Annabel F Valledor

Summary

Country: Spain

Publications

  1. pmc Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression
    Brandee L Wagner
    X Ceptor Therapeutics, San Diego, California 92121, USA
    Mol Cell Biol 23:5780-9. 2003
  2. ncbi Decoding transcriptional programs regulated by PPARs and LXRs in the macrophage: effects on lipid homeostasis, inflammation, and atherosclerosis
    Mercedes Ricote
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, Calif 92093 0651, USA
    Arterioscler Thromb Vasc Biol 24:230-9. 2004
  3. ncbi The innate immune response under the control of the LXR pathway
    Annabel F Valledor
    Macrophage Biology Unit, Parc Científic de Barcelona Institut Recerca Biomèdica de Barcelona, Josep Samitier 1 5, 08028 Barcelona, Spain
    Immunobiology 210:127-32. 2005
  4. ncbi Selective roles of MAPKs during the macrophage response to IFN-gamma
    Annabel F Valledor
    Nuclear Receptors Group, Department of Physiology, School of Biology, Institute for Research in Biomedicine IRB, Barcelona, Spain
    J Immunol 180:4523-9. 2008
  5. ncbi PKC epsilon is involved in JNK activation that mediates LPS-induced TNF-alpha, which induces apoptosis in macrophages
    Monica Comalada
    Macrophage Biology Group, Biomedical Research Institute of Barcelona Science Park, University of Barcelona, Josep Samitier 1 5, 08028 Barcelona, Spain
    Am J Physiol Cell Physiol 285:C1235-45. 2003
  6. ncbi JNK1 Is required for the induction of Mkp1 expression in macrophages during proliferation and lipopolysaccharide-dependent activation
    Ester Sánchez-Tilló
    Institute for Research in Biomedicine and University of Barcelona, Barcelona Science Park, Josep Samitier 1 5, E 08028 Barcelona, Spain
    J Biol Chem 282:12566-73. 2007
  7. pmc Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis
    Annabel F Valledor
    Department of Cellular and Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 101:17813-8. 2004
  8. ncbi Immunosenescence of macrophages: reduced MHC class II gene expression
    Carmen Herrero
    Departament de Fisiologia Biologia del Macròfag, Facultat de Biologia and Fundacio August Pi i Sunyer, Universitat de Barcelona, Avenida Diagonal 645, E 08028 Barcelona, Spain
    Exp Gerontol 37:389-94. 2002
  9. ncbi Macrophage-colony-stimulating factor-induced proliferation and lipopolysaccharide-dependent activation of macrophages requires Raf-1 phosphorylation to induce mitogen kinase phosphatase-1 expression
    Ester Sánchez-Tilló
    Macrophage Biology Group, Institute of Research in Biomedicine University of Barcelona, Barcelona Science Park, Barcelona, Spain
    J Immunol 176:6594-602. 2006
  10. pmc Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma
    Andrew C Li
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0682, USA
    J Clin Invest 114:1564-76. 2004

Collaborators

  • C K Glass
  • Timothy M Willson
  • Roger A Davis
  • Monica Comalada
  • Antonio Celada
  • Jordi Xaus
  • Ester Sánchez-Tilló
  • Jorge Lloberas
  • Consol Farrera
  • Mercedes Ricote
  • Andrew C Li
  • Brandee L Wagner
  • Carmen Herrero
  • Carme Caelles
  • Wulf Palinski
  • Christoph J Binder
  • Alejandra Gutierrez
  • Kathleen K Brown
  • Jennifer W Pattison
  • Christine R Plotkin
  • Ester Sanchez
  • Joseph L Witztum
  • Eric D Bischoff
  • Richard A Heyman
  • Daniel J Pennington
  • Gang Shao
  • Michael G Rosenfeld
  • Chris L Daige
  • Mary Petrowski
  • Ira G Schulman
  • Sung Hee Baek
  • Francesc Ventura
  • Kristen Jepsen
  • Carlos López-López
  • Ignacio Umbert
  • Marina Cardó
  • Laura Marques
  • Carlos Sebastian

Detail Information

Publications15

  1. pmc Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression
    Brandee L Wagner
    X Ceptor Therapeutics, San Diego, California 92121, USA
    Mol Cell Biol 23:5780-9. 2003
    ....
  2. ncbi Decoding transcriptional programs regulated by PPARs and LXRs in the macrophage: effects on lipid homeostasis, inflammation, and atherosclerosis
    Mercedes Ricote
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, Calif 92093 0651, USA
    Arterioscler Thromb Vasc Biol 24:230-9. 2004
    ..This review summarizes recent efforts to decode the differential and overlapping roles of PPARs and LXRs in the context of macrophage lipid homeostasis and the control of inflammation...
  3. ncbi The innate immune response under the control of the LXR pathway
    Annabel F Valledor
    Macrophage Biology Unit, Parc Científic de Barcelona Institut Recerca Biomèdica de Barcelona, Josep Samitier 1 5, 08028 Barcelona, Spain
    Immunobiology 210:127-32. 2005
    ..Agonists that activate the LXR pathway may be used to enhance innate immunity to highly virulent pathogens that otherwise induce macrophage apoptosis as a means to subvert host immune defense...
  4. ncbi Selective roles of MAPKs during the macrophage response to IFN-gamma
    Annabel F Valledor
    Nuclear Receptors Group, Department of Physiology, School of Biology, Institute for Research in Biomedicine IRB, Barcelona, Spain
    J Immunol 180:4523-9. 2008
    ..Modest effects were observed for ERK-1/2 in these studies. Interestingly, some of the MAPK-dependent changes in gene expression observed in these studies are based on posttranscriptional regulation of mRNA stability...
  5. ncbi PKC epsilon is involved in JNK activation that mediates LPS-induced TNF-alpha, which induces apoptosis in macrophages
    Monica Comalada
    Macrophage Biology Group, Biomedical Research Institute of Barcelona Science Park, University of Barcelona, Josep Samitier 1 5, 08028 Barcelona, Spain
    Am J Physiol Cell Physiol 285:C1235-45. 2003
    ..We demonstrated in macrophages that LPS involving PKCepsilon regulates JNK activity and produces TNF-alpha, which induces apoptosis...
  6. ncbi JNK1 Is required for the induction of Mkp1 expression in macrophages during proliferation and lipopolysaccharide-dependent activation
    Ester Sánchez-Tilló
    Institute for Research in Biomedicine and University of Barcelona, Barcelona Science Park, Josep Samitier 1 5, E 08028 Barcelona, Spain
    J Biol Chem 282:12566-73. 2007
    ..This requirement is independent of Mkp1 expression, as shown in Mkp1 knock-out mice. Our results demonstrate a critical role for JNK1 in the regulation of Mkp1 induction and in LPS-dependent macrophage activation...
  7. pmc Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis
    Annabel F Valledor
    Department of Cellular and Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 101:17813-8. 2004
    ....
  8. ncbi Immunosenescence of macrophages: reduced MHC class II gene expression
    Carmen Herrero
    Departament de Fisiologia Biologia del Macròfag, Facultat de Biologia and Fundacio August Pi i Sunyer, Universitat de Barcelona, Avenida Diagonal 645, E 08028 Barcelona, Spain
    Exp Gerontol 37:389-94. 2002
    ..These data could explain, at least in part, the impaired immune response associated to senescence...
  9. ncbi Macrophage-colony-stimulating factor-induced proliferation and lipopolysaccharide-dependent activation of macrophages requires Raf-1 phosphorylation to induce mitogen kinase phosphatase-1 expression
    Ester Sánchez-Tilló
    Macrophage Biology Group, Institute of Research in Biomedicine University of Barcelona, Barcelona Science Park, Barcelona, Spain
    J Immunol 176:6594-602. 2006
    ..The data reported here reveal new insights into how signaling determines opposing macrophage functions...
  10. pmc Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma
    Andrew C Li
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0682, USA
    J Clin Invest 114:1564-76. 2004
    ..In concert, these findings reveal receptor-specific mechanisms by which PPARs influence macrophage cholesterol homeostasis. In the future, these mechanisms may be exploited pharmacologically to inhibit the development of atherosclerosis...
  11. ncbi Macrophage colony-stimulating factor-, granulocyte-macrophage colony-stimulating factor-, or IL-3-dependent survival of macrophages, but not proliferation, requires the expression of p21(Waf1) through the phosphatidylinositol 3-kinase/Akt pathway
    Monica Comalada
    Group of Macrophage Biology, Biomedical Research Institute of Barcelona, Barcelona Science Park, University of Barcelona, E 08028 Barcelona, Spain
    Eur J Immunol 34:2257-67. 2004
    ..Our results show that growth factors in macrophages use two pathways: one for proliferation, mediated by ERK, and the other for survival, which requires the PI-3K/Akt kinases and p21(Waf1)...
  12. ncbi Nuclear receptor signaling in macrophages
    Annabel F Valledor
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0651, USA
    Biochem Pharmacol 67:201-12. 2004
    ..Identification of their mechanisms of action should help guide the development of new therapeutic agents useful in the treatment of diseases in which macrophages play critical pathogenic roles...
  13. ncbi Macrophage colony-stimulating factor-dependent macrophage proliferation is mediated through a calcineurin-independent but immunophilin-dependent mechanism that mediates the activation of external regulated kinases
    Monica Comalada
    Group of Macrophage Biology, Biomedical Research Institute of Barcelona, Barcelona Science Park, University of Barcelona, Barcelona, Spain
    Eur J Immunol 33:3091-100. 2003
    ..First, we showed that in M-CSF-dependent proliferation calcineurin is not involved, and second, that immunophilins play a key role and their activation blocks ERK activation...
  14. ncbi Decorin reverses the repressive effect of autocrine-produced TGF-beta on mouse macrophage activation
    Monica Comalada
    Group of Macrophage Biology, Biomedical Research Institute of Barcelona Sciences Park, Barcelona, Spain
    J Immunol 170:4450-6. 2003
    ..The increase in activation mediated by decorin demonstrates that macrophages are under negative regulation that can be reversed by proteins of the extracellular matrix...
  15. doi IFN-{gamma}-mediated inhibition of MAPK phosphatase expression results in prolonged MAPK activity in response to M-CSF and inhibition of proliferation
    Annabel F Valledor
    Nuclear Receptor Group, Department of Physiology, School of Biology, University of Barcelona, Barcelona, Spain
    Blood 112:3274-82. 2008
    ..These data suggest that subtle changes in the time course of activity of members of the MAPK family contribute to the antiproliferative effects of IFN-gamma in macrophages...