses after intranasal immunisation
    John Stambas
    Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3052, Australia
    Vaccine 20:1877-86. 2002
    ..Immunisation with the oxidised conjugate resulted in significant antigen specific proliferative responses, IL-2, IFN-gamma and IL-4 production when compared to unconjugated controls...
  3. doi request reprint Narrowed TCR diversity for immunised mice challenged with recombinant influenza A-HIV Env(311-320) virus
    Tania Cukalac
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne, VIC 3010, Australia
    Vaccine 27:6755-61. 2009
    ..1/8.2 D(d)Env(311) TCR repertoire diversity. This work further emphasizes the importance of understanding vaccine-induced CD8+ T cell responses...
  4. doi request reprint Diversity and clonotypic composition of influenza-specific CD8+ TCR repertoires remain unaltered in the absence of Aire
    Katherine Kedzierska
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne, Vic, Australia
    Eur J Immunol 40:849-58. 2010
    ..This provides the first demonstration that the selection of an Ag-specific T-cell repertoire is not significantly perturbed in the absence of Aire...
  5. pmc Trivalent live attenuated influenza-simian immunodeficiency virus vaccines: efficacy and evolution of cytotoxic T lymphocyte escape in macaques
    Jeanette C Reece
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Virol 87:4146-60. 2013
    ..More potent and possibly broader immune responses may be required to protect pigtail macaques from SIV...
  6. doi request reprint Recombinant influenza virus expressing HIV-1 p24 capsid protein induces mucosal HIV-specific CD8 T-cell responses
    Hyon Xhi Tan
    Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria 3010, Australia
    Vaccine 34:1172-9. 2016
    ..These findings demonstrate the potential utility of recombinant influenza viruses as vaccines for mucosal immunity against HIV-1 infection. ..
  7. doi request reprint Glutathione peroxidase-1 reduces influenza A virus-induced lung inflammation
    Selcuk Yatmaz
    Department of Pharmacology, The University of Melbourne, Parkville, Vic, Australia
    Am J Respir Cell Mol Biol 48:17-26. 2013
    ..GPx-1(-/-) mice had more MIP-2 protein in BALF at Day 3 and more active MMP-9 protease in BALF at Days 3 and 7 than WT mice. These data indicate that GPx-1 reduces influenza A virus-induced lung inflammation...
  8. pmc Comparison of influenza and SIV specific CD8 T cell responses in macaques
    Sinthujan Jegaskanda
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    PLoS ONE 7:e32431. 2012
    ..Our results suggest that strategies to maintain a more functional CD8(+) T-cell response, profile may assist in controlling HIV disease...
  9. doi request reprint Sindbis virus vectors elicit hemagglutinin-specific humoral and cellular immune responses and offer a dose-sparing strategy for vaccination
    Annett Miller
    Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Australia
    Vaccine 26:5641-8. 2008
    ..This demonstrated the dose-sparing capacity of the SIN vector system and its ability to stimulate long-term memory responses, properties that are highly desirable in any vaccine formulation...
  10. doi request reprint Killer T cells in influenza
    John Stambas
    Department of Microbiology and Immunology, University of Melbourne, Royal Parade, Parkville, Victoria 3010, Australia
    Pharmacol Ther 120:186-96. 2008
    ..Understanding the complexities of CD8+ T cell mediated immunity and memory has the potential for improving vaccine design, particularly to combat pandemics caused by newly emerging influenza viruses...
  11. ncbi request reprint A question of self-preservation: immunopathology in influenza virus infection
    Nicole L La Gruta
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    Immunol Cell Biol 85:85-92. 2007
    ....
  12. pmc Location rather than CD62L phenotype is critical in the early establishment of influenza-specific CD8+ T cell memory
    Katherine Kedzierska
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne 3010, Australia
    Proc Natl Acad Sci U S A 104:9782-7. 2007
    ..It seems that location rather than CD62Lhi/lo phenotype may be the more profitable focus for further dissection of the early establishment of T cell memory...
  13. ncbi request reprint An in vivo cytotoxicity threshold for influenza A virus-specific effector and memory CD8(+) T cells
    John Stambas
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne, Australia
    J Immunol 178:1285-92. 2007
    ..These experiments provide insights that may be of value for adoptive immunotherapy, where careful consideration of both the activation state and the number of effector cells is required...
  14. ncbi request reprint Clustering of Th cell epitopes on exposed regions of HIV envelope despite defects in antibody activity
    Scott A Brown
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 171:4140-8. 2003
    ..To explain the clustering of Th cell epitopes, we propose that localization of peptide on exposed envelope surfaces facilitates proteolytic activity and preferential peptide shuttling through the Ag processing pathway...
  15. pmc Consequences of immunodominant epitope deletion for minor influenza virus-specific CD8+-T-cell responses
    Samita S Andreansky
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Virol 79:4329-39. 2005
    ..A possible explanation is that novel, as yet undetected epitopes emerge following primary exposure to the -NP-PA deletion viruses. These findings have implications for both natural infections and vaccines...
  16. pmc Protection and compensation in the influenza virus-specific CD8+ T cell response
    Richard J Webby
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 100:7235-40. 2003
    ..It seems that the relationship between protective humoral and cellular immunity is neither simple nor readily predicted...
  17. pmc Differential tumor necrosis factor receptor 2-mediated editing of virus-specific CD8+ effector T cells
    Stephen J Turner
    Department of Immunology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 101:3545-50. 2004
    ..Therefore, the massive difference in magnitude for the secondary, although not the primary, response to these D(b)NP(366) and D(b)PA(224) epitopes cannot be considered to reflect differential TNFR2-mediated T cell editing...